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Effect of Input Waveform to Vibration Speaker on Sound Quality of Electric Artificial Voice

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Sound & Vibration 2020年第2期54卷 85-98页

作者： t.Asakura K.shindo tokyo University of Science Chiba278-8510Japan

A number of studies have been conducted on the improvement of the sound quality of electrical artificial laryngeal speech,the speech produced has been difficult to hear compared to a natural *** this reason,it is necessary to effectively improve the frequency characteristics of the input *** the present study,to improve the sound quality of vocalization using an electrical artificial larynx,first,a comparison of the frequency characteristics between the real and artificial voices was conducted,and three filters that can make the frequency characteristics of the artificial voice closer to those of a real voice were ***,the influence of these filters on the quality of the artificial voice was investigated via physical measurement and a subjective evaluation experiment targeted at Japanese five *** was found that the intelligibility of artificial/a/and/o/sounds was improved,whereas little improvement was observed in the case of/i/,/u/,and/e/.the obtained results confirmed the effect of optimizing the input signal into the vibration speaker and indicated areas for further improvement.

关键词： Electriolaryngeal voice intelligibility naturalness loudness

Computed tomography and magnetic resonance imaging features of lipid-rich neuroendocrine tumors of the pancreas

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World Journal of Gastroenterology 2015年第34期21卷 10008-10017页

作者： Yoshihiko Fukukura toshikazu shindo Michiyo Higashi Koji takumi tomokazu Umanodan tomohide Yoneyama takashi Yoshiura De-partment of Radiology Kagoshima University Graduate School of Medical and Dental Sciences Department of Human Pathology Kagoshima University Graduate School of Medical and Dental Sciences

AIM:to clarify the computed tomography(Ct) and magnetic resonance imaging(MRI) characteristics of lipid-rich pancreatic neuroendocrine tumors(Pan NEts).MEtHODS:Enhanced Ct and MRI performed before pancreatectomy in 29 patients with 34 histologicallyconfirmed Pan NEts was retrospectively reviewed. tumor attenuation on Ct and signal intensities on conventional(t1- and t2-weighted) and chemical shift MRI were qualitatively analyzed and compared alongside adipose differentiation-related protein(ADRP) immunostaining(ADRP-positive:lipid-rich; ADRP-negative:non-lipid-rich) results using Fisher's exact test or the Mann-Whitney U test. Signal intensity index on chemical shift MRI was quantitatively ***:there were 15 lipid-rich Pan NEts(44.1%) in 12 patients(41.4%). tumor attenuation during the early,portal venous,and delayed phases of enhanced Ct(P = 0.888,0.443,and 0.359,respectively) and signal intensities on conventional MRI(P = 0.698 and 0.798,respectively) were not significantly differentbetween lipid-rich and non-lipid-rich Pan NEts. Four of the 15 lipid-rich Pan NEts exhibited high signal intensity on subtraction chemical shift MRI,and the association of high signal intensity on subtraction imaging with lipid-rich Pan NEts was significant(4 of 15 lipid-rich Pan NEts,26.73%,vs 0 of 19 non-lipid-rich Pan NEts,0%,P = 0.029). Lipid-rich Pan NEts showed a significantly higher signal intensity index than non-lipidrich Pan NEts(0.6% ± 14.1% vs-10.4% ± 14.4%,P = 0.004). Eight of 15 lipid-rich Pan NEts,vs 0 of 19 nonlipid-rich Pan NEts,had positive signal intensity index values in concordance with lipid contents.C O N C L U S I O N :C t c o n t ra s t e n h a n c e m e n t a n d conventional MR signal intensities are similar in lipidrich and non-lipid-rich Pan NEts. Chemical shift MRI can demonstrate cytoplasmic lipids in Pan NEts.

关键词： Neoplasms Chemical shift magnetic resonance imagin

Clinical characteristics and treatment outcomes of patients with small cell carcinoma of the urinary bladder

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Current Urology 2022年第3期16卷 136-141页

作者： takashi Muranaka Kohei Hashimoto tetsuya shindo Kosuke Shibamori Yuki Kyoda Ko Kobayashi toshiaki tanaka Naoya Masumori Department of Urology Sapporo Medical University School of MedicineSapporo060-8543Japan

