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小窝的作用机制及其影响通路

临床肾脏病杂志 2024年第5期24卷 412-416页

作者：杜秀徐琳程苏王艳茹邵命海上海中医药大学附属曙光医院肾病科上海201203 上海中医药大学中医肾病研究所上海201203 上海中医药大学肝肾疾病病症教育部重点实验室上海201203 上海市中医临床重点实验室上海201203

小窝(Caveolae)作为跨细胞途径的重要组成部分,在不破坏细胞稳态的基础上,实现物质的跨细胞转运。在肾脏中,血清大分子物质如白蛋白通过小窝穿越肾小球滤过屏障。白蛋白的跨细胞运输在蛋白尿的病理学中起到至关重要的作用,其中小窝的重... 详细信息

小窝(Caveolae)作为跨细胞途径的重要组成部分,在不破坏细胞稳态的基础上,实现物质的跨细胞转运。在肾脏中,血清大分子物质如白蛋白通过小窝穿越肾小球滤过屏障。白蛋白的跨细胞运输在蛋白尿的病理学中起到至关重要的作用,其中小窝的重要性也不言而喻。然而,肾脏中小窝影响白蛋白跨细胞运输的作用机制及其信号通路在很大程度上仍然未知。本文总结了近年来小窝影响白蛋白跨细胞运输的调控研究,了解其相关作用机制与影响通路可能在预防和减轻蛋白尿中提供潜在的治疗靶点。

关键词：小窝小窝蛋白血管生成素类血管内皮生长因子

Determination of the toxicities of 16 Halogenated Benzenes to Photobacterium Phosphoreum and 2D- and 3D-QSAR Studies

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1007-1014页

作者： CAO Si-tong WANG xiu LIU Hong-Xia y.NG Guo-y.ng WANG Zun-y.o Garment andArt Design College Jiaxing University Jiaxing Zhefiang 314001 China Biological and Chemical Engineering College Jiaxing Zhejiang 314001 China

In this paper we take photobacterium phosphoreum （t3） as the experimental bacteria, and determine the half-inhibitory.concentration （-1gEC50） against the photobacterium phosphoreum of 16 halogenated benzenes. Using B3Ly. method of DFt in the Gaussian 03 program, we obtain the structural and thermody.amic descriptors of 16 halogenated benzenes by.fully.optimized calculation at the 6-311G＊＊ level. taking the structural and thermody.amic descriptors as theoretical descriptors, the 2D QSAR model （R2 = 0.983） was established, which can be utilized to predict -lgEC50 of halogenated benzene according to the corrected linear solvation energy.theory.based on the experimental data of-lgECs0. In addition, the relationship between the toxicity.and 3D spatial structure of the compound is studied by.comparing the molecular similarity.index analy.is （CoMSIA） of 3D-QSAR method. By.cross validation, the correlation coefficient q2 of CoMSIA model is 0.687, and the conventional correlation coefficient R2 = 0.958. the model is stable and reliable with great predictive ability. the 3D-QSAR model shows that the toxicity.of halogenated benzene compound is mainly.affected by.the characteristics of hy.rophobie field of the substituted halogens.

关键词： halogenated benzene toxicity.(-lgEC50) DFt QSAR

微尺度催化燃烧器中扩散“火焰街”的数值模拟研究

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热能动力工程 2022年第9期37卷 136-142页

作者：叶修斌康鑫武汉理工大学船海与能源动力工程学院湖北武汉430063 武汉理工大学土木工程与建筑学院湖北武汉430070

针对三维y.微通道内的非预混催化燃烧,选择GRI-Mech 3.0气相反应机理与Deutschmann表面催化机理开展了数值模拟研究,分析铂催化剂涂覆位置、催化剂涂覆面积等因素对通道内特殊“火焰街”现象的影响。结果表明:通道内壁面涂覆一定面积... 详细信息

针对三维y.微通道内的非预混催化燃烧,选择GRI-Mech 3.0气相反应机理与Deutschmann表面催化机理开展了数值模拟研究,分析铂催化剂涂覆位置、催化剂涂覆面积等因素对通道内特殊“火焰街”现象的影响。结果表明:通道内壁面涂覆一定面积的铂催化剂可以显著改善燃烧器性能,提升其甲烷转换率以及燃烧效率;相较于内壁面催化剂全涂覆或通道后段局部涂覆的情况,当催化剂仅涂覆于通道前段局部时,甲烷转化率与燃烧效率的提升幅度达到最大,分别为3.5%与7%。

关键词：微尺度燃烧扩散火焰催化反应火焰街

Scheme for Implementation of Ancillary.Free 1→3 Optimal Phase-Covariant Quantum Cloning with trapped Ions

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Communications in theoretical Phy.ics 2008年第6期49卷 1499-1501页

作者： y.NG Rong-Can LI Hong-Cai LIN xiu HUANG Zhi-Ping XIE Hong School of Phy.ics and Opto-Electronics technology Fujian Normal University Fuzhou 350007 China

We propose a simple scheme for the implementation of the ancillary.free 1→3 optimal phase-covariant quantum cloning for x-y.equatorial qubits in ion-trap sy.tem. In the scheme, the vibrational mode is only.virtually.excited, which is very.important in view of decoherence. the present proposal can be realized based on current available technologies.

