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国际医学放射学杂志 2024年第3期 378-378页

作者： R.Smith-Bindman t.kang P.W.Chu Y.Wang C.Stewart M.Das 吴玉平

摘要目的描述辐射剂量减少技术在常规腹部Ct中的应用和影响。方法回顾性分析了由95家医院和成像机构提供的有大剂量登记的成人连续常规腹部Ct扫描。将检查分

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thermodynamic model for deoxidation of liquid steel considering strong metal-oxygen interaction in the quasichemical model framework

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 988-1002页

作者： Yong-Min Cho Youn-Bae kang Graduate Institute of Ferrous and Eco Materials technology Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea N.EX.t Hub POSCO HoldingsPohangKyungbuk37673Rep.of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea

Herein,a thermodynamic model aimed at describing deoxidation equilibria in liquid steel was *** model provides explicit forms of the activity coefficient of solutes in liquid steel,eliminating the need for the minimization of internal Gibbs energy preliminarily when solving deoxidation *** elimination of internal Gibbs energy minimization is particularly advantageous during the coupling of deoxidation equilibrium calculations with computationally intensive approaches,such as computational fluid *** model enables efficient calculations through direct embedment of the explicit forms of activity coefficient in the computing *** proposed thermodynamic model was developed using a quasichemical approach with two key approximations:random mixing of metallic elements(Fe and oxidizing metal) and strong nonrandom pairing of metal and oxygen as nearest *** these approximations,the quasichemical approach yielded the activity coefficients of solutes as explicit functions of composition and temperature without requiring the minimization of internal Gibbs energy or the coupling of separate *** model was successfully applied in the calculation of deoxidation equilibria of various elements(Al,B,C,Ca,Ce,Cr,La,Mg,Mn,Nb,Si,ti,V,and Zr).the limitations of the model arising from these assumptions were also discussed.

关键词： deoxidation equilibria thermodynamics quasichemical approach computational fluid dynamics

Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS t expression levels

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Journal of Integrative Plant Biology 2024年第1期66卷 103-120页

作者： Hayeon Kim Hye Won kang Dae Yeon Hwang Nayoung Lee Akane Kubota takato Imaizumi Young Hun Song Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Biology Ajou UniversitySuwon 16499Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Graduate School of Science and technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Department of Biology University of WashingtonSeattleWA 98195USA Institute of Agricultural Life Sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FLOWERING LOCUS t(Ft).In Arabidopsis,Ft messenger RNA levels peak in the morning and evening under natural long-day conditions(LDs).However,the regulatory mechanisms governing morning Ft induction remain poorly *** morning Ft peak is absent in typical laboratory LDs characterized by high red:far-red light(R:FR)ratios and constant ***,we demonstrate that ZEItLUPE(ZtL)interacts with the Ft repressors tARGEt OF EAts(tOEs),thereby repressing morning Ft expression in natural *** LDs with simulated sunlight(R:FR=1.0)and daily temperature cycles,which are natural LD-mimicking environmental conditions,Ft transcript levels in the ztl mutant were high specifically in the morning,a pattern that was mirrored in the toe1 toe2 double *** night-to-morning temperatures increased the inhibitory effect of ZtL on morning Ft expression by increasing ZtL protein levels early in the ***-red light counteracted ZtL activity by decreasing its abundance(possibly via phytochrome A(phyA))while increasing GIGANtEA(GI)levels and negatively affecting the formation of the ZtL-GI complex in the ***,the phyA-mediated high-irradiance response and GI play pivotal roles in morning Ft *** findings suggest that the delicate balance between low temperature-mediated ZtL activity and the far-red light-mediated functions of phyA and GI offers plants flexibility in fine-tuning their flowering time by controlling Ft expression in the morning.

