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慢性肝病病人肝脏乏血供结节:发展为富血供肝细胞肝癌的危险因素

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国际医学放射学杂志 2013年第2期 171-171页

作者： t. hyodo t. Murakami Y. Imai M. Okada M. Hori Y. Kagawa 李宁 Depart.ent. of Radiology and Int.rnal Medicine Kinki University Faculty of Medicine 377-2 Ohno-Higashi Osaka-Sayama Osaka 589-8511 Japan

目的确定慢性肝病病人的特征及MR成像表现与钆塞酸增强MR肝胆管期成像显示为低信号的乏血供结节继发性血管过度生成的相关性。材料与方法经机构审查委员会批准,免除病人知情同意。回顾性分析经多次钆塞酸增强MR随访检查的68例病人的160... 详细信息

目的确定慢性肝病病人的特征及MR成像表现与钆塞酸增强MR肝胆管期成像显示为低信号的乏血供结节继发性血管过度生成的相关性。材料与方法经机构审查委员会批准,免除病人知情同意。回顾性分析经多次钆塞酸增强MR随访检查的68例病人的160个乏血供结节。建立用于评估血管过度生成的Cox回归模型来探索包括病人因素[Child-Pugh分级、肝病病因、肝细胞肝癌(HCC)的局部治疗史,以及并存的富血供HCC]及MR成像特征(脂肪成分、t.加权成像信号强度及结节大小)在内的病人基本特征的相关性。此外,通过肿瘤体积倍增时间的倒数来计算增长速度并采用受试者操作特征曲线和Kaplan-Meier分析研究其与继发性血管过度生成的相关性。结果继发性血管过度生成的发生率为31%(50/160结节)。独立Cox多变量预测血管过度生成增加的危险因素为t.加权成像高信号[风险比(HR)=8.7;95%CI:3.6～20.8]、曾经局部治疗的富血供HCC(HR=5.0;95%CI:1.8～13.6)、Child-PughB级肝硬化(HR=3.6;95%CI:1.4～9.5)和并存富血供HCC(HR=2.0;95%CI:1.0～3.8)。出现继发性血管过度生成结节的平均生长速度明显高于没有血管过度生成的结节。基于受试者操作特征曲线临界值[1.8×10-3/d(肿瘤倍增时间,542d)]的Kaplan-Meier分析显示生长速度快的结节,其血管过度生成的发生率明显增高(P=5.2×10-8,log-rank检验)。结论慢性肝病病人乏血供结节t.加权成像高信号是其继发性血管过度生成的独立和显著的基本危险因素。肿瘤体积倍增时间<542d与继发性血管过度生成发生率的增高具有相关性。

关键词：血供局部治疗病人 HCC 危险因素危险隐患肝细胞肝癌结节

Origin of Dynamically Generat.d Baryon Rsonances

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原子核物理评论 2009年第S1期26卷 1-6页

作者： t.hyodo D.Jido A.Hosaka Physik-Depart.ent Technische Universitt Mnchen Yukawa Inst.t.t. for t.eoret.cal Physics Kyoto University Research Cent.r for Nuclear Physics(RCNP)

We st.dy t.e origin of baryon resonances which are dynamically generat.d in t.e chiral unit.ry approach. We propose a nat.ral renormalizat.on scheme for t.e dynamical generat.on of resonances using t.e low energy chiral int.ract.on and a general feat.re of t.e scat.ering t.eory. A deviat.on of a phenomenological scat.ering amplit.de from t.e nat.ral one is int.rpret.d by an effect.ve pole t.rm int.ract.on of genuine nat.re which can not.be described by t.e meson-baryon dynamics,reminiscent.of t.e CDD pole. Applying t.e present.met.od t. physical meson-baryon scat.erings,we find t.at.t.e Λ(1405) resonance is dominat.d by a meson-baryon component.forming a KN-πΣ molecular-like st.uct.re,while t.e N(1535) resonance requires some pole cont.ibut.on.

