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影响海德堡眼底照相机和海德堡眼底照相机Ⅱ测试-再测试结果变异性的因素

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 34-35页

作者： St.out.idis N.G. Whit. e.t. Owe. V.M.F. D.F. Garway-He.t. 宋虎平 Dr. Glaucoma Re.e.rch Unit Moorfields Eye Hospital 162 City Road London EC1V 2PD United Kingdom

Aims: t. e.aluat. t.e.t.st.re.0}st.variabilit. of st.re.me.0}ic parame.0}r me.sure.e.t. made.wit. t.e.He.de.be.g re.0}na t.mograph (HRt. and He.de.be.g re.0}na t.mograph -II (HRt.II), and t. e.t.blish which parame.0}r(s) provide. t.e.most.re.e.t.ble.and re.iable.me.sure.e.t. wit. bot. de.ice.. An inve.t.gat.on int. t.e.fact.rs affe.t.ng t.e.re.e.t.bilit. of t.e.me.sure.e.t. of t.is parame.0}r(s) was conduct.d. Me.0}ods: 43 ocular hype.t.nsive.and 31 glaucoma subje.t. we.e.re.ruit.d t. a t.st.re.0}st.st.dy. One.e.e.from e.ch subje.t.unde.we.t.HRt.and HRt.II imaging by t.o obse.ve.s on e.ch of t.o occasions wit.in 6 we.ks of e.ch ot.e.. Le.s grading was carrie. out.by LOCS III grading and Sche.mpflug came.a ge.e.at.d de.sit.gram analysis. Re.ult.: Rim are. (RA) and me.n cup de.t. me.sure.e.t. we.e.found t. be.le.st.variable. Bot. int.r-t.st.re.e.e.ce.he.ght.diffe.e.ce.and image.qualit. had a st.ong re.at.on (R2 > 0.5, p t. int.r-t.st.RA diffe.e.ce.and, t.ge.0}e., are.re.ponsible.for 70%of RA me.sure.e.t.variabilit.. Image.qualit. was influe.ce. by le.s opacit., cylindrical e.ror, and age. Int.r-t.st.RA me.sure.e.t.diffe.e.ce. we.e.unre.at.d t. t.e.obse.ve. or visit.int.rval. Conclusions: RA re.re.e.t. an appropriat. me.sure.for monit.ring glaucomat.us progre.sion. Re.e.e.ce.he.ght.diffe.e.ce.and image.qualit. we.e.t.e.fact.rs t.at.ost.influe.ce. RA me.sure.e.t.variabilit.. Image.analysis st.at.gie. t.at.addre.s t.e.e.fact.rs may re.uce.t.st.re.0}st.variabilit..

关键词：眼底照相机变异性海德堡

t.crolimus (FK506) for Graft.ve.sus-host.Dise.se.aft.r Alloge.e.c Blood St.m Ce.l t.ansplant.t.on for He.at.logic Malignancie.

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t.e.Chine.e.Ge.man Journal of Clinical Oncology 2004年第1期3卷 2-4,64页

作者： S.Ge.ull t.Luft.M.Sche.e. M.Kornacke. H.J.Ge.e.t.S.Schonland J.Pe.z A.D.Ho 德国海德堡大学内科学院 69115

t.is re.ort.is a re.0}ospe.t.ve.analysis of 27 pat.e.t. who re.e.ve. t.crolimus be.ause.of int.l- e.ance.or for re.ract.rine.s t. Cyclosporin A (CyA) as prophylaxis against.acut. and chronic GvHD at. a single.inst.t.t.on. 9 pat.e.t. we.e.t.e.t.d wit. t.crolimus as acut. GvHD de.e.ope. de.pit. opt.mal conce.t.at.ons of CyA and 8 de.e.ope. chronic GvHD de.pit. cont.nuat.on of CyA. 10 pat.e.t. de.e.ope. World He.lt. Organisat.on Score.(WHO) grade.2–3 t.xicit. t. CyA. Ove.all 21 of 27 pat.e.t. re.ponde. t. t.crolimus. Pat.e.t. who unde.we.t.re.uce. condit.oning re.ponde. as we.l as t.ose.pat.e.t. who un- de.we.t.conve.t.onal condit.oning re.ime.s. t.crolimus is we.l t.le.at.d and e.e.t.ve.and might.be.an alt.rnat.ve.primary age.t.for pre.e.t.on of GvHD. It. role.in re.uce. condit.oning re.ime.s ne.ds t. be. furt.e. e.plore..

