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Probiot.c cockt.ils accelerat. baicalin met.bolism in t.e ileum t. modulat. int.st.nal healt. in broiler chickens

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Journal of Animal Science and biot.chnology 2024年第2期15卷 779-794页

作者： Mingkun Gao Chaoyong Liao Jianyang Fu Zhonghua ning Zengpeng Lv Yuming Guo St.t. Key Laborat.ry of Animal Nut.it.on and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Nat.onal Engineering Laborat.ry for Animal breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

background baicalin and probiot.c cockt.ils are promising feed addit.ves wit. broad applicat.on *** probiot.c cockt.ils are known t. enhance int.st.nal healt.,t.e pot.nt.al synergist.c impact.of combining baicalin wit. probiot.c cockt.ils on t.e gut.healt. of broiler chickens remains largely ***,t.is st.dy aims t. invest.gat. t.e influence of t.e combined administ.at.on of baicalin and probiot.c cockt.ils on t.e composit.on of ileal and cecal microbiot. in broiler chickens t. elucidat. t.e underlying mechanisms responsible for t.e healt.promot.ng *** A t.t.l of 3201-day-old male Arbor Acres broilers were divided int. 4 groups,each wit. 8 replicat.s of 10 chicks per *** a period of 42 d,t.e birds were fed a basal diet.or t.e same diet.supplement.d wit. 37.5 g/t.baicalin(bC),1,000 g/t.probiot.c cockt.ils(PC),or a combinat.on of bot. bC(37.5 g/t.and PC(1,000 g/t..t.e result. demonst.at.d t.at.bC+PC exhibit.d posit.ve synergist.c effect.,enhancing int.st.nal morphology,immune funct.on,and barrier *** was evidenced by increased VH/CD rat.o,sIgA levels,and upregulat.d expression of occludin and claudin-1(Pt.d t.at.PC pot.nt.at.d t.e effect. of bC,part.cularly in t.e ileum,where bC+PC significant.y increased t.eα-diversit. of t.e ileal microbiot.,alt.red it.β-diversit.,and increased t.e relat.ve abundance of Flavonifract.r(Pt.bolizing ***,Flavonifract.r posit.vely correlat.d wit. chicken ileum crypt.dept.(PbC+PC had a limit.d effect.on cecal microbiot. st.uct.re,t.e PC group had a very similar microbial composit.on t. bC+PC,suggest.ng t.at.t.e effect.of PC at.t.e dist.l end of t.e gut.overshadowed t.ose of *** We demonst.at.d t.e synergist.c enhancement.of gut.healt. regulat.on in broiler chickens by combining baicalin and probiot.c *** cockt.ils enhanced t.e effect. of baicalin and accelerat.d it. met.b

关键词： baicalin Gut.healt. Ileal microbiot. Probiot.c cockt.ils Synergist.c effect.

Mult.ple conduct.ve net.ork for Kt._(2)(PO_(4))_(3)anode based on MXene as a binder for high-performance pot.ssium st.rage

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Chinese Chemical Let.ers 2024年第8期35卷 539-544页

作者： t.ng Su Yue Wang Qizhen Zhu Mengyao Xu ning Qiao bin Xu St.t. Key Laborat.ry of Organic-Inorganic Composit.s Beijing Key Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China

Kt._(2)(PO_(4))_(3)is a promising anode mat.rial for pot.ssium st.rage,but.suffers from low conduct.vit. and difficult.balance bet.een high capacit. and good st.uct.ral ***,t.e t._(3)C_(2)t.(x)MXene is used as a mult.funct.onal binder t. fabricat. t.e Kt._(2)(PO_(4))_(3)elect.ode by t.e t.adit.onal homogenizing-coat.ng *** MXene nanosheet.,t.get.er wit. t.e conduct.ve agent.super P nanopart.cles,const.uct.a mult.ple conduct.ve net.ork for fast.elect.on/ion t.ansfer and high elect.ochemical ***,t.e net.ork ensures t.e st.uct.ral st.bilit. of t.e Kt._(2)(PO_(4))_(3)elect.ode during t.e de-int.rcalat.on/int.rcalat.on of 4 K^(+)ions,which is beneficial for simult.neously achieving high capacit. and good cycle ***,t.e MXene-bonded Kt._(2)(PO_(4))_(3)elect.ode delivers a reversible capacit. of 255.2 mAh/g at.50 mA/g,out.t.nding rat. capabilit. wit. 132.3 mAh/g at.2 A/g,and ex-cellent.cycle performance wit. 151.6 mAh/g at.1 A/g aft.r 2000 *** work not.only suggest. a high-performance anode mat.rial for pot.ssium-ion bat.eries,but.also demonst.at.s t.at.t.e MXene is a promising binder mat.rial for const.uct.ng conduct.ve elect.odes in rechargeable bat.eries.

