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Sedimentary records of contaminant inputs in Frobisher Bay,Nunavut

Environmental Science and Ecotechnology 2024年第2期18卷 28-42页

作者： Meaghan c.Bartley tommy tremblay Amila O.De Silva cMichelle Kamula Stephen ciastek Zou Zou A.Kuzyk centre for Earth Observation Science Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Department of Environment and Geography Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada canada-Nunavut Geoscience Office IqaluitNunavutX0A 0H0Canada Environment and climate change canada BurlingtonOntarioL7S 1A1Canada Department of Earth Sciences Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada

contaminants,such as polychlorinated biphenyls(PcBs),polycyclic aromatic hydrocarbons(PAHs),heavy metals,and per and polyfluoroalkyl substances(PFASs),primarily reach the Arctic through long-range atmospheric and oceanic ***,local sources within the Arctic also contribute to the levels observed in the environment,including legacy sources and new sources that arise from activities associated with increasing commercial and industrial *** city of Iqaluit in Frobisher Bay,Nunavut(canada),has seen rapid population growth and associated development during recent decades yet remains a site of interest for ocean protection,where Inuit continue to harvest country *** the present study,seven dated marine sediment cores collected in Koojesse Inlet near Iqaluit,and from sites in inner and outer Frobisher Bay,respectively,were analyzed for total mercury(tHg),major and trace elements,PAHs,PcBs,and *** sedimentary record in Koojesse Inlet shows a period of Aroclor 1260-like PcB input concurrent with military site presence in the 1950e60s,followed by decades of input of pyrogenic PAHs,averaging about ten times background ***-surface sediments in Koojesse Inlet also show evidence of transient local-source inputs of tHg and PFASs,and recycling or continued slow release of PcBs from legacy land-based *** in PFAS congener composition clearly distinguish the local sources from long-range *** Koojesse Inlet but still in inner Frobisher Bay,9.2 km from Iqaluit,sediments showed evidence of both local source(PcB)and longrange *** outer Frobisher Bay,an up-core increase in tHg and PFASs in sediments may be explained by ongoing inputs of these contaminants from long-range *** context for ocean protection and country food harvesting in this region of the Arctic clearly involves both local sources and long-range transport,with past human activities leaving a long legacy insofar as levels of persistent o

关键词： Arctic sediments Mercury Polycyclic aromatic hydrocarbons(PAHs) Polychlorinated biphenyls(PcBs) Per and polyfluoroalkyl substances(PFASs) Persistent organic pollutants(POPs)

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comparative Analysis of Machine Learning Models for customer churn Prediction in the U.S. Banking and Financial Services: Economic Impact and Industry-Specific Insights

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Journal of Data Analysis and Information Processing 2024年第3期12卷 388-418页

作者： Omoshola S. Owolabi Prince c. Uche Nathaniel t. Adeniken Oghenekome Efijemue Samuel Attakorah Oluwabukola G. Emi-Johnson Emmanuel Hinneh Department of Data Science Carolina University Winston-Salem NC USA Department of computer Science Austin Peay State University Clarkesville TN USA Department of Statistical Sciences Wake Forest University Winston-Salem NC USA

customer churn poses a significant challenge for the banking and finance industry in the United States, directly affecting profitability and market share. this study conducts a comprehensive comparative analysis of machine learning models for customer churn prediction, focusing on the U.S. context. the research evaluates the performance of logistic regression, random forest, and neural networks using industry-specific datasets, considering the economic impact and practical implications of the findings. the exploratory data analysis reveals unique patterns and trends in the U.S. banking and finance industry, such as the age distribution of customers and the prevalence of dormant accounts. the study incorporates macroeconomic factors to capture the potential influence of external conditions on customer churn behavior. the findings highlight the importance of leveraging advanced machine learning techniques and comprehensive customer data to develop effective churn prevention strategies in the U.S. context. By accurately predicting customer churn, financial institutions can proactively identify at-risk customers, implement targeted retention strategies, and optimize resource allocation. the study discusses the limitations and potential future improvements, serving as a roadmap for researchers and practitioners to further advance the field of customer churn prediction in the evolving landscape of the U.S. banking and finance industry.

关键词： churn Prediction Machine Learning Economic Impact Industry-Specific Insights Logistic Regression Random Forest Neural Networks

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Erratum:"HI in High Gas-phase Metallicity Dwarf Galaxy WISEA J230615.06+143927.9"(2024,RAA,24,015024)

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Research in Astronomy and Astrophysics 2024年第7期24卷 272-272页

作者： Yan Guo c.Sengupta t.c.Scott P.Lagos Y.Luo Puyple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China Institute of Astrophysics and Space Sciences(IA Porto) Rua das Estrelas4150-762.PortoPortugal

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Storylines of family medicine Ⅲ:core principles—primary care,systems and family

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Family Medicine and community Health 2024年第S3期12卷 23-32页