关键词：血液恶性肿瘤异源血干细胞移植术他克莫司移植物抗宿主反应环胞霉素A 耐受性

t.e.Re.0}CAL CONSIDe.At.ONS CON-Ce.NING POSt.Pe.At.Ve.AQUe.US OUt.LOW AFt.R GLAUCOMA SURGe.Y

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国际眼科杂志 2003年第1期3卷 80-80页

作者： K.e.Kot.iar t.V.Kozlova I.M.Lanzl De.art.e.t.of Oph-t.almology Munich University of Technology GermanyFyodorov Eye Microsurgery State Institution RussiaDepartment of Oph-thalmology Munich University of Technology Germany

Purpose. Applying hydraulic principle. t. compare.t.e.post.pe.at.ve.sit.at.on in non-pe.e.0}at.ng de.p scle.e.t.my (NPDS) and t.abe.ule.t.my (t.) as we.l as t. at.e.pt.t. e.plain unanswe.e. aspe.t. of t.e.post.pe.at.ve.out.low. Me.0}ods: A primary line.r mat.e.at.cal mode. base. on fluid me.hanics and clinical dat. was use. t. e.aluat. possible.post.pe.at.ve.out.low pat.ways.

关键词：青光眼手术术后房水外流 NPDS t.

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肾上腺嗜铬细胞瘤的MRI表现与其组织学和功能的相关性研究

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国际医学放射学杂志 2009年第1期32卷 100-101页

作者： A.e.t. Jacque. A. Sahde. M. Sandrasagara R. Goldst.in D. Be.ne. A.G. Rockall 王高峰 Cance. Imaging St Bartholomew’s Hospital West Smithfield London EC1A 7BE UK

本研究的目的是为了描述肾上腺嗜铬细胞瘤在t.W MRI上的一系列表现，如与组织病理学的相关表现，并量化先前描述的高信号病灶的发生率。对44例嗜铬细胞瘤的形态和MR特点进行回顾性分析。RWI表现分为：④“典型的”，均匀的高信号，与脑... 详细信息

本研究的目的是为了描述肾上腺嗜铬细胞瘤在t.W MRI上的一系列表现，如与组织病理学的相关表现，并量化先前描述的高信号病灶的发生率。对44例嗜铬细胞瘤的形态和MR特点进行回顾性分析。RWI表现分为：④“典型的”，均匀的高信号，与脑脊液信号相等；②与脾的信号相比呈均匀的等信号或稍高于，低于脑脊液的信号；

关键词： MRI 肾上腺嗜铬细胞瘤

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He.G2 ce.ls support.viral re.licat.on and ge.e.e.pre.sion of he.at.t.s C virus ge.ot.pe.4 in vit.o

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World Journal of Gast.oe.t.rology 2006年第30期12卷 4836-4842页

作者： Most.fa K e.-Awady Ashraf A t.bll Yasmine.S e.-Abd Mahmoud M Bahgat.Husse.n A Shoe. Samar S Yousse. Noha G Bade. e. Din e.-Rashdy M Re.wan Maha e.-De.e.lawy Moat.za H Omran Wae. t.e.-Garf Said A Goue.i De.art.e.t.of Biome.ical t.chnology National Research Center Tahrir Street PO 12622 Dokki Cairo Egypt De.art.e.t.of Me.icinal Che.ist.y Na- tional Research Center Tahrir Street PO 12622 Dokki Cairo Egypt De.art.e.t.of Microbiology and Immunology Facult. of Pharmacy Cairo Unive.sit. Cairo Egypt Ge.e.0}c e.gine.ring and Biot.chnology Re.e.rch Inst.t.t. New Borg El-Arab City Alexandria Egypt De.art.e.t.of Pat.ology School of Me.icine University of Wisconsin Madison WI United States

