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Chronic pancreat.t.s, pancreat.c adenocarcinoma and t.e black box in-bet.een

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Cell Research 2005年第1期15卷 72-77页

作者： Nat.lia JURA,Herbert.ARCHER,Dafna bar-SAGI Depart.ent.of Molecular Genet.cs and Microbiology St.ny Brook Universit. St.ny Brook NY 11794-5222 USA.Graduat. Program in Molecular and Cellular Biology St.ny Brook Universit. St.ny Brook NY 11794-5222 USA. Depart.ent.of Molecular Genet.cs and Microbiology St.ny Brook Universit. St.ny Brook NY 11794-5222 USA.Graduat. Program in Molecular and Cellular Biology St.ny Brook Universit. St.ny Brook NY 11794-5222 USA. Depart.ent.of Molecular Genet.cs and Microbiology St.ny Brook Universit. St.ny Brook NY 11794-5222 USA.

Pancreat.c cancer is a challenging disease for pat.ent., doct.rs and researchers who for decades have searched for a cure for t.is deadly malignancy. Alt.ough exist.ng mouse models of pancreat.c cancer have shed light.on t.e mecha- nist.c basis of t.e neoplast.c conversion of t.e pancreas, t.eir impact.in t.rms of offering new diagnost.cs and t.erapeu- t.c modalit.es remains limit.d. Chronic pancreat.t.s is an inflammat.ry disease of t.e pancreas t.at.is associat.d wit. a gradual damage of t.e organ and an increased risk of developing neoplast.c lesions. In t.is review, we propose t.at. det.iled st.dies of chronic inflammat.ry processes in t.e pancreas will provide insight. int. t.e evolut.on of pancreat.c cancer. t.is informat.on may prove useful in t.e design of effect.ve t.erapeut.c st.at.gies t. bat.le t.e disease.

关键词： pancreat.c cancer chronic pancreat.t.s heredit.ry pancreat.t.s inflammat.on mouse models.

Quant.ficat.on of wing and body kinemat.cs in connect.on t. t.rque generat.on during damselfly yaw t.rn

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Science China(Physics,Mechanics & Ast.onomy) 2017年第1期60卷 32-41页

作者： Samane Zeyghami Ayodeji t. Bode-Oke HaiBo Dong Depart.ent.of Mechanical and Aerospace Engineering University of Virginia Charlottesville 22903 USA

t.is st.dy provides accurat. measurement. of t.e wing and body kinemat.cs of t.ree different.species of damselflies in free yaw t.rn fight.. t.e yaw t.rn is charact.rized by a short.accelerat.on phase which is immediat.ly followed by an elongat.d decelerat.on phase. Most.of t.e heading change t.kes place during t.e lat.er st.ge of t.e flight. Our observat.ons showed t.at.yaw t.rns are execut.d via drast.c rat.er t.an subt.e changes in t.e kinemat.cs of all four wings. t.e mot.on of t.e inner and out.r wings were found t. be st.ongly linked t.rough t.eir orient.t.on as well as t.eir velocit.es wit. t.e inner wings moving fast.r t.an t.e out.r wings. By cont.olling t.e pit.h angle and wing velocit., a damselfly adjust. t.e angle of at.ack. t.e wing angle of at.ack exert.d t.e st.ongest.influence on t.e yaw t.rque, followed by t.e flapping and deviat.on velocit.es of t.e wings. Moreover, no evidence of act.ve generat.on of count.r t.rque was found in t.e flight.dat. implying t.at.decelerat.on and st.pping of t.e maneuver is dominat.d by passive damping. t.e syst.mat.c analysis carried out.on t.e free flight.dat. advances our underst.nding of t.e mechanisms by which t.ese insect. achieve t.eir observed maneuverabilit.. In addit.on, t.e inspirat.on drawn from t.is st.dy can be employed in t.e design of low frequency flapping wing micro air vehicles （MAV＇s）.

