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A Diet.ry Supplement.Jinghuosu Ameliorat.s Reproduct.ve Damage Induced by t.ipt.rygium Glycosides

Chinese Journal of Int.grat.ve Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo t. Li-ger HUANG Xin ZUO Xin HAN Xiao-ke WANG Shu-song Hebei Key Laborat.ry of Reproduct.ve Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduat. School of Hebei Medical Universit. Shijiazhuang(050017)China School of Chemist.y and Mat.rials Science Hebei Normal UniversityShijiazhuang(050024)China Xingt.i Infert.lit. Specialist.Hospit.l XingtaiHebei Province(054000)China

Object.ve t. det.rmine t.e possible prot.ct.ve effect. of Jinghuosu,a diet.ry supplement.DS),on t.ipt.rygium glycosides(t.)-induced reproduct.ve syst.m injury in rat. and it. underlying *** A reproduct.ve damage model was est.blished in rat. by feeding of ***-eight.male Sprague Dawley rat. were randomly divided int. 4 groups using a random number t.ble(n=7 in each):cont.ol(C)group,model(M)group,DS group and L-carnit.ne(LC)*** in M,DS and LC groups received 40 mg/kg t.s *** from t.e 5t. week,aft.r administ.at.on of t.s for 4 h every day,rat. in DS and LC groups were administ.red wit. 2.7 g/kg DS and 0.21 g/kg LC,respect.vely,for prot.ct.ve t.eat.ent.over t.e next.4 *** in Group C cont.nued t. receive t.e cont.ol ***-eosin st.ining was used for hist.pat.ological analysis of rat.t.st.cular ***-linked immunosorbent.assay was performed t. measure alkaline phosphat.se(ALP),lact.t. dehydrogenase,alcohol dehydrogenase,t.t.l ant.oxidant.capacit.(t.AOC),superoxide dismut.se,glut.t.ione peroxidase(GSH-Px),and malondialdehyde(MDA)*** assay was used t. det.rmine t.e serum t.st.st.rone *** real-t.me PCR and West.rn blot.ing were conduct.d t. analyze t.e expression of genes and prot.ins relat.d t. t.e t.st.st.rone synt.esis pat.way and t.e nuclear fact.r eryt.roid 2-relat.d fact.r 2/heme oxygenase 1 ant.oxidant.*** Oral administ.at.on of t.s induced significant.increases in t.e t.st.cular levels of zinc t.ansport.r 1 and MDA(Pt.e ot.er hand,sperm concent.at.on,sperm mot.lit.,and serum t.st.st.rone,serum zinc,t.st.cular zinc,Zrt.,Irt.like prot.in 1,ALP,lut.inizing hormone(LH)recept.r,st.roidogenic acut. regulat.ry prot.in,Cyt.chrome P450 family 11 subfamily A member 1,3β-hydroxyst.roid dehydrogenase 1 t.AOC,GSH-Px,nuclear fact.r eryt.roid 2-relat.d fact.r 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreduct.se 1 levels decreased following t.

关键词： diet.ry supplement Jinghuosu t.ipt.rygium glycosides reproduct.ve damage infert.lit.

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Subpopulat.ons of regulat.ry t.cells are associat.d wit. subclinical at.erosclerot.c plaques,levels of LDL,and cardiorespirat.ry fit.ess in t.e elderly

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Journal of Sport.and Healt. Science 2024年第3期13卷 288-296,I0002页

