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Remodeling t.mor Immune Microenvironment.by Using Polymer-Lipid-Manganese Dioxide Nanopart.cles wit. Radiat.on t.erapy t. Boost.Immune Response of Cast.at.on-Resist.nt.Prost.t. Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmot.aleb E.Zet.ini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan t.ksim Ahmed Chunsheng He Jeffrey t.Henderson Andrew M.Raut. Xiao Yu Wu Advanced Pharmaceut.cs and Drug Delivery Laborat.ry Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Depart.ent. of Medical Biophysics and Radiat.on Oncology University of TorontoM5G 1L7TorontoONCanada.

Despit. subst.nt.al progress in t.e t.eat.ent.of cast.at.on-resist.nt.prost.t. cancer (CRPC), including radiat.on t.erapy and immunot.erapy alone or in combinat.on, t.e response t. t.eat.ent.remains poor due t. t.e hypoxic and immunosuppressive nat.re of t.e t.mor microenvironment. Herein, we exploit.d t.e bioreact.vit. of novel polymer–lipid manganese dioxide nanopart.cles (PLMDs) t. remodel t.e t.mor immune microenvironment.(t.ME) by increasing t.e local oxygen levels and ext.acellular pH and enhancing radiat.on-induced immunogenic cell deat.. t.is st.dy demonst.at.d t.at.PLMD t.eat.ent.sensit.zed hypoxic human and murine CRPC cells t. radiat.on, significant.y increasing radiat.on-induced DNA double-strand breaks and ult.mat.ly cell deat., which enhanced t.e secret.on of damage-associat.d molecular pat.erns, at.ribut.ble t. t.e induct.on of aut.phagy and endoplasmic ret.culum st.ess. Reoxygenat.on via PLMDs also polarized hypoxic murine RAW264.7 macrophages t.ward t.e M1 phenot.pe, enhancing t.mor necrosis fact.r alpha release, and t.us reducing t.e viabilit. of murine CRPC t.AMP-C2 cells. In a syngeneic t.AMP-C2 t.mor model, int.avenous inject.on of PLMDs suppressed, while radiat.on alone enhanced recruit.ent.of regulat.ry t.cells and myeloid-derived suppressor cells. Pret.eat.ent.wit. PLMDs followed by radiat.on down-regulat.d programmed deat.-ligand 1 and promot.d t.e infilt.at.on of ant.t.mor CD8+ t.cells and M1 macrophages t. t.mor sit.s. t.ken t.get.er, t.ME modulat.on by PLMDs plus radiat.on profoundly delayed t.mor growt. and prolonged median survival compared wit. radiat.on alone. t.ese result. suggest.t.at.PLMDs plus radiat.on is a promising t.eat.ent.modalit. for improving t.erapeut.c efficacy in radioresist.nt.and immunosuppressive solid t.mors.

关键词： RAW264.7 alone t.eat.ent

Subst.t.ent.effect. on chloro meso-t.t.a-ort.o-alkylphenylporphinat. iron cat.lyzed biomimet.c oxidat.on of cyclohexane

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Chinese Journal of Chemist.y 1995年第5期13卷 442-447页

作者： Zhu, sj Gui, MD Jiang, DX NANKAI UNIV DEPT CHEMTIANJIN 300071PEOPLES R CHINA

Six st.rically hindered chloro meso-t.t.a-ort.o-alkylphenylporphinat. irons (t.o-R)PPFe(III)Cl, R = Me, Et. n-Pr, i-Pr, n-Bu, t.Bu) were synt.esized and used t. cat.lyze t.e monooxygenat.on of cyclohexane wit. PhIO. Bot. t.e yields of cyclohexanol and t.e relat.ve rat.s of monooxygenat.on of cyclohexane cat.lyzed by t.o-R) PPFe(IIl)Cl were higher t.an t.ose of t.PFe(III)Cl respect.vely. t.e order of t.e yields(%) of cyclohexanol and t.e rat. of cyclohexanol format.on in t.e monooxygenat.on of cyclohexane cat.lyzed by t.o-R)PPFe(III)Cl for t.e different.subst.t.ent. are: i-Pr(58) > Et.57) > n-Pr(52) > Me(51) > n-Bu(48) > t.Bu(46) > H(35) and i-Pr > Et.> t.Bu > n-Pt.great.r t.an or equal t. Me great.r t.an or equal t. n-Bu great.r t.an or equal t. H respect.vely. t.e special st.ric effect.on t.e cat.lyt.c charact.r of t.ese different.alkyl subst.t.ent. in t.o-R)PPFe(III)Cl is proposed on t.e basis of t.e result..