关键词： MXene t._(3)C_(2)t.(x) Kt._(2)(PO_(4))_(3) Anode Conduct.ve net.ork Pot.ssium st.rage

Comprehensive charact.rizat.on of cell disulfidpt.sis in human cancers:An int.grat.d pan-cancer analysis

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Genes & Diseases 2024年第4期11卷 5-8页

作者： Guo Zhao Yale Jiang Yuning Wang Shuhang Wang ning Li Clinical t.ial Cent.r National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Excessive accumulat.on of disulfide molecules,like cyst.ne,can induce disulfide st.ess and high t.xicit. in cells,but.t.e reduced form of nicot.namide adenine dinucleot.de phosphat. can reverse t.is process and mit.ga... 详细信息

关键词： disulfide cancer charact.rizat.on

t.mor-derived DEFb1 induces immune t.lerance by inhibit.ng mat.rat.on of dendrit.c cell and impairing CD8+t.cell funct.on in esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2024年第4期36卷 351-367页

作者： Jingjing Duan Haot.an Wang Minglu Liu Yin Chen ning Li Jieqiong Liu Lingxiong Wang Lin Li Yaru Liu Pengfei Dong Xiuxuan Wang Zhongyi Fan Shunchang Jiao t.anjin Medical Universit. Cancer Inst.t.t. and Hospit.l National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Depart.ent.of Oncology the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China beijing DCt. biot.ch CO. LTD.Beijing 102200China Depart.ent.of biot.erapy Cent.r Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

Object.ve:CD8+t.cells are t.e key effect.r cells in t.e ant.-t.mor immune *** mechanism underlying t.e infilt.at.on of CD8+t.cells in esophageal squamous cell carcinoma(ESCC)has not.been clearly ***:Fresh ESCC t.ssues were collect.d and grouped according t. t.e infilt.at.on densit. of CD8+t.*** t.e t.anscript.me sequencing on t.ese samples and t.e combined analyses wit. t.e Cancer Genome At.as(t.GA)ESCC dat.,a secret.d prot.in DEFb1 was select.d t. explore it. pot.nt.al role in t.e infilt.at.on of CD8+t.*** analyses,hist.logical verificat.on and in vit.o experiment. were t.en ***:DEFb1 was highly expressed in ESCC,and t.e high expression of DEFb1 was an independent.risk fact.r for overall *** t.e up-regulat.on or down-regulat.on of DEFb1 did not.affect.t.e proliferat.on,migrat.on and apopt.sis of ESCC cells,we speculat.d t.at.t.e oncogenic effect.of DEFb1 was achieved by regulat.ng microenvironment.l *** analyses suggest.d t.at.DEFb1 might.play a major role in t.e inflammat.ry response and ant.-t.mor immune response,and correlat. t. t.e infilt.at.on of immat.re dendrit.c cell(imDC)in *** analyses furt.er confirmed t.at.t.ere were less CD8+t.cells infilt.at.d,less CD83+mat.re DC(mDC)infilt.at.d and more CD1a+imDC infilt.at.d in t.ose ESCC samples wit. high expression of *** t.e t.eat.ent.wit. recombinant.DEFb1 prot.in,t.e mat.rat.on of DC was hindered significant.y,followed by t.e impairment.of t.e killing effect. of t.cells in bot. 2D and 3D cult.re in ***:t.mor-derived DEFb1 can inhibit.t.e mat.rat.on of DC and weaken t.e funct.on of CD8+t.cells,account.ng for t.e immune t.lerance in *** role of DEFb1 in ESCC deserves furt.er explorat.on.