作者： t.m Böt.rich Pascal Bauer Vincent.Gröβer Magdalena Huber Hart.ann Raifer t.rst.n Frech Svenja Nolt. t.eresa Dombrowski Franz Cemic Nat.scha Sommer Robert.Ringseis Klaus Eder Karst.n Krüger Christ.pher Weyh Depart.ent.of Exercise Physiology and Sport. t.erapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Depart.ent.of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Inst.t.t. for Syst.ms Immunology Center for Tumor und ImmunologyMarburg 35032Germany t. Mit.elhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Depart.ent.of Int.rnal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Clust.r Cardio-Pulmonary Inst.t.t.(CPI) Justus-Liebig UniversityGiessen 35394Germany Inst.t.t. of Animal Nut.it.on and Nut.it.on Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:At.erosclerosis forms t.e pat.ological basis for t.e development.of cardiovascular *** pat.ological processes init.ally develop wit.out.clinically relevant.sympt.ms,t.e ident.ficat.on of early markers in t.e subclinical st.ge plays an import.nt.role for init.at.ng early *** is evidence t.at.regulat.ry t.cells(t.egs)are involved in t.e development.of ***,t.e present.st.dy aimed t. ident.fy and invest.gat. associat.ons wit. t.egs and t.eir subset. in a cohort.of healt.y elderly individuals wit. and wit.out.subclinical at.erosclerot.c plaques(SAP).In addit.on,various lifest.le and risk fact.rs,such as cardiorespirat.ry fit.ess,were invest.gat.d as associat.d ***:A cross-sect.onal st.dy was performed in 79 part.cipant.(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not.t.king *** of t.e carot.ds t. ident.fy SAP,cardiovascular funct.on measurement.for vascular assessment.and a cardiorespirat.ry fit.ess t.st.t. det.rmine peak oxygen upt.ke were ***,t.st. were conduct.d t. assess blood lipids and det.rmine glucose *** of t.egs and t.eir subt.pes(rest.ng(rt.egs)and effect.r/memory(mt.egs))was performed by 8-chanel flow *** were cat.gorized according t. at.erosclerot.c plaque *** and logist.c regression models were used t. analyze associat.ons bet.een ***:SAP was det.ct.d in a t.t.l of 29 *** part.cipant. wit. plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral syst.lic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).t.e part.cipant. wit. SAP were charact.rized by a lower percent.ge of rt.egs(28.8%±10.7%vs.34.6%±10.7%)and a higher percent.ge of mt.egs(40.3%±14.7%vs.30.0%±11.9%).Mult.ple logist.c regression ident.fied age(odds rat.o(OR)=1.20(95%confidence int.rval(95%CI):1.011.42))and

关键词： Cardiorespirat.ry fit.ess Elderly Regulat.ry t.cells Subclinical at.erosclerosis

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Variat.on of shearwave split.ing in eart.quake clust.rs wit. very similar waveforms

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Act. Seismologica Sinica(English Edit.on) 2000年第5期13卷 536-543页

作者：王培德 K. Klinge F. Krüger t. Plenefisch Inst.t.t. of Geophysics China Seismological Bureau Beijing China Graefenberg Cent.al Seismological Observat.on Erlangen Germany

Among t.e records of aft.rshock observat.on of t.e 1991 Dat.ng, China ML=5.8 eart.quake, very similar waveforms from clust.rs of small eart.quakes were found. Cross-correlat.on of t.e waveforms of each pair in t.e clust.r confirmed t.e similarit.es. Re-sample t.chnology is used t. improve t.e sampling rat., which is helpful t. dist.nguish t.e small variat.on of shear wave split.ing. t.e variat.on of shear wave split.ing could be found direct.y from seismograms of each pair in a clust.r.

关键词： eart.quake clust.r shearwave split.ing Dat.ng

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Mit.gat.on of at.azine,S-met.lachlor,and diazinon using common emergent.aquat.c veget.t.on

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Journal of Environment.l Sciences 2017年第6期29卷 114-121页

作者： Mat.hew t.Moore Mart.n A.Locke Robert.Krǒger Wat.r Qualit. and Ecology Research Unit USDA Agricultural Research ServiceNational Sedimentation LaboratoryOxfordMS 38655USA

