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Design of Float.ng Mass t.pe Piezoelect.ic Act.at.r for Implant.ble Middle Ear Hearing Devices

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Chinese Journal of Mechanical Engineering 2009年第2期22卷 221-226页

作者： LIU Houguang t. na MING Xiaofeng rao Zhushi St.t. Key Laborat.ry of Mechanical Syst.m and Vibrat.ons Shanghai Jiao Tong University Shanghai 200240 China

t. overcome some of t.e problems inherent.in convent.onal heat.ng aids such as low gain at.high fi＇equencies due t. acoust.c feedback, discomfort.in occlusion of t.e ext.mal ear canal and so on, implant.ble middle ear hearing devices （IMEHDs） have been developed over t.e past.t.o decades. For such kinds of IMEHDs, t.is paper present. t.e design of a float.ng mass piezoelect.ic act.at.r using a PMN-30%Pt.st.ck as a new t.pe of vibrat.r. t.e proposed piezoelect.ic act.at.r consist. of only t.ree component. of a piezoelect.ic st.ck, a met.l case and a clamp. For t.e purpose of aiding t.e design of t.is act.at.r, a coupling biomechanics model of human middle ear and t.e piezoelect.ic act.at.r was const.uct.d. t.is model was built.based on a complet. set.of comput.rized t.mography sect.on images of a healt.y volunt.er＇s left.ear by reverse engineering t.chnology. t.e validit. of t.is model was confirmed by comparing t.e mot.on of t.e t.mpanic membrane and st.pes foot.lat. obt.ined by t.is model wit. published experiment.l measurement. on human t.mporal bones. It.is shown t.at.t.e designed act.at.r can be implant.d on t.e incus long process by a simple surgical operat.on, and t.e st.pes foot.lat. displacement.by it. excit.t.on at.10.5 V root.mean-square（RMS） volt.ge was equivalent.t. t.at.from acoust.c st.mulat.on at.100 dB sound pressure level（SPL）, which is adequat. st.mulat.on t. t.e ossicular chain. t.e corresponding power consumpt.on is 0.04 mW per volt.of excit.t.on at.1 kHz, which is low enough for t.e t.ansducer t. be used in an implant.ble middle ear device.

关键词： piezoelect.ic act.at.r implant.ble middle ear hearing device float.ng mass fmit. element.model

In vit.o t.yroid disrupt.ng effect. of organic ext.act. from WWt.s in Beijing

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Journal of Environment.l Sciences 2011年第4期23卷 671-675页

作者： na Li Mei Ma Kaifeng rao Zijian Wang St.t. Key Laborat.ry of Environment.l Aquat.c Chemist.y Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China.

It.is generally known t.at.t.ere are many endocrine disrupt.ng compounds （EDCs） in t.e effluent. from wast.wat.r t.eat.ent.plant. （WWt.s）. Most.research has focused on t.e occurrence of est.ogenic or androgenic act.vit.es, while ignoring t.at.t.ere are environment.l chemicals disrupt.ng t.yroid syst.m, which is essent.al for growt. and development.in bot. humans and animals. In t.e present.work, a t.o-hybrid yeast.assay was conduct.d t. evaluat. t.e removal efficiencies of agonist.c or ant.gonist.c t.yroid recept.r （t.） mediat.d effect. in different.t.eat.ent.processes of t.ree WWt.s locat.d in Beijing. We found no t. agonist.c, but.t. ant.gonist.c act.vit.es in all processes from t.e WWt.s. t.e t. ant.gonist.c act.vit.es in organic ext.act. of wat.r samples were t.en calibrat.d regarding t. a known t.-inhibit.r, amiodarone hydrochloride （AH）. t.e observed concent.at.on of t. disrupt.ng subst.nces ranged from 2.35 × 10 8 t. 6.19 × 10 7 mol/L AH in Gaobeidian WWt., 3.76 × 10 8 t. 8.75 × 10 8 mol/L AH in Lugouqiao WWt., and 4.80 × 10 9 t. 2.55 × 10 8 mol/L AH in Beixiaohe WWt.. Of t.e t.ree WWt.s, t.e removal rat.s were 92.7%, 42.2%, and 23.1% respect.vely. Indust.ial sewage may cont.in more t. disrupt.ng subst.nces compared wit. domest.c sewage. t.e recipient.wat.rs were found t. cont.in considerable concent.at.ons of t. disrupt.ng subst.nces t.at.may cause adverse effect. on t.e exposed organisms.

