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temperate Stutzerimonas Phage Encoding toxin-Antitoxin System Genes Represents a Novel Genus

Journal of Ocean University of china 2024年第4期23卷 1087-1101页

作者： ZHANG Hong GUO Ruizhe GAO chen ZHENG Kaiyang XIONG Yao DONG Yue LIU Yundan WANG Ziyue cHEN Ying WANG Hongmin SHAO Hongbing SUNG Yeong Yik MOK Wen Jye wong Li Lian McMINN Andrew WANG Min LIANG Yantao college of Marine Life Sciences Institute of Evolution and Marine BiodiversityMOE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266003China UMt-OUc Joint center for Marine Studies Qingdao 266003China Institute of Marine Biotechnology Universiti Malaysia Terengganu21030 Kuala TerengganuMalaysia Institute for Marine and Antarctic Studies University of TasmaniaHobartTAS 7001Australia Haide college Ocean University of ChinaQingdao 266100China the Affiliated Hospital of Qingdao University Qingdao 266001China

Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological ***,research on its phages is currently *** this study,we isolated a novel double-stranded DNA(dsDNA)phage,vB_SstM-PG1,from the marine environment that infects Stutzerimonas stutzeri *** dsDNA genome is 37204 bp long with a G/c content of 64.14%and encodes 54 open reading *** phage possesses a tail packaging structure that is different from known Stutzerimonas stutzeri phages and exhibits structural protein characteristics similar to those of temperate *** addition,two genes of toxin-antitoxin system,including YdaS_antitoxin and HEPN_SAV_6107,were found in the vB_SstM-PG1 genome and play important roles in regulating host growth and *** phylogenetic tree and comparative genomic analysis,it has been determined that vB_SstM-PG1 is not closely related to any phages previously identified in the GenBank ***,it has a connection with enigmatic,uncultured ***,the vB_SstM-PG1 virus exhibits an average nucleotide identity of over 70%with six uncultivated viruses identified in the IMG/VR v4 *** significant finding has resulted in the identification of a novel viral genus known as Metabovirus.

关键词： Stutzerimonas vB_SstM-PG1 Metabovirus temperate phage genomic and phylogenetic analysis

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Experimental and numerical analysis of multi-chamber oscillating water column devices

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Journal of Hydrodynamics 2024年第3期36卷 492-503页

作者： Jorge Gadelho Kourosh Rezanejad c.Guedes Soares centre for Marine technology and Ocean Engineering(cENtEc) Instituto Superior TécnicoUniversidade de LisboaAvenida Rovisco PaisLisboaPortugal

A review of multi-chamber oscillating water column(OWc)device designs is *** significant variations of these devices are discussed,onshore OWc(OOWc)and a floating OWc(FOWc).the efficiency results of several theoretical studies based on low-and high-fidelity numerical models are presented and compared with the model scale ***,low-fidelity numerical models are very fast to run,but their accuracy is limited compared with high-fidelity numerical *** model experiments usually give results much more accurate than numerical models,but they need adequate facilities and are very *** the case of the OOWc,all models show a similar trend of total efficiency,but while the analytical model shows a maximum value of around 90%efficiency,the cFD model shows 60%,and the experiments only go up to 40%.the main reason is connected with the mathematical simplifications and assumptions that do not represent all the hydrodynamic and aerodynamic processes between the water,air,and *** the case of the FOWc,interestingly,the experimental results show a maximum efficiency of almost 100%,while the analytical model only predicts a maximum of 80%.the efficiency seems highly dependent on the heave motion resonance of the entire device,where the analytical model fails to predict this natural frequency.

关键词： Wave energy converters oscillating water column(OWc) multi-chambers experimental modelling numerical modelling

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Immunoregulatory and Anti-cancer Activities of combination treatment of Novel Four-Herb Formula and Doxorubicin in 4t1-Breast cancer Bearing Mice

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chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben chung-Lap chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man tsang clara Bik-San Lau Ping-chung Leung chun-Kwok wong Institute of chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of chemical Pathology The Chinese University of Hong KongHong Kong SARChina china-Australia International Research centre for chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio chin R&D centre for chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective to investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(tNBc).Methods Murine-derived triple-negative mammary carcinoma cell line,4t1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4t1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).the D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).the treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Ptered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as c-c motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(Pcin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines chinese medicine tumor microenvironment

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan teng Wan Ritvik Raina tsz Ki chan Dohyun Ahn Vladimir Kushnarev tsz Kiu cheung Ho ching chan Inseo choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law chi Seng Leung chun Yin tong Kai Kap wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.c.Kong Maria V.Babak Yudai Matsuda Department of chemistry City University of Hong KongHong Kong SARChina iGEM team“Variecure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow clinical Research center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus Atcc *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology terpene synthases Variecolin

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tensor force impact on shell evolution in neutron-rich Si and Ni isotopes

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chinese Physics c 2024年第4期48卷 95-106页

作者： S.V.Sidorov A.S.Kornilova t.Yu.tretyakova Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityMoscow 119991Russia

the influence of the tensor interaction of nucleons on the characteristics of neutron-rich silicon and nickel isotopes was studied in this *** forces are considered within the framework of the Hartree-Fock approach with the Skyrme *** addition of a tensor component of interaction is shown to improve the description of the splittings between different single-particle states and decrease nucleon-nucleon pairing correlations in silicon and nickel *** attention was directed toward the role of isovector tensor forces relevant to the interaction of like nucleons.

