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In vitro and in vivo proves of concept for the use of a chemically cross-linked poly(ester-urethaneurea)scaffold as an easy handling elastomeric biomaterial for bone regeneration

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Regenerative Biomaterials 2019年第6期6卷 311-323页

作者： Geraldine Rohman sylvie changotade Sophie Frasca Salah Ramtani Anne Consalus Credson Langueh Jean-Marc Collombet Didier Lutomski Universite Paris 13 Sorbonne Paris CiteTissue Engineering and Proteomics(TIP)TeamCSPBATUMR CNRS 724474 rue Marcel Cachin93000 BobignyFrance Departement Soutien Medico-Chirurgical des Forces(SMCF) BP73Institut de Recherche Biomedicale des Armees(IRBA)91223 Bretigny-sur-Orge CedexFrance UniversiteParis 13 Sorbonne Paris CiteLBPS TeamCSPBATUMR CNRS 724499 Avenue Jean-Baptiste Clement93430 VilletaneuseFrance

Bone loss can occur as a result of various pathologies,traumas and injuries and poor bone healing leads to functionally debilitating condition,loss of self-sufficiency and deterioration in life *** the increasing incidence of facial trauma and the emergence of new procedural techniques,advanced scaffolds are currently developed as substitutes for bone tissue *** this study,we investigated the capability of a chemically cross-linked e-caprolactone-based poly(esterurethane-urea)(PCLU)scaffold to support bone *** vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold ***,PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement,and allowed osteogenic differentiation under appropriate *** vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in *** histology and microtomography analysis,we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed ***,no sign of inflammation or rejection was *** envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.

关键词： bone regeneration scaffold elastomer PEUU PCLU

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Heparan-mimetics:Potential agents of tissue regeneration for bone and periodontal therapies

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Medicine in Novel Technology and Devices 2021年第3期11卷 1-10页

作者： Maroun Bou Karam Joe El Khoury Carole Chakar sylvie changotade Didier Lutomski Nada Naaman Gaston Godeau Abdellatif Elm’selmi Ronald Younes Karim Senni Craniofacial Research Laboratory Faculty of Dental MedicineSaint Joseph University of BeirutLebanon Department of Periodontology Faculty of Dental MedicineSaint Joseph University of BeirutLebanon Universite Sorbonne Paris Nord Unite de Recherche Biomateriaux Innovants et InterfacesURB2IUR 4462F-93000BobignyFrance Universite de Paris F-92049MontrougeFrance EBInnov School of Industrial Biology-EBICergyFrance Department of Oral Surgery Faculty of Dental MedicineSaint Joseph University of BeirutLebanon

Heparan sulfate glycosaminoglycans are key players of tissue repair and can be regarded as useful compounds for regenerative ***,their therapeutic uses face many technical,industrial,and regulatory hurdles due to their animal ***,some non-animal sulfated polysaccharides mimic heparan sulfate properties and offer interesting solutions to replace *** them,dextran derivatives,seaweed polysaccharides,or marine bacterial polysaccharides are the best known and have demonstrated their pro-regenerative capabilities by promoting both extracellular matrix structuring and angiogenesis and limiting degenerative processes such as inflammatory cell migration or tissue *** polysaccharides have also shown their ability to specifically promote osteoblastic differentiation and bone wound ***,recent works shows that heparan-mimetics can be used as an additive to improve the cytocompatibility of bone substitutes commonly used in periodontal *** use of these polysaccharides can be regarded as a clever approach to improve the biointegration of bone substitutes.

关键词： Bone biomaterials Periodontal surgery Heparan-mimetics Marine biotechnology Dextran derivatives Bacterial exopolysaccharides Fucoidans

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