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Chemical constituents and anticoagulant activity from Delphinium brunonianum Royle

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未来食品学报(英文) 2024年第3期4卷 241-247页

作者： Changyang Ma Sitan Chen syed Arif hussain Rizvi Huihui Zhou Wenyi Kang Xuefeng Xi Zhenhua Liu National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China Pakistan Agricultural Research Council Islamabad 450000Pakistan College of Physical Education Henan UniversityKaifeng 475004China

Delphinium brunonianum Royle belongs to Ranunculaceae family and has the effects of dispelling wind to relieve itching and cooling blood to detoxify.It was found that the extracts of D.brunonianum had good anticoagulant activity which was extracted with 70%ethanol in our previous researches.Then,16 compounds were isolated and identified from the extract of D.brunonianum,among which compounds 5,7-10,12,14,15-16 were isolated from this genus for the first time,and compounds 2-4 were isolated from this plant for the first time.And the coagulation activity assay showed that compounds 10,14 and 15 had good anticoagulant activity by activated partial thromboplastin time(APTT),thrombin time(TT)and prothrombin time(PT)in vitro.

关键词： Delphinium brunonianum Royle 9-Hydroxy-megastigma-4,7-dien-3-one-9-β-Dglucopyranoside 4-O-α-D-Glucosyl benzoic acid Isolariciresinol 4-O-β-D-glucopyranoside Anticoagulant activity

Comprehensive Analysis of Estrogen Receptor 1 Dysregulation in Liver Hepatocellular Carcinoma: Implications for Prognosis and Therapeutic Targeting - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 51-59页

作者： syed hussain Raza Yasir Hameed Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study investigates the expression pattern and regulatory mechanisms of estrogen receptor 1 (ESR1) in liver hepatocellular carcinoma (LIHC) through comprehensive bioinformatics analysis. Utilizing UALCAN and GEPIA2 databases, significant down-regulation of ESR1 expression is observed in LIHC samples compared to normal controls, indicating its potential role in tumor progression. Further analysis reveals consistent down-regulation across different clinical variables including patient age, gender, race, and various stages of LIHC, affirming the regulatory role of ESR1 in tumor development and progression. Additionally, promoter methylation analysis demonstrates hypermethylation of ESR1 in LIHC samples, negatively correlating with its expression. This association persists across different clinical parameters, emphasizing the inverse relationship between ESR1 methylation and expression levels. Survival analysis indicates that up- regulation of ESR1 is associated with better overall survival, suggesting its potential as a prognostic biomarker in LIHC. Furthermore, genetic mutation analysis using cBioPortal reveals a spectrum of alterations in ESR1, including amplification, missense mutation, deep deletion, splice mutation, and truncating mutation, highlighting the genetic complexity of ESR1 in LIHC. These findings collectively contribute to a deeper understanding of ESR1 dysregulation in LIHC and its clinical implications as a potential therapeutic target and prognostic marker.

关键词： Estrogen receptor 1 Liver hepatocellular carcinoma Biomarker Prognosis

Low-velocity simultaneous bilateral femoral neck fracture following long-term antiepileptic therapy:A case report

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World Journal of Orthopedics 2019年第10期10卷 371-377页

作者： Mohammed Sadiq Vikrant Kulkarni syed azher hussain Mohammed Ismail Mayur Nayak Department of Orthopaedics ESIC Medical College

BACKGROUND Simultaneous bilateral femoral neck fractures are relatively rare injuries.They are usually associated with underlying metabolic bone disorders or systemic diseases.Long-term use of narcotics and bisphosphonates can also result in similar fracture patterns;however,association of this fracture type with longterm use of antiepileptic drugs is not very common.Only one such case has been reported in the literature.This article describes the second.CASE REPORT We report a case of simultaneous displaced bilateral femoral neck fractures in a 50-year-old epileptic patient,who had taken phenytoin for the past 3 years.The fractures were a result of low-velocity injury following a fall from the bed.The fractures were managed with a bilateral hemi-replacement arthroplasty.Oral bisphosphonates were given to improve the bone quality in the post-operative period.The patient had a good post-operative outcome,that was sustained throughout the entire follow-up period of 1 year.CONCLUSION Antiepileptic drugs should be supplemented with bisphosphonates and vitamin D to improve bone quality and prevent fractures in epileptic patients.

