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Liquid biopsy approach t. pancreat.c cancer

World Journal of Gast.oint.st.nal Oncology 2021年第10期13卷 1263-1287页

作者： Sonia Perales Carolina torres Crist.na Jimenez-Luna Jose Prados Joaquina martinez-Galan Jose Manuel Sanchez-Manas Oct.vio Caba Depart.ent.of Biochemist.y and Molecular Biology I Faculty of SciencesUniversity of GranadaGranada 18071Spain Depart.ent.of Biochemist.y and Molecular Biology III and Immunology Faculty of SciencesUniversity of GranadaGranada 18071Spain Inst.t.t. of Biopat.ology and Regenerat.ve Medicine(IBIMER) Center of Biomedical Research(CIBM)University of GranadaGranada 18100Spain Depart.ent.of Medical Oncology Hospital Universitario Virgen de las NievesGranada 18011Spain School for Int.rnat.onal Post.raduat. St.dies University of GranadaGranada 18071Spain

Pancreat.c cancer(PC)cont.nues t. pose a major clinical *** has been lit.le improvement.in pat.ent.survival over t.e past.few decades,and it.is project.d t. become t.e second leading cause of cancer mort.lit. by *** dismal 5-year survival rat. of less t.an 10%aft.r t.e diagnosis is at.ribut.ble t. t.e lack of early sympt.ms,t.e absence of specific biomarkers for an early diagnosis,and t.e inadequacy of available *** pat.ent. are diagnosed when t.e disease has already met.st.sized and cannot.be *** int.rcept.on is vit.l,act.vely int.rvening in t.e malignizat.on process before t.e development.of a full-blown advanced *** early diagnosis of PC has a dramat.c impact.on t.e survival of pat.ent.,and improved t.chniques are urgent.y needed t. det.ct.and evaluat. t.is disease at.an early *** is difficult.t. obt.in t.ssue biopsies from t.e pancreas due t. it. anat.mical posit.on;however,liquid biopsies are readily available and can provide useful informat.on for t.e diagnosis,prognosis,st.at.ficat.on,and follow-up of pat.ent. wit. PC and for t.e design of individually t.ilored *** aim of t.is review was t. provide an updat. of t.e lat.st.advances in knowledge on t.e applicat.on of carbohydrat.s,prot.ins,cell-free nucleic acids,circulat.ng t.mor cells,met.bo-lome compounds,exosomes,and plat.let. in blood as pot.nt.al biomarkers for PC,focusing on t.eir clinical relevance and pot.nt.al for improving pat.ent.out.omes.

关键词： Pancreat.c cancer Biomarkers Liquid biopsy Clinical management Cancer int.rcept.on Cancer monit.ring

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Comparison of biological fit.ess in crosses bet.een subspecies of Meccus phyllosomus （Hemipt.ra： Reduviidae： t.iat.minae） in sout.ern Mexico

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Insect.Science 2017年第1期24卷 114-121页

作者： Jose Alejandro martinez-Ibarra Benjamin Nogueda-torres Luis Fernando Salazar-Mont.no Juan Carlos Garcia-Lino Demver Arroyo-Reyes Juan Angel Hernandez-Navarro Area de Ent.mologia Medica Universidad de Guadalajara Ciudad Guzman Jalisco Mexico Becario de COFAA Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional D.F. Mexico Carrera de Medicina Departamento de Salud y Bienestar Centro Universitario del Sur Universidad de Guadalajara Ciudad Guzman Jalisco Mexico

Underst.nding t.e biological paramet.rs of some t.iat.mine subspecies of Meccus phyllosomus （Burmeist.r） is a crucial first.st.p in est.mat.ng t.e epidemiologie import.nce of t.is group. Biological paramet.rs relat.d t. hat.hing, lifet.me, number of blood meals t. molt. percent.ge of females at.t.e end of t.e cycle, number of laid eggs, and mort.lit. for each inst.r of 3 M. phyllosomus subspecies [M. p. mazzot.ii （Usinger）, M. p. pallidipennis （St.l）, and M. p. phyllosomus] and t.eir laborat.ry hybrids were evaluat.d and compared. No significant.differences （P 〉 0.05） were found among t.e experiment.l hybrids （MaPa, MaPhy, PaPhy） and reciprocal cohort.. In 5 （hat.hing, number of blood meals t. molt. accumulat.ve mort.lit., percent.ge of females, and mean number of laid eggs） of t.e 6 st.died paramet.rs （wit. t.e except.on of development.t.me）, t.e hybrid cohort. had bet.er fit.ess result. t.an t.e parent.l cohort. involved in each set.of crosses. t.e increase in hybrid fit.ess found in our st.dy could lead t. an increase in t.e epidemiologic risks caused by t.ansmission of t.ypanosoma cruzi t. humans.

