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Asian Journal of Andrology 2005年第3期7卷 267-275,页

作者： C.Soler J.J.deMonserrat M.Núez R.gutiérrez J.Núez M.Sancho t.g.cooper Departmentof Functional Biology and Physical Anthropology University of ValènciaValència 46112Spain Departamentode Ouímica y Biología Universidad del NorteBarranquillaColombia Instituteof Reproductive Medicine University of MünsterMünster D-48129Germany

Aim： to establish a rat and mouse epididymal map based on the use of the Epiquatre automatic software for histologic image analysis. Methods： Epididymides from five adult rats and five adult mice were fixed in alcoholic Bouin＇s fixative and embedded in paraffin. Serial longitudinal sections through the medial aspect of the organ were cut at 10 jam and stained with hematoxylin and eosin. As determined from major connective tissue septa, nine subdivisions of the rat epididymis and seven for the mouse were determined, consisting of five sub-regions in the caput （rat and mouse）, one （mouse） or three （rat） in the corpus and one in the cauda （rat and mouse）. Using the Epiquatre software, several tubular, luminal and epithelial morphometric parameters were evaluated. Results： Statistical comparison of the quantitative parameters revealed regional differences （2-5 in the rat, 3-6 in the mouse, dependent on parameters） with caput regions 1 and 2 being largely distinguishable from the similar remaining caput and corpus, which were in turn recognizable from the cauda regions in both species. Conclusion： the use of the Epiquatre software allowed us to establish regression curves for different morphometric parameters that can permit the detection of changes in their values under different pathological or experimental conditions. （Asian J Androl 2005 Sep; 7： 267-275）

关键词： rat mouse epididymis morphometry zonation computer-aided image analysis Epiquatre Software

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生物化学工具 1版

生物化学工具

在位狗心代谢增强时的冠脉调节—31P-NMR分析

丛书名：书名原文:the tools of biochemistry

1980年

作者：（美）库珀（t.g.cooper）徐晓利等译

生物化学工具

ISBN: (纸本)14048·3810

生物化学工具

关键词：生物化学

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中国病理生理杂志 1991年第2期 180-180页

作者：宁学寒,M.W.gorman,t.g.cooper,H.V.Sparker 中国科学院上海生理研究所 Jr Michigan State University USA Jr Michigan State University USA Jr Michigan State University USA

为了研究在体心脏的冠脉代谢性调节,在8条麻醉开胸狗上,以去甲肾上腺素（NA）冠状动脉灌注（14.4μg/min/100g心肌）增强代谢,用冠状窦-颈静脉旁路技术测定左心冠脉流量（CBF）及氧耗（VO2）。将犬置于核

关键词： P-NMR 冠脉冠脉流量心肌

Androgens and prostate disease

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Asian Journal of Andrology 2014年第2期16卷 248-255,I0009页

作者： Lori A cooper Stephanie t Page Departments of Medicine Division of Endocrinology and Metabolism University of Washington Seattle University of Washington and Harborview Medical Center Seattle Washington USA.

A growing body of literature has established the anabolic benefits of testosterone （t） therapy in hypogonadal men. However, there remains a paucity of data regarding the risks of exogenous androgen use in older men and the potential for adverse effects on the prostate gland. Whether t therapy in older, hypogonadal men might worsen lower urinary tract symptoms or exacerbate, unmask, or even incite prostate cancer development has tempered enthusiasm for t therapy, while known prostatic disease has served as a relative contraindication to t therapy. Androgens are necessary for the development and maintenance of the prostate gland. However, epidemiologic studies do not consistently find a positive relationship between endogenous serum androgen concentrations and the risk of prostate disease. Recent data demonstrate that 5α-reductase inhibitors decrease the risk of low-grade prostate cancer, suggesting that modifying androgen metabolism may have beneficial effects on prostate health, yet similar reductions in high-grade disease have not been observed, thereby questioning the true clinical benefits of these agents for chemoprevention. Knowing how to best investigate the relationship between androgens and the development of prostate disease given the lack of large, randomized trials is difficult. Accumulating data challenges the assumption that alterations in serum androgens have parallel effects within the prostate hormonal environment or change androgen-regulated processes within the gland. Long-term intervention studies are needed to truly ascertain the effects of androgen manipulation on prostate tissue and disease risk. However, available data do not support the notion that restoring serum androgens to normal physiologic ranges drives prostate disease.