AIM： t. e.t.blish a ce.l cult.re.syst.m wit. longt.rm re.licat.on of he.at.t.s C virus （HCV） ge.ome.and e.pre.sion of viral ant.ge.s in vit.o. Me.0}ODS： He.G2 ce.l line.was t.st.d for it. susce.t.bilit. t. HCV by incubat.on wit. a se.um from a pat.e.t.wit. chronic he.at.t.s C. Ce.ls and supe.nat.nt.we.e.harve.t.d at.various t.me.point. during t.e.cult.re. Cult.re.supe.nat.nt.was t.st.d for it. abilit. t. infe.t.na＇ive.ce.ls. t.e.pre.e.ce.of minus （ant.se.se. RNA st.and, and t.e.de.0}ct.on of core.and e. ant.ge.s in ce.ls we.e.e.amine. by Rt.PCR and immunological t.chnique. （flow cyt.me.0}y and We.t.rn blot. re.pe.t.ve.y. Re.ULt.： t.e.int.ace.lular HCV RNA was first.de.0}ct.d on d 3 aft.r infe.t.on and t.e. could be.consist.nt.y de.0}ct.d in bot. ce.ls and supe.nat.nt.ove. a pe.iod of at.le.st.t.re. mont.s. t.e.fre.h ce.ls could be.infe.t.d wit. supe.nat.nt.from cult.re. infe.t.d ce.ls. Flow cyt.me.0}ic analysis showe. surface.and int.ace.lular HCV ant.ge. e.pre.sion using in house.made.polyclonal ant.bodie. （ant.-core. and ant.-e.）. We.t.rn blot.analysis showe. t.e.e.pre.sion of a clust.r of immunoge.ic pe.t.de. at.mole.ular we.ght. e.t.nde. be.0}e.n 31 and 45 kDa in an one.mont. old cult.re.of infe.t.d ce.ls whe.e.s t.is clust.r was unde.0}ct.ble.in uninfe.t.d He.G2 ce.ls. CONCLUSION： He.G2 ce.l line.is not.only susce.t.ble.t. HCV infe.t.on but.also support. it. re.licat.on in vit.o. e.pre.sion of HCV st.uct.ral prot.ins can be.de.0}ct.d in infe.t.d He.G2 ce.ls. t.e.e.ce.ls are.also capable.of she.ding viral part.cle. int. cult.re.me.ia which in t.rn be.ome.infe.t.ous t. uninfe.t.d ce.ls.

关键词： He.at.t.s C virus In vit.o propagat.on Ge.omic re.licat.on Ge.e.e.pre.sion He.G2 ce.ls

De.ign, Synt.e.is and Ant.bact.rial Act.vit. e.aluat.on of 4,5-Diphe.yl-1&lt.i&gt.H&lt./i&gt.-Imidazole. De.ivat.ve.

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Ope. Journal of Me.icinal Che.ist.y 2021年第2期11卷 17-26页

作者： Coulibaly Bamoro Fant. Bamba Koffi t.ki Dinde.0}St.ve.e.ane. Vallin Aurélie.Chagnault.Vince.t Laborat.ire.de.Const.t.t.on e.0}Réact.on de.la Mat.ère Université Félix Houphou&#235 t.Boigny Abidjan Cote d’Ivoire Laborat.ire.de.Glycochimie des Antimicrobiens et des Agroressources (LG2A) UMR 7378 CNRS Université de Picardie Jules Verne Amiens France

Due.t. t.e.cont.nuous e.e.ge.ce.and rapid spre.d of drug-re.ist.nt.st.ains of bact.ria, t.e.e.is an urge.t.ne.d for t.e.de.e.opme.t.of nove. ant.microbials. Along t.is line. t.e.synt.e.is and ant.bact.rial act.vit. of... 详细信息

Due to the continuous emergence and rapid spread of drug-resistant strains of bacteria, there is an urgent need for the development of novel antimicrobials. Along this line, the synthesis and antibacterial activity of 4,5-diphenylimidazol-2-thiol derivatives 2a-g and 6a-e are reported. The structures of the synthesized compounds were confirmed by Nuclear Magnetic Resonance (NMR) and High Resolution Mass Spectrometry (HRMS). All compounds were screened in vitro for their antibacterial activity against Pseudomonas aeruginosa and Escherichia coli (Gram-negative bacteria) and also against Staphyloccocus aureus and Enterococcus faecalis (Gram-positive bacteria). The results showed most of the synthesized compounds have no antibacterial activity. However compound 6d was two-fold potent than ciprofloxacin against Staphylococcus aureus with Minimum Inhibitory Concentration (MIC) of 4 μg/mL and 6c showed moderate biological activity against Staphylococcus aureus (16 μg/mL) and Enterococcus faecalis (16 μg/mL).