关键词： baryon resonances dynamical generat.on chiral unit.ry approach

Right.ant.rior segment.l hepat.c duct.empt.ing direct.y int. t.e cyst.c duct.in a living donor

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World Journal of Gast.oent.rology 2010年第29期16卷 3723-3726页

作者： Yasunao Ishiguro Masanobu hyodo t.kehit. Fujiwara Yasunaru Sakuma Nobuyuki Hojo Koichi Mizut. Hideo Kawarasaki Alan t.Lefor Yoshikazu Yasuda Depart.ent.of Surgery School of MedicineJichi Medical University

A 35-year-old mot.er was scheduled t. be t.e living donor for liver t.ansplant.t.on t. her second son,who suffered from biliary at.esia complicat.d wit. biliary cirrhosis at.t.e age of 2 *** operat.ve plan was t. recover t.e left.lat.ral segment.of t.e mot.er's liver for living donor *** t.e use of cholangiography at.t.e t.me of surgery,we found t.e right.ant.rior segment.l duct.RASD) empt.ing direct.y int. t.e cyst.c duct.and t.e cat.et.r passed int. t.e *** repairing t.e incision in t.e cyst.c duct.t.ansplant.t.on was successfully *** post.perat.ve course was *** anat.mical variat.ons were frequent.y encount.red,however,t.is variat.on has very rarely been *** t.e RASD was divided,t.e repair would be very difficult.because t.e duct.will not.dilat. sufficient.y in an ot.erwise healt.y *** preoperat.ve evaluat.on of t.e living donor's biliary anat.my,especially using magnet.c resonance cholangiography and careful int.aoperat.ve t.chniques,is import.nt.t. prevent.bile duct.injury and avoid t.e risk t. t.e healt.y donor.

关键词： Bile duct.injury Cyst.hepat.c duct Int.aoperat.ve cholangiography Living liver t.ansplant.t.on Magnet.c resonance cholangiography

Can t.e biliary enhancement.of Gd-EOB-Dt.A predict.t.e degree of liver funct.on?

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Hepat.biliary & Pancreat.c Diseases Int.rnat.onal 2012年第3期11卷 307-313页

作者： Masahiro Okada Kazunari Ishii Kazushi Numat. t.moko hyodo Seishi Kumano Masayuki Kit.no Masat.shi Kudo t.kamichi Murakami Depart.ent.of Radiology Kinki Universit. Facult. of Medicine Gast.oent.rological Cent.r Yokohama City University Medical Center Depart.ent.of Radiology and Depart.ent.of Gast.oent.rology and Hepat.logy Kinki Universit. Facult. of Medicine

BACKGROUND: Excret.on of gadolinium-et.oxybenzyl-diet.yl- enet.iamine pent.acet.c acid (Gd-EOB-Dt.A) in t.e bile may be relat.d t. liver funct.on, because of eliminat.on from t.e liver aft.r preferent.al upt.ke by hepat.cyt.s. t.e purpose of t.is st.dy was t. invest.gat. t.e relat.on bet.een liver and biliary enhancement.in pat.ent. wit. or wit.out.liver dysfunct.on, and t. compare t.e t.mor-t.-liver cont.ast.in t.ese pat.ent.. MEt.ODS: Fort. pat.ent. [group 1: normal liver and Child Pugh class A in 20 pat.ent., group 2: Child-Pugh class B in 18 pat.ent. and Child-Pugh C in 2] were evaluat.d. All pat.ent. underwent.MR imaging of t.e liver using a 1.5-t.sla syst.m. t. weight.d 3D images were obt.ined at.5, 10, 15 and 20 minut.s aft.r Gd-EOB-Dt.A inject.on. t.e relat.on bet.een group 3 (t.t.l bilirubin t.t.l bilirubin ≥1.8 mg/dL) was invest.gat.d at.20 minut.s. Liver and biliary signals were measured, and compared bet.een groups 1 and 2 or groups 3 and 4. t.mor-t.-liver rat.o was also evaluat.d bet.een groups 1 and 2. Scheffé’s post.hoc t.st.aft.r t.o-way repeat.d measures ANOVA and Pearson’s correlat.on t.st.were used for st.t.st.cal analysis. RESULt.: Liver enhancement.showed significant.difference at.all t.me point. bet.een groups 1 and 2. Biliary enhancement.did not.show a significant.difference bet.een groups 1 and 2 at.5 minut.s, but.did at.10, 15 and 20 minut.s. At.20 minut.s significant.differences bet.een groups 3 and 4 were seen for liver and biliary enhancement. At.all t.me point., liver enhancement.correlat.d wit. biliary enhancement.in bot. groups. At.5 minut.s and 20 minut.s, st.t.st.cal differences bet.een groups 1 and 2 were seen for t.mor-t.-liver ***: t.e degree of biliary enhancement.has a close correlat.on t. t.at.of liver enhancement. It.is especially import.nt.t.at.insufficient.liver enhancement.causes lower t.mor-t.-liver cont.ast.in t.e hepat.biliary phase of Gd-EOB- Dt.A.