关键词： Case report Bilateral femoral neck fracture Antiepileptic drug therapy Druginduced osteopenia Bisphosphonates Vitamin D

A comprehensive review of optical wireless power transfer technology

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Frontiers of Information Technology & Electronic Engineering 2023年第6期24卷 767-800页

作者： syed Agha Hassnain MOHSAN Haoze QIAN hussain AMJAD Optical Communication Laboratory Ocean CollegeZhejiang UniversityZhoushan 316021China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Satellite Communication and Networking Laboratory Ocean CollegeZhejiang UniversityZhoushan 316021China

Ground-breaking optical wireless power transfer(OWPT)techniques have gained significant attention from both academia and industry in recent decades.Powering remote systems through laser diodes(LDs)to either operate devices or recharge batteries offers several benefits.Remote LDs can remove the burden of carrying extra batteries and can reduce mission time by removing battery swap-time and charging.Apart from its appealing benefits,laser power transfer(LPT)is still a challenging task due to its low transfer efficiency.In this paper,we discuss the necessity and feasibility of OWPT and discuss several projects,working principle,system design,and components.In addition,we show that OWPT is an essential element to supply power to Internet-of-Things(IoT)terminals.We also highlight the impacts of dynamic OWPT.We outline several OWPT techniques including optical beamforming,distributed laser charging(DLC),adaptive-DLC(ADLC),simultaneous lightwave information and power transfer(SLIPT),Thing-to-Thing(T2T)OWPT,and high intensity laser power beaming(HILPB).We also deal with laser selection,hazard analysis,and received photovoltaic(PV)cell selection for OWPT systems.Finally,we discuss a range of open challenges and counter measures.We believe that this review will be helpful in integrating research and eliminating technical uncertainties,thereby promoting progress and innovation in the development of OWPT technologies.

关键词： Wireless power transmission Optical wireless power transfer Distributed laser charging Laser diode Solar cell

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Invariant of Enhanced AES Algorithm Implementations Against Power Analysis Attacks

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Computers, Materials & Continua 2022年第7期72卷 1861-1875页

作者： Nadia Mustaqim Ansari Rashid hussain Sheeraz Arif syed Sajjad hussain Department of Electronic Engineering Dawood University of Engineering&TechnologyKarachiPakistan Faculty of Engineering Sciences and Technology Hamdard UniversityKarachiPakistan Faculty of Information Technology Salim Habib UniversityKarachiPakistan Faculty of Computer Sciences SZABISTKarachiPakistan

The security of Internet of Things(IoT)is a challenging task for researchers due to plethora of IoT networks.Side Channel Attacks(SCA)are one of the major concerns.The prime objective of SCA is to acquire the information by observing the power consumption,electromagnetic(EM)field,timing analysis,and acoustics of the device.Later,the attackers perform statistical functions to recover the key.Advanced Encryption Standard(AES)algorithm has proved to be a good security solution for constrained IoT devices.This paper implements a simulation model which is used to modify theAES algorithm using logicalmasking properties.This invariant of the AES algorithm hides the array of bits during substitution byte transformation of AES.This model is used against SCAand particularly Power Analysis Attacks(PAAs).Simulation model is designed on MATLAB simulator.Results will give better solution by hiding power profiles of the IoT devices against PAAs.In future,the lightweight AES algorithm with false key mechanisms and power reduction techniques such as wave dynamic differential logic(WDDL)will be used to safeguard IoT devices against side channel attacks by using Arduino and field programmable gate array(FPGA).

