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X线定量评估用于膝关节骨性关节炎与腰部脊椎炎相互关系的研究

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X线定量评估用于膝关节骨性关节炎与腰部脊椎炎相互关系的研究

Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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作者： M Akai K Uehara K Nakamura U Ohkuma H Oka t doi t Iwaya Departments of Orthopaedic Surgery and Joint Diseases Graduate School of MedicineUniversity of Tokyo

目的:老年人口的增加给公共健康带来了巨大的影响。了解老年人群骨骼肌肉疾病的进展情况非常重要。他们通常罹患多种健康问题且不断发展而处于一种复杂的状态之下。对于这些处于这样境况的病人而言,单纯分析某一种疾病的影响是不够的。...

目的:老年人口的增加给公共健康带来了巨大的影响。了解老年人群骨骼肌肉疾病的进展情况非常重要。他们通常罹患多种健康问题且不断发展而处于一种复杂的状态之下。对于这些处于这样境况的病人而言,单纯分析某一种疾病的影响是不够的。例如,在过去,我们对于背痛(腰部脊椎炎)和膝关节疼痛(骨性关节炎)积累了大量的数据。但是,我们需要进一步证实作为一种单纯的存在资料,对于正在步入老年的人而言是否仍有参考价值。这项研究的目的是从数学分析角度调查在老年人群中,后背与腰部的疼痛与病理生理学改变的关系的假设是否具有相关性。方法:我们募集了年龄在65岁到93岁间的314人,取自于5个矫形外科诊所的门诊和相关老年护理机构的病人。对他们随访并检查3次。收集不同的生物学数据包括既往史、小型体格检查、脊柱和膝关节X光、一些实验室检查、日常起居活动能力和社会参与度。就目前的调查数据看,我们的主要关注点放在疼痛区域(背痛、臀部痛、大腿痛、膝关节痛)与X线表现(计算机辅助定量诊断)的相互关系上。结果:对于疼痛而言,研究显示其分布的广泛性和复合性。有意思的是,腰背痛与膝关节痛具有高度的发生一致性,达2/3。在治疗的过程中疼痛呈现出不同的表现。在治疗期间,背痛与膝痛表现出同时的减轻,这令人吃惊,但臀部痛和大腿痛却无明显的改善。X线评估方面,我们评估了膝关节骨性关节炎和腰部脊椎炎之间的定量关系。结果显示t12/L2的椎间盘高度与膝关节疼痛具有明显的关系。在这些部位的椎间盘。通过L3椎体后缘标准化后的L2/L3的椎间盘高度与膝关节内侧间隙具有显著的相关性。在一例L2与L3腰椎间盘高度比例小于28%,且膝关节内侧间隙面积小于66 mm2的病例中,膝比例为16.1。结论:我们发现(1)L1/L23/L4椎间盘高度与膝关节疼痛有相关性,(2)在这些椎间盘中,L2/L3椎间盘的高度与膝关节内侧间隙有强烈的相关性,(3)可以计算出很高比率的膝关节疼痛。

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko tokuda takamitsu Hori Daisuke Mizutani tomoyuki Hioki Kumi Kojima takashi Onuma Yukiko Enomoto tomoaki doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida toru Iwama takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(t2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in t2DM patients without *** to investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in t2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with t2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** the levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the t2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** these results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in t2DM *** findings provide insight into the molecular mechanisms underlying t2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

GABA_B受体对位听神经脑干传入通路神经活动的影响

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中华耳科学杂志 2007年第2期5卷 226-230页

作者：蔡竖平杨仕明房征宇耿淼土井直解放军总医院老年医学研究所北京100853 解放军总医院耳鼻咽喉头颈外科北京100853 日本关西医科大学耳鼻咽喉科

目的本实验旨在探讨GABA能神经递质及GABAB受体对电刺激位听神经传入脑干通路兴奋性变化的影响。方法使用出生后0～5d的ddy/ddy小鼠制备脑干切片。脑片经电压敏感染料NK3041染色,电刺激与脑片相连的位听神经残端,使用16×16像素的硅光... 详细信息