关键词： far-red light FLOWERING LOCUS t flowering time GIGANtEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEItLUPE

Full t-cell activation and function in teleosts require collaboration of first and co-stimulatory signals

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Zoological Research 2024年第1期45卷 13-24页

作者： Wei Liang kang Li Haiyou Gao Kunming Li Jiansong Zhang Qian Zhang Xinying Jiao Jialong Yang Xiumei Wei State Key Laboratory of Estuarine and Coastal Research School of Life SciencesEast China Normal UniversityShanghai 200241China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China

Mammalian t-cell responses require synergism between the first signal and co-stimulatory ***,whether and how dual signaling regulates the t-cell response in early vertebrates remains *** the present study,we discovered that the Nile tilapia(Oreochromis niloticus)encodes key components of the LAt signalosome,namely,LAt,ItK,GRB2,VAV1,SLP-76,GADS,and PLC-γ*** components are evolutionarily conserved,and CD3εmAb-induced t-cell activation markedly increased their ***,at least ItK,GRB2,and VAV1 were found to interact with LAt for signalosome *** of the first signal,the NF-κB,MAPK/ERK,and PI3K-AKt pathways were activated upon CD3εmAb ***,treatment of lymphocytes with CD28 mAbs triggered the AKt-mtORC1 pathway downstream of the co-stimulatory *** CD3εand CD28 mAb stimulation enhanced ERK1/2 and S6 phosphorylation and elevated NFAt1,c-Fos,IL-2,CD122,and CD44 expression,thereby signifying t-cell ***,rather than relying on the first or co-stimulatory signal alone,both signals were required for t-cell *** t-cell activation was accompanied by marked apoptosis and cytotoxic *** findings suggest that tilapia relies on dual signaling to maintain an optimal t-cell response,providing a novel perspective for understanding the evolution of the adaptive immune system.

关键词： Oreochromis niloticus CD3 CD28 t cells Adaptive immunity Evolution

Distributed Mallows Model Averaging for Ridge Regressions

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Acta Mathematica Sinica,English Series 2024年

作者： Haili ZHANG Alan t.K.WAN kang YOU Guohua ZOU School of Mathematical Sciences Capital Normal University Institute of Applied Mathematics Shenzhen Polytechnic University Department of Management Sciences and School of Data Science City University of Hong Kong

Ridge regression is an effective tool to handle multicollinearity in regressions. It is also an essential type of shrinkage and regularization methods and is widely used in big data and distributed data applications. the divide and conquer trick, which combines the estimator in each subset with equal weight, is commonly applied in distributed data. to overcome multicollinearity and improve estimation accuracy in the presence of distributed data, we propose a Mallows-type model averaging method for ridge regressions, which combines estimators from all subsets. Our method is proved to be asymptotically optimal allowing the number of subsets and the dimension of variables to be *** consistency of the resultant weight estimators tending to the theoretically optimal weights is also derived. Furthermore, the asymptotic normality of the model averaging estimator is *** simulation study and real data analysis show that the proposed model averaging method often performs better than commonly used model selection and model averaging methods in distributed data cases.

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Revealing tissue Heterogeneity and Spatial Dark Genes from Spatially Resolved transcriptomics by Multiview Graph Networks

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Research 2024年第2期6卷 629-645页

作者： Ying Li Yuejing Lu Chen kang Peiluan Li Luonan Chen School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang471023China Longmen Laboratory LuoyangHenan471003China Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai201100China Key Laboratory of Systems Health Science of Zhejang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310000China School of Life Science and technology ShanghaiTech UniversityShanghai201100.China

Spatially resolved transcriptomics(SRt)is capable of comprehensively characterizing gene expression patterns and providing an unbiased image of spatial *** fully understand the organizational complexity and tumor immune escape mechanism,we propose stMGAtF,a multiview graph attention fusion model that integrates gene expression,histological images,spatial location,and gene *** better extract information,stMGAtF exploits SimCLRv2 for visual feature exaction and employs edge feature enhanced graph attention networks for the learning potential embedding of each view.A global attention mechanism is used to adaptively integrate 3 views to obtain low-dimensional *** to diverse SRt datasets,stMGAtF is robust and outperforms other methods in detecting spatial domains and denoising data even with different resolutions and *** particular,stMGAtF contributes to the elucidation of tissue heterogeneity and extraction of 3-dimensional expression ***,considering the associations between genes in tumors,stMGAtF can identify the spatial dark genes ignored by traditional methods,which can be used to predict tumor-driving transcription factors and reveal tumor immune escape mechanisms,providing theoretical evidence for the development of new immunotherapeutic strategies.

