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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel f.López-Aranda Juan f.López-téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNf).A knockdown of BDNf gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNf-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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实体与程序双重视角下股东权益的司法保护——以“股东代表诉讼”为切入点

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法学论坛 2024年第1期39卷 103-114页

作者：贺茜中国海洋大学法学院山东青岛266100

公司法赋予股东诉权以保护自身权益,遏制权利滥用,股东代表诉讼已成为化解有限责任公司股东利益冲突的重要手段。司法实践分析表明,股东代表诉讼前置程序的定位、损害赔偿请求的归属以及裁判效力的主观范围等在实体上和程序上均有争议... 详细信息

公司法赋予股东诉权以保护自身权益,遏制权利滥用,股东代表诉讼已成为化解有限责任公司股东利益冲突的重要手段。司法实践分析表明,股东代表诉讼前置程序的定位、损害赔偿请求的归属以及裁判效力的主观范围等在实体上和程序上均有争议。从实体法理论角度而言,立基于股份有限公司的理论预设无法与两权分离不明显的有限责任公司融洽,致使股东代表诉讼无法发挥保护公司和股东利益的制度目的,股东提起诉讼激励不足。从程序法理论角度而言,作为特殊诉讼形态的股东代表诉讼亦需与我国诉讼理论相融合。然而,既有理论无法通过诉讼担当完整表达有限责任公司股东代表诉讼的双重利益性,未能合理配置特定股东的诉讼实施权,诉讼成本与诉讼收益不匹配。在有限责任公司内部治理陷入困境的情形下,应当对股东权益进行穿透式司法保护,允许法官直接豁免前置程序,赋予原告股东基于持股比例的胜诉利益分取请求权,方能给予弱势股东实质性救济。

关键词：股东代表诉讼少数股东诉讼担当前置程序

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Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice

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Asian Pacific Journal of tropical Biomedicine 2024年第5期14卷 199-206页

作者： Lucelina S.Araújo Bruno B.Silva Eduarda N.f.N.Santos Arnaldo S.Bezerra Samuel S.frota Assis R.Montenegro Eridan O.P.t.florean Maurício fvan tilburg Maria Izabel f.Guedes Laboratory of Biotechnology and Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil faculty of Veterinary Medicine State University of CearáFortalezaBrazil

Objective:to evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum,and a purified ***:Mice were subjected to the following treatments:(1)Purified recombinant K39(rK39)protein at a 20μg dose with complete freund’s adjuvant;(2)Inactivated Escherichia coli(BL21 DE3)carrying the K39 protein at an equivalent total protein content of 200μg;(3)Inactivated bacteria lacking the K39 protein;(4)Non-immunized control *** monitoring was *** groups were challenged by intraperitoneal injection of 10^(7) Leishmania infantum *** euthanasia,the liver and spleen were collected to analyze the levels of tNf,IfN-γ,IL-12,IL-4,and ***:Mice immunized with purified rK39 or the inactivated bacterial vector carrying the K39 antigen of Leishmania infantum showed a long-lasting immune response with high levels of polyclonal antibodies specifically recognizing the recombinant *** IgG1 subclass was the predominant immunoglobulin;however,the induction of IgG2a and the profile of cytokines produced were indicative of the induction of a mixed-type ***:the inactivated bacterial vector carrying the K39 antigen,as well as the purified antigen can induce a long-lasting immune response in immunized mice,predominantly favouring a th2 profile response.

关键词： Visceral leishmaniasis K39 Inactivated bacterial vector Vaccine Immune response th1 th2 Leishmania infantum

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Crucial role played by CK8^(+)cells in mediating alveolar injury remodeling for patients with COVID-19

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Virologica Sinica 2024年第3期39卷 390-402页

作者： Yufeng Li Hengrui Hu Jia Liu Longda Ma xi Wang Liang Liu Qian Liu Liang Ren Jiang Li fei Deng Zhihong Hu Yiwu Zhou Manli Wang State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Department of forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan430010China University of the Chinese Academy of Sciences Beijing100049China

the high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after *** address this concern,comparative and systematic analyses of SARS-CoV-2 infection in COVID-19 patients and animals were *** the lungs of nine patients who died of COVID-19 and one recovered from COVID-19 but died of unrelated disease in early 2020,damage-related transient progenitor(DAtP)cells expressing CK8 marker proliferated *** CK8^(+)DAtP cells were derived from bronchial CK5^(+)basal ***,they showed different cell fate toward differentiation into type I alveolar cells in the deceased and convalescent patients,*** using a self-limiting hamster infection model mimicking the dynamic process of lung injury remodeling in mild COVID-19 patients,the accumulation and regression of CK8t cell marker were found to be closely associated with the disease ***,we examined the autopsied lungs of two patients who died of infection by the recent Omicron variant and found that they only exhibited mild pathological injury with no CK8^(+)cell *** results indicate a clear pulmonary cell remodeling route and suggest that CK8^(+)DAtP cells play a primary role in mediating alveolar remodeling,highlighting their potential applications as diagnostic markers and therapeutic targets.

