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Regenerat.on of neurot.ansmission t.anscript.me in a model of epilept.c encephalopat.y aft.r ant.inflammat.ry t.eat.ent

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Neural Regenerat.on Research 2018年第10期13卷 1715-1718页

作者： Dumit.u A.Iacobas Libor Velísek Cent.r for Comput.t.onal Syst.ms Biology Prairie View AM University Prairie View TX USA D.P.Purpura Depart.ent.of Neuroscience Albert Einstein College of MedicineNew York NY USA Depart.ent.of Cell Biology & Anat.my New York Medical CollegeValhalla NY USA Depart.ent.of Neurology New York Medical CollegeValhalla NY USA Depart.ent.of Pediat.ics New York Medical CollegeValhalla NY USA

Inflammat.on is an est.blished et.opat.ogenesis fact.r of infant.le spasms（IS）, a t.erapy-resist.nt.epilept.c syndrome of infancy. We invest.gat.d t.e IS-associat.d t.anscript.mic alt.rat.ons of neurot.ansmission in rat.hypot.alamic arcuat. nucleus, how t.ey are correct.d by ant.inflamat.ry t.eat.ent. and whet.er t.ere are sex differences. IS was t.iggered by repeat.d int.aperit.neal administ.at.on of N-met.yl-D-aspart.c acid following ant.-inflammat.ry t.eat.ent.adreno-cort.co-t.opic-hormone（ACt.） or PMX53）or normal saline vehicle t. prenat.lly exposed t. bet.met.asone young rat.. We found t.at.t.eat.ent. wit. bot. ACt. and PMX53 result.d in subst.nt.al recovery of t.e genomic fabrics of all t.pes of synapt.c t.ansmission alt.red by IS. While ACt. represent. t.e first.line of t.eat.ent.for IS, t.e even higher efficiency of PMX53（an ant.gonist.of t.e complement.C5 a recept.r） in rest.ring t.e normal t.anscript.me was not.expect.d. In addit.on t. t.e childhood epilepsy, t.e recovery of t.e neurot.ansmission genomic fabrics by PMX53 also gives hope for t.e aut.sm spect.um disorders t.at.share a high comorbidit. wit. IS. Our result. revealed significant.sex dichot.my in bot. IS-associat.d t.anscript.mic alt.rat.ons（males more affect.d） and in t.e efficiency of PMX53 ant.-inflammat.ry t.eat.ent.bet.er for males）. Our dat. furt.er suggest.t.at.ant.-inflammat.ry t.eat.ent. correct.ng alt.rat.ons in t.e inflammat.ry t.anscript.me may become successful t.erapies for refract.ry epilepsies.

关键词： adreno-cort.co-t.opic-hormone aut.sm cholinergic t.ansmission hypot.alamus infant.le spasms microarrays PMX53 sex differences

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t.o macrophages, ost.oclast. and microglia: from development.t. pleiot.opy

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Bone Research 2021年第2期9卷 143-152页

作者： Ji-Won Lee In-Hee Lee t.dahiro Iimura sek.Won Kong Depart.ent.of Nephrology Transplant Research ProgramBoston Children’s HospitalBostonMA 02115USA Depart.ent.of Pharmacology Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Comput.t.onal Healt. Informat.cs Program Boston Children’s HospitalBostonMA 02115USA Depart.ent.of Pediat.ics Harvard Medical SchoolBostonMA 02115USA

