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Journal of materials Science & technology 2021年第34期93卷 60-70页

作者： Z.H.wang B.Niu Q.wang C.Dong J.C.Jie t.m.wang t.G.Nieh Key Laboratory of materials modification by Laser Ion and Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Department of materials Science and Engineering The University of TennesseeKnoxville37996TennesseeUSA

the development of ultrastrong maraging stainless steels(mSSs)is always in high ***,traditional high-strength mSSs generally exhibit early plastic instability with a low uniform strain since the precipitated nanoparticles are non-coherent with the body-centered-cubic(BCC)lath martensitic ***,we design a novel ultrahigh strength mSS(Fe-5.30 Cr-13.47 Ni-3.10 Al-1.22 mo-0.50 W-0.23 Nb-0.03 C-0.005 B,wt.%)using a cluster formula approach.A fabulous microstructure consisting of a uniform distribution of high-density coherent B2-Ni Al nanoprecipitates(3-5 nm)in BCC martensitic matrix was successfully *** alloy has not only an exceedingly high ultimate tensile strength of 2.0 GPa,but also a decent uniform elongation of 4.2%-5.1%,which is almost triple of the value observed in existing *** present an in-depth discussion on the origins of ultrahigh strength and uniform plastic strain in the new alloy to validate our design strategy and further offer a new pathway to exploit highperformance mSSs.

关键词： maraging stainless steel Ultrahigh strength Coherent precipitation Strengthening mechanisms Uniform deformation

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Novel insight into dry sliding behavior of Cu-Pb-Sn in-situ composite with secondary phase in different morphology

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Journal of materials Science & technology 2020年第5期40卷 158-167页

作者： B.W.Dong S.H.wang Z.Z.Dong J.C.Jie t.m.wang t.J.Li School of material Science and Engineering Dalian University of TechnologyDalian 116024China

the Cu-24 Pb-x Sn(wt%)(x=0,2,4,6)alloys with Pb-rich second-phase particles(SPPs)in different shapes show obviously differently mechanical and self-lubricating *** influence of the SPPs’shape difference on the alloys’mechanical and self-lubricating properties was ***-24 Pb alloy with continuously netty SPPs shows much more intensive stick-slip phenomenon during dry sliding than the other three alloys with independently rodlike *** is mainly due to insufficient lubrication resulted by the netty SPPs’splitting *** the SPPs transforming from netty to rodlike shape under the addition of Sn,the stick-slip phenomenon was notably weakened,which was proven to be related to the higher self-lubricating property of alloys with rodlike ***,the simultaneous increase of ductility and tensile strength was observed in the Cu-24 Pb-x Sn alloys with increasing Sn content,which is because the netty SPPs’splitting behavior will be weakened with them replaced by the rodlike SPPs.

关键词： Second-phase particles Netty shape Rodlike shape Stick-slip mechanical property Self-lubricating property

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modified endoscopic transnasal orbital apex decompression in dysthyroid optic neuropathy

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Eye and Vision 2021年第1期8卷 183-191页

作者： Yunhai tu mingna Xu Andy D.Kim michael t.m.wang Zhaoqi Pan Wencan Wu the Eye Hospital of Wenzhou medical University No.270 Xueyuan Xi RoadWenzhouZhejiang 325027P.R.China Department of Ophthalmology New Zealand National Eye CentreThe University of AucklandAucklandNew Zealand

Background:to describe the surgical technique and assess the clinical efficacy and safety of modified endoscopic transnasal orbital apex decompression in the treatment of dysthyroid optic ***:In this retrospective research,forty-two subjects(74 orbits)who underwent modified endoscopic transnasal orbital apex decompression for the treatment of dysthyroid optic neuropathy were *** and postoperative best-corrected visual acuity(BCVA),visual field mean deviation(mD),Hertel exophthalmometry,and new onset diplopia were assessed before and after the *** Wilcoxon test was used for differential *** mixed-models’analyses were conducted to assess the potential predictors for BCVA ***:Postoperatively,the mean BCVA improved from 0.70±0.62 logmAR to 0.22±0.33 *** significantly improved in 69 eyes(93%),remained stable in 4 eyes(5%)and deteriorated in 1 eye(1%).mD of visual fields improved from−13.73±9.22 dB to−7.23±7.04 *** decreased from 19.57±3.38mm to 16.35±*** BCVA,mD of visual fields and medical rectus diameter were independent factors associated with improvements in BCVA(Pmixed-models’*** patients(42.9%)developed new diplopia ***:modified endoscopic transnasal orbital apex decompression effectively restores vision in dysthyroid optic neuropathy.