关键词： ancillary.free phase-covariant quantum cloning trapped ions

不同角度对X-Rite’s Shade Vision系统测量结果的影响

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口腔医学 2006年第5期26卷 363-367页

作者：林芝张秀华刘丽朱形好郑顺友 y.LI 温州医学院附属第一医院口腔科浙江大学医学院附属口腔医院修复科 LomaLinda Uni-versity.Loma Linda CA USA 92350

目的观察不同角度对X-Rite’s ShadeVision系统测量比色板结果的影响。方法将一副新的Vita16色比色板固定在粉红色的蜡中。X-Rite’s ShadeVision系统分别在平行于比色板唇面,5°、10°、15°向左右侧和切向、龈向倾斜时测量颜色,以L*,a... 详细信息

目的观察不同角度对X-Rite’s ShadeVision系统测量比色板结果的影响。方法将一副新的Vita16色比色板固定在粉红色的蜡中。X-Rite’s ShadeVision系统分别在平行于比色板唇面,5°、10°、15°向左右侧和切向、龈向倾斜时测量颜色,以L*,a*,b*及Vita16色比色板色片颜色表示测量结果。计算ΔL,Δa,Δb和ΔE*ab,数据用单因素方差分析。结果向右倾斜5°、10°、15°时L*值分别减少0.22,0.97和0.93,而向左倾斜L*增加;垂直向角度改变时,L*值增加;最大的ΔL值在向龈向倾斜15°(2.84)和向切向倾斜15°(2.37),这导致相应位置出现最大的ΔE*ab(3.22±0.37)和(2.50±0.63),15°向左和右倾斜时,ΔE*ab分别为1.87±0.59和1.20±0.25。与其他位置比较,向龈向和切向15°时,ΔE*ab明显高(Pte’sShadeVision测量时,正确的测量位置对获得准确的测量结果非常重要,角度的偏移,尤其是垂直向的倾斜会影响测量结果。

关键词： X—Rite’s ShadeVision系统测量比色板

Determination of zidovudine using anion exchange chromatography.with integrated pulsed amperometric detection

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Chinese Chemical Letters 2012年第6期23卷 715-718页

作者： y. Chen y. xiu Liu Zhi Dong Chen Mei Lan Chen y.n Zhu Hangzhou Vocational and technical College Hangzhou 310018 China School of Chemist.y.and Chemical Engineering Changzhou University Changzhou 213164 China College of Biology.and Envinonment Engineering. Zhejiang Shuren University l-langzhou 310015 China Department of Chemistry Zhejiang University Hangzhou 310028 China

A rapid and practical method for direct detection of zidovudine in high performance anion exchange chromatography.（HPAEC） has been developed with integrated pulsed amperometric detection （IPAD）. Dionex AS18 （250mm × 2mm） and AG18 （50 mm× 2 mm） columns and 11 mmol/L NaOH solution were used for separation. Multi-step potential waveform parameters were optimized to maximize the signal-to-noise ratio （S/N）. Utilizing an optimized waveform, the repeatability.（intra-day. precision and intermediate （inter-day. precision are obtained with relative standard deviation （RSD） of 1.88, 2.27, respectively. the limit of quantification （LOQ） and limit of detection （LOD） were found to be 9.70, 3.0 ng/mL, respectively. with correlation coefficients of 0.9992 over concentration range 0.01-10 μg/mL. the present method was successfully.applied to the determination of zidovudine in human plasma. the recoveries of plasma sample spiked by.0.7 μg/mL, 2.7 μg/mL obtained were 95.3-101.5%, with relative standard deviation （RSD） of 2.54%, 2.21%, respectively.

关键词： Zidovudine AIDS Integrated pulsed amperometry High performance anion exchange chromatography Plasma

Searching for low-cost Li_(x)MO_(y.compounds for compensating Li-loss in sintering of Li-Garnet solid electroly.e

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Journal of Materiomics 2019年第2期5卷 221-228页

作者： Xiao Huang Zhen Song tongping xiu Michael E.Badding Zhaoy.n Wen CAS Key.Laboratory.of Materials for Energy.Conversion Shanghai Institute of CeramicsChinese Academy of ScienceShanghai200050China Corning Research Center China 200 Jinsu RoadShanghai201206China Corning Incorporated CorningNY14831USA University.of Chinese Academy.of Sciences 19 A Yuquan RdShijingshan DistrictBeijing100049China

