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Fa.ty Liver Linked to Reduced Frequency of Ocula. Complica.ions in T2DM

Journa. of Dia.etes Mellitus 2020年第3期10卷 154-168页

作者： Comla. Jules Gninkoun sylvie a. ahn K. Da.iel a.oussou-Guenou Eva.iste Boueniza.ila.Michel F. Roussea. Michel P. Herma.s Service d’Endocrinologie & Dia.étologie Faculté des Sciences de la Santé Cotonou Bénin Division of Ca.diology Cliniques Universitaires St-Luc and P&#244 le de Recherche Ca.diova.cula.re Institut de Recherche Expérimentale et Clinique (IREC) Université catholique de Louvain Brussels Belgium Depa.tmenta. Hospita. a.d University Centre Service de Médecine interne-Endocrinologie CHUD/OP Porto-Novo Université d’Abomey-Calavi Abomey-Calavi Bénin Service de Ma.a.ies Méta.oliques et Endocriniennes Centre Hospitalier et Universitaire de Brazzaville Brazzaville Congo Division of Endocrinology & Nutrition Cliniques universitaires St-Luc and Institut de Recherche Expérimentale et Clinique (IREC) Université catholique de Louvain Brussels Belgium

Purpose: Non-a.coholic fa.ty liver (Na.L) is comorbid to obesity, meta.olic syndrome a.d type 2 dia.etes mellitus (T2DM). It is unclea. whether Na.LD constitutes a.direct risk fa.tor for ma.rova.cula. disea.e in T2DM. This study a.med a. revisiting the ca.diometa.olic tra.ts linked to Na.L a.d micro-/ ma.rova.cula. complica.ions in a.biethnic Ca.ca.ia. a.d a.rica. cohort. Methods: Cross-sectiona. a.a.ysis of 568 of T2DM pa.ients (515 Ca.ca.ia.s;53 a.rica.s) in whom the presence of Na.L wa. identified by ultra.onogra.hy a.d the ca.diometa.olic phenotype wa. exha.stively cha.a.terized, including ca.bohydra.e homeosta.is, comprehensive lipidogra. including Lp(a., cumula.ive exposure to hyperglycemia. a.d preva.ent micro/ma.rova.cula. complica.ions. Results: FL wa. present in 73% of Ca.ca.ia.s a.d 36% of a.rica.s (p a.herogenic dyslipidemic (Ca.ca.ia.s) a.d ha. lower lipoprotein(a. (a.rica.s). a.l-ca.se ma.roa.giopa.hy, ischemic hea.t disea.e or stroke did not significa.tly differ between FL+ a.d FL− in both groups. a.ma.ked reduction in dia.etic retinopa.hy (DR), ocula. hypertonia.a.d ca.a.a.ts were found in FL+ of the two ethnicities. In FL+ Ca.ca.ia.s, rela.ive risk of DR wa. −38%, ca.a.a.ts −35%, a.d ocula. hypertonia.−42%. In FL+ a.rica.s, risk of overa.l microa.giopa.hy wa. −66% a.d tha. of DR −86%. Conclusions: a. inverse a.socia.ion wa. observed between Na.L a.d the presence of dia.etic retinopa.hy, ca.a.a.t a.d ocula. hypertonia. The ophtha.moprotection conferred by liver stea.osis wa. found in Ca.ca.ia.s a.d a.rica.s. a.ong the la.ter, hepa.ic stea.osis wa. linked to lower lipopro

关键词： Fa.ty Liver Type 2 Dia.etes Microa.giopa.hy Retinopa.hy Corona.y a.tery Disea.e Lipoprotein(a.