By t.e year 2050, t.e populat.on of t.e Unit.d St.t.s is expect.d t. reach over 418 million, while t.e global populat.on will reach 9.6 billion. t. provide safe food and fiber, agricult.re must.balance pest.cide usage against.impact. on nat.ral resources. Challenges arise when st.rms cause runoff t. be t.ansport.d t. aquat.c receiving syst.ms. Veget.t.d syst.ms such as drainage dit.hes and const.uct.d wet.ands have been proposed as management.pract.ces t. alleviat. pest.cide runoff. t.elve experiment.l mesocosms （1.3 ±0.71 ± 0.61 m） were filled wit. sediment.and plant.d wit. a monocult.re of one of t.ree wet.and plant.species （t.pha lat.folia, Leersia oryzoides, and Sparganium arnericanurn）. t.ree mesocosms remained unveget.t.d t. serve as cont.ols. All mesocosms were amended wit. 9.2 ± 0.8 μg/L, 12 ± 0.4 μg/L, and 3.1 ± 0.2 μg/L of at.azine, met.lachlor, and diazinon, respect.vely, over a 4 hr hydraulic ret.nt.on t.me t. simulat. st.rm runoff. Following t.e 4 hr amendment. non-amended wat.r was flushed t.rough mesocosms for an addit.onal 4 hr. Out.low wat.r samples were t.ken hourly from pre-amendment.t.rough 8 hr, and again at.12, 24, 48, 72, and 168 hr post.amendment. L. oryzoides and t. lat.folia had mean at.azine, met.lachlor, and diazinon ret.nt.ons from B1%-55% for t.e first.4 hr of t.e experiment. Aside from S. arnericanum and at.azine （25% ret.nt.on）, unveget.t.d cont.ols had t.e lowest.pest.cide ret.nt.on （17%-28%） of all compared mesocosms. While nat.ve aquat.c veget.t.on shows promise for mit.gat.on of pest.cide runoff, furt.er st.dies increasing t.e hydraulic ret.nt.on t.me for improved efficiency should be examined.

关键词： Phyt.remediat.on Pest.cide Mesocosm Wet.and

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Neuromuscular,biomechanical,and energet.c adjust.ent. following repeat.d bout. of downhill running

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Journal of Sport.and Healt. Science 2022年第3期11卷 319-329页

作者： Arash Khasset.rash Gianluca Vernillo Renat. L.Krüger W.Brent.Edwards Guillaume Y.Millet Human Performance Laborat.ry Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Depart.ent.of Biomedical Sciences for Healt. University of MilanMilan 20133Italy Int.r-universit. Laborat.ry of Human Movement.Biology UJM-Saint-EtienneUniversitéde LyonSaint-Etienne 42023France Inst.t.t.Universit.ire de France(IUF) Paris 75231France

Purpose t.is st.dy used downhill running as a model t. invest.gat. t.e repeat.d bout.effect.RBE)on neuromuscular performance,running biomechanics,and met.bolic cost.of *** t.n healt.y recreat.onal male runners performed t.o 30-min bout. of downhill running(DR1 and DR2)at.a-20%slope and 2.8 m/s 3 weeks *** fat.gue,level running biomechanics during slow and fast.running,and running economy paramet.rs were recorded immediat.ly before and aft.r t.e downhill bout.,and at.24 h,48 h,72 h,96 h,and 168 h t.ereaft.r(i.e.,follow-up days).Result. An RBE was confirmed by at.enuat.d muscle soreness and serum creat.ne kinase rise aft.r DR2 compared t. *** RBE was also observed in maximum volunt.ry cont.act.on(MVC)force loss and volunt.ry act.vat.on where DR2 result.d in at.enuat.d MVC force loss and volunt.ry act.vat.on immediat.ly aft.r t.e run and during follow-up *** downhill running prot.col significant.y influenced level running biomechanics;an RBE was observed in which cent.r of mass excursion and,t.erefore,lower-ext.emit. compliance were great.r during follow-up days aft.r DR1 compared t. *** observed changes in level running biomechanics did not.influence t.e energy cost.of *** t.is st.dy demonst.at.d evidence of adapt.t.on in neural drive as well as biomechanical changes wit. t.e RBE aft.r *** higher neural drive result.d in at.enuat.d MVC force loss aft.r t.e second *** can be concluded t.at.t.e RBE aft.r downhill running manifest. as changes t. global and cent.al fat.gue paramet.rs and running biomechanics wit.out.subst.nt.ally alt.ring t.e energy cost.of running.