t.ssue-resident.macrophages are highly specialized t. t.eir t.ssue-specific microenvironment.,act.vat.d by various inflammat.ry signals and modulat.d by genet.c and environment.l *** and microglia are dist.nct.t.ssue-resident.cells of t.e macrophage lineage in bone and brain t.at.are responsible for pat.ological changes in ost.oporosis and Alzheimer’s disease(AD),*** is more frequent.y observed in individuals wit. AD compared t. t.e prevalence in general *** of AD is oft.n delayed unt.l underlying pat.ophysiological changes progress and cause irreversible damages in st.uct.re and funct.on of *** such earlier diagnosis and int.rvent.on of individuals at.higher risk would be indispensable t. modify clinical *** is t.e phenomenon t.at.a genet.c variant.affect. mult.ple t.ait. and t.e genet.c correlat.on bet.een t.o t.ait. could suggest.a shared molecular *** t.is review,we discuss t.at.t.e Pyk2-mediat.d act.n polymerizat.on pat.way in ost.oclast. and microglia in bone and brain,respect.vely,is t.e horizont.l pleiot.opic mediat.r of shared risk fact.rs for ost.oporosis and AD.

关键词： diagnosis ost.oporosis ost.oclast

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用于Friedel-Craft.苯苯甲酰化反应的铟催化剂的多相化(英文)

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催化学报 2012年第11期33卷 1802-1808页

作者： Farook ADAM Kei Lin sek School of Chemical Sciences Universiti Sains MalaysiaPenang 11800Malaysia

Indium incorporat.d silica samples wit. different.indium cont.nt. were synt.esized using a t.mplat. free sol-gel *** silica used was ext.act.d from rice husk(RH) and t.e result.ng cat.lyst.was labeled as RH-xIn(x = 5%,10%,15%,and 20%).From t.e N2 adsorpt.on analysis t.e presence of t.pe IV isot.erm in RH-blank and RH-xIn indicat.d t.e mesoporous nat.re of t.e *** t.e XRD pat.ern,a broad band at.ca.2θ = 25° was observed for all t.e cat.lyst. which showed t.em t. be *** micrographs revealed t.at.t.e mat.rial is composed of ***-Craft.benzoylat.on of t.luene was carried out.using t.e RH-xIn *** opt.mum condit.ons for t.e benzoylat.on of t.luene were det.rmined and at.373 K,100% conversion and 89% select.vit. for t.e para-product.i.e.4-met.ylbenzophenone) were obt.ined.

关键词： LFCO XRD 化学化学动力学

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Superior Propert.es of Mg–4Y–3RE–Zr Alloy Prepared by Powder Met.llurgy

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Journal of Mat.rials Science & t.chnology 2017年第7期33卷 652-660页

作者： Jirí Kubásek.Drahomír Dvorsky Miroslav Cavojsky Dalibor Vojt.ch Nad'a Beronská Michaela Fousová Depart.ent.of Met.ls and Corrosion Engineering University of Chemistry and Technology PragueTechnická 5166 28 Prague 6Czech Republic Inst.t.t. of Mat.rials and Machine Mechanics SAS Slovak Academy of SciencesDúbravskd cesta 9845 13 BratislavaSlovak Republic

Magnesium alloys are import.nt.mat.rials for applicat.on in t.e aut.mot.ve and aviat.on indust.ies. During t.e last.few years, t.e number of possible applicat.ons as biodegradable implant. in medicine has grown. Mg-RE（rare eart.） alloys belong t. t.e most.advanced group of product., offering t.e best.combinat.on of mechanical propert.es and corrosion resist.nce. Among t.ese mat.rials, WE43（Mg-Y-Nd）is a very well-known commercial alloy t.at.has been ext.nsively st.died for applicat.ons at.increased t.mperat.res and also in organisms. Alt.ough t.is mat.rial has been described, t.ere are st.ll possibilit.es t. improve it. propert.es and subsequent.y expand it. applicabilit.. Powder met.llurgy has already been used for t.e preparat.on of magnesium alloys wit. superior mechanical propert.es and occasionally superior corrosion propert.es. t.erefore, t.e present.paper is orient.d t.ward t.e preparat.on of Mg-4Y-3RE-Zr（WE43） alloy by t.e powder met.llurgy t.chnique（WE43-PM） and comparison of t.e final propert.es wit. t.e product.of ext.usion of as-cast.ingot.WE43-IM）. Our processing leads t. a part.al improvement.in t.e mechanical propert.es and superior corrosion resist.nce of WE43-PM. t.e t.xt.re st.engt. of WE43-PM was low, and t.erefore, anisot.opy of mechanical propert.es was suppressed.

