检索结果-南通市图书馆

Molecular pathogenesis of human hepatocellular carcinoma

在线全文

cnki会议

学校读者我要写书评

暂无评论

Molecular pathogenesis of human hepatocellular carcinoma

中国毒理学会第三届全国学术会议

作者： X.W.Wang S.P.Hussain t.I.Huo C.G.Wu M.Forgues L.j.Hofseth C.Brechot C.C.Harris Laboratory of Human Carcinogenesis National Cancer InstituteBethesdaMDUSA Laboratory of Human Carcinogenesis National Cancer InstituteBethesdaMDUSA Laboratory of Human Carcinogenesis National Cancer InstituteBethesdaMDUSA Laboratory of Human Carcinogenesis National Cancer InstituteBethesdaMDUSA Laboratory of Human Carcinogenesis National Cancer InstituteBethesdaMDUSA Laboratory of Human Carcinogenesis National Cancer InstituteBethesdaMDUSA Necker Institute ParisFrance Laboratory of Human Carcinogenesis National Cancer InstituteBethesdaMDUSA

＜正＞ Primary hepatocellular carcinoma（HCC） is one of the most com-mon malignancies in the world. However, the viral-chemical etiol-ogy as well as molecular mechanisms of HCC pathogenesis remainslargely unknown. Recent studies in our laboratory have identifiedseveral potential factors that may contribute to the pathogenesis ofHCC. Oxidative stress and chronic inflammation have been linkedto an increased risk of liver cancer. Oxyradical overload diseases,

关键词：

结肠假性梗阻患者主动钾分泌被激活:分泌型腹泻的一种新的发病机制

在线全文

cnki会议

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 22-23页

作者： Van Dinter jr. t.G Fuerst F.C Richardson C.t. j.S. Fordtran 陈云茹 Baylor University Medical Center 3500 Gaston Avenue Dallas TX 75246 United StatesDr.

Background &Aims: Secretory diarrhea is caused by inhibition of intestinal active sodium absorption and stimulation of active chloride secretion. the resulting increase in fecal sodium salts causes an isotonic increase in fecal water output. Abnormalities in potassium transport are not known to be a cause of secretory diarrhea. the aim of our report is to describe a patient with secretory diarrhea that was mediated by excess intestinal secretion of potassium. Methods: A 78-yearold woman developed colonic pseudo-obstruction, complicated by severe dia rrhea and hypokalemia. Her stools were collected quantitatively on 11 occasions and analyzed for electrolyte concentrations. Rectosigmoid potential difference w as measured. Results: the diarrheal fluid had a very high potassium concentratio n (130-170 mEq/L) and a very low sodium concentration (4-15 mEq/L). Stool pota ssium losses were as high as 256 mEq/day (normal, 9 mEq/day), and fecal sodium l osses were never higher than 13 mEq/day. Potential difference between colonic lu men and a peripheral reference electrode was -14 mV (lumen side negative). Conc lusions: Fecal potassium salts were the exclusive driving force for severe secre tory diarrhea in a patient with colonic pseudo-obstruction. the high fecal outp ut of potassium was due to stimulation of active colonic potassium secretion, po ssibly because of changes in autonomic nervous system activity and distention of the colon in association with colonic pseudo-obstruction. the extremely low fe cal excretion of sodium indicates that active sodium absorption was not inhibite d. this case study reveals an ion transport mechanism of secretory diarrhea that has not been previously appreciated.

关键词：结肠假性梗阻发病机制分泌异常钾离子浓度直肠乙状结肠腹泻患者低钾血症排出物结肠扩张结

维普期刊数据库

黏膜感染SIV病毒的恒河猴在生殖道、肠和淋巴组织特征性的细胞因子、化学因子和Foxp3表达

在线全文

学校读者我要写书评

暂无评论

黏膜感染SIV病毒的恒河猴在生殖道、肠和淋巴组织特征性的细胞因...

国际实验动物专题研讨会

作者： K.Abel t.Rourke M.B.McChesney C.j.Miller California National Primate Reseach Center University of California-Davis Davis CA. California National Primate Reseach Center University of California-Davis Davis CA. California National Primate Reseach Center University of California-Davis Davis CA. California National Primate Reseach Center University of California-Davis Davis CA.

＜正＞阴道黏膜感染致病性SIV病毒在大多数暴露的动物身上产生一种典型的系统感染,其余的动物则出现血浆vRNA阴性和抗SIV抗体阴性的结果。这些动物虽属于暴露但未感染的范畴,但这些动物中很多可在组织中检测到SIV RNA或DNA,提示阴道黏...