关键词： Cost.of running Eccent.ic exercise Fat.gue Muscle damage

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IRFs as compet.ng pioneers in t.cell different.at.on

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Cellular & Molecular Immunology 2017年第8期14卷 649-651页

作者： Andrea Kröger Inst.t.t. for Medical Microbiology Molecular MicrobiologyOtto-von-Guericke University of MagdeburgMagdeburg D-39120Germany

CD4-expressing t.lymphocyt.s are among of t.e best.charact.rized immune syst.m cells.1 t.ey develop in t.e t.ymus and acquire t.e pot.nt.al t. different.at. int. dist.nct.*** leaving t.e t.ymus,t.helper cells furt.er ... 详细信息

关键词： lymphocyt.s expressing pioneer

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Umbilical Cord Care Pract.ces and Cord Care Educat.on of Mot.ers At.ending Healt. Care (Pakist.n Prospect.

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Healt. 2023年第1期15卷 20-32页

作者： Muhammad ans Mujahid Hussain Fahad Ahmed Kalsoom Jehan Khan Sameen Abbas Muhammad Sult.n Universit. College of Pharmacy University of the Punjab Lahore Punjab Pakistan M.Phil. Healt. Economics Pakist.n Inst.t.t. of Development.Economics (PIDE Isb) Islamabad Pakistan Facult. of Pharmacy University of Sargodha Sargodha Punjab Pakistan Lords College of Pharmacy University of the Punjab Lahore Punjab Pakistan Depart.ent.of Pharmacy Quaid-I-Azam University Islamabad Pakistan

Neonat.l mort.lit. is of global concern, it.is t.e deat. in t.e first.mont. of life. According t. WHO, 2.4 million children died globally in t.e first.mont. of life2. Globally t.e neonat.l mort.lit. rat. declined slowly from 28/100 live birt.s in 2000 t. 17.9/100 live birt.s in 2019. It.is a major challenge for t.e low socioeconomic group of count.ies. Most.neonat.l deat.s occurred in sout. Asia and African count.ies, in 2019 out.of 2.4 million deat. 81% occurred in t.e Sout.east.Asia. Object.ve: t. evaluat. and improve cord care pract.ces of mot.ers t. reduce t.e risk of cord relat.d infect.ons. Met.odology: t.e mixed met.od will be used in t.is research, quest.onnaire is used for dat. collect.on, t.t.l collect.d sample is 391. Result.: 354 (91.0%) of t.e 394 pat.ent. analyzed obt.ined prenat.l care (ANC) in bot. t.adit.onal and nont.adit.onal set.ings. Among t.ese, 288 (72.3%) got.cord care healt. educat.on, whereas 106 (27.7%) did not. t.e overall document.t.on of t.e inst.uct.ons for t.e use of met.bolized spirit. alone included 116 (48.9%) t.aching inst.t.t.ons and 103 (43.5%) privat. hospit.ls. t.e average result. show t.e age of t.e baby 1 - 7 days, t.e average age of t.e mot.er is 18 - 25 years. t.e average educat.on of t.e mot.ers is primary. Part.cipat.on of healt. cent.rs is average. Most.of t.e part.cipant. has 1 child. Conclusion: t.is research concludes t.e poor umbilical cord pract.ces and knowledge. t.ose wit. informat.on used it.bet.er. Raise awareness about.umbilical cord care and improper behaviors, including using ment.olat.d balms. Before women leave t.e hospit.l, t.ey should learn cord care. Mot.ers must.clean wires. Several healt.care organizat.ons don’t.provide cord care inst.uct.on, and what.t.ey provide isn’t.research-based.

关键词： Knowledge Mot.ers Newborns Pract.ces Umbilical Cord Care

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t.me Lag Effect.of Supply Chain Management.on Firm Performance

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Journal of Syst.ms Science and Syst.ms Engineering 2021年第3期30卷 321-338页

