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Chinese Physics C 2016年第10期 915-915页

作者： C.Patrignani K.Agashe G.Aielli C.Amsler M.Antonelli D.M.Asner H.Baer Sw.Banerjee R.M.Barnett t.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer S.Bethke H.Bichsel O.Biebel E.Blucher G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerri D.Chakraborty M.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio t.Damour D.de Florian A.de Gouvea t.DeGrand P.de Jong G.Dissertori B.A.Dobrescu M.D'Onofrio M.Doser M.Drees H.K.Dreiner D.A.Dwyer P.Eerola S.Eidelman J.Ellis J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas H.Gallagher L.Garren H.-J.Gerber G.Gerbier t.Gershon t.Gherghetta A.A.Godizov M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu t.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes A.Hebecker B.Heltsley J.J.Hernandez-Rey K.Hikasa J.Hisano A.Hcker J.Holder A.Holtkamp J.Huston t.Hyodo K.Irwin J.D.Jackson K.F.Johnson M.Kado M.Karliner U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss M.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin C.Lippmann t.M.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky A.Lusiani Y.Makida F.Maltoni t.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews U.-G.Meiβner D.Milstead R.E.Mitchell P.Molaro K.Mnig F.Moortgat M.J.Mortonson H.Murayama K.Nakamura M.Narain P.Nason S.Navas M.Neubert P.Nevski Y.Nir K.A.Olive S.Pagan Griso J.Parsons J.A.Peacock M.Pennington S.t.Petcov V.A.Petrov A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffelt B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J.L.Rosner G.Rybka R.A.Ryutin C.t.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg A.J.Schwartz D.Scott V.Sharma S.R.Sharpe t.Shutt M.Silari t.sj.strand P.Skands t.Skwarnicki J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl S.L.Stone Y.Sumino t.Sumiyoshi M.J.Syphers F.takahashi M.tanabashi K.terashi J.terning R.S.thorne L.tiator M.titov N.P.tkachenko N.A.trnqvist D.tovey G.Valencia R.Van de Water N.Varelas G Particle Data Group Universita di Bologna and INFN Dip.Scienze per la Qualita della Vita University of Maryland Department of Physics College Park Universit degli Studi di Roma "tor Vergata" Albert Einstein Center for Fundamental Physics Universitt Bern Stefan Meyer Institute for Subatomic Physics Austrian Academy of Sciences Lab.Nazionali di Frascati dell'INFN Pacific Northwest National Laboratory Department of Physics and Astronomy University of Oklahoma University of Louisville Physics Division Lawrence Berkeley National Laboratory CERN European Organization for Nuclear Research Department of Physics the Ohio State University COMPAS Group Institute for High Energy Physics Max-Planck-Institute of Physics Department of Physics University of Washington Ludwig-Maximilians-Universitt Fakultt fr Physik Enrico Fermi Institute and Department of Physics University of Chicago Department of Physics Columbia University High Energy Physics Group Blackett Laboratory Imperial College Jefferson Lab Department of Physics University of Virginia Fermi National Accelerator Laboratory Kavli Institute for Cosmological Physics University of Chicago Department of Physics and Astronomy University of Sussex Department of Physics Northern Illinois University Department of Physics and Astronomy University of California Michigan State University Dept.of Physics and Astronomy Department of Physics Royal Holloway University of London INFN-Sezione di Napoli Complesso Universitario Monte Sant'Angelo Institut des Hautes Etudes Scientifiques International Center for Advanced Studies(ICAS) UNSAM Department of Physics and Astronomy Northwestern University Department of Physics University of Colorado at Boulder Nikhef P.O.Box 41882 1009 DB Amsterdam and University of Amsterdam Institute for Particle Physics EtH Zurich University of Liverpool Department of Physics Oliver Lodge Lab Physikalisches Institut Universitt Bonn Helsinki Institute of Physics University of Helsinki Department of Physics Budker Institute of Nuclear Physics SB RAS Novosib

the Review summarizes much of particle physics and *** data from previous editions,plus 3,062 new measurements from 721 papers,we list,evaluate,and average measured properties of gauge bosons and the recently discovered Higgs boson,leptons,quarks,mesons,and *** summarize searches for hypothetical particles such as supersymmetric particles,heavy bosons,axions,dark photons,*** the particle properties and search limits are listed in Summary *** also give numerous tables,figures,formulae,and reviews of topics such as Higgs Boson Physics,Supersymmetry,Grand Unified theories,Neutrino Mixing,Dark Energy,Dark Matter,Cosmology,Particle Detectors,Colliders,Probability and *** the 117 reviews are many that are new or heavily revised,including new reviews on Pentaquarks and Inflation.