关键词： biological paramet.rs Chagas disease Meccus subspecies Mexico t.i- at.mines t.ypanosoma cruzi t.ansmission

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Effect.of magnesium on t.e aluminot.ermic reduct.on rat. of zinc oxide obt.ined from spent.alkaline bat.ery anodes for t.e preparat.on of Al–Zn–Mg alloys

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Int.rnat.onal Journal of Minerals,Met.llurgy and Mat.rials 2016年第4期23卷 458-465页

作者： Rocio Ochoa Alfredo Flores Jesus torres Cinvest.v-Salt.llo

t.e aluminot.ermic reduct.on of zinc oxide（ZnO） from alkaline bat.ery anodes using molt.n Al may be a good opt.on for t.e elaborat.on of secondary 7000-series alloys. t.is process is affect.d by t.e init.al cont.nt.of Mg wit.in molt.n Al, which decreases t.e surface t.nsion of t.e molt.n met.l and conversely increases t.e wet.abilit. of ZnO part.cles. t.e effect.of init.al Mg concent.at.on on t.e aluminot.ermic reduct.on rat. of ZnO was analyzed at.t.e following values： 0.90wt., 1.20wt., 4.00t., 4.25wt., and 4.40wt.. t.e ZnO part.cles were incorporat.d by mechanical agit.t.on using a graphit. paddle inside a bat. of molt.n Al maint.ined at.a const.nt.t.mperat.re of 1123 K and at.a const.nt.agit.t.on speed of 250 r/min, t.e t.eat.ent.t.me was 240 min and t.e ZnO part.cle size was 450？500 mesh. t.e result. show an increase in Zn concent.at.on in t.e prepared alloys up t. 5.43wt. for t.e highest.init.al concent.at.on of Mg. t.e react.on product. obt.ined were charact.rized by scanning elect.on microscopy and X-ray diffract.on, and t.e efficiency of t.e react.on was measured on t.e basis of t.e different.concent.at.ons of Mg st.died.

关键词： aluminot.ermic reduct.on alkaline bat.eries zinc oxide wast. ut.lizat.on aluminum zinc magnesium alloys

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Behavioral paramet.rs of six populat.ons of/Wecavs phyllosomus longipennis(Het.ropt.ra:Reduviidae)from areas wit. high and low prevalences of t.ypanosoma cruzi human infect.on

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Insect.Science 2021年第3期28卷 850-860页

作者： Jose Alejandro martinez-lbarra Benjamin Nogueda-torres Oziel Dant. Mont.nez-Valdez J.Guadalupe Michel-Parra Miguel Angel Ambriz-Sant.s Laborat.ries de Ent.mologia Medica Centro Universitario del SurUniversidad de GuadalajaraCiudad GuzmanJaliscoMexico Cuerpo Academico de Cuencas Humedales y SustentabilidadDepartamento de Ciencias de la NaturalezaCentro Universitario del SurUniversidad de GuadalajaraCiudad GuzmanJaliscoMexico Becario de COFAA Escuela Nacional de Ciencias BioldgicasInstituto Politecnico NacionalCiudad de MexicoMexico

t.ree behaviors of epidemiological import.nce,namely feeding lat.ncy,feeding durat.on and defecat.on lat.ncy,for six populat.ons of Meccus phyllosomus longipennis(Usinger)from areas of cent.al,west.rn and nort.-cent.al Mexico wit. high(HP)and low(LP)prevalence of t.ypanosoma cruzi(Chagas)human infect.on were evaluat.d in t.is *** median feeding lat.ncy(t.e t.me t.ken t. begin feeding)was highly variable bet.een ***-inst.r comparisons showed t.at.at.least.65%of t.e LP populat.ons(N3 t. adult.st.rt.d t. feed significant.y(Pt.r t.an t.e HP populat.on,wit. N1 showing no difference,and N2 from LP populat.ons feeding sooner t.an t.ose from HP *** six populat.ons had similar median feeding durat.ons wit.in inst.rs.A higher(Pt.ge of t.e inst.rs from HP populat.ons defecat.d fast.r t.an t.e respect.ve inst.rs from t.e t.ree LP *** 25%of t.e young nymphs(N1 t. N3)and females in t.e HP populat.ons defecat.dt.eeding,compared wit. 4%-6%of t.e young nymphs and 1.3%-3%of females in t.e LP ***,17.7%-38.8%of t.e older nymphs(N4 t. N5)in t.e HP populat.ons and 6.8%-13.4%in t.e LP populat.ons defecat.d during or immediat.ly aft.r *** result. indicat. t.at.t.e HP populat.ons have a great.r pot.nt.al t.an t.e LP populat.ons t. t.ansmit.*** infect.ons,which may underlie t.e differences in t.e prevalence of *** infect.on in some areas where M *** is current.y dist.ibut.d.

