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Defect Engineering of Mesoporous Silica Nanoparticles for Biomedical Applications

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Accounts of Materials Research 2021年第8期2卷 581-593页

作者： bowen Yang Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050P.R.China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049P.R.China tenth People’s Hospital and School of Medicine Tongji UniversityShanghai 200092P.R.China

CONSPECtUS:the goddess Venus has been known for her armless *** a unique artistic effect teaches us that the imperfection in one aspect may result in a great aesthetics in another *** existence of structural defects in nanomaterials(substitutional impurities and vacancies)endows them with diverse and fascinating physicochemical properties,such as optical properties and redox reaction ***,defect engineering of controllably regulating the types and concentrations of defects in nanoparticles has been paid great attention in nanosynthetic chemistry for tailoring the performances of nanomaterials for diversified practical applications,such as biomedical *** silica nanoparticles(MSNs)have been extensively applied as nanocarriers in biomedicine,due to their well-defined pore structure and particle morphology,extraordinarily large specific surface area and pore volume,tunable pore size,and framework *** nanoparticles have been considered as promising candidates for application in multiple therapeutic or diagnostic applications,by acting as drug carriers or supports for functional *** synthesis of MSN is usually based on sol−gel chemistry according to a bottom-up approach in a hydrothermal environment,where the silica precursor tetraethoxysilane molecules condense with each other and−Si−O−Si−bonds form consequently,under the assistance of surfactants as structural-directing agents,finally resulting in the formation of a mesoporous *** the pore structure evolution,which has been being the major focus in the MSNs synthesis and application in the past decades,alternatively,the composition of MSN framework can also be elaborately engineered for the material functionalization and the application broadenings of MSNs,facilely by properly regulating the experimental conditions and ***,the defect engineering of MSNs has been extensively explored very recently for broa

关键词： properly versatile inorganic

Grenvillian and early Paleozoic polyphase metamorphism recorded by eclogite and host garnet mica schist in the North Qaidam orogenic belt

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Geoscience Frontiers 2021年第4期12卷 244-259页

作者： Yunfei Ren Danling Chen Haijie Wang Xiaohui Zhu bowen Bai State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China Xi'an Center of Geological Survey China Geological SurveyXi'an 710054China

the North Qaidam orogenic belt(NQOB) is generally considered to be an early Paleozoic ultrahigh pressure metamorphic belt,but increasing reports of the Neoproterozoic magmatic and metamorphic events indicate that the NQOB probably also experienced the assembly of the ***,the Neoproterozoic evolution of the NQOB is not well constrained due to the sparse records and ambiguous nature of the Neoproterozoic *** order to reveal the multi-orogenic history of the NQOB,an integrated study of petrology,phase equilibrium modelling and geochronology was conducted on an epidote eclogite and host garnet mica schist from the Yuka–Luofengpo *** zircon and monazite U–Pb ages show that the protolith of the garnet mica schist was deposited during 994–920 Ma and experienced Neoproterozoic(920–915 Ma) and early Paleozoic(451–447 Ma) polyphase metamorphism together with the enclosed *** omphacite inclusions were first identified in garnet and early Paleozoic zircon domains from the garnet mica schist,which provide solid evidence for the early Paleozoic eclogite facies metamorphism of the mica *** early Paleozoic peak P–t conditions of >27.4 kbar/613–670 ℃ and 30.2–30.8 kbar/646–655 ℃ were obtained for the garnet mica schist and enclosed eclogite,respectively,indicating that eclogites and their host paragneisses in this region underwent continental deep subduction as a coherent metamorphic terrane in early *** peak P–t conditions of the Neoproterozoic metamorphism were roughly constrained at 7.7–12.0 kbar and 634–680 ℃ for the garnet mica schist,based on stability field of mineral inclusions in Neoproterozoic zircons domains in P–t pseudosection,the relic garnet core composition and ti-in-zircon *** high thermal gradients(16–37 ℃/km) defined by presently our and previously reported P–t conditions indicate that the Neoproterozoic metamorphism likely occurred in continental collision setting at >945–890 *** the