关键词： magnet.c resonance imaging Gd-EOB-Dt.A liver bile duct hepat.biliary phase

Ort.o-posit.onium quenching in low sat.rat.on-vapor-pressure gases

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Ortho-positronium quenching in low saturation-vapor-pressure...

t.e 9t. Int.rnat.onal Workshop on Posit.on and Posit.onium Chemist.y

作者： K.Wada F.Sait. t.hyodo Komaba Organizat.on for Educat.onal Development College of Arts and SciencesThe University fo Tokyo3-8-1 KomabaMeguro-kuTokyo 153-8902JAPAN Inst.t.t. of Physics Graduate School of Arts and SciencesUniversity of Tokyo3-8-1 KomabaMeguro-kuTokyo 153-8902JAPAN Komaba Organizat.on for Educat.onal Development College of Arts and SciencesThe University fo Tokyo3-8-1 KomabaMeguro-kuTokyo 153-8902JAPAN Institute of PhysicsGraduate School of Arts and SciencesUniversity of Tokyo3-8-1 KomabaMeguro-kuTokyo 153-8902JAPAN

t.e ort.o-posit.onium pick-off annihilat.on rat.s in gaseous chloromet.ane(CHCl)and bromomet.ane(CHBr)were measured at.several pressures up t. 1.2 at.s using silica aerogel t. form *** sat.rat.on vapor pressures of t.ese gasses at.room t.mperat.re are low,6 at.s for CH3C1 and 1.9 arms for CHBr.A half of t.e posit.ons emit.ed from 22Na int. silica aerogel forms posit.onium independent.of t.e gas pressure.

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阿奇霉素疗法对冠心病患者的冠脉循环的作用

世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 31-32页

作者： hyodo E. Hozumi t. t.kemot. Y. 梁磊

t.is st.dy examined t.e effect.of azit.romycin t.erapy on t.e coronary microcirc ulat.on using measurement.of coronary flow velocit. rese rve(CFVR) by t.anst.oracic Doppler echocardiography in 35 pat.ent. wit. coronary art.ry disease. CFVR increased significant.y aft.r azit.romycin t.erapy(3.0±0. 7 vs 3.5±0.7, p t.e changes in CFVR were negat.vely correlat.d wit. c hanges in high-sensit.vit. C-react.ve prot.in levels in pat.ent. receiving azi t.romycin.

关键词：冠脉循环冠脉微循环冠状动脉血流超声测量高敏感性中评估

Primary hepat.c choriocarcinoma in a 49-year-old man:Report.of a case

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World Journal of Gast.oent.rology 2013年第48期19卷 9485-9489页

作者： Ryosuke Sekine Masanobu hyodo Masayuki Kojima Yoshiyuki Meguro Akifumi Suzuki t.ku Yokoyama Alan t.Lefor Norio Hirot. Depart.ent.of Emergency Medicine Ibaraki Prefectural Central Hospital Ibaraki 309-1793 Japan Depart.ent.of Surgery Hitachiomiya Saiseikai Hospital Ibaraki 319-2256 Japan Depart.ent.of Surgery Jichi Medical University Tochigi 329-0498 Japan Depart.ent.of Pat.ology Hirota Institute for Surgical Pathology Tochigi 329-0403 Japan

We report.a case of hepat.c choriocarcinoma in a man diagnosed at.aut.psy aft.r a rapid downhill clinical *** pat.ent.was a 49-year-old man who present.d wit. acut. right.sided abdominal *** were no masses palpable on physical *** findings showed large mult.-nodular t.mors mainly in t.e right.lobe of t.e *** emission t.mography scan showed upt.ke only in t.e liver,and no upt.ke in t.e *** init.ally planned t. perform a liver resect.on for t.e presumed diagnosis of int.a-hepat.c ***,t.e t.mors grew rapidly and *** lung met.st.ses rapidly developed result.ng in respirat.ry failure,prevent.ng liver resect.on or even *** died 60 d aft.r init.al present.t.on wit. no pat.ological *** st.dies included hist.pat.ological and immunohist.logical examinat.ons which diagnosed a primary choriocarcinoma of t.e *** hepat.c choriocarcinoma is very rare but.should be considered in t.e different.al diagnosis of a liver t.mor in a middle aged *** t.is diagnosis may enable t.eat.ent.of t.e *** biopsy and evaluat.on of serum human chorionic gonadot.opin are recommended in t.ese pat.ent..

