检索结果-南通市图书馆

在治疗术后眼内炎中作为佐剂应用的玻璃体内地塞米松:一项前瞻性随机研究

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 40-41页

作者： Ugahary L.C. van Dissel j.t. j.C. van Meurs 韩静 the Rotterdam Eye Hospital PO Box 70030 3000 LM Rotterdam Netherlands

PURPOSE: to study whether intravitreal dexamethasone as adjuvant to intravitreal antibiotics improves the outcome in patients with suspected postoperative bacterial endophthalmitis. Design: Prospective randomized clinical trial. Setting: tertiary referral center. Patient population: twenty-nine consecutive patients with suspected postoperative bacterial endophthalmitis within 6 weeks of cataract surgery. Intervention: Patients underwent a vitreous biopsy followed by intravitreal injection of antibiotics (0.2 mg vancomycin and 0.05 mg gentamicin) and 400 μg dexamethasone or placebo. After 3-4 days the intravitreal injection of antibiotics and dexamethasone or placebo was repeated. Primary outcome measure: Snellen visual acuity at 3 and 12 months after treatment. Results: In 20/29 patients (69%) the vitreous cultures were positive. 13/29 patients received dexamethasone. Seven patients had a functionally lost eye (final vision of hand movements or less), in four due to retinal detachment. Visual acuity tended to be better in the dexamethasone treated patients than in those given placebo, at both 3 months (P=0.055) and 12 months (P=0.080). Conclusion: this small prospective, placebo-controlled series showed a trend towards a better visual outcome in patientswith suspected bacterial endophthalmitiswhen treatment with intravitreal antibiotics was combined with intravitreal dexamethasone. Our findings justify a larger multicenter randomized study.

关键词：玻璃体内注射地塞米松治疗前瞻性随机研究术后眼内炎治疗后 Snellen视力佐剂细菌性眼内炎患者数量白内障手术后

评价在乡村初级医疗机构中注意缺陷多动症的诊治情况:美国儿科学会指导方针落实的可行性

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 50-51页

作者： Polaha j. Cooper S.L. Meadows t. Kratochvil C.j. 刘凯 Department of Psychology University of Nebraska 985450 Nebraska Medical Center Omaha NE 68105 United States Dr.

Objective. to examine the implementation of a protocol for the assessment of attention-deficithyperactivity disorder (ADHD)-in rural pediatric practices. the protocol was designed to provide an efficient means for pediatricians to learn and use the ADHD guidelines put forth by the American Academy of Pediatrics (AAP). Methods. Primary care staff (physicians, nurses, etc) from 2 rural pediatric practices were trained to use the ADHD-assessment protocol. Medical records for 101 patients were reviewed from 1 to 2 years before the introduction of the protocol and for 86 patients during the subsequent 2 to 3 years to assess compliance with the AAP guidelines. In addition, 34%of the scales scored by the staff were rescored to check for scoring accuracy. Results. Before the availability of the AAP guidelines and the implementation of the assessment protocol, neither primary care site was consistently collecting the comprehensive information that is now recommended for an ADHD assessment. Parent andor teacher rating scales were collected for only 0%to 21%of assessments across sites. When provided with brief training and supporting materials, medical records reflected significant improvement in the ascertainment of clinically necessary ADHD information, with parent and teacher rating scales present 88%to 100%of the time. Staff demonstrated an ability to score rating scales with a high degree of accuracy. the integrity of protocol collection and management was maintained 2 to 3 years after training. Conclusions. An efficient system for conducting ADHD assessments according to AAP guidelines in rural pediatrics clinics can be initiated and maintained with integrity. Additional research is needed to determine if this system improves diagnostic decision-making and patient outcomes.