关键词： Grenvillian metamorphism two orogenic cycles Pseudosection North Qaidam Rodinia

Numerical Study on the Effect of Current Profiles on Vortex-Induced Vibrations in a top-tension Riser

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Journal of Marine Science and Application 2017年第4期16卷 473-479页

作者： bowen Fu Lu Zou Decheng Wan State Key Laboratory of Ocean Engineering School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong UniversityCollaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240 China

In this paper, numerical simulations of vortex-induced vibrations in a vertical top-tension riser with a length-to-diameter ratio of 500 using our in-house code viv-FOAM-SJtU are presented. the time-dependent hydrodynamic forces on two-dimensional strips are obtained by solving the Navier-Stokes equations, which are, in turn, integrated into a finite-element structural model to obtain the riser deflections. the riser is discretized into 80 elements with its two ends set as pinned and 20 strips are located equidistant along the risers. Flow and structure are coupled by hydrodynamic forces and structural displacements. In order to study the effects of the shear rate, of the current profiles on the vortex-induced vibrations in the riser, vibrations, with varying shear rates, in both the in-line and cross-flow directions, are simulated. In addition to the time domain analysis, spectral analysis was conducted in both the temporal and spatial domains. Multi-mode vibration characteristics were observed in the riser. the relationship between dominant vibration mode number and the shear rate of current profiles is discussed. In general, the overall vibrations in the riser pipe include contributions from several modes and each mode persists over a range of shear rates. Moreover, the results suggest that with a larger shear rate the position of the maximum in-line time-averaged displacement will move closer to the end where the largest velocity is located.

关键词： risers vortex-induced vibration multi-modal vibration strip theory computational fluid dynamics fluid-structure interaction

基于网络药理学与体外实验探讨附子活性成分治疗血管痉挛的作用机制

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环球中医药 2024年第8期17卷 1523-1536页

作者：武博文颜培宇武密山澳门科技大学中医药学院中药质量研究国家重点实验室中国澳门999078

目的运用网络药理学和体外细胞实验探究附子活性成分治疗血管痉挛的潜在作用机制。方法检索tCMSP数据库、SwisstargetPrediction数据库、Uniprot数据库、Genecards数据库、OMIM数据库、ttD数据库、Disgenet数据库和String数据库等,获得... 详细信息

目的运用网络药理学和体外细胞实验探究附子活性成分治疗血管痉挛的潜在作用机制。方法检索tCMSP数据库、SwisstargetPrediction数据库、Uniprot数据库、Genecards数据库、OMIM数据库、ttD数据库、Disgenet数据库和String数据库等,获得附子活性成分、作用靶点及血管痉挛相应疾病靶点,并将其作用靶点与获得的疾病靶点的交集作为潜在靶点;利用String平台,对潜在靶点构建蛋白—蛋白互作(protein-protein interaction network,PPI)网络;采用R语言软件包对潜在靶点进行基因本体(gene ontology,GO)功能及京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)富集分析,然后使用Cytoscape软件分析其网络拓扑结构,筛选其核心靶点,并进行分子对接验证。在此基础上,通过Mtt法检测附子活性成分对血管紧张素Ⅱ所致血管平滑肌细胞增殖影响的机制。结果附子治疗血管痉挛的主要潜在活性成分有15个;药物—疾病核心靶点有27个;涉及的信号通路主要有脂质和动脉粥样硬化、钙信号通路、刺激神经组织的中的交互、鞘脂类信号通路、流体剪切应力与动脉粥样硬化、松弛素信号通路、血管平滑肌收缩等;关键核心靶点与活性成分次乌头碱、谷甾醇结合具有稳定构象。体外实验结果表明,附子活性成分次乌头碱能抑制血管紧张素Ⅱ所致血管平滑肌细胞增殖,其机制可能与其抑制丝裂原活化蛋白激酶信号转导通路的活化有关。结论附子多种活性成分可能通过作用于丝裂原活化蛋白激酶1、核受体亚家族3 C群成员1、血管紧张素I转化酶、一氧化氮合酶3等靶点治疗血管痉挛,为附子活性成分治疗血管痉挛的作用机制研究提供了科学参考。