关键词： SARS-CoV-2 CK8t DAtP cells Cell proliferation Lung injury-remodeling Autopsy Hamster infection model

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In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

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Particuology 2024年第3期86卷 304-312页

作者： Simon Aβmann franz J.t.Huber Stefan Will Lehrstuhl für technische thermodynamik(Ltt) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical technologies(SAOt) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(ttIP)and iron oxide from iron(II)nitrate nonahydrate(INN)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating Mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of ttIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate INN leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis Metal oxide particles Elastic light scattering Droplet size distribution Nanoparticle morphology Particle size distribution

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Chromosome-level genome assembly of the glass catfish(Kryptopterus vitreolus)reveals molecular clues to its transparent phenotype

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Zoological Research 2024年第5期45卷 1027-1036页

作者： Chao Bian Rui-Han Li Zhi-Qiang Ruan Wei-ting Chen Yu Huang Li-Yue Liu Hong-Ling Zhou Cheong-Meng Chong xi-Dong Mu Qiong Shi Laboratory of Aquatic Genomics College of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong 518057China Key Laboratory of Prevention and Control for Aquatic Invasive Alien Species Ministry of Agriculture and Rural AffairsGuangdong Modern.Recreational Fisheries Engineering Technology CenterPearl River Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong 510380China Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineShenzhenGuangdong 518081China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengduSichuan 610041China School of Life Sciences Jiaying UniversityMeizhouGuangdong 514015China China Zebrafish Resource Center National Aquatic Biological Resource CenterState Key Laboratory of Freshwater Ecology and BiotechnologyInstitute of HydrobiologyChinese Academy of ScienceWuhanHubei 430072China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518116China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoMacao 999078China Center for Aquatic Genomics College of Life SciencesNeijiang Normal UniversityNeijiangSichuan 641100China

Glass catfish(Kryptopterus vitreolus)are notable in the aquarium trade for their highly transparent body *** transparency is due to the loss of most reflective iridophores and light-absorbing melanophores in the main body,although certain black and silver pigments remain in the face and *** date,however,the molecular mechanisms underlying this transparent phenotype remain largely *** explore the genetic basis of this transparency,we constructed a chromosome-level haplotypic genome assembly for the glass catfish,encompassing 32 chromosomes and 23344 protein-coding genes,using PacBio and Hi-C sequencing technologies and standard assembly and annotation *** revealed a premature stop codon in the putative albinism-related tyrp1b gene,encoding tyrosinase-related protein 1,rendering it a nonfunctional ***,a synteny comparison with over 30 other fish species identified the loss of the endothelin-3(edn3b)gene in the glass catfish *** investigate the role of edn3b,we generated edn3b^(−/−)mutant zebrafish,which exhibited a remarkable reduction in black pigments in body surface stripes compared to wild-type *** findings indicate that edn3b loss contributes to the transparent phenotype of the glass *** high-quality chromosome-scale genome assembly and identification of key genes provide important molecular insights into the transparent phenotype of glass *** findings not only enhance our understanding of the molecular mechanisms underlying transparency in glass catfish,but also offer a valuable genetic resource for further research on pigmentation in various animal species.

关键词： Glass catfish Whole-genome sequencing edn3b−/−mutant transparent phenotype

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基于PLUS-InVESt-Geodector模型的三江源国家公园碳储量时空变化及驱动力

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环境科学 2024年第10期45卷 5931-5942页

作者：贾天朝胡西武青海民族大学经济与管理学院天津大学-青海民族大学双碳研究院

探究三江源国家公园生态系统固碳服务功能时空变化、驱动力及其未来发展趋势，对实现区域生态保护与可持续发展具有重要意义.以5 a为间隔选取三江源国家公园1990～2020年间7期历史土地利用数据，基于PLUS-InVESt-Geodector模型，分析三... 详细信息

