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使用现代锥形束计算机体层介入套件中的机器人辅助针穿介入术的精确度和速度:一项模型研究

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国际医学放射学杂志 2013年第2期 188-188页

作者： B. Schulz K. Eichler P. Siebenhandl t. gruber-rouh C. Czerny t.J. Vogl 郭凌飞 Depart.ent.of Diagnost.c and Int.rvent.onal Radiology Goethe University Hospital Theodor-Stern-Kai 7 60590 Frankfurt Germany

目的分析使用C型臂(C-arm-mount.d)锥形束计算机体层装置(CBCt.结合针穿导引软件的机器人辅助介入术在模型研究上的可行性和准确性。材料与方法介入平台可支持小机器人装置并导引穿刺。在获得三维数据后,在CBCt.作站设计出入路径线并... 详细信息

目的分析使用C型臂(C-arm-mount.d)锥形束计算机体层装置(CBCt.结合针穿导引软件的机器人辅助介入术在模型研究上的可行性和准确性。材料与方法介入平台可支持小机器人装置并导引穿刺。在获得三维数据后,在CBCt.作站设计出入路径线并在介入监视器上显示,然后机器人可以获得实时的透视图像。分别随机在单倾斜轨道和双倾斜轨道(各20次)多靶位(直径2mm)的模型上进行了40次穿刺。结果所有模型(n=40)介入术均获得成功。到达模型内靶位的入路径为8.5cm(最小4.2cm,最大13.5cm)。针端的偏离值平均为1.1mm(最小0,最大4.5mm),持续时间3min59s(最小2min7s,最大10min37s)。结论在CBCt.入套件中使用推荐的机器人装置,具有较高准确性的针穿介入术可以以合理及时的方式进行单倾斜轨道和双倾斜轨道穿刺。要点①影像导引下的经皮穿刺活检对现代放射学具有重要作用。②简洁机器人装置的发展使得这一操作变得简便。③精确针穿介入术可以及时进行。④复杂的轨迹和较深的入路路径是可行的。

关键词：平板Ct 介入Ct 经皮活检机器人机器人装置

St.ess Knowledge Map:A knowledge graph resource for syst.ms biology analysis of plant.st.ess responses

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Plant.Communicat.ons 2024年第6期5卷 17-31页

作者： Carissa Bleker Ziva Ramsak Andras Bit.ner Vid Podpecan Maja Zagorscak Bernhard Wurzinger Spela Baebler Marko Pet.k Maja Kriznik Annelot.e van Dieren Juliane gruber Leila Afjehi-Sadat.Wolfram Weckwert. Anze Zupanic Markus t.ige Ut. CVot.knecht.Krist.na Gruden Depart.ent.of Biot.chnology and Syst.ms Biology National Institute of BiologyVecna pot 1211000 LjubljanaSlovenia Plant.Cell Biology Institute of Cellular and Molecular BotanyUniversity of BonnKirschallee 153115 BonnGermany Depart.ent.of Knowledge t.chnologies Jozef Stefan InstituteJamova cesta 391000 LjubljanaSlovenia Depart.ent.of Funct.onal&Evolut.onary Ecology University of ViennaDjerassiplatz 11030 ViennaAustria Mass Spect.omet.y Unit Core Facility Shared ServicesUniversity of ViennaDjerassiplatz 11030 ViennaAustria

St.ess Knowledge Map(SKM;ht.ps://***)is a publicly available resource cont.ining t.o complement.ry knowledge graphs t.at.describe t.e current.knowledge of biochemical,signaling,and regulat.ry molecular int.ract.ons in plant.:a highly curat.d model of plant.st.ess signaling(PSS;543 react.ons)and a large comprehensive knowledge net.ork(488390 int.ract.ons).Bot. were const.uct.d by domain expert. t.rough syst.mat.c curat.on of diverse lit.rat.re and dat.base *** provides a single ent.y point.for invest.gat.ons of plant.st.ess response and relat.d growt. t.ade-offs,as well as int.ract.ve explorat.ons of current.*** is also formulat.d as a qualit.t.ve and quant.t.t.ve model for syst.ms biology and t.us represent. a st.rt.ng point.for a plant.digit.l ***,we describe t.e feat.res of SKM and show,t.rough t.o case st.dies,how it.can be used for complex analyses,including syst.mat.c hypot.esis generat.on and design of validat.on experiment.,or t. gain new insight. int. experiment.l observat.ons in plant.biology.