关键词： androgens male hypogonadism prostate testosterone

Improving precision in the assessment of round cell numbers in human semen

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Asian Journal of Andrology 2010年第1期12卷 111-114页

作者： trevor g. cooper Barbara Hellenkemper Centre of Reproductive Medicine and Andrology University of Miinster Domagkstrasse 11 D-48149 Miinster Germany

the aim of this study was to increase the precision of assessment of the number of round cells observed in the per- oxidase test for detection of seminal leukocytes （granulocytes）. the dilution of semen was reduced and the volume of suspension examined was increased for semen samples containing between 0.6 and 6 million round cells per mL. A 1 ＋ 5 （1：6） dilution was compatible with measurable peroxidase activity and a sufficiently clear background for cell assessment. At this dilution, and with assessment of all 18 grids on both sides of the Neubauer-improved counting chamber, only three of the 10 samples （nominal cell concentrations of 1.9 ×10^-6-3.3×10^-6 mL-1） presented 400 round cells or more. As lower seminal dilutions were incompatible with easy detection of round cells or their peroxidase reaction product, it was not pos- sible to provide precise measurements （sampling error 5%） of the suggested lower reference limit of 1 ×10^-6 cells per mL. the results indicate that this poor precision of measuring 1×10^-6 round cells per mL could explain the discrepant reports on the acceptability of the cut-off values for leukocytospermia. Such reference limits need to be established with statistically sound methods.

关键词： cell number peroxidase precision round cells semen

A short note on how tied fights affect cortisol levels

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Integrative Zoology 2013年第3期8卷 324-326页

作者： Edwin L.cooper Kathy t.NgO Department of Neurobiology University of CaliforniaLos AngelesCAUSA Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos AngelesCAUSA

Previous work exploring the interrelationships between sex steroids(***,testosterones and 11-ketotestosterones)and social behavior in teleosts suggest that mirror-elicited aggression in cichlid fish may not trigger a hormonal *** the Mozambique tilapia(Oreochromis mossambicus)to analyze immune responses as a result of social stress,we measured levels of cortisol and melatonin using Enzyme-Linked Immunosorbent Assay(ELISA)*** this work,we demonstrated that cortisol concentrations are significantly lower yet the levels of melatonin remain unchanged in tilapia that are fighting their mirror *** results suggested that in tied fights,certain hormone levels remain unchanged(***)due to the lack of melatonin induction.

关键词： cortisol hormone level melatonin social stress tilapia

Concurrent chemoradiation for high-risk prostate cancer

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World Journal of Clinical Oncology 2015年第4期6卷 35-42页

作者： Benjamin t cooper Nicholas J Sanfilippo Department of Radiation Oncology New York University School of Medicine

there are estimated to be 220800 cases of prostate cancer diagnosed in 2015, making up 26% of all cancer diagnoses. Fortunately, adenocarcinoma of the prostate is often a highly treatable malignancy. Even though the majority of prostate cancer patients present with localized disease, prostate cancer still accounts for over 27000 deaths a year. there is a subset of patients thatare likely to recur after locoregional treatment that is thought of as a "high-risk" population. this more aggressive subset includes patients with clinical stage greater than t2 b, gleason score greater than 7, and prostate specific antigen greater than 20 ng/d L. the rate of biochemical relapse in this high risk group is 32%-70% within five years of definitive focal therapy. given these discouraging outcomes, attempts have been made to improve cure rates by radiation dose escalation, addition of androgen depravation therapy, and addition of chemotherapy either sequentially or concurrently with radiation. One method that has been shown to improve clinical outcomes is the addition of chemotherapy to radiotherapy for definitive treatment. Concurrent chemoradiation with 5-fluorouracil, estramustine phosphate, vincristine, docetaxel, and paclitaxel has been studied in the phase I and/or II setting. these trials have identified the maximum tolerated dose of chemotherapy and radiation that can be safely delivered concurrently and established the safety and feasibility of this technique. this review will focus on the addition of concurrent chemotherapy to radiotherapy in the definitive management of high-risk prostate cancer.