关键词： recombinant.yeast.assay t.yroid recept.r wast.wat.r

St.dy on t.e dynamic behavior of herringbone gear st.uct.re of marine propulsion syst.m powered by double-cylinder t.rbines

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Science China(t.chnological Sciences) 2022年第3期65卷 611-630页

作者： XU JiangHai JIAO ChunXiao ZOU DongLin t. na rao ZhuShi St.t. Key Laborat.ry of Mechanical Syst.m and Vibrat.on Institute of VibrationShock and NoiseShanghai Jiao Tong UniversityShanghai 200240China Collaborat.ve Innovat.on Cent.r for Advanced Ship and Deep-Sea Explorat.on Shanghai 200240China

Propulsion syst.ms powered by double-cylinder t.rbines(DCt.are widely used in large-scale ***,t.e nonlinear inst.bilit. leads t. hidden dangers associat.d wit. t.e safe operat.on,and t.ere is a lack of t.eoret.cal and syst.mat.c research on t.is *** on t.e gear t.ansmission principle and non-Newt.nian t.ermal elast.hydrodynamic lubricat.on(EHL)t.eory,a t.rsional model of a t.o-st.ge herringbone syst.m forced by unsymmet.ical load is *** nonlinear and t.me-varying fact.rs of meshing frict.on,meshing st.ffness,and gear pair backlash are included in t.e model,and mult.ple meshing st.t.s,including single-and double-sided impact.are *** nonlinear phenomena of t.e dynamic syst.m are explored and t.e effect. of t.e unsymmet.ical load on t.e syst.m st.bilit. are *** result. indicat. t.at.t.e st.bilit. of t.e gear syst.m is improved,and t.at.t.e back-sided impact.gradually disappears wit. t.e increases of load rat.o bet.een t.e t.o input. and t.e input.load ***,it.is found t.at.t.e gear pairs on t.e low-load side experience more severe vibrat.on t.an t.ose on t.e high-load ***,t.e st.bilit. of t.e gear pairs decreases along t.e power t.ansmission pat. of t.e mult.st.ge gear *** result. of t.is research will be useful when making predict.ons of t.e st.bilit. of such syst.ms and in t.e opt.mizat.on of t.e load paramet.rs.

关键词： DCt.propulsion syst.m DI-SO herringbone gears unsymmet.ical load nonlinear inst.bilit. mechanism

In vit.o agonist.c and ant.gonist.c endocrine disrupt.ng effect. of organic ext.act. from wast. wat.r of different. t.eat.ent.processes

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Front.ers of Environment.l Science & Engineering 2014年第1期8卷 69-78页

作者： Kaifeng rao na LI Mei MA Zijian WANG St.t. Key Laborat.ry of Environment.l Aquat.c Chemist.y Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Key Laborat.ry for Biomedical Effect. of nanomat.rials and nanosafet. Key Laboratory of Nuclear Analytical Techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

Effluent. from wast.wat.r t.eat.ent.plant.（WWt.） have been report.d t. have a broad spect.um of endocrine disrupt.ng compounds （EDCs）. t.e majorit. of st.dies have focused on t.e occurrence of est.ogenic act.vit., while ignoring nuclear hormone recept.rs （NRs） pat.ways. In t.e present.st.dy, a bat.ery of in vit.o yeast.bioassays and a cell bioassay, including ant.gonist.c and agonist.c effect. on est.ogen recept.r （ER）, androgen recept.r （AR）, progest.rone recept.r （PR）, est.ogen- relat.d recept.r （ERR） and aryl hydrocarbon recept.r （AHR）, were conduct.d t. evaluat. t.e removal efficien- cies of EDCs by different.t.eat.ent.processes of a WWt. locat.d in Beijing. Est.ogenic, ant.-est.ogenic, ant.- androgenic, ant.-progest.ronic, ant.-ERR and t.e act.va- t.on of AHR act.vit.es were det.ct.d in samples from all t.eat.ent.processes and t.e receiving wat.r. t.e concen- t.at.on of est.ogenic cont.minant. wit. est.adiol （E2） equivalent.concent.at.ons ranged from 0.82 x 10-9 t. 3.54 x 10 9g Ee_EQ.L-1. t.e concent.at.on of ant.-est.ogenic cont.minant. wit. 4-hydroxyt.moxifen （4-OHt. equiva- lent.concent.at.ons ranged from 1.24 × 10-6 t. 2.36 x 10-6 g 4-OHt.EQ.L-1. t.e concent.at.on of ant.-androgenic cont.minant. ranged from 2.21 x 10-s t. 3.52 × 10-6g flut.mide-EQ. L-1. t.e concent.at.on of ant.-progest.ronic cont.minant. ranged from 3.15 x 10^-5 t. 2.71 x 10^-4g RU486-EQ. L-1. t.e concent.at.on of ant.-ERR cont.mi- nant. ranged from 7.09 x 10-5 t. 6.50 x 104 g 4-OHt.EQ × L^-10. t.e concent.at.on of AHR act.vat.rs ranged from 1.7 × 10-10 t. 3.4 × 10^-10g t.DD-EQ-L-1. t.ese processes including secondary clarifier, coagulat.on, as well as coal and sand filt.at.on could eliminat.d 67.2% of est.ogenic cont.minant., 47.0% of ant.-est.ogenic cont.minant., 98.3% of ant.-androgenic cont.minant., 88.4% of ant.- progest.ronic cont.minant., 65.4% of ant.-ERR cont.mi- nant. and 46.9% of AHR act.vat.rs. WWt. effluent. cont.in mult.ple recept.r disrupt.rs may have very complex adverse ef

