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Morpholine hydrazone scaffold： Synthesis, anticancer activity and docking studies

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Chinese Chemical Letters 2017年第3期28卷 607-611页

作者： muhammad Taha syed Adnan Ali Shah muhammad Afifi Manar Zulkeflee Sadia Sultan Abdul Wadood Fazal rahim Nor Hadiani Ismail Atta-ur-Rahman Institute for Natural Product Discovery (AuRlns) Universiti Teknologi MARA Puncak Alam Campus 42300 Bandar Puncak Alam SelangorD. E. Malaysia Faculty of Applied Science UiTM Shah Alam 40450 Shah Alam Selangor D.E. Malaysia Faculty of Pharrnacy Universiti Teknologi MARA Puncat~ Alam Campus 42300 Baadar Puncak Alam Selangor D.E. Malaysia Department of Biochemistry Abdul Wali Khan University Mardan 23200 Pakistan Department of Chemistry Hazara University Mansehra 21300 Pakistan

In this paper, synthesis and anticancer activities of morpholine hydrazones scaffold（1-17） thoroughly studied. Small series of morpholine hydrazones synthesized by treating 5-morpholinothiophene-2-carbaldehyde with different aryl hydrazides to form morpholine hydrazones scaffold（1-17）. The in vitro anticancer potential of all these compounds was checked against human cancer cell lines like Hep G2（human hepatocellular liver carcinoma） and MCF-7（human breast adenocarcinoma）. Analogs 13 had similar substantial cytotoxic effects towards Hep G2 with IC_（50） value 6.31±1.03μmmol/L when compared with the standard Doxorubicin（IC_（50）value 6.00±0.80μmmol/L）; while compounds 5,8 and 9 showed potent cytotoxicity against MCF-7 with IC_（50） value 7.08±0.42μmmol/L, 1.26±0.34μmmol/L and11.22±0.22μmmol/L respectively when compared with the standard Tamoxifen（IC_（50）= 11.00±0.40μmol/L）. Molecular docking studies also performed to understand the binding interaction.

关键词： Morpholine hydrazones Synthesis HepG2 MCF-7 Molecular docking

Advances and challenges of methanol-tolerant oxygen reduction reaction electrocatalysts for the direct methanol fuel cell

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Journal of Energy Chemistry 2023年第2期77卷 499-513,I0013页

作者： muhammad Aizaz Ud Din muhammad Idrees Sidra Jamil syed Irfan Ghazanfar Nazir muhammad Ahmad Mudassir muhammad Shahrukh Saleem Saima Batool Nanpu Cheng Rahman Saidur School of Materials and Energy Southwest UniversityChongqing 400715China Additive Manufacturing Institute College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060GuangdongChina Chongqing Key Lab for Advanced Materials and Clean Energies of Technologies School of Materials and EnergySouthwest UniversityChongqing 400715China School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808GuangdongChina Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Chemistry Khawaja Fareed University of Engineering and Information TechnologyRahim Yar Khan 64200Pakistan Laboratory for High Performance Ceramics EmpaSwiss Federal Laboratories for Materials Science and Technology8600 DübendorfSwitzerland Institute for Advanced Study Shenzhen UniversityShenzhen 518060GuangdongChina Research Centre for Nano-Materials and Energy Technology School of Engineering and TechnologySunway UniversityBandar SunwayMalaysia Department of Engineering Lancaster UniversityLancasterUnited Kingdom

Methanol cross-over effects from the anode to the cathode are important parameters for reducing catalytic performance in direct methanol fuel cells.A promising candidate catalyst for the cathode in direct methanol fuel cells must have excellent activity toward oxygen reduction reaction and resistance to methanol oxidation *** review focuses on the methanol tolerant noble metal-based electrocatalysts,including platinum and palladium-based alloys,noble metal–carbon based composites,transition metal-based catalysts,carbon-based metal catalysts,and metal-free *** understanding of the correlation between the activity and the synthesis method,electrolyte environment and stability issues are *** the transition metal-based catalyst,their activity,stability and methanol tolerance in direct methanol fuel cells and comparisons with those of platinum are particularly ***,strategies to enhance the methanol tolerance and hinder the generation of mixed potential in direct methanol fuel cells are also *** review provides a perspective for future developments for the scientist in selecting suitable methanol tolerate catalyst for oxygen reduction reaction and designing high-performance practical direct methanol fuel cells.