关键词： Magnesium alloys REEs(rare eart. element.) Powder met.llurgy Mechanical propert.es Corrosion

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Point.of-care ult.asound ident.ficat.on of pneumat.sis int.st.nalis associat.d wit. Henoch-Schönlein purpura gast.oint.st.nal involvement.A case report

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World Journal of Emergency Medicine 2021年第1期12卷 76-78页

作者： sek.Wan t.n Vigil James Aswin Warier Gene Yong-kwang Ong Children’s Emergency KK Women’s and Children’s Hospital229899Singapore

Dear edit.r,Henoch-Schönlein purpura (HSP) is t.e commonest.asculit.s in children, t.pically affect.ng children agedt.ree t. t.n years.[1] It.is a mult.-syst.mic vasculit.smediat.d by t.pe III hypersensit.vit. wit. deposit.on ofimmunoglobulin. An immune complex-mediat.d vasculit.saffect. small vessels of t.e skin, joint., kidneys, andgast.oint.st.nal (GI) t.act.. HSP is usually a self-limit.ngcondit.on and resolves wit.in six t. eight.weeks.[1]

关键词： gast.oint.st.nal involvement Sch

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VNN disease and st.t.s of breeding for resist.nce t. NNV in aquacult.re

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Aquacult.re and Fisheries 2022年第2期7卷 147-157页

作者： Zit.o Yang Gen Hua Yue sek.Man Wong Depart.ent.of Biological Sciences National University of Singapore14 Science Drive 4117543Singapore t.masek.Life Sciences Laborat.ry 1 Research LinkNational University of Singapore117604Singapore

Viral nervous necrosis(VNN)disease,caused by t.e nervous necrosis virus(NNV),is a devast.t.ng disease,leading t. high mort.lit. rat. and huge economical loss in *** t.e past.30 years,many st.dies on t.e virus,host.responses t. t.e virus infect.on and diagnost.cs have yielded a lot.of knowledge on developing measures t. prevent.t.e VNN *** genet.c improvement.of disease resist.nce t.rough breeding is inherit.ble and has long-last.ng posit.ve effect.on aquacult.re,it.is a very challenging t.sk in convent.onal select.ve breeding for improving disease *** t.e advances in mapping quant.t.t.ve t.ait.loci(Qt.)and genome wide associat.on st.dies(GWAS)for NNV resist.nce in aquacult.re species,DNA markers and genes associat.d wit. NNV resist.nce have been ident.fied,making t.e applicat.on of marker-assist.d select.on(MAS)and genomic select.on(GS)for NNV resist.nce possible.A few genes for NNV resist.nce are ident.fied and are being used for genome edit.ng t. rapidly improve NNV *** t.is review,we present.t.e current.knowledge on t.e NNV,host.responses t. NNV infect.on,diagnost.c met.ods and vaccines available for NNV *** addit.on,we summarize t.e current.st.t.s of convent.onal and molecular breeding for NNV resist.nce and highlight.fut.re direct.ons,including genome edit.ng for improving NNV resist.nce in aquacult.re.

关键词： Aquacult.re Disease NNV Breeding Genome edit.ng

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Charact.rizat.on of t.e High-St.engt. Mg–3Nd–0.5Zn Alloy Prepared by t.ermomechanical Processing

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Act. Met.llurgica Sinica(English Let.ers) 2019年第3期32卷 321-331页

作者： Ji■í Kub■sek.Drahomír Dvorsk■ Jozef Vesel■ Pet.r Min■rik M■ria Zemkov■ Dalibor Vojt.ch Depart.ent.of Met.ls and Corrosion Engineering Faculty of Chemical Technology University of Chemistry and Technology Prague Depart.ent.of Physics of Mat.rials Charles University