关键词： nuclear shell model tensor interaction silicon isotopes nickel isotopes

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Effects of SARS-coV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin chung Xue Li Francisco tsz tsun Lai Eric Yuk Fai Wan celine Sze Ling chui Franco Wing tak cheng Esther Wai Yin chan ching Lung cheung Ivan chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen carlos King Ho wong Ian chi Kei wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BAcKGROUND chronic liver disease(cLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-coV-2)*** to determine the effects of SARS-coV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(Hcc)among patients with *** A retrospective,territory-wide cohort of cLD patients was identified from an electronic health database in Hong *** with confirmed SARS-coV-2 infection[coronavirus disease 2019(cOVID-19)+cLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(cOVID-19-cLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to Hcc(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-coV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 cLD patients(>95%non-cirrhotic)in the cohort,55163 patients with cOVID-19+cLD and 55163 patients with cOVID-19-cLD were included after 1:1 propensity-score *** 249-d median follow-up,cOVID-19+cLD was not associated with increased risk of incident Hcc(IRR:1.19,95%cI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for Hcc(IRR:1.60,95%cI:1.46-1.75,Pcompared to *** both acute and post-acute phases of infection,cOVID-19+cLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%cI:5.78-8.63,Pt-acute:IRR:1.24,95%cI:1.14-1.36,Ptic outcomes(acute:IRR:1.98,95%cI:1.79-2.18,Pt-acute:IRR:1.24,95%cI:1.13-1.35,Pcompared to *** Although cLD patients with SARS-coV-2 infection were not associated with increased risk of Hcc,they

关键词： SARS-coV-2 infection chronic liver disease Long cOVID Post-cOVID-19 syndrome cirrhosis Hepatocellular carcinoma

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Effect of biochar on the metabolome of soybean seedlings

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Oil crop Science 2024年第1期9卷 60-68页

作者： Nathalia E.Silva Mariana G.Aguilar Osania E.Ferreira Gleicia M.Paulino Jaqueline c.L.carvalho Lúcia P.S.Pimenta Alan R.t.Machado Programa de Pos-graduaçao em ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de Engenharia Aplicada e tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de ciencias Exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

the use of biochar can have several effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(ScB300),400℃(ScB400)and 600℃(ScB600).then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the number of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).the extracts were submitted to metabolomics analysis by Proton Nuclear Magnetic *** Relative Germination,Relative Average Radicle Growth and Germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for ScB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most influential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： Germination Metabolomics 1H NMR Pyrolysis Sugarcane bagasse

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh tuck Wah Soong Jason K.W.Lee Ivan c.c.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore centre for translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore campus for Research Excellence and technological Enterprise(cREAtE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(t_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(t_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:t_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in t_(re).With the development of hyperthermia,t_(br)increases and dovetails with the rising t_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(t_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both t_(re)and t_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates t_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity cognition Heat stress Hyperthermia Motor function

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Pathogenic and therapeutic role of exosomes in neurodegenerative disorders

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Neural Regeneration Research 2024年第1期19卷 75-79页

作者： christa c.Huber Hongmin Wang Division of Basic Biomedical Sciences Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming *** therapies exist to aid in symptomatic relief,effective treatments that can stop or reve rse the progress of each neurodegenerative disease are ***,research on the role of extracellular vesicles as disease markers and therapeutics has been intensively ***,30-150 nm in diameter,are one type of extracellular vesicles facilitating cell-to-cell *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,such as Alzheimer's disease,Parkinson s disease,and amyotrophic lateral ***,the exosomes derived from the patients are an invaluable source of disease *** the other hand,exosomes,especially those derived from stem cells,could serve as a therapeutic for these disorders,as seen by a rapid increase in clinical trials investigating the therapeutic efficacy of exosomes in different neurological *** review summarizes the pathological burden and therapeutic approach of exosomes in neurodegenerative *** also highlight how heat shock increases the yield of exosomes while still maintaining their therapeutic ***,this review concludes with outstanding questions that remain to be addressed in exosomal research.

关键词： aging Alzheimer's disease biomarker drug exosome extracellular vesicle neurodegenerative disease Parkinson's disease therapy

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cost effectiveness of nonpharmacological prevention programs for diabetes:A systematic review of trial-based studies

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chronic Diseases and translational Medicine 2024年第1期10卷 12-21页

作者： Yongyi Xiong Zhaohua Huo Samuel Y.S.wong Benjamin H.K.Yip Jockey club School of Public Health and Primary care Prince of Wales HospitalThe Chinese University of Hong KongShatinHong KongChina

trial-based economic value of prevention programs for diabetes is *** aimed to review the cost-effectiveness of nonpharmacological interventions to prevent type-2 diabetes mellitus(t2DM)for high-risk *** electronic databases were searched up to March *** assessing both the cost and health outcomes of nonpharmacological interventions for people at high-risk of t2DM were *** quality of the study was assessed by the consolidated Health Economic Evaluation Reporting Standards 2022 *** primary outcome for synthesis was incremental cost-effectiveness ratios(IcER)for quality-adjusted life years(QALYs),and costs were standardized in 2022 US *** synthesis was performed,considering different types and delivery methods of *** studies included five based on the US diabetes prevention program(DPP),six on non-DPP-based lifestyle interventions,four on health education,and one on screening plus lifestyle *** with usual care,lifestyle interventions showed higher potential of cost-effectiveness than educational *** lifestyle interventions,DPP-based programs were less cost-effective(median of IcERs:$27,077/QALY)than non-DPP-based programs(median of IcERs:$1395/QALY)from healthcare perspectives,but with larger decreases in diabetes ***,the cost-effectiveness of interventions was more possibly realized through the combination of different delivery *** interventions to prevent t2DM in high-risk populations are both cost-effective and feasible in various ***,economic evidence from low-and middle-income countries is still lacking,and interventions delivered by trained laypersons and combined with peer support sessions or mobile technologies could be potentially a cost-effective solution in such settings with limited resources.

关键词： economic evaluation nonpharmacological interventions pre-diabetes prevention

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