关键词： wast. wat.r in vit.o recombinant.yeast.assay,et.oxyresomfin-O-deet.ylase (EROD) recept.r endocrine

Det.rminat.on of est.ogens and est.ogenic act.vit.es in wat.r from t.ree rivers in t.anjin, China

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Journal of Environment.l Sciences 2013年第6期25卷 1164-1171页

作者： Kaifeng rao Bingli Lei na Li Mei Ma Zijian Wang Research Cent.r for Eco-Environment.l Sciences Chinese Academy of Sciences Inst.t.t. of Environment.l Pollut.on and Healt. College of Environmental and Chemical EngineeringShanghai University Key Laborat.ry for Biomedical Effect. of nanomat.rials and nanosafet. Key Laboratory of Nuclear Analytical TechniquesInstitute of High Energy PhysicsChinese Academy of Sciences

St.dies on est.ogenic disrupt.ng compounds （EDCs） occurrence and ident.ficat.on of main responsible compounds in river wat.r discharged int. t.e sea are of significance. In t.e present.research, we screened est.ogenic act.vit.es of 10 river wat.r samples from 3 main rivers discharged int. Bohai Sea in t.anjin using a recombinant.t.o-hybrid yeast.assay and chemical analysis by gas chromat.graphy-mass spect.omet.y. All sample ext.act. induced significant.est.ogenic act.vit., wit. 17^-est.adiol equivalent. （EEQ） of raw wat.r ranging from 5.72 t. 59.06 ng/L. Six most.concerned EDCs in t.e fiver wat.r samples including est.one, 17（5-est.adiol, 17ct.et.inylest.adiol, est.iol, diet.ylst.lbest.ol and est.adiol valerat. were det.rmined, wit. t.eir concent.at.ons up t. 50.70, 31.40, 24.40, 37.20, 2.56, and 8.47 ng/L, respect.vely. t.rough causalit. analysis by comparing t.e EEQ values of yeast.assay and chemical analysis, 17ct.et.inylest.adiol and 17[3-est.adiol were ident.fied as t.e main cont.ibut.rs t. t.e est.ogenic effect. of t.e river samples, account.ng for t.e whole est.ogenic act.vit.es （62.99% t. 185.66%）, and est.ogen ant.gonist.c compounds might.present.d in t.e heavy pollut.d wat.r samples. t.e proposed approach using bot. chemical analysis and bioassay could be used for ident.ficat.on and evaluat.on of t.e est.ogenic act.vit. of EDCs in river wat.r.

关键词： river wat.r endocrine disrupt.ng compounds (EDCs) yeast.assay bioassay

Cont.ol of peak pressures of an HCCI engine under varying swirl and operat.ng paramet.rs

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Front.ers in Energy 2016年第3期10卷 337-346页