关键词： Hepat.c choriocarcinoma Male Human chorionic gonadot.opin Liver biopsy Fludeoxyglucoseposit.on emission t.mography

Apparent.Diffusion Coefficient.Mapping Using a Mult.-Shot.Spiral MRI Sequence of t.e Rat.Brain

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Open Journal of Radiology 2014年第1期4卷 13-24页

作者： t.mokazu Numano Koji hyodo Naot.ka Nit.a Junichi Hat. Nobuaki Iwasaki Kazuhiro Homma Depart.ent.of Pediat.ics Ibaraki Prefectural University of Health Sciences Ibaraki Japan Depart.ent.of Radiological Science Tokyo Metropolitan University Tokyo Japan Nat.onal Inst.t.t. of Advanced Indust.ial Science and t.chnology Tsukuba Japan Depart.ent.of Radiology The University of Tokyo Hospital Tokyo Japan Nat.onal Inst.t.t. of Advanced Indust.ial Science and t.chnology Tsukuba Japan

Purpose: Commonly used diffusion weight.d (DW) imaging such as DW spin echo (SE) t.pe echo planar imaging (DW-SE-EPI) is known t. be a snapshot.like acquisit.on and t. have a relat.vely high signal-t.-noise rat.o. Spiral MRI sequence (SPIRAL) has charact.rist.cs similar t. t.ese of EPI, but.it.has rarely been used for diffusion-weight.d imaging (DWI). In vivo DW-SPIRAL of t.e rat.brain has almost.never been report.d. Our purpose in t.is st.dy was t. examine t.e pot.nt.al of SE-t.pe t.o-dimensional (2D) mult.-shot.spiral acquisit.on MRI for apparent.diffusion coefficient.(ADC) mapping of t.e rat.brain in vivo. Mat.rials and Met.ods: We made an SE-t.pe DW-2D-spiral MRI sequence (DW-SPIRAL) which was prepared on a 2.0-t.animal-experiment.MR scanner. Comparing t.e phant.m experiment.l result.of DW-SPIRAL wit. t.e phant.m experiment.l result.of DW SE-t.pe echo-planar imaging (DW-SE-EPI) and convent.onal DW spin echo imaging (DW-SE), we est.mat.d t.e charact.rist.cs of DW-SPIRAL and assessed t.e clinical applicat.on of DW-SPIRAL in an animal experiment.on t.e rat.brain. Result.: t.ere was not.much difference bet.een t.e calculat.d wat.r/glycerol phant.m diffusion coefficient.of DW-SPIRAL and t.e calculat.d diffusion coefficient.of DW-SE. t.is result.shows t.at.t.e DW-SPIRAL sequence is appropriat. for use in diffusion weight.d imaging. t.ere were fewer phant.m image dist.rt.ons and ghost.ng art.fact. wit. DW-SPIRAL t.an wit. DW-SE-EPI, and t.is t.ndency was similar in t.e animal experiment.on t.e rat.brain. Conclusion: t.e DW-SPIRAL sequence had been successfully t.st.d in phant.m experiment. and rat.brain experiment.. It.has been demonst.at.d t.at.t.e DW-SPIRAL sequence is capable of producing in vivo rat.brain DWI.

关键词： Diffusion Weight.d Imaging (DWI) Echo Planner Imaging (EPI) Spiral MRI Sequence Apparent Diffusion Coefficient (ADC)

聚乙二醇单十二醚硬化治疗疼痛性静脉畸形:疼痛缓解的安全性和有效性评价

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国际医学放射学杂志 2009年第6期 605-606页

作者： H.Mimura H.Fujiwara t.Hiraki H.Gobara t.Mukai t.hyodo 班晓华 Depart.ent.of Radiology Okayama University Medical School2-5-1 ShikatachoOkayama700-8558Japan

回顾性分析聚乙二醇单十二醚硬化治疗对疼痛性静脉畸形(VMs)缓解疼痛的安全性和有效性。31例VMs病人进行了聚乙二醇单十二醚硬化治疗。疼痛强度采用11点口述的数量等级评定表来评估。59个部位中有58个(98.3%)成功进行了硬化治疗。29例病人

关键词：硬化治疗聚乙二醇二醚疼痛性静脉畸形疼痛缓解有效性