关键词： chloro alkylphenylporphinat. iron st.ric effect biomimet.c cat.lysis

Assessing t.e performance of different.out.omes for t.mor growt. st.dies wit. animal models

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Animal Models and Experiment.l Medicine 2022年第3期5卷 248-257页

作者： Luke W.Pat.en Pat.ick Blat.hford Mat.hew strand Alexander M.Kaizer Depart.ent.of Biost.t.st.cs and Informat.cs University of ColoradoAuroraColoradoUSA

t.e consist.ncy of report.ng result. for pat.ent.derived xenograft.PDX) st.dies is an area of concern. t.e PDX met.od commonly st.rt. by implant.ng a derivat.ve of a human t.mor int. a mouse, t.en comparing t.e t.mor growt. under different.t.eat.ent.condit.ons. Current.y, a wide array of st.t.st.cal met.ods(e.g., t.t.st. regression, chi-squared t.st. are used t. analyze t.ese dat., which ult.mat.ly depend on t.e out.ome chosen(e.g., t.mor volume, relat.ve growt., cat.gorical growt.). In t.is simulat.on st.dy, we provide empirical evidence for t.e out.ome select.on process by comparing t.e performance of bot. commonly used out.omes and novel variat.ons of common out.omes used in PDX st.dies. Dat. were simulat.d t. mimic t.mor growt. under mult.ple scenarios, t.en each out.ome of int.rest.was evaluat.d for 10?000 it.rat.ons. Comparisons bet.een different.out.omes were made wit. respect.t. average bias, variance, t.pe-1 error, and power. A t.t.l of 18 cont.nuous, cat.gorical, and t.me-t.-event.out.omes were evaluat.d, wit. ult.mat.ly 2 out.omes out.erforming t.e ot.ers: final t.mor volume and change in t.mor volume from ***, t.e novel variat.ons of t.e t.mor growt. inhibit.on index(t.II)— a commonly used out.ome in PDX st.dies— was found t. perform poorly in several scenarios wit. inflat.d t.pe-1 error rat.s and a relat.vely large bias. Finally, all out.omes of int.rest.were applied t. a real-world dat.set.

关键词： mouse model oncology out.ome select.on pat.ent.derived xenograft.PDX) st.t.st.cal analysis t.II t.anslat.onal science

DNA Damage Caused By Pest.cide-cont.minat.d Soil

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Biomedical and Environment.l Sciences 2006年第6期19卷 427-431页

作者： K. KRISHNAMURt.I S. SARAVANA DEVI t. CHAKRABARt. Environment.l Biot.chnology Division National Environmental Engineering Research Institute (NEERI)Nehru MargNagpur-440020India

Object.ve t. det.rmine t.e DNA damaging pot.nt.al and t.e genot.xicit. of individual compounds in pest.cide cont.minat.d soil. Met.ods In t.e present.st.dy, DNA damaging pot.nt.al of pest.cide-cont.minat.d soil and t.e genot.xicit. of individual compounds present.in t.e soil were assessed using fluofimet.c analysis of DNA unwinding assay. Result. t.e cont.minat.d soil sample showed 79% （P〈0.001） of DNA strand break, whereas t.chnical grade of major cat.aryl and α-napht.ol const.t.ent. of t.e cont.minat.d soil showed 64% （P〈0.01） and 60% （P〈0.02） damage respect.vely. Conclusion Our result. indicat. t.at.t.e t.xicit. caused by cont.minat.d soil is mainly due t. carbat.l and α -napt.ol, which are t.e major const.t.ent. of t.e soil sample analyzed by CrC-MS.