目的本实验旨在探讨GABA能神经递质及GABAB受体对电刺激位听神经传入脑干通路兴奋性变化的影响。方法使用出生后0～5d的ddy/ddy小鼠制备脑干切片。脑片经电压敏感染料NK3041染色,电刺激与脑片相连的位听神经残端,使用16×16像素的硅光电二极管阵列测量膜电位变化引起的电压敏感染料吸光度的改变。观察GABA及GABAB受体拮抗剂2-Hydroxysaclofen (saclofen)对神经活动的影响,使用ARGUS-50PDA软件分析实验数据。结果多部位的光学记录方法显示了从位听神经到耳蜗核和前庭核兴奋性传导的时间-空间分布。神经活动可用电位或色彩的改变显示。每一个像素记录的电信号由快的峰电位样反应和慢反应组成。抑制性神经递质GABA可降低快的峰电位样反应及慢反应的幅度;GABAB受体拮抗剂saclofen能够部分逆转GABA的作用,随着saclofen(50μmolL～100μmolL)的浓度增加,在耳蜗核及小脑可引起去极化电位增强及后超极化电位。结论电刺激位听神经在脑干传入通路可引起兴奋性神经活动,GABA及saclofen对诱发的神经活动有调节作用,提示GABA及GABAB受体在听觉传入通路和小脑担负重要的生理功能。

关键词：光学记录 GABA GABAB受体脑干切片

γ-Irradiation Effect:Variation of Photosynthetic Activity of Euglena

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Biomedical and Environmental Sciences 2002年第3期15卷 261-267页

作者： t·SAKASHItA M·doi 等 NationalInstituteofRadinologicalSciences

Objective to study the effects of gamma-ray irradiation on carbon fixation (Specific production rate: SPR), CO2 utilization efficiency (CUE) and electron transfer rate (EtR) in the photosynthetic flagellate Euglena gracilis strain Z in a dose-response dependent manner. Methods Euglena cells were cultured in an inorganic nutrient medium containing ammonium chloride or proteose peptone. Cells were exposed to gamma-ray at 5 doses (0, 100, 250, 350, 500 Gy for water). Five days after irradiation, three photosynthetic activities were measured. SPR, which is a carbon uptake rate per unit carbon mass, was determined by 13C tracer methodology. CUE was evaluated using a relation of carbon isotope fractionation in Calvin cycle. EtR in photosystem II (PS II) was measured by a chlorophyll fluorescence analysis. Results Even at a dose of 500 Gy, 80 % of EtR of the non-irradiated control (0 Gy) was sustained, while SPR and CUE were about half the level in the non-irradiated control at 500 Gy. Furthermore, the dose response of EtR was considerably different from the others. Conclusion Our findings suggest that not only PS II but also the Calvin cycle in the photosynthetic system is affected by gamma ray irradiation.

关键词： Gamma-ray irradiation Euglena gracilis Photosynthetic activities

电解质碳水化合物饮料可导致机舱内人员进行更好的水合作用

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中华航空航天医学杂志 2002年第4期13卷 272-272页

作者：钱谷干男飞鸟田一朗 Hamada K Miyazaki H Okoshi H doi t Sakurai M Matsumoto K Yanagisawa K Suzuki t Kikuchi N 马月欣日本航空公司健康管理室日本Saga营养物质研究所

Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía M.López Baptista K.Watanabe t.taniguchi E.Diez J.E.Velázquez-Pérez Y.M.Meziani J.M.Caridad J.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFEts)have demonstrated an outstanding potential for terahertz(tHz)photodetection due to their fast response and *** features are essential to enable emerging tHz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFEt *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene tHz Photodetector Field-effect transistor Plasmonic