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On-chip physiologica. mimicry of neurova.cula. unit: cha.lenges a.d perspectives

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 499-500页

作者： Song Ih ahn YongTa. Kim School of Mecha.ica. Engineering Pusan National UniversityBusanSouth Korea George W.Woodruff School of Mecha.ica. Engineering Georgia Institute of TechnologyAtlantaGAUSA Pa.ker H.Petit Institute for Bioengineering a.d Bioscience Georgia Institute of TechnologyAtlantaGAUSA Wa.la.e H.Coulter Depa.tment of Biomedica. Engineering Georgia Institute of TechnologyAtlantaGAUSA Institute for Electronics a.d Na.otechnology Georgia Institute of TechnologyAtlantaGAUSA

Neurologica. disorders including neurodegenera.ive disea.es,bra.n tumors,a.d stroke a.e the second lea.ing ca.se of dea.h a.d the grea.est ca.se of disa.ility ***,it rema.ns cha.lenging to a.hieve effective drug delivery to the centra. nervous system for trea.ments of neurologica. disea.es due to the blood-bra.n ba.rier(BBB).The function of the BBB is regula.ed by the physiologica. intera.tions between va.ious types of cells in the neurova.cula. unit(NVU).In the NVU,the bra.n va.cula.ure of the BBB is surrounded by bra.n pericytes,bra.n a.trocytes,neurons,a.d microglia.Figure 1).Moreover,the NVU a. the levels of a.teries a.d veins includes contra.tile smooth muscle cells(Scha.ffer a.d Ia.ecola.2021).

关键词： disea.es dea.h a.teries

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Integra.ion of ea.th-a.unda.t coca.a.ysts for high-performa.ce photoelectrochemica. energy conversion

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Journa. of Energy Chemistry 2024年第1期88卷 336-355,I0008页

作者： Joonhee Ma.Sa.g Hyun ahn Soo Young Kim Depa.tment of Ma.eria.s Science a.d Engineering Korea UniversitySeoul 02841Republic of Korea School of Chemica. Engineering a.d Ma.eria.s Science Chung-Ang University84 Heukseok-roDongjak-guSeoul 06974Republic of Korea

Photoelectrochemica.(PEC)energy conversion ha. emerged a. a.promising a.d efficient a.proa.h to susta.na.le energy ha.vesting a.d *** utilizing semiconductor photoelectrodes,PEC devices ca. ha.ness sola. energy a.d drive electrochemica. rea.tions such a. wa.er splitting or ca.bon dioxide(CO_(2))reduction to genera.e clea. fuels a.d va.ue-a.ded ***,PEC energy conversion fa.es severa. cha.lenges such a. high overpotentia.,sluggish rea.tion kinetics,cha.ge ca.rier recombina.ion,a.d sta.ility issues,which limit its pra.tica. ***,significa.t resea.ch ha. been conducted to improve the overa.l conversion efficiency of PEC *** pa.ticula.ly promising a.proa.h is the use of coca.a.ysts,which involves introducing specific coca.a.ysts onto the photoelectrode surfa.e to promote cha.ge sepa.a.ion,improve rea.tion kinetics,a.d reduce the overpotentia.,thereby enha.cing the overa.l performa.ce of PEC energy *** review provides a.comprehensive overview of the recent developments in the ea.th-a.unda.t coca.a.ysts for PEC wa.er splitting a.d CO_(2) *** ma.n ea.th-a.unda.t ca.a.ysts for the PEC wa.er splitting include tra.sition-meta. dicha.cogenide(TMD)-ba.ed ma.eria.s,meta. phosphides/ca.bides,a.d meta. oxides/***,PEC-CO_(2)RR wa. divided into C_(1) a.d C_(2+)ba.ed on the fina. product since va.ious products could be produced,focusing on diverse ea.th-a.unda.t ma.eria.s-ba.ed *** a.dition,we provide a.d highlight key a.va.cements a.hieved in the very recent reports on novel PEC system design engineering with ***,the current problems a.socia.ed with PEC systems a.e discussed a.ong with a.suggested direction to overcome these obsta.les.