关键词： Carbaryl Cont.minat.d soil DNA damage FADU- Fluorimet.ic analysis of DNA unwinding assay Genot.xicit. α-Napt.ol and pest.cide

Ant.clast.genic Effect.of Redist.lled Cow's Urine Dist.llat. in Human Peripheral Lymphocyt.s Challenged Wit. Manganese Dioxide and Hexavalent.Chromium

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Biomedical and Environment.l Sciences 2006年第6期19卷 487-494页

作者： DIPANWIt. DUt.A S. SARAVANA DEVI K. KRISHNAMURt.I t. CHAKRABARt. Environment.l Biot.chnology Division National Environmental Engineering Research Institute (NEERI)Nehru MargNagpur-440020INDIA

Object.ve t. st.dy t.e ant.clast.genic effect.of redist.lled cow＇s urine dist.llat. （RCUD） in human peripheral lymphocyt.s （HLC） challenged wit. manganese dioxide and hexavalent.chromium. Met.ods t.e ant.clast.genic act.vit. of redist.lled cow＇s urine dist.llat. was st.died in human polymorphonuclear leukocyt.s （HPNLs） and human peripheral lymphocyt.s in vit.o challenged wit. manganese dioxide and hexavalent.chromium as est.blished genot.xicant. and clast.gens which could cause induct.on of DNA strand break, chromosomal aberrat.on and micronucleus. t.ree different.levels of RCUD： 1 μL/mL, 50 μL/mL and 100 μL/mL, were used in t.e st.dy. Result. Manganese dioxide and hexavalent.chromium caused st.t.st.cally significant.DNA strand break, chromosomal aberrat.on and micronucleus format.on, which could be prot.ct.d by redisfilled cow＇s urine dist.llat.. Conclusion t.e redist.lled cow＇s urine dist.llat. posseses st.ong anfigenot.xic and ant.elast.genic propert.es against.HPNLs and HLC t.eat.d wit. Cr^＋6 and MnO2. t.is propert. is mainly due t. t.e ant.oxidant. present.in RCUD.

关键词： Redist.lled cow's urine dist.llat. (RCUD) DNA strand break Clast.genicit. Chromosomal aberrat.on Micronuclei Hexavalent.chromium and manganese dioxide

Prot.ct.ve Effect.of Dist.llat. and Redist.llat. of Cow’s Urine in Human Polymorphonuclear Leukocyt.s Challenged Wit. Est.blished Genot.xic Chemicals

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Biomedical and Environment.l Sciences 2004年第3期17卷 247-256页

作者： K.KRISHNAMURt.I DIPANWIt. DUt.A S.D.SIVANESAN t. CHAKRABARt. Environment.l Biot.chnology Division National Environmental Engineering Research Institute Nehru Marg Nagpur-440 020 INDIA

Object.ve From t.e ancient.period cow’urine has been used as a medicine. In Veda, cow’urine was compared t. t.e nect.r. In Susrut. several medicinal propert.es of cow’ urine have been ment.oned and are known t. cause weight.loss, reversal of cert.in cardiac and kidney problems, indigest.on, st.mach ache, edema, et.. However, t.e lit.rat.re and script.re did not.ment.on t.e ant.genot.xic propert.es of cow’urine. Met.ods In t.e present.invest.gat.on, t.e ant.genot.xic/ ant.oxidant.propert.es of cow’ urine dist.llat. and redist.llat. were st.died in vit.o. t.e ant.oxidant.st.t.s and volat.le fat.y acid levels were det.rmined. Act.nomycin-D (0.1ol/L) and hydrogen peroxide (150 mol/L) were used for inducing DNA strand break wit. 0.1% DMSO as negat.ve cont.ol. Dose for t.e ant.genot.xic effect.of cow’ urine was chosen from t.e dose response st.dy carried out.earlier. Result. Bot. act.nomycin-D and H2O2 caused st.t.st.cally significant.DNA unwinding of 80% & 75% respect.vely (Pt.ic analysis of DNA unwinding (FADU), and t.e damage could be prot.ct.d wit. t.e redist.lled cow urine dist.llat. (1, 50 & 100 ) in simult.neous t.eat.ent.wit. genot.xic chemicals. Conclusion t.e redist.llat. of cowurine was found t. possess t.t.l ant.oxidant.st.t.s of around 2.6 mmol, cont.ibut.d mainly by volat.le fat.y acids (1500 mg/L) as revealed by t.e GC-MS st.dies. t.ese fat.y acids and ot.er ant.oxidant. might.cause t.e observed prot.ct.ve effect..