关键词： CD8+t.cells DEFb1 dendrit.c cells esophageal squamous cell carcinoma t.mor immune microenvironment

Clinical feat.res of gast.oesophageal reflux disease and erosive esophagit.s:Insight. from pat.ent. undergoing esophagogast.oduodenoscopy in resource-limit.d Et.iopia

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World Journal of Gast.oent.rology 2024年第34期30卷 3883-3893页

作者： Firehiwot.A Mengist.e Abat. b Shewaye Abel t.t.samma Zekarias S Ayalew Depart.ent.of Int.rnal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Depart.ent.of Int.rnal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gast.oent.rology and Hepat.logy Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

bACKGROUND Gast.oesophageal reflux disease(GERD)is a common disease worldwide wit. varying clinical present.t.ons and risk *** dat. for Africa is lacking,but.an increasing t.end is expect.d due t. demographic and epidemiological *** endoscopic st.dies for general gast.oint.st.nal disorders have shown some pat.ent. wit. erosive esophagit.s(EE),no st.dies in Et.iopia have invest.gat.d t.e clinical charact.rist.cs,risk fact.rs,and severit. of GERD using esophagogast.oduodenoscopy(EGD).AIM t. assess t.e clinical feat.res of GERD in Et.iopian pat.ent. who underwent.EGD and det.rmine t.e severit. and risk fact.rs of *** We conduct.d a mult.cent.r,ret.ospect.ve cross-sect.onal st.dy of 221 pat.ent. diagnosed wit. GERD and endoscopic findings of EE at.t.auma Associat.d Severe Hemorrhage and Amniot.c Membrane St.m Cell bet.een January 2019 and August.*** were collect.d from elect.onic medical records and phone call *** used descript.ve st.t.st.cs and binary logist.c regression analysis wit. SPSS version 26 t. ident.fy t.e associat.on bet.een variables wit. a st.t.st.cal significance set.at.P valuet.e mean±SD age of t.e pat.ent. was 44.8(±15.9)years,wit. a male-t.-female rat.o of 1.6:*** most.commonly report.d sympt.m was epigast.ic pain(80.5%),followed by heart.urn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of pat.ent.,followed by LA-b(14.9%),LA-C(7.7%),and LA-D(5.9%).Mult.variat. analysis showed t.at.age 50 or above,presence of bleeding,and endoscopic findings of duodenit.s/duodenopat.y were significant.y associat.d wit. severe EE(Pt.ict.re and barret.’s esophagus were observed in 4.5%and 1.36%of pat.ent. wit. EE,*** Most.of t.e pat.ent. had milder EE wit. fewer ***,severe EE was more prevalent.in older pat.ent. and t.ose wit. duodenit.s/duodenopat.y.

关键词： Gast.oesophageal reflux disease Erosive esophagit.s Hiat.l hernia Esophagogast.oduodenoscopy Heart.burn

EP Aquarii:A New Pict.re of t.e Circumst.llar Envelope

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Research in Ast.onomy and Ast.ophysics 2024年第3期24卷 83-105页

作者： Pham t.Nhung Do t.Hoai Pierre Darriulat.Pham t.an-Anh Pham N.Diep Nguyen b.Ngoc t.an t.t.ai Depart.ent.of Ast.ophysics Vietnam National Space CenterVietnam Academy of Science and Technology18Hoang Quoc VietNghia DoCau GiayHa Noivietnam

New analyses of earlier ALMA observat.ons of oxygen-rich AGb st.r EP Aquarii are present.d,which complet. a previously published analysis and offer a different.int.rpret.t.on of t.e morpho-kinemat.cs of t.e circumst.llar *** birt. of t.e equat.rial densit. enhancement.EDE)is shown t. occur very close t. t.e st.r where evidence for rot.t.on has been *** t. t.e st.r and where out.lows have been observed:t.eir int.ract.on wit. t.e gas of t.e nascent.EDE is seen t. play an import.nt.role in t.e development.of t.e wind and t.e evolut.on of it. radial velocit. from 8 t. 10 km s^(-1) on t.e polar symmet.y axis t.~2 km s^(-1) at.t.e *** implies complex morpho-kinemat.cs:making reliable int.rpret.t.ons wit. reasonable confidence is *** part.cular,it.quest.ons an earlier int.rpret.t.on implying t.e presence of a whit. dwarf companion orbit.ng t.e st.r at.an angular dist.nce of -0″4 from it. *** proposes inst.ad an int.rpret.t.on in t.rms of a st.ndard mass eject.on associat.d wit. a shock wave leaving a void of emission in it. *** Doppler velocit. wings are seen t. consist.of t.o component.,t.e upper velocit. end of t.e global wind,reaching above±12 km s^(-1),and an effect.ve line broadening,confined wit.in 200 mas from t.e cent.r of t.e st.r,reaching above±20 km s^(-1) and int.rpret.d as caused by t.e pat.ern of shock waves result.ng from t.e int.ract.on bet.een st.llar pulsat.on and convect.ve cell part.t.on.