关键词：美国儿科学会初级医疗机构注意缺陷多动症乡村病案记录诊治儿科医师 ADHD 医疗记录执行情况

在线全文

学校读者我要写书评

暂无评论

平面心肌灌注成像评价急性胸痛患者的价值

世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 44-45页

作者： Yamada A.t. Soares jr. j. Meneghetti j.C. 郝广华 Heart Institute (InCor) Univ. of S. Paulo Medical School Av. Dr. Eneas Carvalho A. S. ao Paulo Brazil

Background: Rest single-photon emission computed tomographic(SPECt) perfusion imaging identifies acute myocardial ischemia in patients with chest pain in the emergency department; however, the costs are high and radioisotopic services are usually not available 24 h a day. Planar imaging through a portable gamma camera may be useful in this setting. However, planar imaging might be associated with less predictive values in comparison with a gated SPECt imaging. We sought to evaluate rest planar myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia. Methods: Patients within 6 h of chest pain onset and nondiagnostic electrocardiograms(ECGs) underwent planar myocardial perfusion imaging. Studies showing perfusion defects were considered suggestive of acute coronary syndromes. the results of planar scintigraphy were compared with the clinical diagnosis and outcomes. All patients were followed up and monitored for the occurrence of major cardiac events 120 days after hospital discharge. Results: 71 patients underwent scintigraphy. twenty-one(30%) patients had acute coronary syndromes, 15(21%) had major cardiac events(8 had myocardial infarction and 7 underwent myocardial revascularization). Planar scintigraphy demonstrated perfusion defects in 21 patients, 16 (76%) patients with acute coronary syndromes, 12(80%) patients who had major cardiac events and in 7(88%) patients with myocardial infarction. the negative predictive value of planar scintigraphy was 90%for diagnosis of acute coronary syndromes and 94%for detecting major cardiac events. Conclusion: Early planar myocardial perfusion imaging allowed rapid and accurate risk stratification of emergency departments patients with possible myocardial ischemia and nondiagnostic ECGs.

关键词：急性胸痛灌注成像灌注缺损心脏事件急性心肌缺血急诊科阴性预测值门控检查费用风险度

聚醚酰亚胺中空纤维超滤膜的研究(Ⅰ)膜结构、热性能和机械性能

在线全文

学校读者我要写书评

暂无评论

膜科学与技术 2001年第2期21卷 33-36页

作者：许振良 t.S.Chung 华东理工大学化工学院上海200237 国立新加坡大学新加坡119260

以聚醚酰亚胺 (PEI)为膜材料 ,聚乙烯吡咯烷酮 (PVP)和聚乙二醇 (PEG)等为添加剂 ,N -甲基吡咯烷酮 (NMP)和二甲基乙酰胺 (DMAc)为溶剂 ,采用干 /湿法纺丝技术制备出聚醚酰亚胺中空纤维膜 ,提高了PEI超滤膜的耐污染性 .通过改变纺丝液... 详细信息

以聚醚酰亚胺 (PEI)为膜材料 ,聚乙烯吡咯烷酮 (PVP)和聚乙二醇 (PEG)等为添加剂 ,N -甲基吡咯烷酮 (NMP)和二甲基乙酰胺 (DMAc)为溶剂 ,采用干 /湿法纺丝技术制备出聚醚酰亚胺中空纤维膜 ,提高了PEI超滤膜的耐污染性 .通过改变纺丝液中不同的添加剂 (如PEG或PVP) ,PEI中空纤维膜断面可从指状孔转变成海绵状 .此外 ,讨论了聚醚酰亚胺中空纤维的膜结构。

关键词：中空纤维膜超滤膜聚醚酰亚胺膜结构热性能机械性能

Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Natural Medicines 2019年第6期17卷 446-460页

作者： LI Da XIAO jian-Qi LIU Wen-Yuan ZHANG Chao-Feng AKIHISA toshihiro ABE Masahiko MAStERS Eliot-t. ZHAI Wei-Wei FENG Feng ZHANG jie jiangsu Food and Pharmaceutical Science College Huai’an 223003China Department of Pharmaceutical Analysis China Pharmaceutical UniversityNanjing 210009China Research Institute for Science and technology Tokyo University of ScienceChiba 278-8510Japan World Agroforestry Centre(ICRAF) Nelson Marlbolough Institute of Technology(NMIT)Nelson 7010New Zealand School of traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China Key Laboratory of Biomedical Functional Materials China Pharmaceutical UniversityNanjing 211198China

the aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-tOF-MS and phytochemical methods in V. paradoxa nutshell methanol extract. Based on HPLC fingerprints, four characteristic constituents were quantified and the origin of twenty-eight V. paradoxa nutshells from seven sub-Saharan countries was compared, which were classified into three groups with chemometric method. twenty-eight samples contained high total phenolic content, and exhibited moderate-higher antioxidant activity and strong α-glucosidase inhibitory activity. Furthermore, all fractions and isolated compounds were evaluated for their antioxidant and α-glucosidase inhibitory activities, and α-glucosidase inhibitory action mechanism of four characteristic constituents including protocatechuic acid, 3, 5, 7-trihydroxycoumarin,(2 R, 3 R)-(+)-taxifolin and quercetin was investigated via molecular docking method, which were all stabilized by hydrogen bonds with α-glucosidase. the study provided an effective approach to waste utilization of V. paradoxa nutshell, which would help to resolve waste environmental pollution and provide a basis for developing potential herbal resource for treating diabetes.