关键词： Oxygen reducing reaction Methanol tolerant electrocatalyst Portable power sources Direct methanol Fuel cell

Intelligent Cloud Based Load Balancing System Empowered with Fuzzy Logic

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Computers, Materials & Continua 2021年第4期67卷 519-528页

作者： Atif Ishaq Khan syed Asad Raza Kazmi Ayesha Atta muhammad Faheem Mushtaq muhammad Idrees Ilyas Fakir muhammad Safyan muhammad Adnan Khan Awais Qasim Department of Computer Science Government College UniversityLahore54000Pakistan Department of Information Technology Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan Department of Computer Science and Engineering University of Engineering and Technology LahoreNarowal Campus51600Pakistan Department of Computer Science Riphah International University Lahore CampusLahore54000Pakistan

Cloud computing is seeking attention as a new computing paradigm to handle operations more efficiently and *** computing uses dynamic resource provisioning and de-provisioning in a virtualized *** load on the cloud data centers is growing day by day due to the rapid growth in cloud computing *** in cloud computing is one of the fundamental properties,and elastic load balancing automatically distributes incoming load to multiple virtual *** work is aimed to introduce efficient resource provisioning and de-provisioning for better load *** this article,a model is proposed in which the fuzzy logic approach is used for load balancing to avoid underload and overload of resources.A Simulator in Matlab is used to test the effectiveness and correctness of the proposed *** simulation results have shown that our proposed intelligent cloud-based load balancing system empowered with fuzzy logic is better than previously published approaches.

关键词： Cloud computing fuzzy logic load balancing

Energy Cost Minimization Using String Matching Algorithm in Geo-Distributed Data Centers

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Computers, Materials & Continua 2023年第6期75卷 6305-6322页

作者： muhammad Imran Khan Khalil syed Adeel Ali Shah Izaz Ahmad Khan Mohammad Hijji muhammad Shiraz Qaisar Shaheen Department of Computer Science&Information Technology University of Engineering&TechnologyPeshawar25000Pakistan Department of Computer Science Bacha Khan UniversityCharsadda24541Pakistan Computer Science Department University of TabukTabuk47512Saudi Arabia Department of Computer Science Federal Urdu University of ArtsScience and Technology Islamabad44000Pakistan Department of Computer Science and Information Technology The Islamia University of BahawalpurRahim Yar Khan CampusPunjabPakistan

Data centers are being distributed worldwide by cloud service providers(CSPs)to save energy costs through efficient workload alloca-tion *** CSPs are challenged by the significant rise in user demands due to their extensive energy consumption during workload *** research studies have examined distinct operating cost mitigation techniques for geo-distributed data centers(DCs).However,oper-ating cost savings during workload processing,which also considers string-matching techniques in geo-distributed DCs,remains *** this research,we propose a novel string matching-based geographical load balanc-ing(SMGLB)technique to mitigate the operating cost of the geo-distributed *** primary goal of this study is to use a string-matching algorithm(i.e.,Boyer Moore)to compare the contents of incoming workloads to those of documents that have already been processed in a data center.A successful match prevents the global load balancer from sending the user’s request to a data center for processing and displaying the results of the previously processed workload to the user to save *** the contrary,if no match can be discovered,the global load balancer will allocate the incoming workload to a specific DC for processing considering variable energy prices,the number of active servers,on-site green energy,and traces of incoming *** results of numerical evaluations show that the SMGLB can minimize the operating expenses of the geo-distributed data centers more than the existing workload distribution techniques.

关键词： String matching optimization geo-distributed data centers geographical load balancing green energy

Indirect Vector Control of Linear Induction Motors Using Space Vector Pulse Width Modulation

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Computers, Materials & Continua 2023年第3期74卷 6263-6287页

作者： Arjmand Khaliq syed Abdul Rahman Kashif Fahad Ahmad muhammad Anwar Qaisar Shaheen Rizwan Akhtar muhammad Arif Shah Abdelzahir Abdelmaboud Electrical Engineering Department University of Engineering and TechnologyLahore54700Pakistan Department of Basic Sciences Deanship of Common First YearJouf UniversitySakakaAljouf72341Saudi Arabia Department of Information Science Division of Science and TechnologyUniversity of EducationLahore54000Pakistan Department of Computer Science and Information Technology The Islamia University of BahawalpurRahim Yar Khan Sub CampusPakistan Department of IT and Computer Science Pak-Austria Fachhochschule Institute of Applied Sciences and TechnologyHaripurPakistan Department of Information Systems King Khalid UniversityMuhayel Aseer61913Saudi Arabia

Vector control schemes have recently been used to drive linear induction motors(LIM)in high-performance *** trend promotes the development of precise and efficient control schemes for individual *** research aims to present a novel framework for speed and thrust force control of LIM using space vector pulse width modulation(SVPWM)*** framework under consideration is developed in four *** begin,MATLAB Simulink was used to develop a detailed mathematical and electromechanical *** research presents a modified SVPWM inverter control *** tuning the proportional-integral(PI)controller with a transfer function,optimized values for the PI controller are *** the subsystems mentioned above are integrated to create a robust simulation of the LIM’s precise speed and thrust force control *** reference speed values were chosen to evaluate the performance of the respective system,and the developed system’s response was verified using various data *** the low-speed range,a reference value of 10m/s is used,while a reference value of 100 m/s is used for the high-speed *** speed output response indicates that themotor reached reference speed in amatter of seconds,as the delay time is between 8 and 10 *** maximum amplitude of thrust achieved is less than 400N,demonstrating the controller’s capability to control a high-speed LIM with minimal thrust *** to the controlled speed range,the developed system is highly recommended for low-speed and high-speed and heavy-duty traction applications.