关键词： st.rs AGb and post.AGb-(st.rs) circumst.llar mat.er-radio lines st.rs

Simult.neous det.ct.on of flare-associat.d kink oscillat.ons and ext.eme-ult.aviolet.waves

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Science China(t.chnological Sciences) 2024年第5期67卷 1592-1601页

作者： LI Dong HOU ZhenYong bAI XianYong LI Chuan FANG Mat.hew ZHAO HaiSheng WANG JinCheng ning ZongJun Key Laborat.ry of Dark Mat.er and Space Ast.onomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing210023China Yunnan Key Laborat.ry of t.e Solar Physics and Space Science Kunming650216China School of Eart. and Space Sciences Peking UniversityBeijing100871China Nat.onal Ast.onomical Observat.ries Chinese Academy of SciencesBeijing100101China School of Ast.onomy and Space Science University of Chinese Academy of SciencesBeijing100049China School of Ast.onomy and Space Science Nanjing UniversityNanjing210023China Key Laborat.ry of Modern Ast.onomy and Ast.ophysics Ministry of EducationNanjing UniversityNanjing210023China Columbus Academy GahannaOhio43230USA Key Laborat.ry of Part.cle Ast.ophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Yunnan Observat.ries Chinese Academy of SciencesKunming650216China

Kink oscillat.ons,which are frequent.y observed in coronal loops and prominences,are oft.n accompanied by ext.eme-ult.aviolet.EUV)***,much more needs t. be explored regarding t.e causal relat.onships bet.een kink oscillat.ons and EUV *** t.is art.cle,we report.t.e simult.neous det.ct.on of kink oscillat.ons and EUV waves t.at.are bot. associat.d wit. an X2.1 flare on 2023 March 03(SOL2023-03-03t.7:39).t.e kink oscillat.ons,which are almost.perpendicular t. t.e axes of loop-like st.uct.res,are observed in t.ree coronal loops and one *** short.loop shows in-phase oscillat.on wit.in t.e same period of 5.2 min at.t.ree *** oscillat.on could be t.iggered by t.e pushing of an expanding loop and int.rpret.d as t.e st.nding kink *** lags are found bet.een t.e kink oscillat.ons of t.e short.loop and t.o long loops,suggest.ng t.at.t.e kink wave t.avels in different.*** kink oscillat.ons of one long loop and t.e prominence are possibly driven by t.e dist.rbance of t.e coronal mass eject.on(CME),and t.at.of anot.er long loop might.be at.ribut.d t. t.e int.ract.on of t.e EUV *** onset.t.me of t.e kink oscillat.on of t.e short.loop is nearly same as t.e beginning of an EUV *** fact.demonst.at.s t.at.t.ey are almost.*** EUV wave is most.likely excit.d by t.e expanding loop st.uct.re and shows t.o *** leading component.is a fast.coronal wave,and t.e t.ailing one could be due t. t.e st.et.hing magnet.c field lines.

关键词： coronal loops solar flares solar prominence solar oscillat.ons ext.eme-ult.aviolet.wave magnet.hydrodynamic

Masses of t.e conject.red H-dibaryon at.different.t.mperat.res

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Chinese Physics C 2024年第8期48卷 83-93页

作者： Liang-Kai Wu Han t.ng ning Li Xin-Yang Wang School of Physics and Elect.onic Engineering Jiangsu UniversityZhenjiang 212013China Cent.r for Fundament.l Physics School of Mechanics and PhysicsAnhui University of Science and TechnologyHuainan 232001China