Cubic Li-Garnet Li_(7)La_(3)Zr_(2)O_(12)(c-LLZO)is one of the promising solid-state electroly.e candidates for the next generation high safety.solid-state ***,preparing the electroly.e has many.***-loss during high temperature sintering is one of *** powder with the same component of green garnet pellets is often used to co-fire with the pellets to compensate the *** to the high weight ratio of rare earth element La and non-recy.lability.of mother powder,it is wort.y.to explore low-cost mother powders to replace *** this paper,low cost compounds such as Li_(5)AlO_(4),Li_(2)tiO_(3),Li_(2)SiO_(3),Li4SiO_(4)and(Li_(2)O)x-(ZrO_(2))_(1-x)(x=0.6-0.8)are investigated for substitution of the mother powder for compensating Li-loss during the sintering of *** Li_(6.4)La_(3)Zr_(1.4)ta_(0.6)O_(12)(LLZtO)samples have been prepared by.sintering with(Li_(2)O)0.733(ZrO_(2))0.267 powder at 1150℃for 5 h with the relative density.of 95%and conductivity.of 5.7×10^(-4)S cm^(-1)at 25℃,which show same performance with LLZtO ceramics sintered with LLZO mother powder.

关键词： Li-garnet c-LLZO Solid electroly.e Li-loss Low-cost Sintering

兼抗河北省茎基腐病致病菌小种的小麦种质筛选

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河北农业科学 2024年第4期28卷 68-76页

作者：康旭王晓彤李国良张华宁孟祥照刘子会马贞玉郭秀林赵敏段硕楠河北工程大学园林与生态工程学院河北邯郸056038 河北省农林科学院生物技术与食品科学研究所/河北省植物转基因中心重点实验室河北石家庄050051

发掘小麦种质资源中具有茎基腐病(Fusarium crown rot,FCR)抗性的品种,可以为小麦抗茎基腐病研究和抗病品种选育提供抗病材料。首先,以黄淮麦区小麦茎基腐病高致病力假禾谷镰刀菌(Fusarium psendograminearum,Fp)菌株WZ-8A为接种致病菌... 详细信息

发掘小麦种质资源中具有茎基腐病(Fusarium crown rot,FCR)抗性的品种,可以为小麦抗茎基腐病研究和抗病品种选育提供抗病材料。首先,以黄淮麦区小麦茎基腐病高致病力假禾谷镰刀菌(Fusarium psendograminearum,Fp)菌株WZ-8A为接种致病菌,利用病情指数(disease index,DI),对来自国内外不同生态区的260份小麦品种进行3次苗期温室小麦茎基腐病抗病鉴定,结果显示,没有免疫和高抗的小麦材料,有中等抗性材料1份(轮选49,DI为16.67)、低抗材料80份、中感材料153份、高感材料26份。随后,以筛选出的具有良好抗性(DI≤27.50)的14份小麦品种为供试材料,分别接种分离于河北省不同地区且具有不同遗传背景的4个小麦茎基腐病致病菌小种,通过苗期抗病性评价获得兼抗多个河北省小麦茎基腐病小种的小麦种质,结果显示,衡y.6观164、农大2011、茶淀红对4个致病菌小种的平均DI较低,综合抗病性较好。衡y.6观164、农大2011、茶淀红可以为河北省小麦茎基腐病研究和抗病品种选育提供抗病材料。

关键词：假禾谷镰刀菌小麦茎基腐病抗性评价种质筛选兼抗

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Influence of acid leaching and calcination on iron removal of coal kaolin

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International Journal of Minerals,Metallurgy.and Materials 2014年第4期21卷 317-325页

作者： Pei-wang Zhu Wei-qiang Zeng xiu-lin Xu Le-ming Cheng Xiao Jiang Zheng-lun Shi State Key.Laboratory.of Clean Energy.Utilization Zhejiang University

Calcination and acid leaching of coal kaolin were studied to determine an effective and economical preparation method of calcined kaolin. thermogravimetric-differential thermal analy.is （tG-DtA） and X-ray.diffraction （XRD） demonstrated that 900＆#176;C was the suitable temperature for the calcination. Leaching tests showed that hy.rochloric acid was more effective for iron dissolution from raw coal kaolin （RCK）, whereas oxalic acid was more effective on iron dissolution from calcined coal kaolin （CCK）. the iron dissolution from CCK was 28.78wt%, which is far less effective than the 54.86wt% of RCK under their respective optimal conditions. through analy.is by.using M？ssbauer spectroscopy. it is detected that nearly.all of the structural ferrous ions in RCK were removed by.hy.rochloric acid. However, iron sites in CCK changed slight.y.by.oxalic acid leaching because nearly.all ferrous ions were transformed into ferric species after firing at 900＆#176;C. It can be concluded that it is difficult to remove the structural ferric ions and ferric oxides evolved from the structural ferrous ions. thus, iron removal by.acids should be conducted prior to calcination.

关键词： kaolin iron removal calcination acid leaching extraction MSssbauer spectroscopy