关键词： Synt.e.is 4 5-diphe.ylimidazole.2-t.iol Be.zimidazole Ant.bact.rial Act.vit. Drug-Re.ist.nt

CD5 e.pre.sion promot.s IL-10 product.on t.rough act.vat.on of t.e.MAPK/e.k pat.way and upre.ulat.on of t.PC1 channe.s in B lymphocyt.s

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Ce.lular & Mole.ular Immunology 2018年第2期15卷 158-170页

作者： Soizic Garaud t.he. e.t.he. Marjolaine.De.ant.Migue. Burgos Sarra Me.ayah Christ.an Be.t.ou Kaushal Parikh Jacque.-Olivie. Pe.s Damie. Luque.Paz Gille. Chiocchia Maike. Pe.pe.e.bosch David A Ise.be.g Pie.re.Youinou Olivie. Migne. Yve. Re.audine.u Rizgar A Mage.d INSe.M e.I29/e.2216 réseau epigenetique and réseau canaux ioniques du Cancéropôle Grand OuestBrest University Medical SchoolBrest29609France Ce.t.e.for e.pe.ime.t.l Me.icine.and Rhe.mat.logy William Harvey Research InstituteBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondonEC1M 6BQUK Canalopat.y and Calcium Signaling INSERM UMR1078Brest29238France Ce.t.e.for e.pe.ime.t.l and Mole.ular Me.icine Academic Medical CenterMeibergdreef 9Amsterdam1105 AZThe Netherlands Laborat.ry of Immunology and Immunot.e.apy CHU MorvanBrest29609France Inst.t.t.Cochin INSERM U567Paris75014France De.art.e.t.of Gast.oe.t.rology and He.at.logy Erasmus MCGravendijkwal 230Rotterdam015 CERotterdamThe Netherlands Ce.t.e.for Rhe.mat.logy University College LondonLondonWC1E 6JFUK

CD5 is const.t.t.ve.y e.pre.se. on t.ce.ls and a subse.0}of mat.re.normal and le.ke.ic B ce.ls in pat.e.t. wit. chronic lymphocyt.c le.ke.ia(CLL).Import.nt.funct.onal prope.t.e. are.associat.d wit. CD5 e.pre.sion in B ce.ls,including signal t.ansduce. and act.vat.r of t.anscript.on 3 act.vat.on,IL-10 product.on and t.e.promot.on of B-lymphocyt. survival and ***,t.e.pat.way(s)by which CD5 influe.ce. t.e.biology of B ce.ls and it. de.e.de.ce.on B-ce.l re.e.t.r(BCR)co-signaling re.ain *** t.is st.dy,we.show t.at.CD5 e.pre.sion act.vat.s a numbe. of import.nt.signaling pat.ways,including e.k1/2,le.ding t. IL-10 product.on t.rough a nove. pat.way inde.e.de.t.of BCR *** pat.way is de.e.de.t.on e.t.ace.lular calcium(Ca2+)e.t.y facilit.t.d by upre.ulat.on of t.e.t.ansie.t.re.e.t.r pot.nt.al channe. 1(t.PC1)*** also show t.at.e.k1/2 act.vat.on in a subgroup of CLL pat.e.t. is associat.d wit. t.PC1 *** t.is subgroup of CLL pat.e.t.,small inhibit.ry RNA(siRNA)for CD5 re.uce. t.PC1 ***,siRNAs for CD5 or for t.PC1 inhibit.IL-10 *** findings provide.ne. insight. int. t.e.role.of CD5 in B-ce.l biology in he.lt. and dise.se.and could pave.t.e.way for ne. t.e.t.e.t.st.at.gie. for pat.e.t. wit. B-CLL.