关键词： Prostate cancer Chemoradiation Highrisk prostate cancer Concurrent chemotherapy Chemotherapy Intensity modulated radiation therapy

the discovery of t–B cell lineages:An interview with Professor Max D cooper

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hLife 2023年第1期1卷 3-7页

作者： Chen Dong Max D cooper Shanghai Immune therapy Institute Shanghai Jiao Tong UniversityShanghaiChina Institute for Immunology Tsinghua UniversityBeijingChina School of Medicine Emory UniversityGeorgiaUSA

In the early 1960s,despite a general understanding of antibodies and immunoglobulins,their source and their relationship with anti-infection immunity remained largely ***,this changed with the groundbreaking discoveries of *** D cooper,professor at Emory University School of *** the 1960s,*** D cooper discovered the existence of two different lymphoid lineages,B and t cells,which are now widely recognized as the cornerstone components of the adaptive immune system.B and t cells are responsible for humoral and cellular immunity,*** discovery served as the foundation of modern ***,*** D cooper shares his inspiring journey,from career choice to research experiences,as well as offering sage advice to aspiring immunologists.

关键词： cooper Max immunity

A Special Issue on the Epididymis ＆ the Proceedings of the Fourth Workshop on the Epididymis （Epid Ⅳ）

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Asian Journal of Andrology 2007年第4期9卷 I0002-I0003页

作者： Joel R. Drevet Barry t. Hinton trevor g. cooper

the Fourth Epididymis （Epid Ⅳ） Workshop was held between December 4th and 7th 2006 in Chatel-guyon, France. this was the first European venue for these workshops following Epid Ⅲ held in Charlottesville, Virginia, USA in 2002, Epid Ⅱ held in Newcastle, Australia in 1998 and a one-day meeting （later named Epid Ⅰ） in Hong Kong, China in 1992. the 2006 meeting was organised by Drs Joeol R. Drevet （Aubi6re, France） and trevor g. cooper （Muenster, germany） and was a satellite meeting of the Fourth European Congress of Andrology （ECA2006） which followed in toulouse （France） from December 8th to 10th.

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Non-Uniformity and generalised Sacks Splitting

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Acta Mathematica Sinica,English Series 2002年第2期18卷 327-334页

作者： cooper S.Barry Department of Pure Mathematics School of Mathematics University of Leeds Leeds UK Institute of Software Chines Academy of Sciences Beijing P. R. China

We show that there do not exist computable fimetions f_1(e,i).f_2(e,i).g_1(e,i),g_2(e,i)such that for all e,i ∈ω, (1)(W_(f_1)(e,i)-W_(f_2)(e,i))≤t(W_e-W_1): (2)(W_(g_1)(e,i)-W_(g_2)(e,i))≤t(W_e-W_i): (3)(W_w-W_i)≤t(W_(f_1)(e,i)-W_(f_2)(e,i))⊕(W_(g_1)(e,i)-W_(g_2)(e,i)): (4)(W_e-W_i)t(W_(f_1)(e,i)-W_(f_2)(e,i))uuless(W_e-W_i)≤t:and (5)(W_e-W_i)t(E_(g_1)(e,i)-W_(g_2)(e,i))unless(W_w-W_i)≤t. It follows that the splitting theorems of Sacks and cooper cannot be combined uniformly.

关键词： Computably enumerable(c.e.) Difference of computably enumerable sets(d.c.e.,or 2-c.e.) turing degrees Splitting and nonsplitting