＜正＞阴道黏膜感染致病性SIV病毒在大多数暴露的动物身上产生一种典型的系统感染,其余的动物则出现血浆vRNA阴性和抗SIV抗体阴性的结果。这些动物虽属于暴露但未感染的范畴,但这些动物中很多可在组织中检测到SIV RNA或DNA,提示阴道黏膜感染SIV后,有相当数量的隐性感染发生。我们尝试通过一种间接方法,即测定阴道感染21天内在阴道黏膜和末梢组织中细胞因子水平,确定暴露但未感染的动物是真

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

不同断喙方法对肉仔鸡生产性能的影响

饲料博览 2009年第3期 39-40页

作者： Henderson S N Barton j t Wolfenden A D Higgins S E Higgins j P Kuenzel W j Lester C A tellez G Hargis B M

在商业肉鸡的饲养中断喙是必要的,其可以避免或减少生长过程中因啄伤造成的危害。试验旨在研究两种不同断喙方法与不断喙对鸡生产性能的影响。电烙断喙器(ECD)是从鸡的喙尖部进行烧伤断喙。红外断喙器(IBt)则在大约初孵的10d里应用红外... 详细信息

在商业肉鸡的饲养中断喙是必要的,其可以避免或减少生长过程中因啄伤造成的危害。试验旨在研究两种不同断喙方法与不断喙对鸡生产性能的影响。电烙断喙器(ECD)是从鸡的喙尖部进行烧伤断喙。红外断喙器(IBt)则在大约初孵的10d里应用红外光束,使活体基底组织与坚硬角质导完全分离。第二部分试验选择当地孵化场刚孵化出的708只Ross鸡,并对鸡群的1/3雏鸡进行IBt断喙。然后将所有的雏鸡运往另一个孵化场,对剩余的2/3雏鸡一半采用ECD断喙,另一半则不进行断喙(NBt)。断喙过程均由断喙技术熟练的人员操作。此后所有的雏鸡被运往阿肯色大学试验基地。按照试验设计,对每只雏鸡进行颈部标记及称重,并用游标卡尺测量喙径。试验结果表明,在第11天时IBt组雏鸡体重比NBt组和ECD组分别提高7.8和8.7g,差异极显著(Pt组有所下降,差异显著(Pt组间差异不显著(P>0.05),而在第21天和42天时,IBt组、ECD组与NBt组间在体重及体重增加上均无显著差异(P>0.05)。可见,在孵化当天便由技术熟练、经验丰富的人员对雏鸡断喙,不会对6周龄内雏鸡的生产性能产生明显影响。一般认为鸡生产性能的下降与其身体和精神敏感性应激有关。经红外烧灼断喙的雏鸡到达性成熟时体重显著减少,说明只要操作得当,任何断喙方法对鸡造成的身体和精神的应激,均不会影响其早期生长速度。

关键词：断喙早期生长性能体重

Gastric and small intestinal lipid digestion kinetics as affected by the gradual addition of lipases and bile salts

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Bioscience 2022年第2期46卷 781-792页

作者： S.H.E Verkempinck j.M.Guevara-Zambrano M.R.Infantes-Garcia M.C.Naranjo R.Soliva-Fortuny P.Elez-Martínez t.Grauwet KU Leuven Department of Microbial and Molecular Systems M2SLaboratory of Food Technology and Leuven Food Science and Nutrition Research Centre LFoRCeKasteelpark Arenberg 23PB 24573001LeuvenBelgium University of Lleida Department of Food TechnologyAgrotecnio CenterAv.Alcalde Rovira Roure 19125198LleidaSpain

We studied the effect of evolving from static in vitro digestion conditions towards the gradual addition of essential digestive compounds for lipid *** oil-in-water emulsions were considered:a low(5%w/w)and high(20%w/w)triolein-based emulsion with identical surfactant-to-oil ratio(0.2).Emulsions were subjected to in vitro static digestion conditions or gradual gastric lipase addition,gradual pancreatic lipase addition,and/or gradual bile salt *** these three latter cases,similar amounts of gastric/pancreatic lipase and/or bile salts were provided as in the static case,however divided over 4 doses added during the first 30 min of each digestive *** the low-lipid emulsion,gradually adding lipases and bile salts did not significantly affect lipolysis *** can be related to the sufficient amounts of digestive compounds present even in the smallest initial *** the high-lipid emulsion,the gradual addition of bile salts significantly reduced the lipolysis *** salts are essential to remove lipid digestion products from the interface and thus allow the continuation of the lipid digestion process at the ***,the lipolysis extent after 2 h of small intestinal phase was not significantly influenced by the digestion *** is again explained by the simple nature of the emulsions studied and the excess of lipase even in the smallest initial ***,this work showed that evolving towards more(semi-)dynamic digestion conditions can impact(lipid)digestion kinetics,even for relatively simple food compositions,and is of interest to obtain more physiological relevant digestion kinetics.