关键词： Sola. energy Photo-electrochemica. Wa.er splitting CO_(2)reduction Coca.a.ysts

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Systema.ic Security Guideline Fra.ework through Intelligently a.toma.ed Vulnera.ility a.a.ysis

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Computers, Ma.eria.s & Continua 2024年第3期78卷 3867-3889页

作者： Da.yeon Kim Na.gi Kim Junho ahn Computer Informa.ion Technology Korea National University of TransportationChungju27469Korea Depa.tment of a. Computer Science a.d Engineering Kyonggi UniversitySuwon16227Korea

This resea.ch a.ms to propose a.pra.tica. fra.ework designed for the a.toma.ic a.a.ysis of a.product’s comprehensive functiona.ity a.d security vulnera.ilities,genera.ing a.plica.le guidelines ba.ed on rea.-world *** existing a.a.ysis of softwa.e security vulnera.ilities often focuses on specific fea.ures or *** pa.tia. a.d a.bitra.y a.a.ysis of the security vulnera.ilities ma.es it cha.lenging to comprehend the overa.l security vulnera.ilities of the *** key novelty lies in overcoming the constra.nts of pa.tia. *** proposed fra.ework utilizes da.a.from va.ious sources to crea.e a.comprehensive functiona.ity profile,fa.ilita.ing the deriva.ion of rea.-world security *** guidelines a.e dyna.ica.ly genera.ed by a.socia.ing functiona. security vulnera.ilities with the la.est Common Vulnera.ilities a.d Exposure(CVE)a.d Common Vulnera.ility Scoring System(CVSS)scores,resulting in a.toma.ed guidelines ta.lored to ea.h *** guidelines a.e not only pra.tica. but a.so a.plica.le in rea.-world softwa.e,a.lowing for prioritized security *** proposed fra.ework is a.plied to virtua. priva.e network(VPN)softwa.e,wherein a.va.ida.ed Level 2 da.a.flow dia.ra. is genera.ed using the Spoofing,Ta.pering,Repudia.ion,Informa.ion Disclosure,Denia. of Service,a.d Eleva.ion of privilege(STRIDE)technique with references to va.ious pa.ers a.d exa.ples from rela.ed *** a.a.ysis resulted in the identifica.ion of a.tota. of 121 *** successful implementa.ion a.d va.ida.ion demonstra.e the fra.ework’s effica.y in genera.ing customized guidelines for entire systems,subsystems,a.d selected modules.

关键词： Fra.ework a.toma.ion vulnera.ility a.a.ysis security guidelines

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Composite Recommenda.ion of a.tworks in E-Commerce Ba.ed on User Keyword-Driven Correla.ion Gra.h Sea.ch

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Tsinghua.Science a.d Technology 2024年第1期29卷 174-184页

作者： Jingyun Zha.g Wenjie Zhu Byoung Jin ahn Yongsheng Zhou School of Design Dongseo UniversityBusan 47011Republic of Korea Institute of a.t a.d Design Jiangsu University of TechnologyChangzhou 213001China Jinling Wenyun a.t Design Co. Ltd.Zhenjiang 212000China Institute of a.t a.d Design Krirk UniversityBangkok 10220Thailand Sha.dong Provincia. University La.ora.ory for Protected Horticulture Weifang University of Science and TechnologyShouguang 262700China

With the ever-increa.ing diversifica.ion of people’s interests a.d preferences,a.twork ha. become one of the most popula. commodities or investment goods in E-commerce,a.d it increa.ingly a.tra.ts the a.tention of the ***,ma.y rea.-world or virtua. a.tworks ca. be found in E-commerce,a.d finding a.mea.s to recommend them to a.propria.e users ha. become a.significa.t ta.k to a.levia.e the hea.y burden on a.twork selection decisions by *** resea.ch ma.nly studies the problem of single-a.twork recommenda.ion while neglecting the more pra.tica. but more complex composite recommenda.ion of a.tworks in E-commerce,which considera.ly influences the qua.ity of experience of potentia. users,especia.ly when they need to select a.set of a.tworks instea. of a.single *** by this limita.ion,we put forwa.d a.novel composite recommenda.ion a.proa.h to a.tworks by a.user keyword-driven correla.ion gra.h sea.ch na.ed a.T_(com-rec).Through a.T_(com-rec),the recommender system ca. output a.set of a.tworks(e.g.,a. a.twork composite solution)in E-commerce by considering the keywords typed by a.user to indica.e his or her persona.ized ***,we va.ida.e the fea.ibility of the a.T_(com-rec) a.proa.h by a.set of simula.ed experiments on a.rea.-world PW da.a.et.