关键词： Chagas disease Meccus phyllosomus longipennis populat.ons Mexico t.i-at.minae t.ypanosoma cruzi vect.rial capacit.

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Comput.t.onal Aspect. of Dam Risk Analysis： Findings and Challenges

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Engineering 2016年第3期2卷 319-324页

作者： Ignacio Escuder-Bueno Guido Mazza Adrian Morales-torres Jesica t. Cast.llo-Rodriguez Inst.t.t. for Wat.r and Environment.l Engineering Universitat Polit~cnica de Valencia Valencia 46022 Spain Ricerca sul Sist.ma Energet.co--RSE SpA Milan 20134 Italy iPresas Risk Analysis Valencia 46023 Spain

In recent.years, risk analysis t.chniques have proved t. be a useful t.ol t. inform dam safet. manage- ment. t.is paper summarizes t.e out.omes of t.ree t.emes relat.d t. dam risk analysis discussed in t.e Benchmark Workshops organized by t.e Int.rnat.onal Commission on Large Dams t.chnical Com- mit.ee on ＂Comput.t.onal Aspect. of Analysis and Design of Dams.＂ In t.e 2011 Benchmark Workshop, est.mat.on of t.e probabilit. of failure of a gravit. dam for t.e sliding failure mode was discussed. Next. in 2013, t.e discussion focused on t.e comput.t.onal challenges of t.e est.mat.on of consequences in dam risk analysis. Finally, in 2015, t.e probabilit. of sliding and overt.pping in an embankment.was an- alyzed. t.ese Benchmark Workshops have allowed a complet. review of numerical aspect. for dam risk analysis, showing t.at.risk analysis met.ods are a very useful t.ol t. analyze t.e risk of dam syst.ms, including downst.eam consequence assessment. and t.e uncert.int. of st.uct.ral models.

关键词： DamsRisk analysisComput.t.onal met.odsSafet. management.ydraulic st.uct.res

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Biodegradable Addit.ve for t.e Const.uct.on Indust.y

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Journal of Renewable Mat.rials 2019年第6期7卷 523-525页

作者： Juan Carlos torres Lozada AIBRIM San SebastiánGuipúzcoa Spain

t.is paper present. t.e pat.nt.of a new addit.ve for t.e const.uct.on indust.y,which is obt.ined from t.e biomass residues of t.e wood *** addit.ve is biodegradable and has fluidifying,foaming,plast.cizing and st.bilizing *** t.e addit.ve is mixed wit. cement.binder composit.ons,cement.mort.r and concret.,light.eight.flame-ret.rdant.cellular mat.rials,t.ermal and acoust.c insulat.rs are obt.ined.

关键词： Wood biomass wast. addit.ves const.uct.on

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Pot.nt.al risk genes for primary Sjogren's syndrome from a met.-analysis by linear regression and random forest.classificat.on

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Genes & Diseases 2024年第3期11卷 128-131页

作者： t.mas Cerdo t.resa torres Moral Maimonides Biomedical Research Inst.t.t. of Cordoba(IMIBIC) Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Cent.e for Rheumat.logy Research Division of MedicineUniversity College LondonLondon W1T 4JFUK Facult. of Comput.r Sciences Multimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermat.logy Depart.ent Melanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Cent.r for Net.orked Biomedical Research on Rare Diseases(CIBERER) Carlos II Health InstituteMadrid 28029Spain

Primary Sjogren's syndrome(psS)is one of t.e most.widespread aut.immune diseases wit. unknown origin,charact.rized by a lymphocyt.c infilt.at. of t.e exocrine glands and t.e product.on of ant.-SSA/Ro and ant.-SSB/La ant.bodies t.at.cause dysfunct.on and dest.uct.on mainly of salivary and lachrymal glands,leading t. dry eyes and dry *** t.e absence of a st.ndardized evidence-based screening t.ol t. decide which pat.ent. wit. dry eye must.be referred for st.dy of t.is pat.ology.

关键词： Sjogren lymphocyt.c salivary

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Challenges in managing hepat.t.s C virus infect.on in cancer pat.ent.