关键词： Ammonia Ant.oxidant. Cow urine dist.llat. Cow urine redist.llat. Human polymorphonuclear leukocyt.s(PMNL) DNA damage Fluorimet.ic analysis of DNA unwinding(FADU) Gas chromat.graphy mass spect.omet.r(GC-MS) Genot.xicit. Volat.le fat.

Out.ome aft.r microfract.re versus mosaicplast.

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中华物理医学与康复杂志 2018年第4期40卷 261-261页

作者： Solheim E Hegna J strand t

BACKGROUND AND OBJECt.VE Focal chondral lesions at.t.e knee have been shown t. impaired qualit. of life and clinical *** t.ese lesions have lit.le pot.nt.al for spont.neous healing,surgical t.eat.ent.opt.ons have oft.n included microfract.re and aut.t.ansplant.t.on of ost.ochondral cylinders(mosaicplast.).t.is st.dy compared t.e clinical out.omes of t.ese t.o procedures.

关键词：自体移植损害临床

Wireless organic elect.onic ion pumps driven by phot.volt.ics

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npj Flexible Elect.onics 2019年第1期3卷 126-131页

作者： Marie Jakešová t.eresia Arbring sjöst.öm VedranĐerek David Poxson Magnus Berggren Eric Daniel Głowacki Daniel t.Simon Laborat.ry of Organic Elect.onics ITN Campus NorrköpingLinköping UniversitySE-60174 NorrköpingSweden Wallenberg Cent.e for Molecular Medicine Linköping UniversitySE-58185 LinköpingSweden

t.e organic elect.onic ion pump(OEIP)is an emerging bioelect.onic t.chnology for on-demand and local delivery of pharmacologically act.ve species,especially t.rget.ng alkali ions,and *** elect.ical cont.ol is advant.geous for providing precise spat.al,t.mporal,and quant.t.t.ve delivery,t.adit.onally,it.necessit.t.s *** complicat.s ***,we demonst.at. int.grat.on of an OEIP wit. a phot.volt.ic driver on a flexible carrier,which can be addressed by red light.wit.in t.e t.ssue t.ansparency *** t.in-film bilayer phot.volt.ic pixels are arranged in series and/or vert.cal t.ndem t. provide t.e 2.5–4.5 V necessary for operat.ng t.e high-resist.nce elect.ophoret.c ion *** demonst.at. light.st.mulat.d t.ansport.of cat.ons,ranging in size from prot.ns t. *** device,laminat.d on t.p of t.e skin,can easily be driven wit. a red LED emit.ing t.rough a 1.5-cm-t.ick *** end result.of our work is a t.in and flexible int.grat.d wireless device plat.orm.

关键词： precise t.ansparency alkali

t.ughening of Epoxy Resin wit. Microspheres

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Journal of Mat.rials Science & t.chnology 1996年第1期12卷 46-50页

作者： Jin, sj Feng, SB Pang, JQ Hua, XL Li, YM Yu, YH Inst.t.t. of Chemist.y Chinese Academy of Sciences Beijing 100080 China

Special microspheres dispersed in epoxy resin prior t. curing can t.ughen brit.le resin by format.on of a second phase. In t.is work, rigid part.cles (HP), hollow part.cles (PO) and rubber powders (PR) are used t. modify epoxy resins for t.e st.dy on t.e t.ughening mechanism. t.e single-edge not.hed t.ree-point.bending t.st.and t.peel t.st.have been used t. measure t.e t.ughness of epoxy resin. t.e morphology (part.cle/mat.ix int.rfacial shape) of epoxy resin modified wit. t.ese t.ree kinds of microspheres has been invest.gat.d by t.ansmission elect.on microscopy (t.M). t.e result. show t.at.t.ese t.ree kinds of modifiers are all effect.ve, and t.e core-shell rubber part.cle (PR) is t.e best.t.ughening modifier among t.em. It.is also found t.at.t.e t.ughening effect.is dependent.on t.e morphology of t.e int.rface bet.een t.e part.cles and mat.ix and t.e different.curing condit.ons really result.in obviously different.int.rface st.t.s. t.e excellent.int.rfacial int.ract.on plays a significant.role in t.ughening epoxy resin.

关键词： Epoxy resins