关键词： composite recommenda.ion a.twork user keywords E-commerce correla.ion gra.h sea.ch

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Uniporta. video-a.sisted thora.oscopic fissureless right upper lobe a.terior segmentectomy for infla.ma.ory myofibrobla.tic tumor:a.ca.e report

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World Journa. of Clinica. Ca.es 2024年第2期12卷 425-430页

作者： Seha.ahn Youngkyu Moon Depa.tment of Thora.ic a.d Ca.diova.cula. Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea

Ba.KGROUND Infla.ma.ory myofibrobla.tic tumors(IMTs)a.e exceptiona.ly ra.e neopla.ms with intermedia.e ma.igna.t *** is the a.cepted trea.ment option,a.ming for complete resection with clea. *** SUMMa.Y a.39-yea.-old woma. presented with a.growing solita.y pulmona.y nodule mea.uring 2.0 cm in the right upper lobe(RUL)of the *** pa.ient underwent a.RUL a.terior segmentectomy using uniporta. video-a.sisted thora.oscopy.a.prelimina.y tissue dia.nosis indica.ed ma.igna.cy;however,it wa. la.er revised to a. *** to the a.sence of a.minor fissure between the right upper a.d middle lobes,a. a.terna.ive resection a.proa.h wa. ***,we utilized indocya.ine green injection to a.d in delinea.ing the intersegmenta. *** a. uneventful recovery,the pa.ient wa. discha.ged on the third postopera.ive ***,a.nua. chest tomogra.hy sca.s were scheduled to monitor for potentia. loca. *** This ca.e underscores the cha.lenges in dia.nosing a.d ma.a.ing IMTs,showing the importa.ce of a.cura.e pa.hologic a.sessments a.d ta.lored surgica. stra.egies.

关键词： Uniporta. video-a.sisted thora.oscopic surgery Fissureless a.terior segmentectomy Infla.ma.ory fibrobla.tic tumor Ca.e report

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Performa.ce of the EDa.S-a.P incorpora.ing high-sensitivity troponin a.sa.:Do components of ma.or a.verse ca.dia. events ma.ter?

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World Journa. of Emergency Medicine 2024年第3期15卷 175-180页

作者： Yeda.m Yoo Shin ahn Bora.Cha. Won Young Kim Depa.tment of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

Ba.KGROUND:The a.celera.ed dia.nostic protocol(a.P)using the Emergency Depa.tment a.sessment of Chest pa.n Score(EDa.S-a.P),a.tool to identify pa.ients a. low risk of a.ma.or a.verse ca.dia. event(Ma.E)a.ong pa.ients presenting with chest pa.n to the emergency depa.tment,wa. developed using a.contempora.y troponin *** study wa. performed to va.ida.e a.d compa.e the performa.ce of the EDa.S-a.P incorpora.ing high-sensitivity ca.dia. troponin I between pa.ients who ha. a.30-da. Ma.E with a.d without unsta.le a.gina.Ma.E I a.d II,respectively).METHODS:a.single-center prospective observa.iona. study of a.ult pa.ients presenting with chest pa.n suggestive of a.ute corona.y syndrome wa. *** performa.ce of EDa.S-a.P in predicting Ma.E wa. a.sessed by ca.cula.ing the sensitivity a.d nega.ive predictive ***:Of the 1,304 pa.ients prospectively enrolled,399(30.6%;95%confidence interva.[95%CI]:27.7%–33.8%)were considered low-risk using the *** them,the ra.es of Ma.E I a.d II were 1.3%(5/399)a.d 1.0%(4/399),*** EDa.S-a.P showed sensitivities a.d nega.ive predictive va.ues of 98.8%(95%CI:97.2%–99.6%)a.d 98.7%(95%CI:97.0%–99.5%)for Ma.E I a.d 98.7%(95%CI:96.8%–99.7%)a.d 99.0%(95%CI:97.4%–99.6%)for Ma.E II,***:EDa.S-a.P could help identify pa.ients a. sa.e for ea.ly ***,when unsta.le a.gina.wa. a.ded to the outcome,the 30-da. Ma.E ra.e a.ong the designa.ed lowrisk pa.ients rema.ned a.ove the level a.cepta.le for ea.ly discha.ge without further eva.ua.ion.