关键词： Space vector pulse width modulation linear induction motor proportional-integral controller indirect vector control electromechanical dynamic modeling

Preparation,characterization and thermophysical properties investigation of A70/polyaniline nanocomposite phase change material for medium temperature solar applications

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能源与人工环境(英文) 2021年第3期2卷 271-277页

作者： A.K.Pandey Mathew George Nasrudin Abd rahim V.V.Tyagi syed Shahabuddin R.Saidur Research Centre for Nano-Materials and Energy Technology(RCNMET) School of Science and TechnologySunway UniversityNo.5Jalan UniversitiBandar SunwayPetaling Jaya47500 Selangor Darul EhsanMalaysia Higher Institution Centre of Excellence(HICoE) UM Power Energy Dedicated Advanced Centre(UMPEDAC)Level 4Wisma R&DUniversity of MalayaJalan Pantai Baharu59990 Kuala LumpurMalaysia Renewable Energy Research Group King Abdulaziz UniversityJeddah 21589Saudi Arabia School of Energy Management Shri Mata Vaishno Devi UniversityKatra 182320(J&K)India Department of Science School of TechnologyPandit Deendayal Petroleum UniversityKnowledge CorridorRaisan VillageGandhinagar 382007GujratIndia

The ever-present demand for energy from various application in industrial and domestic processes has led to the consumption of fossil fuel at a rapid rate with adverse effect due to global *** study focuses on the thermal energy storage aspect intended for medium temperature applications.A novel composite A70 and PANI was prepared and *** study investigates the composites thermophysical and optical *** Scanning Calorimetry and Transient Hot Bridge measured thermal storage capacity and thermal conductivity of the composite,*** heat storage capacity of the composite remained stable within 4%whereas a highest rise of 11.96%in thermal conductivity was *** composites thermal,chemical,and physical stability were analysed from Thermogravimetric Analyser,Fourier Infrared Transform,and Scanning Electron Microscope,*** composites were thermally stable up to a temperature of 250°*** chemical reaction occurred between the nanomaterial and base PCM *** microscopic visuals did not show any considerable change in the microscopic structure of the *** the case of optical properties,the composites showed significant reduction in transmittance of solar spectrum with respect to pure *** maximum decrement in transmission was around~89%compared to *** the composite prepared were thermally stable till 250°C,hence may be utilized for solar thermal and low concentrated photovoltaic application but not limited to these.

关键词： Phase change materials Solar energy Thermal conductivity Latent heat Polyaniline

Estimation of Genetic Divergence and Character Association Studies in Local and Exotic Diversity Panels of Soybean(Glycine max L.)Genotypes

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Phyton-International Journal of Experimental Botany 2023年第6期92卷 1887-1906页

作者： syed Ali Zafar muhammad Aslam Haroon Zaman Khan Sehrish Sarwar Rao Saad Rehman Mariam Hassan Ramala Masood Ahmad Rafaqat AGill Basharat Ali Ibrahim Al-Ashkar Abdullah Ibrahim Md Atikur Rahman Ayman El Sabagh Oilseeds Research Institute Ayub Agricultural Research InstituteFaisalabadPakistan Department of Plant Breeding and Genetics University of AgricultureFaisalabadPakistan Department of Agronomy University of AgricultureFaisalabadPakistan College of Plant Science and Technology Huazhong Agricultural UniversityWuhanChina Key Laboratory of Biology and Genetic Improvement of Oil Crops The Ministry of Agriculture and Rural AffairsOil Crops Research Institute of Chinese Academy of Agricultural SciencesWuhan430062China Department of Agricultural Engineering Khwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadhSaudi Arabia Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonanKorea Department of Agronomy Faculty of AgricultureUniversity of KafrelsheikhKafr ElsheikhEgypt

The availability of favorable genetic diversity is a thriving vitality for the success of a breeding *** provides a firm basis of selecting superior breeding lines for the development of high yielding crop *** this context,present investigation aimed to generate information on genetic divergence and character association in a diversity panel of 123 local and exotic soybean *** of variance revealed significant response of the evaluated genotypes based on studied *** depicted the probability of selecting desirable soybean genotypes by focusing on character association studies and genetic diversity *** analysis revealed that seed yield per plant showed high positive correlation with 100-seed weight followed by pods per plant and plant ***,path coefficient analysis exposed that pods per plant had maximum direct contribution in seed yield per plant followed by 100-seed weight,days to flowering and SPAD *** named“G-10”showed maximum yield per plant followed by 24607,G-52,24593,Arisoy,24566,17426,A-3127,24570 and *** diversity analysis grouped the evaluated germplasm into 17 *** clusters showed zero intra-cluster variability;while inter-cluster divergence ranged from 9.00 to *** V showed maximum inter-cluster distance with cluster XII followed by that of between V and ***,cluster IV with superior genotypes(G-10,24607,24593 and 24566),VI(17426 and 24567),XIII(24570)and X(Arisoy and G-52)showed above mean values for most of the studied ***,the results of hybridization between the superior genotypes of these cluster pairs might be useful for soybean breeding with improving agronomic traits and adaptability.

关键词： Genetic variability correlation path analysis genetic diversity analysis soybean selective breeding