关键词： CA Organization Chinese Physics C USA DESY CERN

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福建省莆田地区大肠癌流行病学调查

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第四军医大学学报 2005年第19期26卷 1822-1822页

作者：黄中华陈思杰傅建梅龚锦容郭建民张建平莆田市第一医院消化内科福建莆田351100 莆田市第二医院消化内科福建莆田351100 涵江医院消化内科福建莆田351100 仙游县医院消化内科福建莆田351100

1 临床资料 1988-11/2003-10莆田市第一医院、第二医院,涵江医院,仙游县医院行肠镜检查20 465例,病理证实为大肠癌1027（男621,女406）例,男女之比为1.53∶ 1,年龄19～82（55.9±5.6）岁. 直肠癌615例,占59.88%;乙状结肠癌278例,占27.0... 详细信息

1 临床资料 1988-11/2003-10莆田市第一医院、第二医院,涵江医院,仙游县医院行肠镜检查20 465例,病理证实为大肠癌1027（男621,女406）例,男女之比为1.53∶ 1,年龄19～82（55.9±5.6）岁. 直肠癌615例,占59.88%;乙状结肠癌278例,占27.07%;降结肠癌13例,占1.266%;横结肠癌57例,占5.55%;升结肠癌41例,占3.99%;回盲部癌23例,占2.24%. 主要组织学分型依次为：管状腺癌611例,占59.49%;乳头状腺癌197例,占19.24%;黏液腺癌98例,占9.6%;息肉恶变84例,占8.2%;印戒细胞癌37例,占3.6%. 常见症状依次为便血、大便习惯改变、腹痛、腹块、黏液便、贫血、粪隐血阳性.以每5 a为单位段算出年段检出率,对大肠癌及年段检出率及病变部位进行分析比较见表1,采用t检验或χ2检验作显著性分析,P〈0.05被认为有统计学意义.[第一段]

关键词：大肠癌流行病学特点

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AtM-dependent monoubiquitination of histone H2B at DNA double strand breaks is required for timely damage repair

ATM-dependent monoubiquitination of histone H2B at DNA doubl...

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21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Lilach Moyal Mali Gana-Weisz Yaniv Lerenthal Gilad Mass Sairei So Shih-Ya Wang Young Min Chung Gil Shalev Efrat Shema Dganit Shkedy Nechama I.Smorodinsky Berina Eppink Nicole van Vliet Bernhard Kuster Matthias Mann Aaron Ciechanover Roland Kanaar Mickey C-t.Hu David J.Chen Moshe Oren Yosef Shiloh

＜正＞Genome stability is essential for prevention of undue cellular death and neoplasia.A central axis in maintaining genome stability is the DNA damage response（DDR） - a complex network of signaling pathways that responds to DNA damage by activating DNA repair and cell-cycle checkpoints and modulating many signaling *** DDR is vigorously activated by DNA double strand breaks（DSBs）,the most cytotoxic lesions induced by

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杂合型CtLA-4基因与重度先兆子痫

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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 59-59页

作者： Samsami Dehaghani A Doroudchi M Kalantari t 朱晓明

One of the major complications of pregnancy, preeclampsia makes pregnancy term ination inevitable in most cases. Similarities exist between the mechanisms that maintain normal pregnancy, allograft transplants, and, it is postulated, periph eral self-tolerance. In addition, the critical role of the cytotoxic t-lymphoc yte antigen-4 (CtLA-4) molecule in maintaining self-tolerance has been establ ished. therefore, the frequency of CtLA-4 A49G polymorphism was investigated in severe preeclampsia. Genomic DNA extracted from mononuclear cells of the periph eral blood of 36 pregnant women with severe preeclampsia and 151 healthy women w as analyzed. A49G polymorphism in position 49 of exon-1 of the CtLA-4 gene was studied by the polymerase chain reaction-single-strand conformation polymorph ism (PCR-SSCP) method. the frequency of the GG genotype was 2 (5.6%) in patien ts and 19 (12.6%) in controls, while the frequency of the AA genotype was 4 (11 .1%) and 60 (39.7%). Interestingly, the frequency of the AG genotype was signi ficantly higher in preeclamptic than in healthy women from the general populatio n (83.3%vs. 47.7%; P=0.0005). these data suggest that heterozygosity in the Ct LA-4 A49G allele might be a predisposing factor for severe preeclampsia. Whethe r the observed association results from linkage imbalance with other loci on chr omosome 2 or other polymorphisms of the CtLA-4 gene or even from a preferential transfer and/or expression of one allele from a heterozygous mother to the fetu s will be the subject of future investigations.

