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单功能肾病人经皮射频消融治疗肾小肿瘤的长期疗效

the Xixth Congress the Internat.onal Primatological Society

作者： V.Nijman C.Yeager A.Marshall D.Kitchener R.Lee J.Supriatna t.o’brien M.Kinnaird University of Amsterdam Zoological Museum The Netherlands USAID J1. Merdeka Selatan No. 3 Jakarta Indonesia Harvard University Boston MA USA the Nature Conservancy J1. Hang Tuah No. 42 Jakarta Indonesia Wildlife Conservat.on Society J1. Pangrango No. 8 Bogor Indonesia Conservat.on Internat.onal J1. Taman Margasatwa No. 61 Jakarta Indonesia Wildlife Conservat.on Society J1. Pangrango No. 8 Bogor Indonesia Wildlife Conservat.on Society J1. Pangrango No. 8 Bogor Indonesia

＜正＞ the four Indonesian provinces of Kalimantan （Borneo） contain fourteen primate species, three of which are endemic. t.o species （Nasalis larvatus and Pongo pygmaeus） are considered Endangered, one （Macaca nemestrind） is listed as Vulnerable, four are considered Lower Risk （Hylobates muelleri, H. agilis, M. fascicularis, and Presybytis femoralis）, and five (P. frontata, P. hosei, trachypithecus

关键词： Kalimantan Nasalis trachypithecus Presbytis Hylobates Macaco Nycticebus tarsier Pongo conservat.on status

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国际医学放射学杂志 2013年第5期 494-495页

作者： M.Krokidis S.Spiliopoulos M.Jarzabek N.Fotiadis t.Sabharwal t.o’brien 谢明伟 Department.of Radiology Guy ’s and St Thomas ’ Hospitals NHS Foundation Trust

摘要目的评估经皮射频消融在治疗单功能肾病人肾小肿瘤的长期疗效。方法这是一个单中心的前瞻性研究。单功能肾且肾肿瘤<3.5 cm,并接受射频消融治疗超过7.5年的病人纳入分析。连续19例(男性12例)病人,年龄在33～83岁之间(平均61.4岁),... 详细信息

摘要目的评估经皮射频消融在治疗单功能肾病人肾小肿瘤的长期疗效。方法这是一个单中心的前瞻性研究。单功能肾且肾肿瘤<3.5 cm,并接受射频消融治疗超过7.5年的病人纳入分析。连续19例(男性12例)病人,年龄在33～83岁之间(平均61.4岁),共23个病灶接受了治疗。主要关注点是技术的成功和肿瘤复发率,次要关注点是肾功能恶化及总的成活率。结果平均随访时间为56.1个月(36～102个月),主要技术成功率为100%,没有严重的围手术期并发症,

关键词：单功能病人射频消融治疗肾肿瘤泌尿系肿瘤经皮射频消融长期疗效泌尿系统疾病肾病

Accret.on in st.ong field gravity with eXtP

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Science China(Physics,Mechanics & Ast.onomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando t.omas Dauser Melania Del Santo Barbara De Marco tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu t.omas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul t.o'brien Julian P.osborne Pierre olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio tamburini t.omas M.tauris Francesco tombesi Gabriel torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Ast.ofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Ast.onomy University of Amsterdam Nat.onal Ast.onomical observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field theory and Particle Physics and Department.of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-osservatorio Ast.onomico di Brera Department.of Physics and Ast.onomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-osservatorio Ast.onomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department.of Physics University of OxfordClarendon Laboratory Ast.onomical Institute Academy of Sciences School of Ast.onomy and Space Science Nanjing University MIt Kavli Institute for Ast.ophysics and Space Research Institut für Ast.onomie und Ast.ophysik Eberhard Karls Universität Department.of Physics Anhui Normal University Department.of Ast.onomy and Institute of theoretical Physics and Ast.ophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Ast.ofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Ast.ofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and StAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computat.onal Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department.of Physics Middle East Technical University Department.of Ast.onomy and Ast.ophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-osservatorio Ast.ofisico di Arcetri INAF-osservatorio Ast.onomico di Padova INFN-tIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray timing and Polarimetry(eXtP) mission for studies related to accret.on flows in the st.ong field gravity regime around both stellar-mass and supermassive black-holes. eXtP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variat.ons with three ort.ogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of st.ong field gravity on the material within them and the powerful outflows which are driven by the accret.on process.

关键词： X-ray black holes physics accret.on

Diversity of yo t-cell antigens

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Cellular & Molecular Immunology 2013年第1期10卷 13-20页

作者： Willi K Born M Kemal Aydintug Rebecca L o'brien Integrated Department.of Immunology National Jewish Health Denver CO USA University of Colorado Denver Aurora CO USACorrespondence: Dr WK Born National Jewish Health 1400 Jackson Street GB K409 Denver CO 80206 USA.