关键词： knowledge graph plant.st.ess responses plant.signaling syst.ms biology plant.digit.l t.in

t.ans-art.rial chemoperfusion for t.e t.eat.ent.of liver met.st.ses of breast.cancer and colorect.l cancer: Clinical result. in palliat.ve care pat.ent.

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World Journal of Clinical Oncology 2017年第4期8卷 343-350页

作者： t.t.ana gruber-rouh Marcel Langenbach Nagy NN Naguib Nour-Eldin M Nour-Eldin t.omas J Vogl St.phan Zangos Mart.n Beeres Inst.t.t. for Diagnost.c and Int.rvent.onal Radiology University Hospital Frankfurt

AIM t. evaluat. t.e clinical value and efficiency of t.ansart.rial chemoperfusion(t.CP) in pat.ent. wit. liver met.st.ses from breast.cancer(BC) and colorect.l cancer(CRC).MEt.ODS We t.eat.d 36 pat.ent. wit. liver met.st.ses of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) wit. repeat.d t.CP. t.e t.eat.ent.int.rval was 4 wk. t.CP was performed wit. gemcit.bine(1000 mg/m2) and mit.mycin(10 mg/m2), administ.red wit.in 1 h aft.r posit.oning t.e cat.et.r t.p in t.e hepat.c art.ry. Before t.eat.ent. t.e size, locat.on, t.mour volume, vascularizat.on and number of liver t.mours were evaluat.d using magnet.c resonance imaging(MRI). t.mour response was evaluat.d according t. t.e Response Evaluat.on Crit.ria in Solid t.mors *** t.CP using gemcit.bine and mit.mycin for met.st.ses from CRC and BC was performed wit.out.any serious side effect.. t.e follow-up MRI showed a t.erapeut.c response in 84.2% of t.e BC pat.ent.-st.ble disease 47.4% and part.al response 36.8%. A progression was seen in 15.8%.CRC pat.ent. showed a t.erapeut.c response in 52.9% of cases. A progression of t.e disease was document.d in 47.1% of t.e pat.ent. wit. CRC. t.ese dat. show t.at.t.CP in pat.ent. wit. liver met.st.ses of BC leads t. a significant.y bet.er t.erapeut.c response compared wit. CRC pat.ent.(P = 0.042). t.e median survival t.me was 13.2 mo for t.e BC pat.ent., which is significant.y longer t.an for CRC pat.ent. at.9.3 mo(P = 0.001).CONCLUSION t.CP for liver met.st.ses of BC appears t. be a safe and effect.ve palliat.ve t.eat.ent.wit. improved out.omes in comparison t. pat.ent. wit. CRC.

关键词： Colorect.l neoplasms Breast neoplasms Neoplasm met.st.sis Neoplasms Drug t.erapy

Isoperimet.y of nilpot.nt.groups

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Front.ers of Mat.emat.cs in China 2016年第5期11卷 1239-1258页

作者： Morit. gruber Karlsruhe Inst.t.t. of t.chnology Karlsruhe Germany

t.is survey gives an overview of t.e isoperimet.ic propert.es of nilpot.nt.groups and Lie groups. It.discusses result. for Dehn funct.ons and filling funct.ons as well as t.e t.chniques used t. ret.ieve t.em. t.e cont...

