Challenges in managing hepatitis C virus infection in cancer patients

作     者：Roy A Borchardt Harrys A Torres 

作者机构：Department of Infectious DiseasesInfection Control and Employee HealthThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第11期

页      面：2771-2776页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hepatitis C virus Cancer Hematopoietic stem cell transplant Chemotherapy Treatment Antiviral Pegylated interferon Ribavirin 

摘      要：Cancer patients have unique problems associated with hepatitis C virus(HCV)infection and treatment not seen in the general *** infection poses additional challenges and considerations for the management of cancer,and vice *** infection also can lead to the development of cancer,particularly hepatocellular carcinoma and non-Hodgkin *** severely immunocompromised cancer patients,diagnosis of HCV infection requires increased reliance on RNA detection *** infection can affect chemotherapy,and delay of HCV infection treatment until completion of chemotherapy and achievement of cancer remission may be required to decrease the potential for drug-drug interactions between antineoplastic agents and HCV therapeutics and potentiation of side effects of these *** addition,hematopoietic stem cell transplant(HSCT)recipients have an increased risk of early development of cirrhosis and *** this increased risk applies to all patients regardless of cancer treatment is ***,patients with cancer may have poorer sustained virological responses to HCV infection treatment than do those without ***,not all cancer patients are candidates for HCV infection *** this article,we review the challenges in managing HCV infection in cancer patients and HSCT recipients.