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Chinese Journal of Cancer Research 2013年第3期25卷 354-357页

作者： Lung-Yun Kang szu-pei ho Yi-Pin Chou Department of Emergency Medicine Kaohsiung Veterans General Hospital Department of Pathology Kaohsiung Veterans General Hospital

Mucosa-associated lymphoid tissue （MALT） lymphoma of the thymus is rare. We reported a case of a 37-year-old Chinese female with Sjtgren＇s syndrome and hyperglobulinemia. She suffered from chronic cough for 3 weeks. Chest computed tomography （CT） demonstrated a multiloculated cystic mass in mediastinum prevascular space and multiple lung cysts. Laboratory exam of autoimmune markers showed positive of antinuclear antibody （ANA）, Sjtgren＇s syndrome A （SSA）, Sjtgren＇s syndrome B （SSB）, and rheumatoid factors （RF）. Thymectomy with lymph node dissection was performed. The pathology report revealed thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Under immunohistochemical stains, CD20 and Bcl-2 were positive. No evidence of recurrence of disease was found.

关键词： Mucosa-associated lymphoid tissue (MALT) lymphoma thymus Sj6gren's syndrome hyperglobulinemia

Optimized speed control for electric vehicles on dynamic wireless charging lanes: An eco-driving approach

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Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2024年第1期7卷 52-63页

作者： Lingshu Zhong ho Sheau En Mingyang pei Jingwen Xiong Tao Wang School of Systems Science and Engineering Sun Yat-sen UniversityGuangzhou 510399China Faculty of Business and Management UCSI UniversityKuala Lumpur 56000Malaysia Department of Civil Engineering and Transportation South China University of TechnologyGuangzhou 510641China School of Automotive and Transportation Engineering Hefei University of TechnologyHefei 230000China

As the adoption of Electric Vehicles(EVs)intensifies,two primary challenges emerge:limited range due to battery constraints and extended charging *** traditional charging stations,particularly those near highways,exacerbate these issues with necessary detours,inconsistent service levels,and unpredictable waiting *** emerging technology of dynamic wireless charging lanes(DWCLs)may alleviate range anxiety and eliminate long charging stops;however,the driving speed on DWCL significantly affects charging efficiency and effective charging ***,the existing research has addressed load balancing optimization on Dynamic Wireless Charging(DWC)systems to a limited *** address this critical issue,this study introduces an innovative eco-driving speed control strategy,providing a novel solution to the multi-objective optimization problem of speed control on *** utilize mathematical programming methods and incorporate the longitudinal dynamics of vehicles to provide an accurate physical model of *** objective functions are formulated to tackle the challenges at hand:reducing travel time,increasing charging efficiency,and achieving load balancing on DWCL,which corresponds to four control *** results of numerical tests indicate that a comprehensive control strategy,which considers all objectives,achieves a minor sacrifice in travel time reduction while significantly improving energy efficiency and load ***,by defining the energy demand and speed range through an upper operation limit,a relatively superior speed control strategy can be *** work contributes to the discourse on DWCL integration into modern transportation systems,enhancing the EV driving experience on major roads.

关键词： dynamic wireless charging(DWC) electric vehicle(EV) eco-driving speed control load balancing

Core-shell heterostructure by coupling layered ReS_(2) with Co_(9)S_(8) nanocubes for boosted oxygen evolution reaction

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Chinese Chemical Letters 2024年第3期35卷 518-522页

作者： Xu Yu Zhiqiang Pan Chengang pei Longjie Lin Yanhui Lu ho Seok Park Huan Pang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China School of Chemical Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-do 440-746Republic of Korea