关键词： Vitellaria paradoxa HPLC fingerprints Antioxidant activity α-Glucosidase inhibitory activity Molecular docking

在线全文

学校读者我要写书评

暂无评论

预测耕作引起侵蚀的数学模型(tEP)

水土保持科技情报 2001年第1期19卷 17-19页

作者： M.j.Lindstrom j.A.Schumacher t.E.Schumacher 张庆利王飞山东农业大学

美国农业研究机构通过研究建立了能够描述山坡断面上土壤再分布的耕蚀预测模型 (tEP) ,并用此模型来解释坡耕地上耕作引起的土壤侵蚀和沉积模式 ,此模型以分散率为基础 ,其中表示土壤迁移和坡度关系的回归系数用分散系数k′来描述。利... 详细信息

美国农业研究机构通过研究建立了能够描述山坡断面上土壤再分布的耕蚀预测模型 (tEP) ,并用此模型来解释坡耕地上耕作引起的土壤侵蚀和沉积模式 ,此模型以分散率为基础 ,其中表示土壤迁移和坡度关系的回归系数用分散系数k′来描述。利用已公布的有壁犁的k′值 ,计算了Minnesota中西部地区一个已测定好的地形断面上5 0a内土壤的再分布情况 ,另外还模拟总结出了二次耕作 (串连耙 )和坡段的检测长度对模型计算出的土壤再分布率的影响。结果表明 ,使用k′为 2 34kg/m的有壁犁耕作时 ,所测断面土壤侵蚀和沉积率大于 10t/ (hm2 ·a)的面积为 14 7% ,若k′为 3 30kg/m时 ,则侵蚀或沉积率大于 10t/ (hm2 ·a)的面积增加到 2 6 % ,另外的二次耕作 (串连耙 )将进一步使土壤再分布的面积增加到 5 9%。

关键词：耕作沉积侵蚀土壤迁移美国预测数学模型坡耕地

Fast photocurable thiol-ene elastomers with tunable biodegradability,mechanical and surface properties enhance myoblast differentiation and contractile function

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第7期6卷 2120-2133页

作者： Mohamed Alaa Mohamed Aref Shahini Nika Rajabian julia Caserto Ahmed M.A.El-Sokkary Magda A.Akl Stelios t.Andreadis Chong Cheng Department of Chemical and Biological Engineering University at BuffaloThe State University of New YorkBuffaloNY14260USA Chemistry Department College of ScienceMansoura UniversityMansoura35516Egypt Department of Biomedical Engineering University at BuffaloThe State University of New YorkBuffaloNY14260USA Center of Excellence in Bioinformatics and Life Sciences BuffaloNY14263USA

Biodegradable elastomers are important emerging biomaterials for biomedical applications,particularly in the area of soft-tissue engineering in which scaffolds need to match the physicochemical properties of native ***,we report novel fast photocurable elastomers with readily tunable mechanical properties,surface wettability,and *** elastomers are prepared by a 5-min UV-irradiation of thiol-ene reaction systems of glycerol tripentenoate(GtP;a triene)or the combination of GtP and 4-pentenyl 4-pentenoate(PP;a diene)with a carefully chosen series of di-or *** the subsequent application study,these elastomers were found to be capable of overcoming delamination of myotubes,a technical bottleneck limiting the in vitro growth of mature functional *** glycerol-based elastomers supported the proliferation of mouse and human myoblasts,as well as myogenic differentiation into contractile *** notably,while beating mouse myotubes detached from conventional tissue culture plates,they remain adherent on the elastomer *** results suggest that these elastomers as novel biomaterials may provide a promising platform for engineering functional soft tissues with potential applications in regenerative medicine or pharmacological testing.