关键词：重度先兆子痫 CtLA-4 杂合型妊娠并发症妊娠组自身耐受正常妊娠终止妊娠多态性频率外周血单核细胞

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60例蕈样肉芽肿和Sézary综合征患者淋巴结的分子学疾病分期:组织病理学与研究结果相关联提示与蕈样肉芽肿的预后有关

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世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 14-页

作者： Fraser-Andrews E.A. Mitchell t. Ferreira S. 周少娜 Skin tumour Unit St. John's Institute of Dermatology St. Thomas'Hospital London SE1 7EH United Kingdom

Background: Histological evidence of lymph node involvement is associated with a poor prognosis in patients with cutaneous t-cell lymphoma (CtCL). Objectives: to determine whether t-cell receptor (tCR) gene analysis is of prognostic relevance in CtCL. Methods: tCR gene analysis was performed on lymph node specimens from 60 patients with mycosis fungoides (MF) and Sézary syndrome (SS) using a highly sensitive polymerase chain reaction (PCR)/single-strand conformational polymorphism analysis and results were correlated with skin, overall clinical and histological lymph node stages. Results: the frequency with which a t-cell clone was detected in lymph node samples from patients with MF increased with skin stage, overall clinical stage and with the degree of histological involvement: six of 19 patients with uninvolved lymph nodes or limited histological involvement (LN0-2) and 13 of 14 patients with advanced histological involvement (LN3-4) had a detectable t-cell clone. In SS, 22 of 27 patients had a detectable lymph node t-cell clone. the clonal patients had a poorer prognosis than nonclonal patients (median survival from biopsy of > 72 months vs. 16 months for MF and 41.5 vs. 16.5 months for SS). Regression analysis confirmed that tCR gene analysis identifies a group of MF patients with a worse prognosis (P = 0.013). However, the molecular lymph node stage did not provide independent prognostic information in this cohort of patients in multivariate analysis. Conclusions: Molecular staging in MF and SS using a PCR-based method for tCR gene analysis provides additional information to histological examination. Specifically, this study identified a group of MF patients with early lymph node involvement with a poorer prognosis. However, a larger prospective study of patients with MF and early histological lymph node involvement is required to confirm whether molecular staging of lymph nodes provides independent prognostic information in a multivariate model.

关键词：淋巴结淋巴组织分子学 zary 患者肉芽肿炎症疾病综合征综合病症预后

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视神经脊髓炎IgG刺激原代培养大鼠星形胶质细胞免疫反应

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神经损伤与功能重建 2014年第3期9卷 239-239页

作者： Howe CL Kaptzan t Magaa SM Ayers-Ringler JR LaFrance-Corey RG Lucchinetti CF Department of Neurology Mayo ClinicRochesterMinnesota Department of Immunology Mayo ClinicRochesterMinnesota Clinical and translational Science PhD program Mayo Graduate SchoolMayo ClinicRochesterMinnesota Neurobiology of Disease PhD program Mayo Graduate SchoolMayo ClinicRochesterMinnesota

视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形... 详细信息

视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形胶质细胞的动态免疫过程。培养原代大鼠星形胶质细胞,加入从NMO患者血清中提取或纯化的IgG,星形胶质细胞出现炎性增殖,同时基因表达出现与之匹配的明显变化。且星形胶质细胞反应因子脂质运载蛋白-2、多种趋化因子、细胞因子、应激反应因子的表达均增加。而在培养的原代星形胶质细胞中加入从正常对照者血清中提取的IgG则无上述变化。此星形胶质细胞的反应还与疾病种类相关。从复发缓解型多发硬化、sj觟gren's或系统性红斑狼疮患者血清中提取的IgG加入培养的原代星形胶质细胞中也不能导致上述变化。笔者推测是NMO IgG与AQP4结合,导致星形胶质细胞出现炎症反应,并出现基因在转录和翻译水平的相应变化。抑制星形胶质细胞的炎症反应可能有助于减少星形胶质细胞增殖,缓解NMO病灶的发展。