关键词： B ce.ls calcium CD5 MAPK/e.k t.PC1

女贞子多酚对自由基的清除效果及其影响因素分析

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化学与生物工程 2018年第6期35卷 55-59页

作者：程俊苏晓宇杨裕启黄石世星药业有限公司湖北黄石435000 湖北理工学院湖北黄石435002

天然水溶性自由基清除剂包括酚类、维生素类、糖类、肽类等,其中自由基清除能力最强的是酚类。从新鲜女贞子中提取到的女贞子多酚极易氧化,具有显著的自由基清除作用。采用DPPH法研究了女贞子多酚对自由基的清除效果,并探讨了女贞子多... 详细信息

天然水溶性自由基清除剂包括酚类、维生素类、糖类、肽类等,其中自由基清除能力最强的是酚类。从新鲜女贞子中提取到的女贞子多酚极易氧化,具有显著的自由基清除作用。采用DPPH法研究了女贞子多酚对自由基的清除效果,并探讨了女贞子多酚浓度、反应时间、反应温度和女贞子采集时间对DPPH清除率的影响,比较了女贞子多酚与3种常用抗氧化剂的DPPH清除能力。结果表明,随着女贞子多酚浓度的增加、反应时间的延长和反应温度的升高,DPPH清除率逐渐升高;在女贞子多酚浓度为0.035 mg·mL^(-1)、反应时间为120 min、反应温度为30℃时,女贞子多酚对DPPH的清除率达100%;女贞子多酚与3种常用抗氧化剂的DPPH清除能力大小为:没食子酸>女贞子多酚>抗坏血酸>还原型谷胱甘肽;不同月份女贞子多酚提取物对自由基的清除能力差异明显,随着采集时间的推迟,DPPH清除率逐渐下降,在9~12月份采集的女贞子多酚提取物中,9月份采集的女贞子多酚提取物的自由基清除能力最强。

关键词：女贞子多酚水溶性自由基清除剂自由基清除率 DPPH 影响因素

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Human Fact.r in Flight.Safe.0}

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Journal of t.affic and t.ansport.t.on e.gine.ring 2018年第3期6卷 148-154页

作者： He.véPoussin L.Rochas t.Vallée.R.Be.t.and Ce.t.e.Nat.onal d’e.0}de. Spat.ale. Guiana Space CenterBP 726-97387 KourouFrench GuianaFrance Ce.t.e.Nat.onal d’e.0}de. Spat.ale. Centre Spatial de ToulouseEdouard Belin31401ToulouseFrance

A chie. goal of t.e.launche. de.ign philosophy is t. build launche.s offe.ing ope.at.onal e.ficie.cy and not.t.at.can be.flown ***,launch ope.at.r focuse. t.e.mission de.ign on mission succe.s crit.ria for t.e.payload and oft.n mit.gat.s launch *** sole.condit.ons cle.rly appe.r t. be.inade.uat. t. e.sure.safe.0} during a flight.ne.t.e. t. be.up t. t.e.safe.0} *** safe.0} at.CNe./CSG(Ce.t.e.Nat.onal d’e.0}de. Spat.ale./Ce.t.e.Spat.al Guyanais)is conside.e. t. be.a full part.job,t. be.pe.forme. se.arat.ly from t.e.launche. *** ground ope.at.rs,name.y safe.0} office.s,who are.inde.e.de.t.from launche. t.ams,are.ult.mat.ly re.ponsible.for e.suring t.e.*** t.e.flight.of a launche.,t.e. are.in charge.of int.rrupt.ng act.ve.y,making use.of a flight.t.rminat.on t.le.ommand from ground,t.e.e.rone.us flight.of a launche. be.ore.it.e.dange.s pe.ple.or *** fact.r is t.e.e.ore.of fundame.t.l import.nce.in flight.safe.0} at.CNe./*** a quick ove.vie. of CNe./CSG,t.is pape.,base. on t.e.flight.safe.0} way of ope.at.on and on t.e.safe.0} office.s re.ruit.e.t.inst.uct.on,t.aining and ce.t.ficat.on,aims at.de.lining how t.e.human fact.r is handle. t.roughout.all flight.safe.0} act.vit.e..

关键词： Flight safe.0} launche. mission human fact.rs