关键词： damselfly yaw t.rn angle of at.ack low flapping frequency wing kinemat.cs flapping flight.dynamics

Precise int.grat.on met.ods based on t.e Chebyshev polynomial of t.e first.kind

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Eart.quake Engineering and Engineering Vibrat.on 2008年第2期7卷 207-216页

作者： Wang Mengfu F. t. K. Au Depart.ent.of Civil Engineering Hunan University Changsha 410082 China Depart.ent.of Civil Engineering The University of Hong Kong China

t.is paper int.oduces t.o new t.pes of precise int.grat.on met.ods based on Chebyshev polynomial of t.e first.kind for dynamic response analysis of st.uct.res, namely t.e int.gral formula met.od （IFM） and t.e homogenized init.al syst.m met.od （HISM）. In bot. met.ods, nonlinear variable loadings wit.in t.me int.rvals are simulat.d using Chebyshev polynomials of t.e first.kind before a direct.int.grat.on is performed. Developed on t.e basis of t.e int.gral formula, t.e recurrence relat.onship of t.e int.gral comput.t.on suggest.d in t.is paper is combined wit. t.e Crout.decomposed met.od t. solve linear algebraic equat.ons. In t.is way, t.e IFM based on Chebyshev polynomial of t.e first.kind is const.uct.d. t.ansforming t.e non-homogenous init.al syst.m t. t.e homogeneous dynamic syst.m, and developing a special scheme wit.out.dimensional expansion, t.e HISM based on Chebyshev polynomial of t.e first.kind is able t. avoid t.e mat.ix inversion operat.on. t.e accuracy of t.e t.me int.grat.on schemes is examined and compared wit. ot.er commonly used schemes, and it.is shown t.at.a great.r accuracy as well as less t.me consuming can be achieved. t.o numerical examples are present.d t. demonst.at. t.e applicabilit. of t.ese new met.ods.

关键词： st.uct.ral dynamics Chebyshev polynomial of t.e first.kind t.e Crout.decomposed met.od int.gral formula met.od homogenized init.al syst.m met.od

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Biobanking and omics

Front.ers in Biology 2018年第4期13卷 287-292页

作者： David t. Harris Execut.ve Direct.r Biorepository University of Arizona PO Box 245221. AHSC 6122 Tucson AZ 85724 USA

BACKGROUND： t.e ＂Era of Big Dat.＂ and ＂Precision Medicine＂ is now upon us. t.at.is, int.rrogat.on of large dat. set. obt.ined from groups of similar pat.ent. or from t.e pat.ent.t.emselves over t.me will now hypot.et.cally permit.t.erapies t. be designed t. provide maximal efficacy wit. minimal side effect.. However, such discoveries depend upon recruit.ent.of very large numbers of subject. （t.ns of t.ousands） along wit. t.eir associat.d biospecimens and medical records. When considering t.e est.blishment.of a biobank or t.e refocusing of an exist.ng reposit.ry for t.e purpose of＂omics＂ research （i.e., genomics, met.bolomics, prot.omics, microbiomics, et..） and/or precision medicine, t.ere are a number of considerat.ons t. ponder. Each of t.ese facet. is discussed. OBJECt.VE： t.e object.ve of t.is review is t. describe best.pract.ces for t.e est.blishment.and operat.ons ofa biobank t.at.will be used for omics （genomics, prot.omics, met.bolomics, microbiomics） analyses based on published lit.rat.re and our own pract.cal experiences. MEt.ODS： We describe t.e most.commonly described approaches t. a variet. of biobanking issues, including our own pract.cal experiences over t.e past.5 years. RESULt.： Based on t.e part.cular biobanking sit.at.on and downst.eam applicat.on, we have described best.pract.ces based on t.e lit.rat.re and own experience, t.king int. considerat.on ease of applicat.on and cost.. CONCLUSIONS： t.e banking of various t.pes of clinical biospecimens has many valuable uses but.oft.n depends on overall cost. versus sample ut.lit.. In addit.on, specimen flexibilit. is import.nt.but.is influenced by t.e ease or difficult. of t.e applicat.on. It.is always preferable t. collect.and st.red a biospecimen in a format.t.at.allows for mult.ple t.pes of downst.eam analyses, but.t.at.oft.n requires addit.onal expert.se, equipment.and reagent. t.at.can increase overall cost.. We have described t.e met.odologies most.successfully applied t. many sit.at.ons.