关键词： Side channel attacks power analysis attacks network security masking advance encryption standard

Trust-based Intelligent Scheme for Mitigating Black Hole Attacks in IoT

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Journal of Harbin Institute of Technology(New Series) 2024年第3期31卷 39-50页

作者： Feroz Khan A.B Weslin D Dilli Babu M Mohammed Muzaffar hussain Department of Computer Science Syed Hameedha Arts and Science CollegeKilakarai 623806Tamil NaduIndia Department of Information Technology Mohamed Sathak AJ College of EngineeringSiruseriChennai 603103India Department of Information Technology Panimalar Engineering CollegeChennai 600123India Department of Information Technology C.Abdul Hakeem College of Engineering and TechnologyMelvisharam 632509India

Internet of Things(IoT)networks are characterized by a multitude of wireless,interconnected devices that can dynamically join or exit the network without centralized administration or fixed infrastructure for routing.While multipath routing in IoT networks can improve data transmission reliability and load balancing by establishing multiple paths between source and destination nodes,these networks are susceptible to security threats due to their wireless nature.Traditional security solutions developed for conventional networks are often ill-suited to the unique challenges posed by IoT environments.In response to these challenges,this paper proposes the integration of the Ad hoc On-demand Multipath Distance Vector(AOMDV)routing protocol with a trust model to enhance network performance.Key findings from this research demonstrate the successful fusion of AOMDV with a trust model,resulting in tangible improvements in network performance.The assessment of trustworthiness bolsters both security and routing capabilities in IoT networks.The trust model plays a crucial role in mitigating black hole attacks in IoT networks by evaluating the trustworthiness of nodes and helping in the identification and avoidance of malicious nodes that may act as black holes.Simulation results validate the efficacy of the proposed trust-based routing mechanism in achieving its objectives.Trust plays a pivotal role in decision-making and in the creation of secure distribution systems.By assessing the trustworthiness of nodes,both network security and routing efficiency can be enhanced.The effectiveness of the proposed trust-based routing mechanism is scrutinized through simulations,offering insights into its potential advantages in terms of improved network security and routing performance in the context of the IoT.

关键词： Mobile ad-hoc network(MANET) routing Ad hoc On-demand Multipath Distance Vector(AOMDV) trust model security

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A modelling method for large-scale open spaces orientated toward coordinated control of multiple air-terminal units

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Building Simulation 2023年第2期16卷 225-241页

作者： Pei Zhou Songjie Wang Jintao Zhou syed Asad hussain Xiaoping Liu Jiajia Gao Gongsheng Huang School of Civil Engineering Hefei University of TechnologyHefeiAnhuiChina Life Cycle Management Laboratory School of EngineeringUniversity of British Columbia(Okanagan Campus)KelownaBritish ColumbiaCanada Department of Building Environment&Energy Engineering Wuhan University of Science&TechnologyWuhanChina Department of Architectural and Civil Engineering City University of Hong KongTat Chee AvenueKowloonHong KongChina

The temperature distribution is always assumed to be homogeneous in a traditional singleinput-single-output(SISO)air conditioning control strategy.However,the airflow inside is more complicated and unpredictable.This study proposes a zonal temperature control strategy with a thermal coupling effect integrated for air-conditioned large-scale open spaces.The target space was split into several subzones based on the minimum controllable air terminal units in the proposed method,and each zone can be controlled to its own set-point while considering the thermal coupling effect from its adjacent zones.A numerical method resorting to computational fluid dynamics was presented to obtain the heat transfer coefficients(HTCs)under different air supply scenarios.The relationship between heat transfer coefficient and zonal temperature difference was linearized.Thus,currently available zonal models in popular software can be used to simulate the dynamic response of temperatures in large-scale indoor open spaces.Case studies showed that the introduction of HTCs across the adjacent zones was capable of enhancing the precision of temperature control of large-scale open spaces.It could satisfy the temperature requirements of different zones,improve thermal comfort and at least 11%of energy saving can be achieved by comparing with the conventional control strategy.