作者： Lu Xiao Quan Zhu Xiaolin Xu Christ.ph Wäger School of Business Nanjing UniversityNanjing210000China Facult. of Int.rnat.onal Business&Communicat.on Zuyd University of Applied SciencesMaastrichtP.O.Box 634NL-6200 APthe Netherlands Universit. of Göt.ingen Göttingen37083Germany

t.e object.ve of t.is paper is t. ident.fy t.me lag effect.in t.e relat.onship bet.een supply chain management.and financial *** hypot.esize t.at.firms wit. higher supply chain management.capabilit. are associat.d wit. higher financial performance and t.e impact.would last.*** addit.on,we int.oduce t.o cont.xt.al variables,ownership and market.orient.t.on,t. det.ct.t.e moderat.ng effect.of ownership st.uct.re and organizat.onal cult.re,*** use firm-level empirical dat. from 1,131 public Chinese manufact.ring firms for t.e 2010–2019 period t. invest.gat. t.e effect.and t.e result.shows t.at.t.ere is a t.o-year t.me lag effect.in t.e relat.onship,which means t.e posit.ve impact.of current.supply chain management.would last.for t.ree ***,we find evidence t.at.supply chain management.in non-st.t.-owned firms is more efficient.and it. posit.ve financial impact.would last.longer t.an t.at.in st.t.-owned ***,we indicat. t.at.market.orient.t.on can’t.moderat. t.e relat.onship bet.een supply chain management.and financial performance.

关键词： Supply chain management financial performance t.me lag effect ownership market.orient.t.on

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Add on t.e next.level—t.e t.me point.of t.e t.pe I IFN response orchest.at.s t.e immune response

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Cellular & Molecular Immunology 2020年第8期17卷 791-793页

作者： Angela Wedekind David Frit.sch Andrea Kröger Research Group Molecular Microbiology Institute of Microbiology and Hospital HygieneOtto von Guericke University39120MagdeburgGermany Research Group Innat. Immunit. and Infect.on Helmholtz Centre for Infection Research38124BraunschweigGermany

t.e direct.d cont.ol of an effect.ve cellular or adapt.ve immune response is t.e aim of vaccine st.at.gies and t.mor *** ant.bodies prevent.t.e spread of pat.ogens,while efficient.cellular immunot.erapy is used t. overcome t.cell exhaust.on and unresponsiveness t.ward *** such set.ings,t.e t.pe I int.rferon(IFN)syst.m mediat.s pleiot.opic effect. of t.e immune syst.m t.at.can be eit.er immunost.mulat.ng or *** a recent.work,De Giovanni et.*** a novel regulat.ry checkpoint.by which t.pe I IFN regulat.s CD4^(+)t.cell *** st.dy dissect. t.e t.me point.of t.pe I IFN induct.on as a cent.al regulat.r of t.e adapt.ve immune response t.at.det.rmines t.e balance bet.een humoral and cellular *** findings ident.fy an int.iguing and previously undescribed checkpoint.t.at.can pot.nt.ally be manipulat.d for ***,t.e aut.ors demonst.at. t.at.CD4^(+)t.cell polarizat.on could be influenced by manipulat.ng t.e IFN response during infect.on.

关键词： al. vaccine int.rferon

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More bricks in t.e wall against.SARS-CoV-2 infect.on:involvement.of γ9δ2 t.cells

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Cellular & Molecular Immunology 2020年第7期17卷 771-772页

作者： ger Rijkers t.ees Vervenne Piet.r van der Pol St.Elisabet. Hospit.l TilburgThe Netherlands Admiral De Ruyt.r Hospit.l GoesThe Netherlands Science Depart.ent University College RooseveltMiddelburgThe Netherlands

t.e SARS-CoV-2 virus which emerged in lat. December 2019 had reached pandemic proport.ons by March 2020.1 Host.defence mechanisms against.t.is new member of t.e corona virus family will include innat. immunit.,humoral,and cellular immune responses,of yet.unknown relat.ve *** CD8^(+) αβt.R cyt.t.xic t.cells and nat.ral killer cells are mainly responsible for det.ct.on and eliminat.on of virus infect.d cells,wit. a special role for t.e CD94/NK group 2 member A(NKG2A)recept.r as report.d by Zheng et.*** t.is journal.2,3 We want.t. report.yet.anot.er brick in t.e wall against.SARS-CoV-2 infect.on,made of a subset.of γδt.R t.cells.

关键词： NKG2A involvement infect.on

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