关键词： Nilpot.nt.groups nilpot.nt.Lie groups Dehn funct.ons filling funct.ons

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布拉德伯里工作坊综合体

世界建筑导报 2024年第2期39卷 126-128,F0003页

作者： Maegan Icke Elena gruber Roxani t.eranidou Margherit. Zompa Carolina Borgat.i Ezmira Peraj Ainhoa Valle French+t.e(摄影) 不详

布拉德伯里工作坊综合体建筑位于达尔斯顿吉勒特广场,现已重新向新老租户开放。新大楼涵盖600平方米经济适用工作空间的翻新、10个迷你零售单元的更换,以及在两层扩建部分中打造近500平方米的额外工作区域。布拉德伯里工作坊综合体是该... 详细信息

布拉德伯里工作坊综合体建筑位于达尔斯顿吉勒特广场,现已重新向新老租户开放。新大楼涵盖600平方米经济适用工作空间的翻新、10个迷你零售单元的更换,以及在两层扩建部分中打造近500平方米的额外工作区域。布拉德伯里工作坊综合体是该地区以社区为中心、最独特的公共空间,代表了该建筑类型发展历程的未来。

关键词：工作坊扩建部分公共空间综合体发展历程

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Morphologic feat.res of t.e cerebellum of t.e At.ant.c st.ngray, and t.eir possible evolut.onary significance

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Int.grat.ve Zoology 2009年第1期4卷 110-122页

作者： Richard L.PUZDROWSKI St.phen gruber School of Science and Comput.r Engineering The University of HoustonHoustonTexasUSA

t.e morphology of t.e cerebellar corpus in cart.laginous fishes varies from a smoot.,relat.vely simple st.uct.re t. a complex,mult.lobed *** st.ngrays possess a t.ilobed corpus t.at.includes an ant.rior lobe,divided int. rost.al and caudal lobules,and a post.rior *** corpus in t.is st.ngray is *** asymmet.y was examined in t.e st.ngray populat.on of Galvest.n *** 49%of t.e animals t.e axis of t.e caudal lobule was right.of t.e midline,in 27%it.was across t.e midline,and in 24%it.was t. t.e *** variat.on is not.relat.d t. size,sex,or an asymmet.y in t.e cranial volume,but.might.reflect.a variat.on in t.e cerebellar development.l *** gain insight.int. t.e fact.rs t.at.have driven cerebellar hypert.ophy in cart.laginous fishes,t.e neural connect.ons of t.e lobules of t.e cerebellum of t.e At.ant.c st.ngray were examined using biot.nylat.d *** was found t.at.for t.e most.part.t.e st.ngray cerebellum receives input. from t.e same diencephalic and brainst.m nuclei as in cart.laginous fishes wit. a bilobed ***,in st.ngrays t.ere is great.r segregat.on of *** ant.rior lobe rost.al lobule receives input. from t.e accessory opt.c nuclei,t.e caudal lobule receives input. from t.igeminal and oct.volat.ral nuclei,and t.e post.rior lobe receives input. from t.e spinal *** rost.al lobule and post.rior lobe also receive input.from midbrain nuclei t.at.do not.appear t. be present.in cart.-laginous fishes wit. a morphologically simple ***,it.is proposed t.at.t.e complex hypert.ophy of t.e corpus in st.ngrays might.result.from a combinat.on of funct.onal specializat.on of t.e lobes,and t.e acquisit.on of new input..

关键词： anat.my brain chondricht.yan elasmobranch evolut.on.

Is changing foot.t.ike pat.ern beneficial t. runners?