The controllable morphology and composition of catalysts are crucial to improving the electrocatalytic activity of oxygen evolution reaction(OER).Herein,we construct a bimetallic heterostructure by sulfidation and hydrothermal methods,and the layered ReS_(2)is vertically aligned on Prussian blue-derived hollow Co_(9)S_(8)nanocubes(Co_(9)S_(8)@ReS_(2)).The core-shell structure of Co_(9)S_(8)@ReS_(2)can effectively prevent the restacking of layered ReS_(2),expose the abundant surface area and improve the utilization of electrocatalytic sites,resulting in fast electrolyte diffusion and charge transfer during *** to the synergistic effect of the core-shell morphology and the formed bimetallic heterostructure,Co_(9)S_(8)@ReS_(2)exhibits excellent catalytic OER *** 10 mA/cm^(2),only 288 mV of overpotential is required with the Tafel slope of 73.3 mV/dec for Co_(9)S_(8)@ReS_(2),which are both lower than that of Co_(9)S_(8)and ReS_(2).Meanwhile,Co_(9)S_(8)@ReS_(2)exhibits high catalytic stability and low charge transfer resistance and the boosted active sites are confirmed by density functional *** work provides a rational design of the OER catalysts by constructing the bimetallic heterostructure.

关键词： Oxygen evolution reaction Rhenium disulfide Metal-organic framework Heterostructure Core-shell

RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo ho-Pui ho Yuchao Li Longqing Cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and *** is also an emerging omics technique for metabolic profiling to shape precision ***,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is *** Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information ***,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral *** can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human *** experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established *** this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint *** precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse *** scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

Apple polyphenol phloretin inhibits type II glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer

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Food Science and Human Wellness 2024年

作者： Han-Sheng Chang Tzu-Chun Cheng Shih-Hsin Tu pei-Han Liao Yu-Ching Lee Chi-Tang ho Min-Hsiung Pan Li-Ching Chen Yuan-Soon ho Department of Biological Science & Technology， College of Life Sciences， China Medical University Institute of Biochemistry and Molecular Biology， College of Life Sciences， China Medical University Department of Surgery， School of Medicine， College of Medicine， Taipei Medical University Research Center of Cancer Translational Medicine， Taipei Medical University Department of Food Science， Rutgers University New Jersey， USA Institute of Food Sciences and Technology， Taiwan University

This study presents novel findings on the potential of phloretin， an apple polyphenol， to enhance the effectiveness of anti-HER2 antibody therapy in HER2-positive breast cancer patients. Our research reveals that phloretin inhibits type II glucose transporter (GLUT2) activity， significantly reducing cancer cell glucose uptake. We confirmed the overexpression of GLUT1 and GLUT2 mRNA in paired human breast tumor tissues， with GLUT2 overexpression associated explicitly with poorer survival rates in breast cancer patients. Treatment with phloretin was observed to increase the interaction between GLUT2 and HER2 proteins， attenuate glycolysis， and enhance the binding affinity of anti-HER2 antibody drugs to target human breast cancer cells. Furthermore， the efficacy of the combination therapy involving phloretin and antibody drugs was reaffirmed in a cell-derived xenograft (CDX) tumor animal model， particularly in suppressing the growth of Trastuzumab-resistant HER2+ breast cancer. These significant findings suggest that targeting GLUT2 activity with phloretin in combination with anti-HER2 antibody drugs may help mitigate the development of drug-resistant breast cancer， offering valuable insights for enhancing tumor treatment strategies and contributing to developing more effective therapies.

关键词：

Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study

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World Journal of Diabetes 2024年第10期15卷 2111-2122页

作者： Lan-Gen Zhuang Rong Zhang Guo-Xi Jin Xiao-Yan pei Qiong Wang Xiao-Xu Ge Department of Endocrinology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233004Anhui ProvinceChina Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrinology Tongren Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200336China