In the last t.o decades, it has become clear that yo t cells recognize a diverse array of antigens including self and foreign, large and small, and peptidic and non-peptidic molecules. In this respect, 78 antigens as a whole resemble more the antigens recognized by antibodies than t.ose recognized by t cells. Because of this antigenic diversity, no single mechanism--such as the major histocompatibility complex （MHC） restrict.on of ap t cells--is likely to provide a basis for all observed t-cell antigen receptor （tCR）-dependent 78 t-cell responses. Furthermore, available evidence suggests that many individual 78 t cells are poly-specific, probably using different modes of ligand recognit.on in their responses to unrelated antigens. While posing a unique challenge in the maintenance of self-tolerance, this broad reactivity pattern might enable multiple overlapping uses of 78 t-cell populat.ons, and thus generate a more efficient immune response.

关键词： antigen recognit.on ligand t-cell receptor yo t cells

Virulence and mycotoxic effects of Metarhizium anisopliae on Mahogany shoot borer,Hypsipyla robusta(Lepidoptera:Pyralidae)

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Journal of Forestry Research 2012年第4期23卷 651-659页

作者： M.Balachander o.K.Remadevi t.o Sasidharan N.Sapna Bai Wood Biodegradat.on Division Institute of Wood Science&Technology(Indian Council for Forestry Research and Education)Malleswaram P.O.Bangalore-560003KarnatakaIndia. Ashoka trust for Research in Ecology and the Environment Jakkur P.O.Bangalore 560064KarnatakaIndia

Developing appropriate cont.ol measures for the Mahogany shoot borer, Hypsipyla robusta Moore has become increasingly important due to the severe damaging effect.of the pest.on the establishment.of the saplings of Swietenia mahagoni Jacq （Sapindales： Meliaceae）. Existing management met.ods are largely limited to silvicultural practices and spraying of chemical insecticides. to identify a potential fungal biocont.ol agent, we compared the virulence of six native and t.o standard ARSEF isolates of Metarhizium anisopliae Metsch. against this pest. the average survival time and conidial yield of IWSt-Ma7 was higher （6.2 to 7.3 days and 4.9 to 4.7 x 105 conidia/ml） than the standards. Sig- nificant difference in sporulat.on on the cadavers between isolates, doses and incubat.on periods were substantiated for the select.on of potential strain. the mycotoxic effects of crude soluble protein extract when in- corporated in the artificial diet, the ARSEF 2596 and ARSEF 3603 showed LDs0 value of 3.7% and 5.6%. However, IWSt-Ma7 was highly lethal with significant lowest LDs0 value of 2.6%. the enzyme activity of IWSt-Ma7 was highest for chitinase, CDA, protease and lipase viz., 1.90 U/mg, 1.80 U/mg, 0.98 U/mg and 0.80 U/mg respectively. However the enzyme activity of chitinase and Chitin deacetylase assay for all the isolates was significantly higher than protease and lipase activity. the ItS regions （5.8S rDNA and 28S rDNA） of seven isolates of M. anisopliae were amplified using the ItS1 and ItS4 primers which was a unique fragment.of approximately 550 bp. Based on ItS regions, phy- logenetic tree have been constructed and the isolates have been grouped in to 5 clades. the virulence and mycotoxic effects of different isolates could rat.onally be used to employ them for the management.of the mahogany borer.

关键词： Metarhizium anisopliae mycotoxin mahogany shoot borer,Hypsipyla robusta

Calculat.on of electric field–temperature (E, t) phase diagram of a ferroelectric liquid crystal near the SmA–SmC_α~* transit.on

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Chinese Physics B 2018年第3期27卷 444-450页

作者： F trabelsi H Dhaouadi o Riahi t.othman Universite de tunis El-Manar Faculte des Sciences de TunisLaboratoire de physique de la matiere molle et de modelisation electromagnetique(LP3ME)Campus Universitaire Farhat Hached 2092 Tunis Tunisie

In this work we perform a theoretical calculat.on in order to reconstitute the （E-t） phase diagram of a chiral smectic liquid crystal in the vicinity of the SmA-SmCα＊ transit.on. this reconstruct.on is carried out.on the basis of a thermo-dynamic calculat.on of the slope of the curve joining the SmC＊ domain and the unwound SmC＊. An empiric correct.on of the mean field term of Landau De-Gennes development is necessary to accomplish this reconstruct.on. thereafter, an experimental validat.on is performed to verify our calculat.ons.

关键词： field-temperature phase diagram liquid orystal

20-HEtE increases NADPH oxidase-derived RoS product.on and stimulates L-type calcium channel via PKC-dependent mechanism in cardiomyocytes

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20-HETE increases NADPH oxidase-derived ROS production and s...