关键词： biobanking genomics met.bolomics microbiomics met.odology precision medicine big dat.

Fabricat.on, modificat.on and environment.l applicat.ons of t.O2 nanot.be arrays （t.t.s） and nanopart.cles

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Front.ers of Chemical Science and Engineering 2012年第1期6卷 112-122页

作者： S. ROHANI t. ISIMJAN A. MOHAMED H. KAZEMIAN M. SALEM t. WANG Depart.ent.of Chemical and Biochemical Engineering The University of Western Ontario London N6A 5B9 Canada

Among t.e semiconduct.rs, t.t.nium dioxide has been ident.fied as an effect.ve phot.cat.lyst.due t. it. abundance, low cost. st.bilit., and superior elect.onic energy band st.uct.re. Highly ordered nanot.be arrays of t.t.nia were produced by anodizat.on and mild sonicat.on. t.e band gap energy of t.e t.t.nia nanot.be arrays was reduced t. 2.6 eV by co-doping wit. Fe, C, N at.ms using an elect.olyt. solut.on cont.ining K3Fe（CN）6. t.e phot.- conversion of phenol in a bat.h phot.react.r increased t. more t.an 18% based on t.e init.al concent.at.on of phenol by using a composit. nanomat.rial consist.ng of t.t.nia nanot.be arrays and Pt.ZIF-8 nanopart.cles. A layer-by- layer assembly t.chnique for t.e deposit.on of t.t.nia nanopart.cles was developed t. fabricat. air filt.rs for t.e degradat.on of t.ace amount. of t.luene in t.e air and preparat.on of superhyrophobic surfaces for oil-wat.r separat.on and ant.-corrosion surfaces.

关键词： t.O2 nanot.be arrays and nanopart.cles,anodizat.on bandgap modificat.on layer-by-layer deposi-t.on oil-wat.r separat.on

St.at.fied magnet.hydrodynamic flow of t.ngent.hyperbolic nanofluid induced by inclined sheet

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Applied Mat.emat.cs and Mechanics(English Edit.on) 2017年第2期38卷 271-288页

作者： t. HAYAt.M. MUMt.Z A. SHAFIQ A. ALSAEDI Depart.ent.of Mat.emat.cs Quaid-i-Azam University 45320 Islamabad 44000 Pakistan Nonlinear Analysis and Applied Mat.emat.cs (NAAM) Research Group Department of Mathematics Faculty of Science King Abdulaziz University Jeddah 21589 Saudi Arabia Depart.ent.of Mat.emat.cs Preston University Kohat Islamabad Campus Islamabad 44000 Pakistan

t.is paper st.dies st.at.fied magnet.hydrodynamic （MHD） flow of t.n- gent.hyperbolic nanofluid past.an inclined exponent.ally st.et.hing surface. t.e flow is subject.d t. velocit., t.ermal, and solut.l boundary condit.ons. t.e part.al different.al syst.ms are reduced t. ordinary different.al syst.ms using appropriat. t.ansformat.ons. t.e reduced syst.ms are solved for convergent.series solut.ons. t.e velocit., t.mperat.re, and concent.at.on fields are discussed for different.physical paramet.rs. t.e result. indi- cat. t.at.t.e t.mperat.re and t.e t.ermal boundary layer t.ickness increase not.ceably for large values of Brownian mot.on and t.ermophoresis effect.. It.is also observed t.at.t.e buoyancy paramet.r st.engt.ens t.e velocit. field, showing a decreasing behavior of t.mperat.re and nanopart.cle volume fract.on profiles.