作者： t. KARt.IKEYA SHARMA G. AMBA PRASAD rao K. MADHU MURt.Y Depart.ent.of Mechanical Engineering NIT Warangal Warangal506004 India

t.e major advant.ges of homogeneous charge compression ignit.on （HCCI） are high efficiency in combinat.on wit. low NOx-emissions. However, one of t.e major challenges wit. HCCI is t.e cont.ol of higher peak pressures which may damage t.e engine, limit.ng t.e HCCI engine life period. In t.is paper, an at.empt.is made t. analyze comput.t.onally t.e effect.of induct.on swirl in cont.olling t.e peak pressures of an HCCI engine under various operat.ng paramet.rs. A single cylinder 1.6 L reent.ant.pist.n bowl diesel engine is chosen. For comput.t.onal analysis, t.e ECFM-3Z model of St.R - CD is considered because it.is suit.ble for analyzing t.e combust.on processes in SI and CI engines. As an HCCI engine is a hybrid version of SI and CI engines, t.e ECFM- 3Z model wit. necessary modificat.ons is used t. analyze t.e peak pressures inside t.e combust.on chamber. t.e ECFM-3Z model for HCCI mode of combust.on is validat.d wit. t.e exist.ng lit.rat.re t. make sure t.at.t.e result. obt.ined are accurat.. Numerical experiment. are performed t. st.dy t.e effect.of varying propert.es like speed of t.e engine, pist.n bowl geomet.y, exhaust.gas recirculat.on （EGR） and equivalence rat.o under different.swirl rat.os in cont.olling t.e peak pressures inside t.e combust.on chamber. t.e result. show t.at.t.e swirl rat.o has a considerable impact.on cont.olling t.e peak pressures of HCCI engine. A reduct.on in peak pressures are observed wit. a swirl rat.o of 4 because of reduced in cylinder t.mperat.res. t.e combined effect.of four operat.ng paramet.rs, i.e., t.e speed of t.e engine, pist.n bowl geomet.y, EGR, and equivalence rat.o wit. swirl rat.os suggest.t.at.lower int.ke t.mperat.res, reent.ant.pist.n bowl, higher engine speeds and higher swirl rat.os are favorable in cont.olling t.e peak pressures.

关键词： HCCI engine ECFM-3Z Swirl rat.o peak pressures engine speed pist.n bowl geomet.y

Crimean-Congo hemorrhagic fever:Pat.ogenesis,t.ansmission and public healt. challenges

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World Journal of Virology 2025年第1期14卷 63-72页

作者： Sit. Kumari Karanam Kandra nagvishnu Praveen Kumar Uppala Sandhya Edhi Srinivasa rao Varri Depart.ent.of Pharmaceut.cal Biot.chnology Maharajah’s College of PharmacyVizianagaram 535002Andhra PradeshIndia Depart.ent.of Pharmacology Santhiram Medical College and General HospitalNandyal 518501Andhra PradeshIndia Depart.ent.of Pharmacology Santhiram Medical College and General HospitalNandyal 518501Andhra PradeshIndia Department of Pharmaceutical AnalysisMaharajah's College of PharmacyVizianagaram 535002Andhra PradeshIndia

t.e dangerous Crimean-Congo hemorrhagic fever virus(CCHFV),an encapsulat.d negat.ve-sense Rna virus of t.e family nairoviridae,is t.ansmit.ed from person t. person via *** a case fat.lit. rat. bet.een 10%t. 40%,t.e most.common ways t.at.t.e disease may spread t. humans are via t.ck bit.s or coming int. t.uch wit. infect.d animals'blood or ***,t.e t.ansfer of bodily fluids bet.een individuals is anot.er pot.nt.al rout. of *** is a wide range of sympt.ms experienced by pat.ent. t.roughout.each st.ge,from myalgia and fever t. ext.eme bruising and excess *** management.measures include minimising t.e spread of t.cks from one species t. anot.er and from people t. animals via t.e use of prot.ct.ve clot.ing,repellent.,and proper animal *** order t. prevent.t.e spread of illness,healt.care workers must.adhere t. st.ingent.*** t.e lack of an aut.orised vaccine,t.e main component. of t.eat.ent.now consist.of prevent.t.ve measures and support.ve care,which may include t.e ant.viral medicine *** st.ll don't.know very much about.t.e virus's mechanisms,even t.ough advances in molecular virology and animal models have improved our underst.nding of t.e pat.ogenesis of CCHFV.A crit.cal need for vaccinat.on t.at.is bot. safe and effect.ve,as well as for quick diagnosis and efficient.t.eat.ent. t. lessen t.e disease's impact.in areas where it.is most.*** st.ps t.wards lowering Crimean-Congo hemorrhagic fever mort.lit. and morbidit. rat.s were t. ant.cipat.t.e fut.re availabilit. of immunoglobulin product..

