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抗心律失常药:甲磺胺心安

Oncology and translational Medicine 1995年第3期 60-60页

作者： S.Herzig t.beyer 姚小宙 Germany Hospitalstr.4 Institut für Pharmakologie der Universitat D-24105 Kiel 同济医科大学附属同济医院

甲磺胺心安原是一种非选择性β受体阻滞剂,在Vaughan-Williams抗心律失常药物分类中属Ⅱ类,但本药又有对心肌细胞K~+通道的阻滞作用,属Ⅲ类抗心律失常药的特性。本药的两种异构体(左旋及右族体)对K~+通道均有阻滞作用,而对β受体而言,... 详细信息

甲磺胺心安原是一种非选择性β受体阻滞剂,在Vaughan-Williams抗心律失常药物分类中属Ⅱ类,但本药又有对心肌细胞K~+通道的阻滞作用,属Ⅲ类抗心律失常药的特性。本药的两种异构体(左旋及右族体)对K~+通道均有阻滞作用,而对β受体而言,与其它β受体阻滞剂一样,其两种异构体作用不同,即有立体异构选择性,其左旋体有较强的β受体阻滞作用;其右旋体对β受体的亲合力甚小。

关键词：抗心律失常药物受体阻滞剂抗心律失常药磺胺磺胺类药阻滞作用右旋体

Near infrared light-induced dynamic modulation of enzymatic activity through polyphenol-functionalized liquid metal nanodroplets

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Chinese Chemical Letters 2023年第2期34卷 475-480页

作者： Chaojun Zhang Yang tang Qin Wang Yunxiang He Xiaoling Wang Sebastian beyer Junling Guo BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China School of Pharmacy Southwest Minzu UniversityChengdu 610225China National Engineering Research Center of Clean technology in Leather Industry Sichuan UniversityChengdu 610065China Department of Biomedical Engineering Chinese University of Hong KongHong Kong 999077China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China Bioproducts Institute Department of Chemical and Biological EngineeringUniversity of British ColumbiaVancouverBC V6T 1Z4Canada

Dynamic manipulation of enzymatic activity is a challenging task for applications in chemical and pharmaceutical industries due to the difficult modification and variable conformation of various ***, we report a new strategy for reversible dynamic modulation of enzymatic activity by near-infrared light-induced photothermal conversion based on polyphenol-functionalized liquid metal nanodroplets(LM). the metal-phenolic nanocoating not only provides colloidal stability of LM nanodroplets but also generates nanointerfaces for the assembly of various enzymes on the LM nanodroplets. Upon near infrared(NIR) irradiation, the localized microenvironmental heating through photothermal effect of the LM nanodroplets allows tailoring the enzymatic activity without affecting the bulk temperature. A library of functional enzymes, including proteinase K, glucoamylase, glucose oxidase, and Bst DNA polymerase, is integrated to perform a reversible control and enhanced activities even after five times of cycles, demonstrating great potential in bacterial fermentation, bacteriostasis, and target gene amplification.

关键词： Enzymatic activity Photo-modulation Near infrared light Liquid metal nanodroplets Metal-phenolic nanocoating

Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framework of technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Mechanical Properties of Remote-Laser Cut CFRP and thermographic Laser-Process Monitoring

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Materials Sciences and Applications 2020年第8期11卷 560-575页

作者： Michael Rose Sebastian Schettler Florian Klemm Eckhard beyer Martina Zimmermann technische Universitä t Dresden Institute of Materials Science Dresden Germany Fraunhofer Institute for Material and Beam technology Dresden Germany technische Universitä t Dresden Institute of Manufacturing Science and Engineering Dresden Germany

Remote-laser beam cutting is a productive technology without tool wear. Especially when cutting carbon fiber reinforced polymers (CFRP), it offers constant manufacturing quality. Since it is a thermal process, a heat-affected zone (HAZ) is formed at the edge of the cut. Based on quasi-static and cyclic mechanical tests on open-hole specimens, the influence of the process on the mechanical properties of CFRP is shown. the quasi-static tests are in good correlation with results from other researchers by indicating an increase in the maximum tensile stress of the test specimens, cut by remote-laser. the reason is the rearrangement of the shear stresses and a reduction of the notch stress concentration. However, the results of the present study show that excessive expansion of the HAZ leads to a reduction in the maximum tensile stress compared to milled test specimens. Under cyclic load conditions, remote-laser beam cutting does not lead to a more pronounced degradation than milling. the mechanical properties of the notched test pieces are sensitive to the expansion of the HAZ. For the production of components it is therefore necessary that the remote-laser beam cutting is carried out under controlled and documentable conditions. For this purpose, process thermography was tested as a tool for quality assurance. the results show that the technology is basically suitable for this task.