关键词： t.o-dimensional magnet.hydrodynamic (MHD) flow t.ngent.hyperbolicnanofluid mixed convect.on exponent.al st.et.hing double st.at.ficat.on inclined sheet

Mult.-quasipart.cle excit.t.ons in ^(145)t.

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Science China(Physics,Mechanics & Ast.onomy) 2004年第5期47卷 561-570页

作者： t. Hayakawa M. Oshima t. t.h t. Shizuma J. Kat.kura Y. Hat.ukawa M. Mat.uda H. Kusakari M. Sugawara Japan At.mic Energy Research Inst.t.t. Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanChiba University Inage-ku Chiba 263-8512 JapanChiba Institute of Technology Narashino Chiba 275-0023 Japan

High-spin st.t.s in 145t. have been populat.d using t.e 118Sn (32S, 1p4n) react.on at.beam energy of 165 MeV. t.e level scheme of 145t. has been est.blished up t. Ex ≈7.4 MeV. t.e level scheme shows charact.rist.cs of a spherical or slight.y oblat. nucleus. Based on t.e syst.mat.c t.ends of t.e level st.uct.re in t.e neighboring N = 80 isot.nes, t.e level st.uct.re in 145t. below 2 MeV excit.t.on is well explained by coupling an h11/2valence prot.n t. t.e even-even 144Gd core. Above 2 MeV excit.t.on, most.of t.e yrast.levels are int.rpret.d wit. mult.-quasipart.cle shell-model configurat.ons.

关键词： high-spin st.t.s, level scheme, mult.-quasipart.cle excit.t.ons.

Prolog t. t.e Sect.on on Radar Syst.m Engineering

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Journal of Syst.ms Engineering and Elect.onics 1995年第1期6卷 46-47页

作者： R. t. Hill Radar consult.nt USA November 1994 Beijing

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ＰｒｏｌｏｇｔｏｔｈｅＳｅｃｔｉｏｎｏｎＲａｄａｒＳｙｓｔｅｍＥｎｇｉｎｅｅｒｉｎｇ￥／／ＩｎｔｈｅＥｎｇｌｉｓｈｌａｎｇｕａｇｅｗｅｈａｖｅａｎｅｘｐｒｅｓｓｉｏｎｔｈａｔｓａｙｓｉｔｉｓｐｏｓｓｉｂｌｅ＂ｔｏｌｏｓｅｓｉｇｈｔｏｆｔｈｅｆｏｒｅｓ...

关键词： Prolog t. t.e Sect.on on Radar Syst.m Engineering

Effect.ve t.uncat.on of a St.dent.s &lt.i&gt.t.lt./i&gt.-Dist.ibut.on by t.uncat.on of t.e Chi Dist.ibut.on in a Chi-Normal Mixt.re

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Open Journal of St.t.st.cs 2012年第5期2卷 519-525页

作者： Daniel t. Cassidy Depart.ent.of Engineering Physics McMaster University Hamilton Canada

A St.dent.s t.dist.ibut.on is obt.ined from a weight.d average over t.e st.ndard deviat.on of a normal dist.ibut.on, σ, when 1/σ is dist.ibut.d as chi. Left.t.uncat.on at.q of t.e chi dist.ibut.on in t.e mixing int.gral leads t. an effect.vely t.uncat.d St.dent.s t.dist.ibut.on wit. t.ils t.at.decay as exp (-q2t.). t.e effect.of t.uncat.on of t.e chi dist.ibut.on in a chi-normal mixt.re is invest.gat.d and expressions for t.e pdf, t.e variance, and t.e kurt.sis of t.e t.like dist.ibut.on t.at.arises from t.e mixt.re of a left.t.uncat.d chi and a normal dist.ibut.on are given for select.d degrees of freedom 5. t.is work has value in pricing financial asset., in underst.nding t.e St.dent.s t.-dist.ibut.on, in st.t.st.cal inference, and in analysis of dat..

关键词： Asset Pricing St.dent.s t.Dist.ibut.on Cauchy t.uncat.on Moment. Kurt.sis