Macular carotenoid supplementat.on improves disability glare performance and dynamics of photostress recovery

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Stephen t.o’Rourke Department.of Pharmaceutical Sciences North Dakota State University

the product.on of 20-hydroxyeicosatetraenoic acid(20-HEtE) is increased during ischemia-reperfusion and inhibit.on of 20-HEtE product.on has been shown to reduce infarct size caused by *** study was aimed at discovering the molecular mechanism underlying the act.on of 20-HEtE in cardiac *** effect.of 20-HEtE on L-type calcium channel currents(I) was examined in rat isolated cardiomyocytes by patch clamp recording in the whole-cell *** of cardiomyocytes with 20-HEtE(10-100 nmol/L) resulted in a concentrat.on-dependent increase in I and this act.on of 20-HEtE was attenuated by a specific NADPH oxidase inhibitor,gp91ds-tat(5μmol/L),or a superoxide scavenger,PEG-SoD(25 U/mL),suggesting that NADPH-oxidase -derived superoxide is involved in the stimulatory act.on of 20-HEtE on *** of cardiomyocytes with 20-HEtE(100 nmol/L) increased both NADPH oxidase activity and superoxide product.on by approximately *** study the molecular mechanism mediating the 20-HEtE-induced increase in NADPH oxidase activity, protein kinase C(PKC) activity was measured in *** of the cells with 20-HEtE(100 nmol/L) significantly increased PKC activity,and pretreatment.of cardiomyocytes with the selective PKC inhibitor,GF109203 (1μmol/L),attenuated 20-HEtE-induced increases in I and in NADPH oxidase *** summary,20-HEtE stimulates NADPH oxidase-derived superoxide product.on,which activates L-type calcium channels via a PKC-dependent mechanism in cardiomyocytes.20-HEtE and 20-HEtE-producing enzymes could be the novel targets for treatment.of cardiac ischemic diseases.

关键词： 20-HEtE L-type calcium channel PKC cardiac myocytes reactive oxygen species

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Eye and Vision 2016年第1期3卷 231-238页

作者： James M.Stringham Kevin J.o’brien Nicole t.Stringham Nutrit.onal Neuroscience Laboratory Department of Physiology and PharmacologyUniversity of GeorgiaAthensGA 30602USA Vision Sciences Laboratory Department of PsychologyUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Neuroscience Program Biomedical Health Sciences InstituteUniversity of GeorgiaAthensGA 30602USA

Background:the so-called macular carotenoids(MC)lutein(L),zeaxanthin(Z),and meso-zeaxanthin(MZ)comprise the diet-derived macular pigment(MP).the purpose of this study was to determine effects of MC supplementat.on on the optical density of MP(MPoD),repeated-exposure photostress recovery(PSR),and disability glare(DG)***:this was a double-blind,placebo-cont.olled ***-nine young(mean age=21.7),healthy volunteers participated in this *** supplemented their daily diet with either 10 mg L+2 mg total Z(1 mg Z+1 mg MZ;n=24),20 mg L+4 mg total Z(2 mg Z+2 mg MZ;n=25),or placebo(n=10)for 12 *** primary out.ome was a composite measure of visual performance in glare,defined by change in DG and *** out.omes included MPoD and visual *** primary endpoint for out.omes was 12 *** was assessed with customized heterochromatic flicker *** times for an 8 cycle/degree,15%contrast Gabor patch target were determined after each of five successive exposures to intense LED *** threshold was defined as the intensity of a ring of lights through which subjects were able to maintain visibility of the aforement.oned *** of all parameters were conducted at baseline,6 months,and 12 ***-measures ANoVA,and Pearson product-moment correlat.ons were used to determine statistically significant correlat.ons,and changes within and between ***:MPoD for subjects in both supplementat.on groups increased significantly versus placebo at both 6-and 12-month visits(por all).Addit.onally,PSR times and DG thresholds improved significantly from baseline compared to placebo at 6-and 12-month visits(por all).At baseline,MPoD was significantly related to both DG thresholds(r=0.444;p=0.0021)and PSR times(r=-0.56;pt.on of MPoD,the repeated-exposure PSR curves became more asymptotic,as opposed to *** change in subjects’DG thresholds were significantly related to chang

关键词： Lutein Zeaxanthin Mesozeaxanthin Visual performance Photostress recovery Disability glare Macular pigment Visual cycle

Connexins in neurons and glia: targets for intervent.on in disease and injury

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Neural Regenerat.on Research 2015年第7期10卷 1013-1017页

作者： Keith B.Moore John o'brien Richard S.Ruiz M.D.Department of Ophthalmology & Visual Science The University of Texas Health Science Center at Houston the University of texas Graduate School of Biomedical Sciences

Both neurons and glia throughout the central nervous system are organized into net.orks by gap junct.ons. Among glia, gap junct.ons facilitate metabolic homeostasis and intercellular communicat.on. Among neurons, gap junct.ons form electrical synapses that funct.on primarily for communicat.on. However, in neurodegenerative states due to disease or injury gap junct.ons may be detrimental to survival. Electrical synapses may facilitate hyperactivity and bystander killing among neurons, while gap junct.on hemichannels in glia may facilitate inflammatory signaling and scar format.on. Advances in understanding mechanisms of plasticity of electrical synapses and development.of molecular therapeutics to target glial gap junct.ons and hemichannels offer new hope to pharmacologically limit neuronal degenerat.on and enhance recovery.

关键词： ischemia retinal degenerat.on amacrine cells ast.ocytes dopamine receptors adenosine receptors NMDA receptors connexin mimetic peptides