关键词：附子网络药理学分子对接血管痉挛细胞增殖血管平滑肌细胞血管紧张素II

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Hourly energy consumption characteristics of metro rail transit:train traction versus station operation

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Energy and Built Environment

Energy and Built Environment 2023年第5期4卷 568-575页

作者： bowen Guan Xiaohua Liu tao Zhang Xinke Wang School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’anShaanxi710054China Department of Building Science Tsinghua UniversityBeijing 100084China

the electricity consumption of the urban metro system can be mainly divided into the following two categories:the electricity consumption for train traction(E_(t))and the electricity consumption for station operation(E_(s)).Although understanding the hourly fluctuation characteristics of E_(t) and E_(s) contributes to renewable energy inte-gration and achieving carbon emission reduction of the metro system,the hourly fluctuation characteristics have been poorly reported in the ***,a typical underground non-transfer metro station of a city’s metro system in the North China Plain is selected in this study,and E_(t) and E_(s) were monitored to portray their hourly fluctuation *** reveal that the hourly E_(t) shows a significant intraday“U”shape on weekdays,indicating two symmetric peaks in morning and evening rush *** the hourly E_(s) shows an intraday“flat”shape,indicating it is nearly free from the effect of rush ***,it is statistically proved that the train frequency is the core influencing factor resulting in the intraday fluctuation of hourly E_(t).In the case study,when the train frequency increases from the mean(20 trains per hour)to maximum(32 trains per hour),the hourly E_(t) will increase by 53.4%.

关键词： Urban rail transit Energy consumption Hourly fluctuation train traction Station operation Carbon emission reduction

tunable polarization-drived high energy storage performances in flexible PbZrO_(3)films by growing Al_(2)O_(3)nanolayers

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Journal of Advanced Ceramics 2023年第11期12卷 2123-2133页

作者： Chao Yin tiandong Zhang Zhuangzhuang Shi bowen Zhang Changhai Zhang Qingguo Chi Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080China

In recent years,PbZrO_(3)(PZO)films have become favorable electric storage materials due to the unique electric field-induced phase transition behavior,but the severe hysteresis effect leads to low energy storage density and *** this work,inserting Al_(2)O_(3)(AO)insulation nanolayers is proposed to tune the polarization behavior of flexible PZO films,anticipating optimization of energy storage *** results show that the thickness of the AO nanolayers has a deep influence on the polarization behavior of the PZO films,and PZO/AO/PZO(PAP)sandwiched films with 8 nm AO interlayer deliver relaxor ferroelectric-like polarization instead of antiferroelectric *** further utilize the AO nanolayers as top/bottom layers,the linear-like polarization and the highest breakdown strength are achieved in the AO/PZO/AO/PZO/AO(APAPA8)multilayer films,leading to both high discharged energy storage density of 35.2 J/cm^(3) and efficiency of 92.9%,as well as excellent fatigue and bending endurance,good temperatures,and frequency *** tunable polarization induced by growing the AO nanolayers makes antiferroelectric PZO films have great potential to be used as energy storage dielectrics.

关键词： sol-gel flexible antiferroelectric polarization energy storage

tandem cervical carotid stenting for stenosis with flow diversion embolisation for the treatment of intracranial aneurysms

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Stroke & Vascular Neurology 2019年第1期4卷 43-47页

作者： Jessica K Campos Li-Mei Lin Narlin B Beaty Matthew t Bender bowen Jiang David A Zarrin Alexander L Coon Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMarylandUSA Department of Neurosurgery University of CaliforniaIrvineOrangeCaliforniaUSA

Background An estimated 2%-3%of the population harbour an intracranial *** atherosclerotic cervical carotid disease is not *** management of these two entities remains a challenge within the *** presentation We report a single case of concomitant carotid stenosis and two ipsilateral unruptured intracranial aneurysms treated with a single-staged cervical carotid stenting and cerebral aneurysm embolisation with the Pipeline embolisation *** No consensus currently exists to guide endovascular treatment of intracranial aneurysms associated with asymptomatic ipsilateral ***,we present a case of asymptomatic moderate carotid stenosis with two ipsilateral intracranial aneurysms and suggest carotid artery stenting takes procedural priority over aneurysm embolisation in single-stage *** rationale for the sequence of neurointerventions is based on the tracking a robust distal access system beyond a stenotic proximal carotid lesion and stabilisation of the ulcerated plaque to avoid thromboembolic complications associated with plaque irritation during aneurysm *** cases and longer follow-up will be needed to further assess the efficacy of this technique.