BACKGROUND Diabetic nephropathy(DN)is a severe microvascular complication of diabetes characterized by inflammation,oxidative stress,and renal ***(AC)exhibits anti-inflammatory,antioxidant,and anti-fibrotic properties,suggesting potential therapeutic benefits for *** study aimed to investigate the protective effects of AC against DN and elucidate the underlying mechanisms involving the nuclear factor erythroid 2-related factor 2(NRF2)/heme oxygenase-1(ho-1)antioxidant *** The effects of AC on high glucose(HG)-induced proliferation,inflammation,oxidative stress,and fibrosis were evaluated in rat glomerular mesangial cells(HBZY-1)in vitro.A streptozotocin-induced DN rat model was established to assess the in vivo impact of AC on renal injury,inflammation,oxidative stress,and *** involvement of the NRF2/ho-1 pathway was examined using pharmacological inhibition studies in the cell *** AC inhibited HG-induced HBZY-1 cell proliferation and significantly improved various indicators of DN in rats,including reduced body weight,and elevated blood glucose,serum creatinine,blood urea nitrogen,and 24-h urine *** in vitro and in vivo studies demonstrated that AC decreased inflammation and oxidative stress by reducing interleukin(IL)-6,IL-8,tumor necrosis factor-alpha,reactive oxygen species,and malondialdehyde levels while increasing superoxide dismutase ***,AC suppressed the expression of fibrogenic markers such as collagen I,collagen IV,and *** activated NRF2 expression in the nucleus and increased ho-1 and NAD(P)H dehydrogenase(Quinone)1 protein expression in renal tissues and HG-induced HBZY-1 *** AC improves DN by reducing inflammation,oxidative stress,and fibrosis through the activation of the NRF2/ho-1 signaling *** findings not only highlight AC as a promising therapeutic candidate for DN but also underscore the potential of targeting the NRF2/ho-1 pathway in

关键词： Asiaticoside Diabetic nephropathy Inflammation Renal fibrosis Reactive oxygen species

Effect of substrate bias on microstructure and tribological performance of GLC films using hybrid HIPIMS technique

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中国有色金属学会会刊：英文版 2012年第S3期22卷 740-744页

作者： ZHANG Xue-qian KE pei-ling WANG Ai-ying HUANG Mei-dong Kwang ho KIM Ningbo Key Laboratory of Marine Protection Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of Sciences College of Physics and Electronic Information Tianjin Normal University National Core Research Center for Hybrid Materials Solution Pusan National University

The Cr-doped hydrogen-GLC films were prepared by a hybrid magnetron sputtering system composed of a direct current magnetron sputtering (DC-MS) source of carbon and a high power impulse magnetron sputtering (HIPIMS) source of Cr with reactive gas of *** hydrogen-free GLC and Cr-doped GLC films were also prepared for *** influence of substrate bias on the Cr-doped hydrogen-GLC films was *** the increase of substrate bias from 100 V to 250 V,the re-sputtering of weak bonding sp2 firstly occurred and induced an increased sp3 ***,the following sp3 to sp2 transformation resulted in a decreased sp3 *** change trends of surface roughness and friction coefficient with the increased bias voltages were the same as those of sp3 *** lowest surface roughness and lowest friction coefficient corresponded to the highest sp3 with the Cr-GLC-H films at the bias voltage of-100 V.

关键词： graphite-like carbon high power impulse magnetron sputtering substrate bias microstructure tribological behavior

A Novel Application of the Pulsed Nitrogen Discharge in the Synthesis of Aluminum Nitride Powder by Laser Ablation

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Chinese Physics Letters 1997年第12期14卷 953-956页

作者： WANG pei-nan Pan Qi Cheung Nai-ho Chen Shu-Chi State Key Joint Laboratory for Materials Modification by Triple Beams Department of PhysicsFudan UniversityShanghai 200433 Departnient of Physics Hong Kong Baptist UniversityHong Kong

Pulsed discharge of nitrogen was applied in the laser ablation synthesis of aluminum nitride powder to provide more atomic *** high concentration of aluminum nitride was then *** nitrogen discharge plasma was studied ... 详细信息

关键词： spectroscopy Application nitride

Primary lung cancer with radioiodine avidity: A thyroid cancer cohort study

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World Journal of Clinical Cases 2021年第1期9卷 71-80页

作者： Yu-Ling Lu szu-Tah Chen Tsung-Ying ho Wen-Hui Chan Richard J Wong Chuen Hsueh Shu-Fu Lin Department of Internal Medicine New Taipei Municipal TuCheng HospitalNew Taipei City 236Taiwan Department of Internal Medicine Chang Gung Memorial HospitalTaoyuan 333Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Nuclear Medicine Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalTaoyuan 333Taiwan Institute for Radiological Research College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNY 10065United States Department of Pathology Chang-Gung Memorial HospitalTaoyuan 333Taiwan

