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Effect of antigens on colony forming efficiency of stromal clonogenic cells and expression of cytokine genes in primary cultures of bone marrow and spleen of mice

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Advances in Bioscience and Biotechnology 2011年第5期2卷 315-319页

作者： U.F. Gorskaya t.a. danilova M.V. Mezentseva I.M. Shapoval V.G. Nesterenko 不详

Presence of microbial cells preparation (HCL – ext.a.t of group A streptococcus) in primary cell cultures of bone marrow (BMCC) and spleen (SCC) of CBA mice induced the expression mRNA of proinflammatory cytokines genes: IL-2, IL-6 and IL-8 in BMCC;in SCC cultures mRNA IL-1 β and IL-6 appeared and mRNA IL-4 disappeared. Injection of S. typhimurium antigen complex to mice CBA increased 5 times colony forming efficiency (CFE) and, respectively, content of stromal precursor cells (CFU-F) in femur bone marrow and 9 times in spleen of these animals with maximum at the first day. In both primary BMCC and SCC from immunized animals expression of proinflammatory cytokines genes IL-1 β, IL-6, IL-8 and tNF- α was revealed - in BMCC on 1 - 3 day after immunization, and in SCC – up to 15 days. In CBA mice injected with polyvinylpyrrolidone (PVP) CFE and number of CFU-F in BMCC and SCC increased 1, 9 and 1, 8 times only and expression of genes IL-6, IL-8 and tNF- was observed only on the first day. In СВА/N xid mice there was neither increase CFU-F in the corresponding organs, nor expression of proinflammatory cytokines genes in primary cultures. the data suggest the possibility of positive participation of stromal cells in the development on of immune response in organism. Degree of activation of stromal tissue in immunized mice, apparently, correlates with the degree of immune response, supposing a close relationship between stromal tissue and immune system.

关键词： Stromal Cells-Immunity

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Features of the Soft.a.e as an End Product in the Modern Market

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厦门大学学报（自然科学版） 2002年第S1期41卷 190-191页

作者： Ulyana V danilova Institute of Automation and Control Processes

the developing market of information technologies i s the most dynamical and thriving business in the modern world. the law of supply and demand establishes repeating, st.a.y cause and effect relation between three economic phenomena-price, supply and demand. Demand is an ideal need and a real opportunity of the customer to buy the goods. Supply is an ideal readiness and a real opportunity of the commodity producer to put the goods on the market . A plethora of factors affect the supply and demand. there is inverse dependenc e between the market price of the goods and the quantity which is in the demand. there is direct dependence between the market price of the goods and the qu antity which is offered to the buyer. the following features distinguish the sof t.a.e from the usual goods in the consumer market: high science intensity, simpl icity of replicating, relative simplicity of modification and updating, high req uirements to quality of the soft.a.e, at sale the buyer gets it, but it does no t disappear in sale, there is no physical deterioration, but there is a fast ob solescence. to protect the programs against the non-authorized access (the copy ings and operation) technical and legal methods are used: the patent protection, status of industrial secret, license agreements.

关键词： market of soft.a.e programs licensing electroni c commerce in Internet

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Genetics of macrovascular complications in type 2 diabetes

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World Journal of Diabetes 2021年第8期12卷 1200-1219页

作者： Ziravard N tonyan Yulia A Nasykhova Maria M danilova Andrey S Glotov Department of Genomic Medicine D.O.Ott Research Institute of ObstetricsGynecology and ReproductologySaint-Petersburg 199034Russia Laboratory of Biobanking and Genomic Medicine of Institute of t.a.slation Biomedicine St.Petersburg State UniversitySaint-Petersburg 199034Russia

type 2 diabetes mellitus(t2DM)is a metabolic disorder t.a. currently affects more t.a. 400 million worldwide and is projected to cause 552 million cases by the year ***-term vascular complications,such as coronary artery disease,myocardial infarction,stroke,are the leading causes of morbidity and mortality among diabetic *** recent.a.vances in genome-wide technologies have given a powerful impetus to the study of risk markers for multifactorial *** date,the role of genetic and epigenetic factors in modulating susceptibility to t2DM and its vascular complications is being successfully studied t.a. provides the accumulation of genomic *** the future,this will provide an opportunity to reveal the pathogenetic pathways in the development of the disease and allow to predict the macrovascular complications in t2DM *** review is focused on the evidence of the role of genetic variants and epigenetic changes in the development of macrovascular pathology in diabetic patients.

关键词： type 2 diabetes Epigenetics Genetics Macrovascular complications

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