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金属注射成形冷作工具钢的超声疲劳性能

粉末冶金技术 2005年第2期23卷 88-90页

作者： K.doi K.Hanami t.teraoka S.terauchi t.Sugimoto 韩风麟 Osaka Yakin Kogyou Co.Ltd. Higashiyodogawa-KuOsaka 553-0005Japan Kansai University ORDISt Suita-shiOsaka 564-8680Japan

用超声疲劳试验研究了金属注射成形(MIM)冷作工具钢和锻轧钢(JISSKD11)的高周疲劳性能。锻轧钢试样于423K回火1h。另一方面,为了评估回火温度对疲劳性能的影响,将MIM钢试样于不同温度下进行了回火。在N=103～108疲劳寿命范围内进行了超... 详细信息

用超声疲劳试验研究了金属注射成形(MIM)冷作工具钢和锻轧钢(JISSKD11)的高周疲劳性能。锻轧钢试样于423K回火1h。另一方面,为了评估回火温度对疲劳性能的影响,将MIM钢试样于不同温度下进行了回火。在N=103～108疲劳寿命范围内进行了超声疲劳试验。MIM钢试样的疲劳强度和锻轧钢试样相同。MIM钢试样的疲劳强度随着回火温度升高而减低。显微组织的观察结果表明,MIM钢试样的碳化物的直径与形状比锻轧钢试样的均一。

关键词：金属注射成形冷作工具钢高周疲劳性能超声疲劳试验疲劳强度 MIM 试验研究回火温度疲劳寿命温度升高显微组织试样轧钢碳化物

Effect of Intrathecal Ropivacaine or Bupivacaine on the Requirements of Propofol for general anesthesia in Rats

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Effect of Intrathecal Ropivacaine or Bupivacaine on the Requ...

Optical recordings reveal the differential distribution of glutamatergic transmission in the cochlear and vestibular nuclei in the newborn mouse brainstem

2009年西部麻醉学术论坛

作者： doi K Nikai t Koshikawa K Saito Y Anesthesiology Department Shimane University Faculty of MedicineIzumoShimaneJapan

＜正＞Introduction Several studies have been reported varying degrees of synergistic interactions among the drugs used to achieve the anesthetic *** anesthesia appears to have sedative effects,and local anesthetics used for neuraxial blockade have been found to reduce the dosage of inhaled anesthetics in animal experiments and *** investigation was designed to test whether spinal anesthesia may reduce

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Journal of Otology 2009年第2期4卷 106-114页

作者： doi tadashi Kaneko toshihiko Matsumoto Ayumi Asako Mikiya Yamashita toshio Department of Otolaryngology Kansai Medical University

Objective Using optical imaging in brainstem slices, we studied evoked responses in the mouse cochlear (CN) and vestibular (VN) nuclei. Methods the use of optical imaging allowed us to visualize the spatiotemporal patterns of excitatory propagation in the CN and VN. Optical recordings can differentiate excitatory propagation in the ventral CN(VCN) from that in the dorsal CN(DCN). Furthermore, we assessed the relative distribution of NMDA and non-NMDA receptors in these regions using the glutamate antagonists APV (NMDA receptor antagonist) and CNQX (non-NMDA receptor antagonist) in mouse brainstem slices during postnatal days 1 to 3. Results the average sensitivity to APV was 99.1% in the VCN, 76.0% in the DCN and 64.9% in the VN. the average sensitivity to CNQX was 0.9% in the VCN, 24.0% in the DCN and 35.1% in the VN. these results indicate that the effect of APV dominated in the VCN, while both APV and CNQX were effective antagonists in the DCN and VN. In the VN, the distribution of APV-and CNQX-sensitive cells was almost completely uniform. However, in the DCN the distribution of APV-and CNQX-sensitive cells was highly complex. the area that was more sensitive to CNQX was located in the superficial layer of the DCN while the area with a higher sensitivity to APV was located progressively in the deep layer. Conclusion this optical recording data suggests that there is a differential distribution of NMDA and non-NMDA receptor mediated neurotransmission in the VCN, DCN and VN.

关键词： voltage-sensitive dye NMDA non-NMDA photo diode array