关键词： Biodegradable elastomers Cell culture substrate Skeletal muscle regeneration thiol-ene synthesis tissue engineering

维生素E和由香芹酚、肉桂醛和辣椒油树脂组成的植物提取物对仔猪饲粮中由高浓度多不饱和脂肪酸诱导的氧化应激的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

维生素E和由香芹酚、肉桂醛和辣椒油树脂组成的植物提取物对仔猪...

青藏高原及其周边古近纪综合地层、生物群与古地理演化

中国畜牧兽医学会动物营养学分会第七届中国饲料营养学术研讨会

作者： t.Frankic A.Levart j.Salobir Chair of Nutrition Department of Animal ScienceBiotechnical FacultyUniversity of LjubljanaGroblje 31230 DomzaleSlovenia

本试验旨在探讨由香芹酚、肉桂醛和辣椒油树脂组成的植物提取物对抑制由高n-3多不饱和脂肪酸诱发的氧化应激作用的影响。选用32头体重相近的(平均体重为10.9kg)断奶去势仔猪,随机分为4个日粮处理组,每组8只。阴性对照组(Cont)日粮包含17... 详细信息

本试验旨在探讨由香芹酚、肉桂醛和辣椒油树脂组成的植物提取物对抑制由高n-3多不饱和脂肪酸诱发的氧化应激作用的影响。选用32头体重相近的(平均体重为10.9kg)断奶去势仔猪,随机分为4个日粮处理组,每组8只。阴性对照组(Cont)日粮包含17.2%的能量,来自油脂。其余的三个试验组日粮中含有富含多不饱和脂肪酸的亚麻籽油,亚麻籽油取代小麦淀粉使来自油脂的能量提高到34.1%,其中一组日粮作为阳性对照

关键词：猪营养饲料添加剂植物提取物氧化应激

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国科学：地球科学 2024年第4期54卷 1308-1342页

作者：刘佳宋艾丁林苏涛周浙昆中国科学院西双版纳热带植物园热带森林生态学重点实验室勐腊666303 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 云南大学古生物研究院昆明650500 中国科学院青藏高原研究所地球系统科学与资源环境重点实验室北京100101

古近纪是陆地和海洋生态系统劫后复苏并逐渐接近其现代面貌的关键时期.在青藏高原及其周边区域,古近纪也是青藏高原-喜马拉雅造山带构造活动、亚洲气候重组、生物多样性演化的重要时期.限于研究条件、认识程度等的制约,青藏高原及其周... 详细信息

古近纪是陆地和海洋生态系统劫后复苏并逐渐接近其现代面貌的关键时期.在青藏高原及其周边区域,古近纪也是青藏高原-喜马拉雅造山带构造活动、亚洲气候重组、生物多样性演化的重要时期.限于研究条件、认识程度等的制约,青藏高原及其周边地区在地层划分方面还存在诸多争议.近年来,该区域开展了大量的沉积岩石学、磁性地层学、同位素年代学等工作,发现和报道了大量各种门类的化石,更系统地深化了生物地层学研究,为梳理青藏高原及其周边古近纪综合地层、生物群和古地理演化打下了坚实的基础.本文基于国际古近系划分和对比标准,以岩石地层和生物地层为基础,综合近年来同位素年代学、磁性地层学和地球化学等研究工作,在前人工作基础上梳理青藏高原及其周边不同构造单元的地层划分与对比框架.第二次青藏高原综合科学考察开展以来,古近纪植物群相关研究逐渐丰富.依据这些植物群最新的年代结果,本文讨论了灭绝类群和新出现类群的生物地层意义.对“桉属”、棕榈科等化石类群的新认识将古近纪青藏地区植物区系与冈瓦纳大陆的大洋洲、南美洲生物区系建立联系.雅鲁藏布江缝合带两侧植物群重要类群的演化历史也指示印度板块和欧亚大陆的碰撞时间在约65~54Ma.植物群的古高程重建结果表明,横断山区在早渐新世之前就已经形成现今的地貌格局;古近纪青藏地区主要缝合带附近的温暖湿润低地是动植物类群交流的主要通道;古近纪低矮的喜马拉雅山脉不能对南来的印度洋水汽形成有效的阻隔作用.

关键词：青藏高原化石生物地层古环境古地理古近纪