关键词： Endoscopic transnasal orbital decompression Dysthyroid optic neuropathy thyroid-associated ophthalmopathy Visual acuity Visual field

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振荡式小型氢脉泽的特性

宇航计测技术 1984年第S1期 201-206页

作者： Harry t.m.wang 唐建康

本文对CHYmNS-Ⅰ型和CHYmNS-Ⅱ振荡式小型氢脉泽和它们的稳定度性能作了说明。两种脉泽的工作原理完全相同,但体积和重量相差很大。它们可以采用小型化腔体结构。由稳定性数据能够判断,当脉泽体积减小时,性能有所下降。CHYmNS-Ⅰ型的腔... 详细信息

本文对CHYmNS-Ⅰ型和CHYmNS-Ⅱ振荡式小型氢脉泽和它们的稳定度性能作了说明。两种脉泽的工作原理完全相同,但体积和重量相差很大。它们可以采用小型化腔体结构。由稳定性数据能够判断,当脉泽体积减小时,性能有所下降。CHYmNS-Ⅰ型的腔体尺寸是15厘米（外径）×15厘米（长）,τ=100秒时,测出的根值阿仑方差σy（τ）=6.6×10-14。CHYmNS-Ⅱ型的体积较小,相应的数据是11厘米（外径）×15厘米（长）,τ=100秒时,σy（τ）=1.3×10-13。从使用观点看,优先考虑的是它的长期稳定性。两个小型脉泽直接比对测出的数据是:τ=10～5秒时,σy（τ）=4×10-15。这一测试结果说明,用电子的方法稳定腔体,对克服环境扰动的影响是卓有成效的,从而保证脉泽的频率输出长期稳定。

关键词：脉泽腔体振荡式

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利用金属氢化物处理氢激射器中的气体

宇航计测技术 1985年第S1期 1-6页

作者： Harry t.m.wang 唐健康

氢与某些金属和合金之间相互作用的可逆性,在满足氢激射器的氢源供应、氢气流量调节以及保持真空度等方面,得到了十分有效的应用。此外,氢化物在减小激射器的体积、重量和功耗以及改进系统的可靠性等方面都有重要作用。可供振荡式小型... 详细信息

氢与某些金属和合金之间相互作用的可逆性,在满足氢激射器的氢源供应、氢气流量调节以及保持真空度等方面,得到了十分有效的应用。此外,氢化物在减小激射器的体积、重量和功耗以及改进系统的可靠性等方面都有重要作用。可供振荡式小型化氢激射器运行七年的氢源,可以存储在50克LaNi5或50克LaNi4.7Al0.3中。包括一个电控钯银合金稳流器在内,氢源所占的容积小于50毫升。为氢激射器配套的吸气剂——离子真空泵组合装置中,用锆石墨作吸气剂。工作经验表明,为确保激射器运行可靠,需要具备洁净的、可烘烤的真空系统。这种真空系统的设计要求是十分严格的。

关键词：激射器量子放大器氢化物氢化合物离子泵真空泵吸气泵吸附泵吸气剂氢源离解压力高压容器压力容器氢气流量流量调节器

HYPOtENSIVE ACtION OF β-(2,2,6,6-tEtRAmEtHYLPIPERIDINO)-EtHYL-GUANIDINE SULPHAtE(BD-31)

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Science in China,Ser.A 1964年第9期 1527-1531页

作者：白东鲁陈维洲王志敏丁光生嵇汝运

One of the antihypertensive drug widely used clinically is guanethidine,[2-(octa-hydro-1-azocinyl)-ethyl]-guanidine *** lowers the high blood pressure slowly butpersistently,and lacks the side effects common to ganglion-blocking *** onthe structure-activity relationship disclosed that the 8-membered ring might be displacedby other appropriate rings without loss of activity,the side chain had to be 2 carbon atomsnot bearing any substituents,and the terminal guanidine-moiety might be replaced byamidine or amidoxime without reducing the hypotensive effect.

关键词： BD-31 tEtRAmEtHYLPIPERIDINO HYPOtENSIVE ACtION OF EtHYL-GUANIDINE SULPHAtE

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期68卷 249-262页

作者： Jinliang wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo Li Chunwei Xu Wenxian wang Shangli Cai Zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAmS Key Laboratory of translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic medicine and Cancer (IBmC) Chinese Academy of Sciences Department of Clinical trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).these results were validated using a larger public ICI cohort(n=208,Pinteractionmultiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+t cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).this multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN t.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： Peclet number

the impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CtP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER mULLA YOUSEF KAtIB ASIm m.ALmUGHAmSI DUAA S.ALKHAYAt mOHAmED mOSAAD SAmIR t.ALFOtIH RAWAN ALAOFI Department of Internal medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz medical City Madinah42311Saudi Arabia Prince mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of tNm staging,Alfa-fetoprotein(AFP),and Child-turcotte Pugh(CtP)on patients’overall survival(OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:the mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CtP score and OS(p-value=0.02).CtP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:the most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CtP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue wang Lijie Huang Su Zhang Ruixin Zhang Song wang Guangxu Lu Peifu tang Zhongyang Liu Kai wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of training and Sports medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive materials for the ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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