Magnesium alloys based on Nd and Zn are promising mat.rials for bot. aviat.on indust.y and medical *** mechanical propert.es of t.ese mat.rials can be achieved by t.ermomechanical processing such as ext.usion or rolling and by aging t.eat.ent. which can significant.y st.engt.en t.e alloy. t.e quest.on remains especially about.t.e connect.on of t.xt.re st.engt. creat.d in t.e alloys based on t.e specific condit.ons of preparat.on. t.is work focuses on t.e Mg–3 Nd–0.5 Zn magnesium alloy prepared by hot.ext.usion of t.e as-cast.st.t. at.t.o different.t.mperat.res combined wit. heat.pre-t.eat.ent. Ext.usion rat.o of 16 and rat. of 0.2 mm/s at.350 and 400 °C were select.d for mat.rial preparat.on. t.e st.uct.res of prepared mat.rials were st.died by scanning elect.on microscopy and t.ansmission elect.on microscopy. t.e effect.of microst.uct.re on mechanical propert.es was evaluat.d. Obt.ined result. revealed t.e st.ong effect.of t.ermal pre-t.eat.ent.on final microst.uct.re and mechanical propert.es of ext.uded mat.rials. t.e Hall–Pet.h relat.on bet.een grain size and t.nsile yield st.engt. has been suggest.d in t.is paper based on t.e lit.rat.re review and present.d dat.. t.e observed behavior st.ongly support. t.e fact.t.at.t.e Hall–Pet.h of ext.uded Mg–3Nd–0.5 Zn alloys wit. different.t.xt.re int.nsit.es cannot.be clearly est.mat.d and predict.d. In addit.on, Hall–Pet.h relat.ons present.d in lit.rat.re can be sufficient.y obt.ined only for fract.on of t.e Mg–3Nd–0.5 Zn alloys.

关键词： Mg–Nd–Zn alloys Ext.usion t.ermal t.eat.ent Microst.uct.re Mechanical propert.es

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Informat.on needs of older people wit. heart.failure： list.ning t. t.eir own voice

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Journal of Geriat.ic Cardiology 2016年第5期13卷 435-438页

作者： Ming-Ming YU sek.Ying Chair Carmen WH Chan Kai Chow Choi School of Nursing Peking Union Medical College Beijing China Net.ersole School of Nursing The Chinese University of Hong Kong Hong Kong China

According t. a large-scale census in 2000, t.ere were approximat.ly 4,000,000 pat.ent. wit. heart.failure （HF） aged bet.een 35 and 74 years in China. Pat.ent.educat.on shows it. import.nce and essent.alit. in cont.olling t.e disease by improving t.e self-care abilit.es of pat.ent.,t.1 However, a short.ned period of hospit.lizat.on compromises t.e effect.veness and efficacy of t.e educat.on. It.is t.erefore suggest.d t.at.t.e informat.on needs of pat.ent. wit. HF should be simult.neously addressed t. make educat.on more appropriat. and t.ilored.

关键词： Educat.on Heart.failure Informat.on needs Qualit.t.ve st.dy

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Microst.uct.re and corrosion resist.nce of a duplex st.uct.red Mg–7.5Li–3Al–1Zn

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Journal of Magnesium and Alloys 2021年第2期9卷 467-477页

作者： Anna Dobkowska Bogusława Adamczyk–Cieslak JiríKubásek.Dalibor Vojt.ch Dariusz Kuc Eugeniusz Hadasik Jarosław Mizera Facult. of Mat.rials Science and Engineering Warsaw University of Technology141 Wołoska St02-507 WarsawPoland Chemist.y Depart.ent Western University of Ontario1151 Richmond StLondonON N6A 5B7Canada Depart.ent.of Met.ls and Corrosion Engineering University of Chemistry and TechnologyTechnicka 516628 Prague 6Czechia Inst.t.t. of Mat.rials Engineering Silesian University of TechnologyKrasinskiego 8St40-019 KatowicePoland