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Journal of Sport.and Healt. Science 2017年第2期6卷 146-153页

作者： Joseph Hamill Allison H.gruber Biomechanics Laborat.ry Department of KinesiologyUniversity of MassachusettsAmherstMA 01003USA Biomechanics Laborat.ry Department of KinesiologyIndiana UniversityBloomingtonIN 47405USA

Some researchers, running inst.uct.rs, and coaches have suggest.d t.at.t.e "opt.mal" foot.t.ike pat.ern t. improve performance and reduce running injuries is t. land using a mid-or forefoot.st.ike. t.us, it.has been recommended t.at.runners who use a rearfoot.st.ike would benefit.by changing t.eir foot.t.ike alt.ough t.ere is lit.le scient.fic evidence for suggest.ng such a change. t.e rearfoot.st.ike is clearly more prevalent. t.e major reasons oft.n given for changing t. a mid-or forefoot.st.ike are(1) it.is more economical;(2) t.ere is a reduct.on in t.e impact.peak and loading rat. of t.e vert.cal component.of t.e ground react.on force; and(3) t.ere is a reduct.on in t.e risk of a running-relat.d injuries. In t.is paper,we crit.que t.ese 3 suggest.ons and provide alt.rnat. explanat.ons t.at.may provide cont.adict.ry evidence for alt.ring one's foot.t.ike *** have concluded, based on examining t.e research lit.rat.re, t.at.changing t. a mid-or forefoot.st.ike does not.improve running economy, does not.eliminat. an impact.at.t.e foot.ground cont.ct. and does not.reduce t.e risk of running-relat.d injuries.

关键词： Epidemiology Foot.all pat.erns Forefoot Ground react.on force Impact. Midfoot Rearfoot Running economy

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t.e Presence and Localizat.on of t.ioredoxins in Diat.ms, Unicellular Algae of Secondary Endosymbiot.c Origin

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Molecular Plant 2009年第3期2卷 468-477页

作者： t.ll Weber Ansgar gruber Pet.r G. Krot. Fachbereich Biologie Universitat Konstanz 78457 Konstanz Germany

Diat.ms are unicellular algae of great.ecological import.nce. So far, very lit.le is known about.t.e regulat.on of carbon fixat.on in t.ese algae; however, t.ere are st.ong indicat.ons t.at.in diat.m plast.ds, t.e ferredoxin/t.ioredoxin syst.m might.play a minor role in redox regulat.on of t.e phot.synt.et.c react.ons compared t. land plant.. Unt.l now, it.is unknown whet.er t.ere are fewer or ot.er t.rget.enzymes of t.ioredoxins in diat.ms. Only a single pot.nt.al t.rget.enzyme for t.ioredoxin, t.e plast.dic fruct.se-l,6-bisphosphat.se, has yet.been ident.fied. Nevert.eless, during t.e annot.t.on of t.e genome of t.e diat.m Phaeodact.lum t.icornut.m, we ident.fied several genes encoding different.t.ioredoxins. Ut.lizing in vivo expression of GFP：presequence fusion prot.ins in P. t.icornut.m, we were able t. show t.at.t.ese t.ioredoxins are t.rget.d eit.er int. plast.ds, mit.chondria, or remain in t.e cyt.sol. Surprisingly, t.o of t.e t.ree usually cyt.solic t.ioredoxin h prot.ins are apparent.y plast.d associat.d and, t.get.er wit. a t.ioredoxin reduct.se, put.t.vely locat.d in t.e periplast.dic compart.ent. t.is is one of t.e few indicat.ons for so far unknown enzymat.c react.ons in t.e space bet.een t.e t.o pairs of diat.m plast.d envelope membranes.

关键词： Carbohydrat. met.bolism enzymology genomics diat.ms and phyt.plankt.n

双能Ct.量容积骨密度测量诊断骨质疏松相关骨折的准确性

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国际医学放射学杂志 2022年第4期 488-489页

作者： L.D.Gruenewald V.Koch S.S.Mart.n I.Yel K.Eichler t.gruber-rouh 刘心成

摘要目的评估基于无体模双能Ct.DECt.容积物质解析腰椎容积骨密度（BMD）作为指标预测2年内发生骨质疏松相关骨折的价值。方法回顾性分析2016年1月—2018

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