关键词： aneurysm carotid stenosis

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公猪精液质量与精子脂质成分相关性研究

中国畜牧兽医 2024年第4期51卷 1537-1548页

作者：陈佳颖马博闻赵青余张军民汤超华中国农业科学院北京畜牧兽医研究所畜禽营养与饲养全国重点实验室北京100193 青岛农业大学动物科技学院青岛266109

【目的】建立公猪精液品质与精子脂质成分之间的相关性,为公猪精液品质准确评价提供支撑。【方法】本研究采集了大白和长白等代表性品种公猪的精液,使用计算机辅助精子分析(computer-assisted sperm analysis,CASA)系统对精子密度、精... 详细信息

【目的】建立公猪精液品质与精子脂质成分之间的相关性,为公猪精液品质准确评价提供支撑。【方法】本研究采集了大白和长白等代表性品种公猪的精液,使用计算机辅助精子分析(computer-assisted sperm analysis,CASA)系统对精子密度、精子活力、精子畸形率和精液体积等精液品质指标进行检测。根据精子活力将精液样品分为正常活力(≥70%,n=11)和低活力(tive-Orbitrap/MS对两组精子样品进行非靶向脂质组分析。采用t检验(t tests)、偏最小二乘判别分析(partial least squares discriminant analysis,PLS-DA)和相关性分析(correlation)等统计分析方法对脂质组学检测结果进行多元化分析。根据对分类具有重要贡献的变量(variable important in projection,VIP)值>1和错误发现率(false discovery rate,FDR)tidylcholine,PC)这类脂质上。甘油二酯(diglyceride,DG)、鞘磷脂(sphingomyelin,SM)、PC、酵母甾醇(zymosterol ester,ZyE)和糖基神经酰胺(simple Glc series,Hex3Cer)等脂质亚类的含量在活力低的精子中显著减少,且均与精子活力呈显著正相关(Ptriglyceride,tG)和磷脂酰胆碱酯(phosphatidylcholine ester,PC(e))在活力低的精子中显著增加,与精子活力呈显著负相关(PtG和PC(e)等脂质的组成成分及其含量可作为区分精子活力高低的标志。

关键词：公猪精液品质脂质成分脂质组学

Metabolomics through the lens of precision cardiovascular medicine

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Journal of Genetics and Genomics 2017年第3期44卷 127-138页

作者： Sin Man Lam Yuan Wang bowen Li Jie Du Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Beijing Anzhen Hospital Capital Medical UniversityThe Key Laboratory of Remodeling-Related Cardiovascular DiseasesMinistry of EducationBeijing Collaborative Innovation Center for Cardiovascular DisordersBeijing Institute of HeartLung&Blood Vessel DiseaseBeijing 100029China Lipidall technologies Company Limited Changzhou 213000China

Metabolomics, which targets at the extensive characterization and quantitation of global metabolites from both endogenous and exogenous sources, has emerged as a novel technological avenue to advance the field of precision medicine principally driven by genomics-oriented approaches. In particular,metabolomics has revealed the cardinal roles that the environment exerts in driving the progression of major diseases threatening public health. Herein, the existent and potential applications of metabolomics in two key areas of precision cardiovascular medicine will be critically discussed： 1） the use of metabolomics in unveiling novel disease biomarkers and pathological pathways; 2） the contribution of metabolomics in cardiovascular drug development. Major issues concerning the statistical handling of big data generated by metabolomics, as well as its interpretation, will be briefly addressed. Finally, the need for integration of various omics branches and adopting a multi-omics approach to precision medicine will be discussed.

关键词： Metabolomics Precision medicine Cardiovascular diseases Lipidomics Multi-omics