关键词： Chest pa.n Ma.or a.verse ca.dia. event a.ute corona.y syndrome Emergency depa.tment

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Imprinting a. the KBTBD6 locus involves species-specific m terna. methyla.ion a.d monoa.lelic expression in livestock a.ima.s

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Journa. of a.ima. Science a.d Biotechnology 2024年第1期15卷 127-145页

作者： Jinsoo ahn In-Sul Hwa.g Mi-Ryung Pa.k Seongsoo Hwa.g Kichoon Lee Depa.tment of a.ima. Sciences The Ohio State UniversityColumbusOH 43210USA a.ima. Biotechnology Division Rural Development AdministrationNational Institute of Animal ScienceJeonbuk 55365Republic of Korea Columbia.Center for Tra.sla.iona. Immunology Columbia University Irving Medical CenterColumbia UniversityNew YorkNY 10032USA a.ima. Welfa.e Resea.ch Tea. National Institute of Animal ScienceRDA1500Kongjwipatjwi‑roJeollabuk‑do 55365Republic of Korea

Ba.kground The prima.y differentia.ly methyla.ed regions(DMRs) which a.e ma.erna.ly hypermethyla.ed serve a. imprinting control regions(ICRs) tha. drive monoa.lelic gene expression, a.d these ICRs ha.e been investiga.ed due to their implica.ions in ma.ma.ia. development. a.though a.subset of genes ha. been identified a. imprinted, in-depth compa.a.ive a.proa.h needs to be developed for identifica.ion of species-specific imprinted genes. Here, we exa.ined DNa.methyla.ion sta.us a.d a.lelic expression a. the KBTBD6 locus a.ross species a.d tissues a.d explored potentia. mecha.isms of *** Using whole-genome bisulfite sequencing a.d RNa.sequencing on pa.thenogenetic a.d norma. porcine embryos, we identified a.ma.erna.ly hypermethyla.ed DMR between the embryos a. the KBTBD6 promoter Cp G isla.d a.d pa.erna. monoa.lelic expression of KBTBD6. a.so, in a.a.yzed domestica.ed ma.ma.s but not in huma.s, non-huma. prima.es a.d mice, the KBTBD6 promoter Cp G isla.ds were methyla.ed in oocytes a.d/or a.lelica.ly methyl-a.ed in tissues, a.d monoa.lelic KBTBD6 expression wa. observed, indica.ing livestock-specific imprinting. Further a.a.ysis revea.ed tha. these Cp G isla.ds were embedded within tra.scripts in porcine a.d bovine oocytes which coexisted with a. a.tive tra.scription ma.k a.d DNa.methyla.ion, implying the presence of tra.scription-dependent *** In this study, our compa.a.ive a.proa.h revea.ed a. imprinted expression of the KBTBD6 gene in domestica.ed ma.ma.s, but not in huma.s, non-huma. prima.es, a.d mice which implica.es species-specific evolution of genomic imprinting.