We present.a lat.ice QCD det.rminat.on of masses of t.e conject.red H-dibaryon,denot.d as mH,at.nine different.t.mperat.res:t.t.(c)=0.24,0.63,0.76,0.84,0.95,1.09,1.27,1.52,and *** masses of baryons N,Σ,Ξ,andΛat.different.t.mperat.res were also *** simulat.ons were performed on an anisot.opic lat.ice wit. N_(f)=2+1 flavours of clover fermion at.a quark mass corresponding t. mπ=384(4)*** t.ermal ensembles were provided by t.e FASt.UM collaborat.on,whereas t.e zero t.mperat.re ensembles were provided by t.e Hadspec *** also calculat.d t.e spect.al densit. of t.e correlat.on funct.on of t.ose *** spect.al densit. dist.ibut.ons show a rich peak st.uct.re at.t.e lowest.t.mperat.re;at.int.rmediat. t.mperat.res,t.e mass values of t.ose part.cles obt.ined by t.e ext.apolat.on met.od reflect.a t.o-peak *** t.e spect.al densit. for t.e oct.t.baryon becomes smoot. at.t.t.(c)=1.27,1.52,and 1.90,t.e spect.al densit. for t.e H-dibaryon becomes smoot. at.t.t.(c)=*** t.t.(c)=0.24,t.e mass difference of t.e H-dibaryon andΛpair,expressed asΔm=m_(H)−2m_(Λ),was est.mat.d t. beΔm=−14.6(6.2)MeV,which suggest. t.e exist.nce of a bound H-dibaryon st.t..

关键词： lat.ice QCD H-dibaryon spect.al funct.on clover fermion finit. t.mperat.re

Diet.ry crude prot.in t.me-dependent.y modulat.s t.e bact.rial communit. and met.bolit.s and changes diet.ry nut.ient.efficiency in growing pigs

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Animal Nut.it.on 2024年第2期17卷 1-10页

作者： Yuming Wang Junyan Zhou ning Cao Lu Wang Jiayu t. Xiangfang Zeng Shiyan Qiao St.t. Key Laborat.ry of Animal Nut.it.on and Feeding Institute of Animal Sciences of Chinese Academy of Agricultural Sciences Animal Science and t.chnology College Beijing University of Agriculture St.t. Key Laborat.ry of Animal Nut.it.on and Feeding Ministry of Agriculture Feed Industry CentreChina Agricultural University

t.e reduced nut.ient.digest.bilit. of low-prot.in(LP) diet. has been shown t. be caused by t.e weakened ferment.t.ve capacit. of t.e post.gut.flora. t.e dynamic regulat.on of diet.ry prot.in cont.nt. on post.gut.microbial populat.on and ferment.t.ve met.bolism is unclear. t.elve growing barrows(19.9 ± 0.8 kg) fit.ed wit. a t.cannula at.t.e blind end of t.e cecum were randomly administ.red a highprot.in(HP, 21.5% crude prot.in [CP]) diet.or an LP(15.5% CP) diet.for 28 d. t.e cecal cont.nt.and feces were collect.d at.d 1, 14, and 28 of t.e experiment.for microflora st.uct.res and met.bolit. concent.at.ons analysis. t.e nut.ient.digest.bilit. coefficient.and plasma biochemical paramet.rs were also det.rmined. Compared wit. t.e HP t.eat.ent. t.e LP t.eat.ent.showed decreased plasma urea nit.ogen concent.at.on and apparent.t.t.l t.act.digest.bilit. of dry mat.er, gross energy, and CP(P t.on, urinary nit.ogen losses, t.t.l nit.ogen losses, and daily nit.ogen ret.nt.on in t.e LP t.eat.ent.were lower t.an t.ose in t.e HP t.eat.ent.P t.e nit.ogen ret.nt.on-t.-nit.ogen int.ke rat.o in t.e LP t.eat.ent.was increased(P t.e HP group showed increased cecal t.t.l short.chain fat.y acids(SCFA) concent.at.on and fecal propionat., but.rat., and t.t.l SCFA concent.at.ons(P be mainly relat.d t. t.e elevat.d abundance of SCFA-producing bact.ria, such as Ruminococcus, Lact.bacillus, and Prevot.lla(P biot.cs, such as bifidobact.rium, bact.roidales S24-7, and Rikenella, enriched in t.e LP t.eat.ent.possibly cont.ibut.d t. reduced plasma endot.xin cont.nt. t.e differences in t.e abundances of almost.all t.e above-ment.oned flora appeared on d 28 but.not.d 14. Likewise, differences in t.e Simpson and Shannon indices and clust.ring pat.erns of t.e microbiot. bet.een t.eat.ent. were also only observed on d 28. t. sum up, in a t.me-dependent.manner, t.e LP diet.increased probiot.cs wit. gut.improving funct.ons a

关键词： Low-prot.in diet Microorganism Nut.ient.digest.bilit. Pig Short.chain fat.y acid