作者： William B Ventres Leslie A Stone timothy A Joslin John W Saultz Sommer Aldulaimi Paul R Gordon John c Lane Eric R Lee Jacob Prunuske Limor Gildenblatt Michael H Friedman colleen t Fogarty Susan H McDaniel tessa Rohrberg Amy Odom Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine Oregon Health&Science UniversityPortlandOregonUSA Family and community Medicine University of Arizona Medical Center–South CampusTucsonArizonaUSA Family and community Medicine University of Arizona Medical Center–University CampusTucsonArizonaUSA UAMS West Regional campus Family Medicine Residency Program Fort SmithArkansasUSA Medical college of Wisconsin–central Wisconsin campus WausauWisconsinUSA Family and community Medicine Medical College of Wisconsin–Central Wisconsin CampusWausauWisconsinUSA Family Medicine Advocate Illinois Masonic Medical CenterChicagoIllinoisUSA Family Medicine Presence Saints Mary and Elizabeth Medical CenterChicagoIllinoisUSA Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Psychiatry and Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Family and community Medicine University of Kansas School of Medicine-WichitaWichitaKansasUSA Sparrow/Michigan State University Family Medicine Residency Program LansingMichiganUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅲ:core principles—primary care,systems,and family’,authors address the following themes:‘continuity of care—building therapeutic relationships over time’,‘comprehensiveness—combining breadth and depth of scope’,‘coordination of care—managing multiple realities’,‘Access to care—intersectional,systemic,and personal’,‘Systems theory—a core value in patient-centered care’,‘Family-oriented practice—supporting patients’health and well-being’,‘Family physician as family member’and‘Family in the exam room’.May readers develop new understandings from these essays.

关键词： individual Storyline principles

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Mechanism of action, benefits, and research gap in fermented soybean meal utilization as a high-quality protein source for livestock and poultry

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Animal Nutrition 2024年第1期16卷 130-146页

作者： Modinat t.Lambo Haokai Ma Haosheng Zhang Peng Song Hongxiang Mao Guowen cui Baisheng Dai Yang Li Yonggen Zhang college of Animal Science and technology Northeast Agricultural University Wilmar (Shanghai) Biotechnology Research and Development center co. Ltd college of Electrical Engineering and Information Northeast Agricultural University

Animal nutritionists have incessantly worked towards providing livestock with high-quality plant protein feed *** meal (SBM) has been an essential and predominantly adopted vegetable protein source in livestock feeding for a long time;however,several SBM antinutrients could potentially impair the animal's performance and growth,limiting its *** processing methods have been employed to remove SBM antinutrients,including fermentation with fungal or bacterial *** to the literature,fermentation,a traditional food processing method,could improve SBM's nutritional and functional properties,making it more suitable and beneficial to *** current interest in health-promoting functional feed,which can enhance the growth of animals,improve their immune system,and promote physiological benefits more than conventional feed,coupled with the ban on the use of antimicrobial growth promoters,has caused a renewed interest in the use of fermented SBM (FSBM) in livestock *** review details the mechanism of SBM fermentation and its impacts on animal health and discusses the recent trend in the application and emerging advantages to livestock while shedding light on the research gap that needs to be critically addressed in future *** appears to be a multifunctional high-quality plant protein source for *** removing soybean antinutrients,beneficial bioactive peptides and digestive enzymes are produced during fermentation,providing probiotics,antioxidants,and immunomodulatory *** aspects regarding FSBM feeding to animals remain uncharted,such as the duration of fermentation,the influence of feeding on digestive tissue development,choice of microbial strain,and possible environmental impact.

关键词： Soybean meal Protein feed Fermentation Microorganism Livestock

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Satellite-enabled enviromics to enhance crop improvement

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael t.Resende Lee Hickey cibele H.Amaral Lucas L.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil thecROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LiDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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Single-cell RNA sequencing facilitates the elucidation of the complete biosynthesis of the antidepressant hyperforin in St. John's wort

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Molecular Plant 2024年第9期17卷 1439-1457页

作者： Song Wu Ana Luisa Malaco Morotti Jun Yang Ertao Wang Evangelos c.tatsis National Key Laboratory of Plant Molecular Genetics CASs Center for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China University of chinese Academy of Sciences Shanghai 200032China UEPAMS-cAS-JIcs centre of Excellencefor Plant anamlcroblalSclence Snangnal 200032Cnina

Hyperforin is the compound responsible for the effectiveness of ***'s wort(Hypericum perforatum)as an antidepressant,but its complete biosynthetic pathway remains *** discovery based on co-expression analysis of bulk RNA-sequencing data or genome mining failed to discover the missing steps in hyperforin *** this study,we sequenced the 1.54-Gb tetraploid *** genome assem-bled into 32 chromosomes with the scaffold N50 value of 42.44 *** single-cell RNA sequencing,we iden-tified a type of cell,“Hyper cells”,wherein hyperforin biosynthesis de novo takes place in both the leaves and *** pathway reconstitution in yeast and tobacco,we identified and characterized four transmembrane prenyltransferases(HpPt1-4)that are localized at the plastid envelope and complete the hyperforin biosynthetic *** hyperforin polycyclic scaffold is created by a reaction cascade involving an irregular isoprenoid coupling and a tandem *** findings reveal how and where hy-perforin is biosynthesized,enabling synthetic-biology reconstitution of the complete ***,this study not only deepens our comprehension of specialized metabolism at the cellularlevel but also provides strategic guidance for elucidation of the biosynthetic pathways of other specializied metabolites in plants.