Background:Small cell carcinoma of the urinary bladder(SCUB)is *** optimal treatment for SCUB remains *** address the problem of appropriate treatment for each case,we assessed single-modality and surgery-based multimodality treatments in patients with *** and methods:We retrospectively reviewed the medical records of 12 patients with SCUB between 1990 and *** pa-tients underwent transurethral resection of the bladder tumor and were diagnosed with *** clinicopathological characteristics were assessed,and the outcomes were compared according to the treatment ***:the median(range)age at diagnosis was 66 years(range,53-85 years).t1-4N0M0 was observed in 8 patients(66%),N1-3M0 in 2(17%),and NanyM1 in 2(17%).After transurethral resection of the bladder tumor,6 patients(50%)underwent cystectomy alone,and 4(33%)underwent cystectomy and presurgical or adjuvant chemotherapy with etoposide and *** the median follow-up period of 20.7 months,6 patients(50%)died of cancer,and 2 patients(17%)died of other *** median overall survival period was 1.9 *** 5-year overall survival rate in patients who underwent cystectomy and chemotherapy was 75%,whereas that in those who underwent cystectomy alone and transurethral resection alone were 22%and 0%,respectively(p=0.012).Recurrence-free survival was significantly correlated with cause-specific survival(r=0.95;95%confidence interval,0.81-0.99;ptectomy with chemotherapy using the etoposide and cisplatin regimen improved the prognosis of patients with SCUB and *** time from initial progression to death due to cancer was very short,indicating that the initial treatment strategy is crucial.

关键词： Bladder cancer Small cell carcinoma treatment Chemotherapy Radical cystectomy

Is the CD4/CD8 Ratio an Effective Indicator for Clinical Estimation of Adoptive Immunotherapy for Cancer treatment?

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Journal of Cancer therapy 2013年第8期4卷 1382-1390页

作者： Goki shindo takayoshi Endo Masamitsu Onda Shigenori Goto Yoju Miyamoto toru Kaneko Cardiothoracic Department Meditopia Numazu Clinic Numazu Japan Department of Immunotherapy Seta Clinic Shin-Yokohama Yokohama Japan Department of Immunotherapy Seta Clinic Tokyo Tokyo Japan

Background: the importance of immunotherapy in cancer treatment has been increased owing to its non-toxicity and application to personalized medicine. However, precise estimation indices of immunotherapy have yet to be established. to determine effective evaluation indices of immunotherapy for cancer treatment, we analyzed the CD4/CD8 ratio under various conditions in clinical patients with advanced cancer. Patients and Methods: thirty-four patients who underwent one course of adoptive activated immunotherapy with or without additional conventional chemotherapy were enrolled. Before and after one course of immunotherapy, changes in the CD4/CD8 ratio were estimated by flow cytometry. Results: All patients showed a tendency toward a decrease in the CD4/CD8 ratio during a 3-month period after one course of adoptive activated t lymphocyte immunotherapy. Patients who had undergone prior surgery showed a remarkable increase in CD8 t cell number. thus, adoptive activated t lymphocyte immunotherapy improves immunological ability against cancer invasion. the Eastern Cooperative Oncology Group’s performance status during one course of immunotherapy was significantly improved in the antecedent surgery group, with no evidence of improved PS in the non-antecedent surgery group. Patients with an increased CD4/CD8 ratio (n = 6) may have a worse outcome during adoptive activated t lymphocyte immunotherapy even with an additional course of immunotherapy. Improved actuarial survival rate of patients in the antecedent surgery group showed significant long-term benefit compared to those in the non-antecedent surgery group (p = 0.0298), as previously reported. Conclusion: the CD4/CD8 ratio is a significant indicator of outcome of adoptive activated t lymphocyte immunotherapy.

关键词： Immunotherapy Adoptive Activated t Lymphocyte therapy Flow Cytometry Performance Status Advanced Cancer

干扰素-拉米夫定联合治疗HBeAg阳性的慢性乙肝可以减少早期感染的肝细胞数量,并可使血清转换率升高

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 53-54页

作者： shindo M. Hamada K. Muramatsu A. 宋平 Liver Diseases Section Akashi Municipal Hospital1-33 TakashoumachiAkashi 673-8501Japan