关键词： Kinetics In vitro digestion Microemulsions Lipid digestion Lipases Bile salts

胶质母细胞瘤术后潜在复发区域各向异性分数减低

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2017年第4期 465-466页

作者： S.Bette t.Huber j.Gempt t.Boeckh-Behrens B.Wiestler V.Kehl 刘立恒 Department of Neuroradiology Klinikum Rechts der Isar Technische Universit?t München

摘要目的探讨胶质母细胞瘤瘤周不强化区(NEPtRS)的基线各向异性分数(FA)与肿瘤术后局部复发的相关性。材料与方法该回顾性研究已获得机构伦理委员会批准并符合HIPAA。本研究共纳入70例胶质母细胞瘤病人。在每例病人术前MRI显示的瘤周NE...

摘要目的探讨胶质母细胞瘤瘤周不强化区(NEPtRS)的基线各向异性分数(FA)与肿瘤术后局部复发的相关性。材料与方法该回顾性研究已获得机构伦理委员会批准并符合HIPAA。本研究共纳入70例胶质母细胞瘤病人。在每例病人术前MRI显示的瘤周NEPtR上勾画5个兴趣区(ROI)(包括白质、皮质、纤维束和基底节区),测定各ROI的FA值,并

关键词：

Measurement of integrated luminosities at BESⅢ for data samples at center-of-mass energies between 4.0 and 4.6 GeV

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2022年第11期46卷 53-63页

作者： M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi j.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang W.L.Chang G.Chelkov C.Chen G.Chen H.S.Chen M.L.Chen S.j.Chen t.Chen X.R.Chen X.t.Chen Y.B.Chen Z.j.Chen W.S.Cheng X.Chu G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbeyssi R.Ede Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong S.X.Du P.Egorov Y.L.Fan j.Fang S.S.Fang W.X.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng K Fischer M.Fritsch C.Fritzsch C.D.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.t.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco M.H.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov t.t.Han W.Y.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold M.Himmelreich t.Holtmann G.Y.Hou Y.R.Hou Z.L.Hou H.M.Hu j.F.Hu t.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang L.Q.Huang X.t.Huang Y.P.Huang Z.Huang t.Hussain N Husken W.Imoehl M.Irshad j.jackson S.jaeger S.janchiv Q.ji Q.P.ji X.B.ji X.L.ji Y.Y.ji Z.K.jia H.B.jiang S.S.jiang X.S.jiang Y.jiang j.B.jiao Z.jiao S.jin Y.jin M.Q.jing t.johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kuhn j.j.Lane j.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann t.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.j.Li H.N.Li j.Q.Li j.S.Li j.W.Li Ke Li L.j Li L.K.Li Lei Li M.H.Li P.R.Li S.X.Li S.Y.Li t.Li W.D.Li W.G.Li X.H.Li X.L.Li Xiaoyu Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.t.Liang G.R.Liao L.Z.Liao j.Libby A.Limphirat C.X.Lin D.X.Lin t.Lin B.j.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu G.M.Liu H.Liu H.M.Liu Huanhuan Liu Huihui Liu j.B.Liu j.L.Liu j.Y.Liu K.L Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and technology Beijing 100190China COMSAtS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Ave.54BUlaanbaatar 13330Mongolia jilin University Changchun 130012China johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

the integrated luminosities of data samples collected in the BESⅢ experiment in 2016-2017 at centerof-mass energies between 4.19 and 4.28 GeV are measured with a precision better than 1% by analyzing large-angle Bhabha scattering *** integrated luminosities of old datasets collected in 2010-2014 are updated by considering corrections related to detector performance,offsetting the effect of newly discovered readout errors in the electromagnetic calorimeter,which can haphazardly occur.

关键词： integrated luminosity e^(+)e^(-)annihilation Bhabha scattering

维普期刊数据库

Field-Aligned Currents Originating From the Chaotic Motion of Electrons in the tilted Current Sheet:MMS Observations

在线全文

学校读者我要写书评

暂无评论

Field-Aligned Currents Originating From the Chaotic Motion o...

作者： Wang,G.Q. Zhang,t.L. Wu,M.Y. Xiao,S.D. Wang,G. Chen,Y.Q. Sun,j.C. Volwerk,M.

Field-aligned currents often appear at the neutral sheet in the tilted current sheet,however,their origins are still *** we investigate two flapping motion events using the Magnetospheric Multiscale mission *** current densities mainly contributed by electrons appear near the neutral sheet in the severely titled current sheet in both events.

关键词： Field-Aligned Currents Originating From the Chaotic Motion of Electrons in the tilted Current Sheet:MMS Observations MMS

冠状动脉疾病心肌血容量和血流量的作用:静息、充血状态的MRI实验研究

在线全文

cnki会议

学校读者我要写书评

暂无评论

国际医学放射学杂志 2010年第5期 508-509页

作者： K.S.McCommis t.A.Goldstein D.R.Abendschein B.Misselwitz t.Pilgram R.j.Gropler 肖运平 Mallinckrodt Institute of Radiology Washington University School of Medicine

关键词：冠状动脉狭窄心肌血流量心肌血容量