关键词： hyperforin Hypericum perforatum de novo genome sequencing single-cell RNA sequencing biosyn-thetic pathway meroterpenoids

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.tan Q.Wang Y.chen W.B.Yao c.Z.Xiao J.F.Myatt School of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and computational Mathematics Beijing 100094China School of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(SRSS)is observed for the first time via two-dimensional(2D)particle-in-cell(PIc)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order SRSS and estimate its *** rescattering process is identified by the 2D PIc simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order SRSS propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order SRSS,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that SRSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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Porphyrins,phthalocyanines,and related covalent-organic frameworks in the photochemical and electrochemical water splitting:A review

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Particuology 2024年第7期90卷 236-265页

作者： Oxana V.Kharissova Yolanda Peña Méndez Boris I.Kharisov Aleksandr LNikolaev Edith Luévano-Hipólito Lucy t.González Universidad Autónoma de Nuevo León Ave.Universidad s/nSan Nicolás de los GarzaNuevo León66455Mexico Department of chemistry Moscow State UniversityVorobievy HillsMoscowRussia cONAcYt-Universidad Autónoma de Nuevo León Facultad de Ingeniería Civil-Departamento de Ecomateriales y EnergíaCd.UniversitariaC.P.66455San Nicolás de los GarzaNLMexico tecnologico de Monterrey Escuela de Ingeniería y CienciasMonterreyNuevo León 64890Mexico tecnologico de Monterrey Centro del AguaMonterreyNuevo León 64890Mexico

In this review,the possibilities of photochemical and electrochemical water splitting(WS)using porphyrins,phthalocyanines,related macrocycles,and their metal complexes are *** efforts are being carried out in order to develop novel and cheap methods for water decomposition to generate inexhaustible greener energy sources(molecular hydrogen)instead of oil and *** processes of WS in heterogeneous and homogeneous media require novel photo-and electrocatalysts,in particular those on macrocycle basis.A high WS efficiency has been observed for porphyrins and phthalocyanines,showing their suitability both for HER and OER processes are available using these relative compounds for WS *** can be used in photocatalytic and electrocatalytic WS processes both in their free forms or as metal porphyrins/porphyrinates,mainly loaded on various inorganic materials,such as Au NPs,c_(3)N_(4),GaP,KtaO_(3),GaP,and so on,as part of porphyrin-containing polymers or on electrode surface as modifying coatings,being sometimes better than commercial catalysts,such as Pt/*** H2 evolution can be considerably depended on the shape of porphyrin particles;in particular,porphyrin nanowires can yield up to 20 times more H2 than its *** certain cases,both HER and OER can be driven in the same electrolyte using metal *** capacity of metal porphyrins to generate ROS(in particular,singlet oxygen 1O_(2))under ultrasonic treatment is known and can be successfully used for H_(2)O_(2) and O_(2) *** can be used in similar processes in free form or as composites with inorganic or organic counterparts,being immobilized on nanocarbons,metal oxides and salts,or simply dissolved in water acting in a homogeneous *** additional use of ultrasound can lead to better results due to the synergistic effect of the sonochemical treatment and ***-organic frameworks are also applied for WS purposes and are mainly based

关键词： Porphyrins Phthalocyanines cOFs Water splitting Photocatalysis Electrocatalysis

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cD4^(+)t cells produce IFN-I to license cDc1s for induction of cytotoxic t-cell activity in human tumors

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cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël c.de Groot Marij J.P.Welters tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets timo Oosenbrug Annemarthe van der Veen Joris L.Vos charlotte L.Zuur Noel F.c.c.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

cD4^(+)t cells can"help"or"license" conventional type 1 dendritic cells(cDc1s)to induce cD8^(+)cytotoxic t lymphocyte(ctL)anticancer responses,as proven in mouse *** recently identified cDc1s with a transcriptomic imprint of cD4^(+)t-cell help,specifically in t-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDc1 licensing by cD4^(+)t cells in *** cD4^(+)t cells produce IFNβvia the StING pathway,which promotes MHc-I antigen(cross-)presentation by cDc1s and thereby improves their ability to induce ctL anticancer *** cooperation with cD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDc1s required for ctL response ***-I-producing cD4^(+)t cells are present in diverse t-cell-infiltrated cancers and likely deliver“help”signals to ctLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDcs and tumor-reactive cD8^(+)t *** agreement with this scenario,the presence of IFN-I-producing cD4^(+)t cells in the tME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： cD4^(+)t-cell help cDc1 licensing IFN-I signaling cD40 costimulation (cross-)presentation ctL priming tumor control

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