关键词： Spatial integrate driving

CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory t cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong Geon Ho Bae Ji Hyeon kang Mingyu Lee Brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory t(t_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and tNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of treg cells,while the administration of anα-CD200R antibody inhibited treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory t cells

targeted G-to-t base editing for generation of novel herbicide-resistance gene alleles in rice

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Journal of Integrative Plant Biology 2024年第6期66卷 1048-1051页

作者： Yifu tian Xinbo Li Jiyong Xie Zai Zheng Rundong Shen Xuesong Cao Mugui Wang Chao Dong Jian-kang Zhu Ministry of Agriculture and Rural Affairs Key Laboratory of Gene Editing technologies(Hainan) Institute of Crop Sciences and National Nanfan Research InstituteChinese Academy of Agricultural SciencesSanya 572024China Hainan Seed Industry Laboratory Sanya 572024China Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesThe Chinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China Institute of Advanced Biotechnology and School of MedicineSouthern University of Science and TechnologyShenzhen 518055China

Deaminase-based cytosine base editors(CBEs)and adenine base editors(ABEs)induce C-to-t and A-to-G transitions,respectively,enabling single-nucleotide variants(SNVs)in plants for research and crop enhancement(Li et al.,2023a).the C-to-G base editors(CGBEs)and A-to-Y base editors(AYBEs),developed by incorporating glycosylases with CBEs and ABEs,expand the repertoire of base editing products,allowing C-to-t/G and A-to-t/G transversions in plants(Li et al.,2023b,2023c;Sretenovic et a.,2021).

关键词： base alleles CBE

Biotic and abiotic stresses on honeybee health

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Integrative Zoology 2024年第3期19卷 442-457页

作者： Zheguang LIN Siyi SHEN kang WANG ting JI Apicultural Research Institute College of Animal Science and TechnologyYangzhou UniversityYangzhouChina

Honeybees are the most critical pollinators providing key ecosystem services that underpin crop production and sustainable *** a backdrop of rapid global change,this eusocial insect encounters a succession of stressors during nesting,foraging,and *** mites,together with vectored viruses,have been recognized as central biotic threats to honeybee health,while the spread of invasive giant hornets and small hive beetles also increasingly threatens colonies *** of agrochemicals,including acaricides used for mite treatment,and other pollutants of the environment have been widely documented to affect bee health in various ***,expanding urbanization,climate change,and agricultural intensification often result in the destruction or fragmentation of flower-rich bee *** anthropogenic pressures exerted by beekeeping management practices affect the natural selection and evolution of honeybees,and colony translocations facilitate alien species invasion and disease *** this review,the multiple biotic and abiotic threats and their interactions that potentially undermine bee colony health are discussed,while taking into consideration the sensitivity,large foraging area,dense network among related nestmates,and social behaviors of honeybees.

关键词： abiotic stressor Apis biotic stressor colony losses interaction effect pollinator decline

Heterobimetallic[NiCo]integration in a hydrogenase mimic for boosting light-driven hydrogen evolution in CatiO_(3)

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Nano Research 2024年第8期17卷 6888-6894页

作者： kang Li Juanji Hong Ningning Song Zhanjun Guo Minmin Liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 10081China

Light-drive hydrogen production using titanium-based perovskite is one sustainable way to reduce current reliance on fossil fuels,but its wide applications are still limited by high electron−hole recombination and sluggish surface ***,the developments for low-cost and highly efficient co-catalysts remain *** by natural[NiFe]-hydrogenase active center structure,a hydrogenase-mimic,NiCo_(2)S_(4)nanozyme was synthesized,and subsequently decorated onto the CatiO_(3)to catalyze the hydrogen evolution reaction(HER).Among the following test,CatiO_(3)with a 15%loading of NiCo_(2)S_(4)nanozyme exhibited the highest HER rate of 307.76μmol·g^(–1)·h^(–1),which is 60 times higher than that of the CatiO_(3)*** results reveal that NiCo_(2)S_(4)not only significantly increased the charge separation efficiency of the photogenerated carriers,but also substantively lowered the HER activation *** studies show that NiCo_(2)S_(4)readily splits H_(2)O by forming the Ni(OH)-Co intermediate and only Ni in the bimetallic center alters the oxidation state during the HER process in a manner analogous to the[NiFe]-*** contrast to the often-expensive synthetic catalysts that rely on rare elements such as ruthenium and platinum,this study shows a promising way to develop the nature-inspired cocatalysts to enhance the photocatalysts’HER performance.

关键词： hydrogen evolution reaction hydrogenase-mimic nanozyme photocatalyst water-splitting