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World Journal of Gast.oent.rology 2014年第11期20卷 2771-2776页

作者： Roy A Borchardt.Harrys A torres Depart.ent.of Infect.ous Diseases Infection Control and Employee HealthThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

Cancer pat.ent. have unique problems associat.d wit. hepat.t.s C virus(HCV)infect.on and t.eat.ent.not.seen in t.e general *** infect.on poses addit.onal challenges and considerat.ons for t.e management.of cancer,and vice *** infect.on also can lead t. t.e development.of cancer,part.cularly hepat.cellular carcinoma and non-Hodgkin *** severely immunocompromised cancer pat.ent.,diagnosis of HCV infect.on requires increased reliance on RNA det.ct.on *** infect.on can affect.chemot.erapy,and delay of HCV infect.on t.eat.ent.unt.l complet.on of chemot.erapy and achievement.of cancer remission may be required t. decrease t.e pot.nt.al for drug-drug int.ract.ons bet.een ant.neoplast.c agent. and HCV t.erapeut.cs and pot.nt.at.on of side effect. of t.ese *** addit.on,hemat.poiet.c st.m cell t.ansplant.HSCt.recipient. have an increased risk of early development.of cirrhosis and *** t.is increased risk applies t. all pat.ent. regardless of cancer t.eat.ent.is ***,pat.ent. wit. cancer may have poorer sust.ined virological responses t. HCV infect.on t.eat.ent.t.an do t.ose wit.out.***,not.all cancer pat.ent. are candidat.s for HCV infect.on *** t.is art.cle,we review t.e challenges in managing HCV infect.on in cancer pat.ent. and HSCt.recipient..

关键词： Hepat.t.s C virus Cancer Hemat.poiet.c st.m cell t.ansplant Chemot.erapy t.eat.ent Ant.viral Pegylat.d int.rferon Ribavirin

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Renal eliminat.on of organic anions in cholest.sis

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World Journal of Gast.oent.rology 2008年第43期14卷 6616-6621页

作者： Adriana Mónica torres Facult.d de Ciencias Bioquimicas y Farmacéut.cas Universidad Nacional de RosarioCONICETSuipacha 5312000RosarioArgentina

t.e disposit.on of most.drugs is highly dependent.on specialized t.ansport.rs. OAt. and OAt. are t.o organic anion t.ansport.rs expressed in t.e basolat.ral membrane of renal proximal t.bule cells, ident.fied as cont.ibut.rs t. xenobiot.c and endogenous organic anion secret.on. It.is well known t.at.cholest.sis may cause renal damage. Impairment.of kidney funct.on produces modificat.ons in t.e renal eliminat.on of drugs. Recent.st.dies have demonst.at.d t.at.t.e renal abundance of OAt. and OAt. plays an import.nt.role in t.e renal eliminat.on of organic anions in t.e presence of ext.ahepat.c cholest.sis. t.me elapsed aft.r obst.uct.ve cholest.sis has an import.nt.impact.on t.e regulat.on of bot. t.pes of organic anion t.ansport.rs. t.e renal expression of OAt. and OAt. should be t.ken int. account.in order t. improve pharmacot.erapeut.c efficacy and t. prevent.drug t.xicit. during t.e onset.of t.is hepat.c disease.

关键词： Organic anions P-aminohippurat. Furosemide OAt. OAt. Ext.ahepat.c cholest.sis

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Current.view of t.e immunopat.ogenesis in inflammat.ry bowel disease and it. implicat.ons for t.erapy

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World Journal of Gast.oent.rology 2008年第13期14卷 1972-1980页

作者： MI torres A Ríos Depart.ent.of Experiment.l Biology University of Jaén Jaén 23071 Spain Depart.ent.of Cell Biology University of Granada Granada 18071 Spain

Alt.ough t.e aet.ology of inflammat.ry bowel disease (IBD) remains unknown, t.e pat.ogenesis is gradually being unravelled, seeming t. be t.e result.of a combinat.on of environment.l, genet.c, and immunological fact.rs in which an uncont.olled immune response wit.in t.e int.st.nal lumen leads t. inflammat.on in genet.cally predisposed individuals. Mult.fact.rial evidence suggest. t.at.a defect.of innat. immune response t. microbial agent. is involved in IBD. t.is edit.rial out.ines t.e immunopat.ogenesis of IBD and t.eir current.and fut.re t.erapy. We present.IBD as a result.of dysregulat.d mucosal response in t.e int.st.nal wall facilit.t.d by defect. in epit.elial barrier funct.on and t.e mucosal immune syst.m wit. excessive product.on of cyt.kines growt. fact.rs, adhesion molecules, and react.ve oxygen met.bolit.s, result.ng in t.ssue injury. Est.blished and evolving t.erapies are discussed in t.e second part.of t.is edit.rial and at.t.e end of t.is sect.on we review new t.erapies t. modulat. t.e immune syst.m in pat.ent. wit. IBD.

关键词： Inflammat.ry bowel disease Ulcerat.vecolit.s Crohn's disease t.lerance Cyt.kines Mucosalinflammat.on

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