探究三江源国家公园生态系统固碳服务功能时空变化、驱动力及其未来发展趋势，对实现区域生态保护与可持续发展具有重要意义.以5 a为间隔选取三江源国家公园1990～2020年间7期历史土地利用数据，基于PLUS-InVESt-Geodector模型，分析三江源国家公园历史碳储量时空变化情况，结合多方面因子对其历史碳储量时空分异驱动力进行探析，并在自然发展和生态保护情景下对2030年三江源国家公园碳储量进行预测.结果表明：(1) 1990～2020年三江源国家公园碳储量呈“增加-减少-增加-减少”波动型变化特征，总体上碳储量增加41.85×10～6 t，草地是贡献度最大的地类.(2)1990～2020年三江源国家公园碳储量空间分布总体特征变化不大，空间分布演化状态较为平稳，长江源园区∶澜沧江源园区∶黄河源园区多年平均碳储量贡献率为7∶1∶2，这与其园区面积比例大致相当.(3)1990～2020年三江源国家公园碳储量时空分异的主要驱动因子为fVC、土壤类型和年降水量，各驱动因子交互探测均呈现双因子增强和非线性增强作用.(4)2020～2030年，自然发展情景和生态保护情景下三江源国家公园碳储量分别下降4.87%和3.98%，生态保护情景下的碳储量减少抑制作用明显.研究结果可为三江源国家公园未来国土空间规划，提升陆地生态系统碳储量提供数据支撑.

关键词：碳储量时空分异 PLUS模型 InVESt模型三江源国家公园

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A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： Ping Yu tanwei Gu Yueyang Rao Weimin Liang xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng tu Lan tang Xuefeng Zhou Guangdong Provincial Key Laboratory of New Drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key Laboratory of tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMPA Key Laboratory for Research and Evaluation of Drug Metabolism School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S14,targeting peroxiredoxin 1(PRDX1).By binding to Cys83 of PRDX1 and augmenting its peroxidase activity,S14 alleviates kidney injury efficiently in Prdx1-overexpression(Prdx1-OE)***,S14 also increases PRDX1 nuclear translocation and directly activates the Nrf2/HO-1/NQO1 pathway to inhibit ROS *** to the limited druggability of S14 with low bioavailability(2.6%)and poor renal distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticle system is constructed to load S14 for precise treatment of AKI.L-Serine conjugation to chitosan imparts specificity to kidney injury molecule-1(Kim-1)-overexpressed *** developed S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsulation with micelles,the AUC_(0-t),half-life time,and renal distribution of S14 increase 2.5-,1.8-,and 3.1-fold,*** main factors contributing to the improved druggability of S14 nanodrugs include the lower metabolic elimination rate and UDPglycosyltransferase(UGt)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent while enhancing its ADME properties and druggability through nanotechnology,thereby driving advancements in marine drug development for AKI.

关键词： Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability

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Observation of spectral lines in the exceptional GRB 221009A

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu Zhang Shao-Lin xiong Ji-Rong Mao Shuang-Nan Zhang Wang-Chen Xue Chao Zheng Jia-Cong Liu Zhen Zhang xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song Zheng-Hua An Ce Cai xin-Qiao Li Wen-xi Peng Wen-Jun tan Chen-Wei Wang xiang-Yang Wen Yue Wang Shuo xiao fan Zhang Peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

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Cardiac Piezo1 Exacerbates Lethal Ventricular Arrhythmogenesis by Linking Mechanical Stress with Ca^(2+) Handling After Myocardial Infarction

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Research 2024年第1期2023卷 583-594页

作者： Sheng-an Su Yuhao Zhang Wudi Li Yutao xi Yunrui Lu Jian Shen Yuankun Ma Yaping Wang Yimin Shen Lan xie Hong Ma Yao xie Meixiang xiang Department of Cardiology Cardiovascular Key Laboratory of Zhejiang ProvinceThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Endocrinology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China texas Heart Institute HoustonTX 77030USA

Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarction(MI).Accumulating data show that ischemia,sympathetic activation,and inflammation contribute to ***,the role and mechanisms of abnormal mechanical stress in ventricular arrhythmia following MI remain *** aimed to examine the impact of increased mechanical stress and identify the role of the key sensor Piezo1 in ventricular arrhythmogenesis in *** with increased ventricular pressure,Piezo1,as a newly recognized mechano-sensitive cation channel,was the most up-regulated mechanosensor in the myocardium of patients with advanced heart ***1 was mainly located at the intercalated discs and t-tubules of cardiomyocytes,which are responsible for intracellular calcium homeostasis and intercellular communication.

关键词： ventricular homeostasis Ventricular

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