BACKGROUND A proportion of lung cancers show sodium/iodide symporter(NIS)*** cancers with NIS expression may uptake radioiodine(RAI)and show RAIavid lesions on RAI scan for differentiated thyroid cancer(DTC)*** To investigate the possibility of RAI uptake by lung cancer in a cohort with thyroid *** RAI-avid lung cancers were analyzed using a prospectively maintained database of patients with thyroid cancer who were registered at a medical center between December 1,1976 and May 28,*** expression in lung cancer was assessed using immunohistochemical *** Of the 5000 patients with thyroid cancer from the studied dataset,4602 had *** follow-up,33 patients developed primary lung *** these patients,nine received an iodine-131(131I)scan within 1 year before the diagnosis of lung *** of these nine lung cancers was *** expression was evaluated,and three of the eight available lung cancers revealed NIS *** proportions of lung cancer cells with NIS expression were 60%,15%,and 10%.The RAI-avid lung cancer had the highest level of expression(60%).The RAI-avid lung cancer had a spiculated border upon single-photon emission computed tomography/computed tomography,which led to an accurate *** A proportion of lung cancer demonstrates NIS expression and is *** should be aware of this possibility in the interpretation of RAI scintigraphy.

关键词： Lung cancer Radioiodine Thyroid cancer Adenocarcinoma Sodium/iodide symporter

珠三角夏秋转换季臭氧污染成因及前体物减排策略分析

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环境科学 2024年第10期45卷 5695-5705页

作者：尉晴晴杨威强裴成磊王新明广东轻工职业技术学院轻化工技术学院广州510300 广东省环境科学研究院广州510045 粤港澳生态环境科学中心大气光化学联合研究实验室广州510045 中国科学院广州地球化学研究所有机地球化学国家重点实验室广州510640 广东省广州生态环境监测中心站广州510060

为分析夏秋转换季珠三角地区臭氧(O_(3))污染成因及防控策略,以珠三角中心城市广州为例,在综合观测基础上,使用盒子模型分析O_(3)生消路径及减排方案.结果表明,观测期间呈静稳气象条件且温度偏高,非常适宜O_(3)的二次生成,并导致出现大... 详细信息

为分析夏秋转换季珠三角地区臭氧(O_(3))污染成因及防控策略,以珠三角中心城市广州为例,在综合观测基础上,使用盒子模型分析O_(3)生消路径及减排方案.结果表明,观测期间呈静稳气象条件且温度偏高,非常适宜O_(3)的二次生成,并导致出现大范围长时间O_(3)污染.芳香烃类物质对O_(3)生成潜势(OFP)贡献最大,间/对-二甲苯、甲苯和邻-二甲苯是对OFP贡献最大的挥发性有机物(VOCs)物种.盒子模型分析发现污染期间O_(3)平均净生成速率为23.2×10^(-9) h^(-1),峰值可高达39.2×10^(-9) h^(-1);ho_(2)·+NO和NO_(2)+·OH反应途径分别对本地光化学O_(3)生成(51.2%)和去除(47.0%)贡献率最大,观测O_(3)体积分数受本地光化学O_(3)生成和以输出性为主的传输共同控制.相对增量反应活性(RIR)和经验动力学模型曲线(EKMA)分析可知,夏秋转换季广州市O_(3)生成主要受VOCs控制,芳香烃类对O_(3)生成敏感性最大,其中甲苯、间/对-二甲苯、邻-二甲苯、正丁烷和丙烯是影响O_(3)生成的5大关键组分.削减情景分析表明,单独减少人为源VOCs排放最有利降低O_(3)体积分数,但若在减排人为源VOCs后再强化NO_(x)排放管控,则会使O_(3)体积分数短时反弹,结果表明实施以VOCs减排为主的VOCs和NO_(x)协同减排策略才能使未来O_(3)体积分数持续降低.

关键词：珠三角(PRD) 盒子模型臭氧(O_(3))成因挥发性有机物(VOCs) 减排分析