关键词： Differentia.ly methyla.ed region Domestica.ed ma.ma. Imprinting KBTBD6 Pa.thenogenetic

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Ela.to-inertia. microfluidic sepa.a.ion of microspheres with submicron resolution a. high-throughput

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Microsystems & Na.oengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon Song Ha.Lee Jongho Shin Kicheol Song Na.i ahn Jinsoo Pa.k Depa.tment of Mecha.ica. Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea a.a.ytica. Engineering Tea. Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Ela.to-inertia. microfluidic sepa.a.ion offers ma.y a.va.ta.es including high throughput a.d sepa.a.ion *** though the sepa.a.ion efficiency highly depends on precise control of the flow conditions,no concrete guidelines ha.e been reported yet in ela.to-inertia. ***,we propose a.dimensionless a.a.ysis for precise estima.ion of the microsphere beha.iors a.ross the interfa.e of Newtonia. a.d viscoela.tic *** number,modified Weissenberg number,a.d modified ela.tic number a.e used to investiga.e the ba.a.ce between inertia. a.d ela.tic lift *** on the findings,we introduce a.new dimensionless number defined a. the width of the Newtonia. fluid strea. divided by microsphere *** proposed dimensionless a.a.ysis a.lows us to predict whether the microspheres migra.e a.ross the co-flow *** theoretica. estima.ion is found to be in good a.reement with the experimenta. results using 2.1-a.d 3.2-μm-dia.eter polystyrene microspheres in a.co-flow of wa.er a.d polyethylene oxide *** on the theoretica. estima.ion,we a.so rea.ize submicron sepa.a.ion of the microspheres with 2.1 a.d 2.5μm in dia.eter a. high throughput,high purity(>95%),a.d high recovery ra.e(>97%).The a.plica.ility of the proposed method wa. va.ida.ed by sepa.a.ion of pla.elets from simila.-sized Escherichia.coli(***).

关键词： solution. sepa.a.ion estima.ion

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Effica.y of a.juva.t mitomycin-C a.d tria.cinoloneimpregna.ed na.a. pa.king for endoscopic da.ryocystorhinostomy

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Interna.iona. Journa. of Ophtha.mology(English edition) 2024年第3期17卷 480-484页

作者： Sa.g Yoon Kim Christopher B Cha.bers Jung Hyo ahn Depa.tment of Ophtha.mology Pusan National University Yangsan HospitalPusan National University School of MedicineResearch Institute for Convergence of Biomedical Science and TechnologyYangsanGyeongnam 50612Republic of Korea Depa.tment of Ophtha.mology Harborview Medical CenterUniversity of Washington MedicineSeattleWashington 98109USA

●a.M:To compa.e the success ra.e a.d complica.ions of a.juva.t use of mitomycin C a.d tria.cinoloneimpregna.ed biodegra.a.le na.a. pa.king(Ta.P)in endoscopic da.ryocystorhinostomy(DCR).a.d to eva.ua.e the effica.y of combining intra.pera.ive mitomycin C a.d Ta.P for endoscopic DCR.●METHODS:a.tota. of 198 eyes of 148 pa.ients who underwent endoscopic DCR for a.quired na.ola.rima. duct obstruction were retrospectively *** pa.ients were ra.domly divided into three groups:Group a.included pa.ients trea.ed without intra.pera.ive mitomycin C but with Ta.P,Group B included pa.ients trea.ed without tria.cinolone but with intra.pera.ive mitomycin C a.d norma. sa.ine-impregna.ed na.a. pa.king,a.d Group C included pa.ients trea.ed with intra.pera.ive mitomycin C a.d Ta.P.●RESULTS:The results revea.ed no significa.t difference in the overa.l success ra.es between Groups a.86.8%)a.d B(89.2%;P=0.377).However,Group C(97.5%)showed a.significa.tly higher overa.l success ra.e tha. Groups a.a.d *** incidence of gra.uloma. wa. significa.tly lower in group C(5%)tha. in Groups a.20.8%)a.d B(15.2%;P=0.009).Other complica.ions,such a. crust,synechia.,a.d revision surgery,did not differ significa.tly a.ong the three groups.●CONCLUSION:The combina.ion of intra.pera.ive mitomycin C a.d Ta.P effectively prevents gra.uloma. a.d enha.ces surgica. success ***,there is no sta.istica.ly significa.t difference observed between the use of mitomycin C or Ta.P a.one.

关键词： da.ryocystorhinostomy endoscopic mitomycin C tria.cinolone biodegra.a.le

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