关键词： CFRP Remote Laser Cutting Fatigue Process thermography Process Monitoring

Achieving exceptional wear resistance in a crack-free high-carbon tool steel fabricated by laser powder bed fusion without pre-heating

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Journal of Materials Science & technology 2023年第25期156卷 1-19页

作者： Konrad Kosiba Daniel Wolf Matthias Bönisch Kai Neufeld Ruben Hühne tobias Gustmann Jozef Bednarčík Hongyu Chen Xiaoliang Han Volker Hoffmann Lukas beyer Uta Kühn Sergio Scudino Lars Giebeler Julia K.Hufenbach Leibniz Institute for Solid State and Materials Research (IFW) Dresden E.V. Helmholtzstr. 20Dresden 01069Germany Department of Materials Engineering KU LeuvenKasteelpark Arenberg 44bus 2450Leuven 3001Belgium Department of Condensed Matter Physics Institute of PhysicsP.J. Safarik University in KosicePark Angelinum 9Kosice 04154Slovakia Institute of Experimental Physics Slovak Academy of ScienceWatsonova 47Kosice 040 01Slovakia Key Laboratory of Impact and Safety Engineering of Ministry of Education of China Ningbo UniversityNingbo 315211China tU Bergakademie Freiberg Institute of Materials ScienceGustav-Zeuner-Str. 5Freiberg 09599Germany

Laser powder bed fusion(LPBF)for the fabrication of dense components used for tooling applications,is highly *** stresses,which evolve in the additively manufactured part,are inherent to LPBF *** additional stress contribution in high-carbon steels arises from the austenite-to-martensite phase transformation,which may eventually lead to cracking or even *** an alternative to pre-heating the base plate,which is not striven by industry,lowering the martensite content which forms in the part,is essential for the fabrication of dense parts by LPBF of high-carbon tool steels which are then adapted to *** this study,a successful strategy demonstrates the processing of the Fe85Cr4Mo1V1W8C1(wt%)high-carbon steel by LPBF into dense parts(99.8%).the hierarchical microstructure consists of austenitic and martensitic grains separated by elemental segregations in which nanoscopic carbide particles form a network.A high density of microsegregation was observed at the molten pool boundary ultimately forming a *** LPBF-fabricated steel shows a yield strength,ultimate compressive stress,and total strain of 1210 MPa,3556 MPa,and 27.4%,*** mechanical and wear performance is rated against the industrially employed and highly wear-resistant 1.2379 tool steel taken as the *** its lower macro-hardness,the LPBF steel(58.6 HRC,0.0061 mm^(3) Nm^(-1))shows a higher wear resistance than the reference steel(62.6 HRC,0.0078 mm^(3) Nm^(-1)).this behavior results from the wear-induced formation of martensite in a microscale thick layer directly at the worn surface,as it was proven via high-energy X-ray diffraction mapping.

关键词： Additive manufacturing Laser powder bed fusion Steel Wear tRIP

X线造影剂的副反应和合并症——危险性的减少和预防

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放射学实践 1989年第1期4卷 16-19页

作者： Von H.K.beyer 陈绍红 Klinik für Radiologie des Katholischen Marienhospitals Herne Ruhr-Universitt Bochum 同济医科大学附属同济医院

数十年来,自脉管内注入高密度造影剂以显示器官和大血管早已成为常规方法。现在,它已大量用于肾盂、尿路、胆囊、动脉造影以及Ct 诊断。目前在德国每年大约进行200万次X 线造影检查。然而其缺点也是明显的。

关键词： X线造影剂副作用合并症预防

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胸部Ct应用静脉内造影剂注射的价值

放射学实践 1989年第3期4卷 97-103页

作者： S.A.beyer-Enke J.Grich M.Müller S.tüngerthal G.van Kaick 张本固 Abteilung für Onkologische Diagnostik und therapie Institut für Radiologie und Pathophysiologie des Deutschen Krebsforschungszentrums Heidelberg 同济医科大学附属同济医院

胸部Ct有较高诊断能力。在Ct连续断层时应用造影剂(有时为附加应用)能明显减少对血管结构和肿瘤块影的分辨困难。

关键词：胸 Ct诊断 X线造影剂静脉注射