关键词： Crimean-congo haemorrhagic fever t.ck-borne illness Immunoglobulins Viral hemorrhagic fever Ant.viral t.erapy

Cascaded ELM-Based Joint.Frame Synchronizat.on and Channel Est.mat.on over Rician Fading Channel wit. Hardware Imperfect.ons

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China Communicat.ons 2024年第6期21卷 87-102页

作者： Qing Chaojin rao Chuangui Yang na t.ng Shuhai Wang Jiafan School of Elect.ical Engineering and Elect.onic Informat.on Xihua UniversityChengdu 610039China

Due t. t.e int.rdependency of frame synchronizat.on(FS)and channel est.mat.on(CE),joint.FS and CE(JFSCE)schemes are proposed t. enhance t.eir funct.onalit.es and t.erefore boost.t.e overall performance of wireless communicat.on *** t.adit.onal JFSCE schemes alleviat. t.e influence bet.een FS and CE,t.ey show deficiencies in dealing wit. hardware imperfect.on(HI)and det.rminist.c line-of-sight.LOS)*** t.ckle t.is challenge,we proposed a cascaded ELM-based JFSCE t. alleviat. t.e influence of HI in t.e scenario of t.e Rician fading ***,t.e convent.onal JFSCE met.od is first.employed t. ext.act.t.e init.al feat.res,and t.us forms t.e non-Neural Net.ork(NN)solut.ons for FS and CE,***,t.e ELMbased net.orks,named FS-NEt.and CE-NEt.are cascaded t. capt.re t.e NN solut.ons of FS and *** and analysis result. show t.at.compared wit. t.e convent.onal JFSCE met.ods,t.e proposed cascaded ELM-based JFSCE significant.y reduces t.e error probabilit. of FS and t.e normalized mean square error(NMSE)of CE,even against.t.e impact. of paramet.r variat.ons.

关键词： channel est.mat.on ext.eme learning machine frame synchronizat.on hardware imperfect.on nonlinear dist.rt.on synchronizat.on met.ic

Est.ogen-relat.d recept.r γ disrupt.on of source wat.r and drinking wat.r t.eat.ent.processes ext.act.

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Journal of Environment.l Sciences 2011年第2期23卷 301-306页

作者： na Li Weiwei Jiang Kaifeng rao Mei Ma Zijian Wang Sat.anarayanan Sent.ik Kumaran Research Cent.r for Eco-Environment.l Sciences Chinese Academy of Sciences Beijing 100085 China Unit.of t.xicology Bharathiar University Coimbatore 641046 India

Environment.l chemicals in drinking wat.r can impact.human healt. t.rough nuclear recept.rs. Addit.onally, est.ogen-relat.d recept.rs （ERRs） are vulnerable t. endocrine-disrupt.ng effect.. t. dat., however, ERR disrupt.on of drinking wat.r pot.ncy has not.been report.d. We used ERRy t.o-hybrid yeast.assay t. screen ERRy disrupt.ng act.vit.es in a drinking wat.r t.eat.ent.plant.（DWt.） locat.d in nort. China and in source wat.r from a reservoir, focusing on agonist.c, ant.gonist.c, and inverse agonist.e act.vit. t. 4-hydroxyt.moxifen （4-OHt.. Wat.r t.eat.ent.processes in t.e DWt. consist.d of pre-chlorinat.on, coagulat.on, coal and sand filt.at.on, act.vat.d carbon filt.at.on, and secondary chlorinat.on processes. Samples were ext.act.d by solid phase ext.act.on. Result. showed t.at.ERRγ ant.gonist.c act.vit.es were found in all sample ext.act., but.agonist.c and inverse agonist.c act.vit. t. 4-OHt.was not.found. When calibrat.d wit. t.e t.xic equivalent.of 4-OHt. ant.gonist.c effluent.effect. ranged from 3.4 t. 33.1 μg/L. In t.e t.eat.ent.processes, secondary chlorinat.on was effect.ve in removing ERRy ant.gonist., but.t.e coagulat.on process led t. significant.y increased ERRy ant.gonist.c act.vit.. t.e drinking wat.r t.eat.ent.processes removed 73.5 % of ERRy ant.gonist.. t. our knowledge, t.e occurrence of ERRy disrupt.on act.vit.es on source and drinking wat.r in vit.o had not.been report.d previously. It.is vit.l, t.erefore, t. increase our underst.nding of ERRγ disrupt.ng act.vit.es in drinking wat.r.

关键词： drinking wat.r est.ogen recept.r est.ogen-relat.d recept.r t.o-hybrid yeast solid phase ext.act.on