Background:It has been found that the efficacy of lamivudine(LAM)therapy can be improved by preceding administration with a short course of corticosteroid that induces a flare of the disease upon its *** of the side effects of corticosteroid,we tested the effect of a short course of interferon(IFN)as the primer instead of prednisolone,which was followed by LAM when the hepatitis flare *** incidence of LAM resistance mutations and the effect of core promoter and precore mutations on the durability of the responses were also ***:Patients treated with interferon(IFN)-LAM therapy(n = 73)were compared to those treated with IFN alone(n = 117).the IFN-LAM group received IFN-α6 MU/day,*** a 3-month ***(10mg/day during 1 year)was started when IFN withdrawal hepatitis occurred during 2-10 months after stopping *** LAM-resistant,core promoter,and precore mutations were examined by ***:(1)the IFN-LAM group developed exacerbated hepatitis following IFN withdrawal in 63 patients before starting LAM *** seroconversion(SC)rate was significantly higher in the IFN-LAM group than in the IFN-alone group(61%vs 26%,P = 0.0001).(2)the LAM resistance mutation rate was 31%at 1 year after initiating LAM therapy.(3)In a stepwise discriminant-function analysis,decreased level of HBeAg determined at 4 weeks after LAM administration and increased level of HBeAb before the start of LAM administration contributed significantly on seroconversion to anti-HBe(P = 0.0073 and 0.004,respectively).(4)the reappearance rate of HBeAg within 6 months after the therapy(relapse)was 33%in the IFN-LAM group and 10%in the IFN-alone *** prevalence of core promoter and precore mutations did not change before and after the therapy,nor did these mutations correlate with the relapse after stopping IFN-LAM ***:(1)Our findings suggest that early reduction of infected hepatocytes expressed by HBeAg by LAM may contribute to a

关键词： HBeAg阳性联合治疗拉米夫定干扰素慢性乙肝血清转换率细胞数量早期感染

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胰腺腺癌扩散加权MRI的不同表现

国际医学放射学杂志 2012年第4期 384-384页

作者： Y. Fukukura K. takumi K. Kamimura t. shindo Y. Kumagae A. tateyama 唐光健 Department of Radiology Kagoshima University RSNA 2012 Graduate School of Medical and Dental Sciences8 -35 -1 Sakuragaoka Kagoshima 890 -8544 Japan

摘要目的对照扩散加权MR影像上表现为边界清楚高信号(清楚高信号)的胰腺腺癌与表现为非清楚高信号的胰腺腺癌的表观扩散系数(ADC)。材料与方法学院审查委员会批准此项检查或免除知情同意通知。80例组织学证实的胰腺腺癌(肿瘤平均大小为3... 详细信息

摘要目的对照扩散加权MR影像上表现为边界清楚高信号(清楚高信号)的胰腺腺癌与表现为非清楚高信号的胰腺腺癌的表观扩散系数(ADC)。材料与方法学院审查委员会批准此项检查或免除知情同意通知。80例组织学证实的胰腺腺癌(肿瘤平均大小为32mm)病人接受了脂肪抑制单次激发回波平面

关键词：扩散加权胰腺 MRI 腺癌腺瘤

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帕金森病随意收缩时腱反射调节异常

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 29-29页

作者： Morita H. shindo M. Ikeda S.-I. 高中宝 third Department of Medicine Shinshu University School of MedicineAsahi 3-1-1 Matsumoto 390-8621 Japan

Objective: Inadequate supraspinal modulation of spinal motor control mechanism s such as α-γcoactivation is supposed to cause difficulty in maintaining prop er voluntary contraction in Parkinson’s disease (PD). Methods: Subjects were 42 patients with PD and 20 normal volunteers. Soleus H-reflex and tendon tap refl ex (t-reflex) were recorded. the maximal reflexes (Hmax and tmax) at rest were recorded first. Next, the stimulus intensities were fixed to obtain a reflex siz e of around 25%of Mmax at rest for both H-and t-reflexes, and the reflexes we re recorded at rest, during tonic plantarflexion (tPF), and at the onset of plan tarflexion. Results: Hmax at rest was 55%and tmax 30%in normal subjects, while they were 36 and 31%, respectively,in PD. the size ratio of tmax and Hmax at r est in PD was larger than normal. In PD, the size of H-reflex increased with tP F as in normal subjects, but t-reflex decreased. these changes in t-reflex wer e correlated with the grade of rigidity, bradykinesia,and time for 10 m gait. H -reflex had no such ***: t-reflex was abnormally modulate d in PD especially during tonic contraction. Significance: Inappropriate suprasp inal modulation of the spinal reflex pathways disturbs motor performance in PD.

关键词：帕金森病腱反射脊髓反射正常受试者跖屈比目鱼肌反射活动刺激强度时间相关

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