t.is st.dy describes t.e corrosion resist.nce of ext.uded,and ext.uded wit. post.processing annealing,Mg–7.5 Li–3 Al–1 Zn *** result. demonst.at. t.at.ext.usion at.350°C wit. an ext.usion speed 0.5 s^(-1) does not.lead t. t.e full recryst.llizat.on of t.e alloy,and t.e mat.rial st.ll exhibit. a dendrit.c *** post.processing annealing t.iggers t.e microst.uct.re t.ansformat.on,and t.e relat.ve composit.on of t.e alloy *** rat.o ofβ(Li)t.α(Mg)in t.e ext.uded alloy was 29–71%;aft.r annealing amount.ofβ(Li)increased,and t.e rat.o ofβ(Li)t.α(Mg)in t.e annealed alloy was 35–65%.Corrosion t.st.ng shows t.at.in 3.5 wt.Na Cl t.e ext.uded alloys immediat.ly undergo st.ong *** a result.of t.e subsequent.annealing,an improvement.of corrosion resist.nce is *** higher amount.ofβ(Li)in t.e annealed alloy reduces t.e area rat.o of cat.odic t. anodic sit.s of corrosion,and t.is makes t.e annealed alloy more resist.ve under t.e analyzed condit.ons.

关键词： Magnesium-Lit.ium corrosion Ext.usion Annealing

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t.pe D personalit. negat.vely associat.d wit. self-care in Chinese heart.failure pat.ent.

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Journal of Geriat.ic Cardiology 2016年第5期13卷 401-407页

作者： Xi CAO Xiu-Hua WANG Eliza ML Wong Choi Kai Chow sek.Ying Chair t.e Net.ersole School of Nursing The Chinese University of Hong Kong Hong Kong China Nursing School Central South University Changsha China

Background Lit.le is known about.t.e associat.on bet.een t.pe D personalit. and self-care behaviors in heart.failure （HF） pat.ent.. We examined t.e effect.of t.pe D personalit. on self-care behaviors and self-efficacy among Chinese HF pat.ent.. Met.ods A cross-sect.onal st.dy wit. a convenience sample was conduct.d. All part.cipant. complet.d t.e quest.onnaires of t.e self-care of HF index （V6） and t.pe D personalit. scale. Demographic and clinical variables were obt.ined from medical records and pat.ent.int.rviews. t.e me- t.ods used for dat. analysis included descript.ve analysis, independent.sample t.t.st. Z2 t.st. and mult.ple linear regression. Result. A t.t.l of 127 HF pat.ent. were included and 61.4% of t.em were male. t.e average age for t.is st.dy sample was 64.9± 12.34 years. t.e majorit. of t.e part.cipant. were in a New York Heart.Associat.on class III or IV （87%）, and t.e average lengt. of living wit. HF was 38.24 ± 41.1 mont.s. A t.t.l of 33.1% of t.e part.cipant. were ident.fied as having t.pe D personalit.. No significant.differences were det.rmined in t.e demographic and clinical variables bet.een t.pe D and non-t.pe D pat.ent., except.for t.e mean age and t.e lengt. of living wit. HF. t.pe D pat.ent. were younger and had a short.r t.me of living wit. HF t.an t.eir non-t.pe D count.rpart.. Mult.ple regression demonst.at.d significant.associat.ons bet.een t.pe D personalit. and self-care maint.nance and self-efficacy aft.r adjust.ng t.e demographic and clinical fact.rs. However, t.pe D personalit. was not.significant.y associat.d wit. self-care management.behaviors. Conclusions t.pe D personalit. was negat.vely relat.d t. self-care maint.nance and self-efficacy in Chinese HF pat.ent.. Fut.re st.dy is warrant.d t. develop a t.ilored int.rvent.on t. improve engagement.in self-care behaviors in HF pat.ent. wit. t.pe D personalit..

关键词： Heart.failure Self care Self-efficacy t.pe D personalit.

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