关键词： CCL2 CCL5 CXCL1 脂质运载蛋白 -2 核因子水通道蛋白 -4 粒细胞固有免疫

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疗效较好的慢性丙性肝炎患者体内丙型肝炎病毒的持续存在

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 41-41页

作者： Radkowski M. Gallegos-Orozco J.F. Jablonska J. t. Laskus 杨雪娟 Division of transplantation Medicine SC Johnson Bldg Sj3 Mayo Clinic Scottsdale AZ 85259 United States

It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV) infection results in complete elimination of the virus, or whether small quantities of virus persist. Our study group comprised 17 patients with chronic HCV who had sustained virological response (SVR) after interferon/ribavirin treatment. Serum and peripheral blood mononuclear cells were collected 2 to 3 times at 3-to 6-month intervals starting 40 to 109 months (mean, 64.2 ±18.5 months) after the end of therapy. In addition, lymphocyte and macrophage cultures were established at each point. In 11 patients, frozen liver tissue samples were available from follow-up biopsies performed 41 to 98 months (mean, 63.6 ±16.7 months) after therapy. Presence of HCV RNA was determined by sensitive reverse-transcriptase polymerase chain reaction, and concentration of positive and negative strands was determined by a novel quantitative realtime reverse transcriptase polymerase chain reaction. Only 2 of 17 patients remained consistently HCV RNA negative in all analyzed compartments. HCV RNA was detected in macrophages from 11 patients (65%) and in lymphocytes from 7 patients (41%). Viral sequences were also detected in 3 of 11 livers and in sera from 4 patients. Viral replicative forms were found in lymphocytes from 2 and in macrophages from 4 patients. In conclusion, our results suggest that in patients with SVR after therapy, small quantities of HCV RNA may persist in liver or macrophages and lymphocytes for up to 9 years. this continuous viral presence could result in persistence of humoral and cellular immunity for many years after therapy and could present a potential risk for infection reactivation.

关键词：丙型肝炎病毒持续病毒学应答抗病毒复制型外周血单核细胞巨噬细胞组织学检查血清样本负链细胞免疫

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Scleroderma and HIV Infection: A Case Report with Literature Review

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Open Journal of Internal Medicine 2018年第4期8卷 255-260页

作者： I. A. Dembélé N. R. Nyanke D. traore A. K. Souckho D. Sy M. Cissoko A. Sanogo B. B. Sangaré O. A. Cisse K. Dao K. t. tighankpa M. Malle M. togo A. Keita A. traore M. Saliou Y. Fofana D. Sangaré N. tolo N. Doumbia A. Doumbia B. B. Berthé B. D. Camara S. A. Coulibaly N. Sawadogo M. Dembélé A. K. traore H. A. traore Internal Medicine Department Point G Teaching Hospital Bamako Mali Department of Internal Medicine Kaya Regional Hospital Kaya Burkina Faso

Introduction: Acquired immunodeficiency syndrome (AIDS) linked to HIV infection is accompanied by auto-immune phenomena. Autoimmune diseases can develop in people living with HIV, most in a context of good immunological control (vasculitis, anti-phospholipid syndrome). Since the advent of antiretroviral therapy, an increasing number of autoimmune connective tissue diseases such as systemic lupus erythematosus, dermatomyositis, and syndromes of sj?gren and scleroderma have been reported. Purpose: to describe this association’s not very common scleroderma and HIV infection. Observation: We report the case of a 56-year-old lady admitted into the service for functional impotence that would have been evolving for a week. Prior to her hospitalization, she presented edemas of the lower limbs associated with anesthesia of the lower limbs for 5 months. the painting is accompanied by a productive cough and an intermittent fever. At the physical examination a weight loss (BMI = 13.74 Kg/m2), fever (38.7°C): Oral candidiasis, lower lip ulceration, perlicking, undernutrition folds, sclerodactyly and homogeneous hepatomegaly was noted. the diagnosis of immunosuppression to HIV Stage 3 with tB co-morbidity and positive hepatitis B Serology was retained while diffuse Scleroderma was selected from the ACR/EULAR criteria of 2012 with a score of 10 (sclerodactyly = 4 point;Raynaud’s phenomenon = 3 point and Ac Anti Scl 70 positive = 3 point). Conclusion: these associations of chronic pathology must be described to improve the future treatment of our patients.

关键词： Scleroderma HIV Internal Medicine

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