关键词： large-scale open space zonal temperature control CFD thermal coupling heat transfer coefficient TRNSYS

Thickness-dependent monochalcogenide GeSe-based CBRAM for memory and artificial electronic synapses

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Nano Research 2022年第3期15卷 2263-2277页

作者： Asif Ali Haider Abbas Muhammad hussain syed Hassan Abbas Jaffery Sajjad hussain Changhwan Choi Jongwan Jung HMC(Hybrid Materials Center)and Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 143–747Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea

Investigating the promising chalcogenide materials for the development of memory and advanced neuromorphic computing applications is a critical step in realizing electronic memory and synaptic devices that can efficiently emulate biological synaptic functions.However,the assessment of monochalcogenide materials for the fabrication of highly scalable memory and electronic synaptic devices that can accurately mimic synaptic functions remain limited.In the present study,we investigated the thickness-dependent resistive switching(RS)behavior of conductive bridge random access memory(CBRAM)based on a monochalcogenide GeSe switching medium for its possible application in high-performance memory and electronic synapses.GeSe thin films of different thicknesses(6,13,24,35,47,and 56 nm)were deposited via sputtering to fabricate CBRAM devices with a stacking sequence of Ag/GeSe/Pt/Ti/SiO_(2).The devices exhibited compliance current(CC)-free and electroforming-free RS with highly stable endurance and retention characteristics with no major degradation.All devices with a thickness of 6 nm had a low-resistance state(LRS),which required an initial reset to ensure reliable switching cycles.The devices with a thickness of 47 nm and above exhibited the co-existence of unipolar resistive switching(U-RS)and bipolar resistive switching(B-RS)with the CC-controlled transition between the two switching behaviors.Multilevel resistance states in the 24-nm device between a high-resistance state(HRS)and an LRS were achieved by controlling the set-CC(from 5 mA to CC-free)and the reset stop voltage(from–0.5 to–1.0 V)during the set and reset processes,respectively.The analog RS behavior of the device was further investigated with appropriate pulse measurements to emulate vital synaptic functions,including long-term potentiation(LTP),long-term depression(LTD),spike-rate-dependent plasticity(SRDP),spike-timing-dependent plasticity(STDP),paired-pulse facilitation(PPF),paired-pulse depression(PPD)and post-tetanic potentiation(PTP).Overall,the deta

关键词： conductive bridge random access memory(CBRAM) resistive memory switching monochalcogenide material bipolar and unipolar resistive switching multilevel resistive switching electronic synapses

Impact of Fractures and Diagenesis on Reservoir Potential of Inner Ramp Paleocene Carbonates Exposed in Western Part of the Lesser Himalayas of Pakistan

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Journal of Earth Science 2023年第2期34卷 536-555页

作者： Waleed Tariq Gohar Rehman syed Ahsan hussain Gardezi Nawaz Ikram National Center of Excellence in Geology University of PeshawarPeshawarKhyber Pakhtunkhwa 25120Pakistan Department of Geology University of PeshawarPeshawarKhyber Pakhtunkhwa 25120Pakistan Geological Survey of Pakistan Azad Jammu&Kashmir DirectorateMuzaffarabad 13100Pakistan Institute of Geology University of Azad Jammu&KashmirMuzaffarabad 13100Pakistan

The outcrop investigations provide a better comprehension to interrelate facies-diagenesis and fracture networks for the evaluation of reservoir potential of the carbonate rocks.In this paper,we targeted Kahi-Section(Nizampur Basin)and Peeran Tangai-Section(Kalachitta Range)to analyze structural-kinematics,Discrete Fracture Network Modelling,microfacies identification and diagenesis to interpret their impact on reservoir potential of Lockhart Limestone(Paleocene).The structural grain within the study area mostly represents the typical east-west trending tight to overturned folds and north-dipping thrust faults that mimic the north-south Indo-Eurasian collision.However,a second phase of deformation related to east-west compressions also identified which rotated the axes of preexisting structures.Fracture analysis revealed that extensional fractures are oriented at high angle to bedding and are differentiated into three orthogonal sets trending northeast-southwest,northwest-southeast and east-west,whereas,the shear fractures formed two conjugate sets trending northeastsouthwest.The Lockhart Limestone was deposited in the inner ramp setting and microfacies types are packstone,wackestone and wacke-packstone with seven sub-microfacies types.It has been identified that the Lockhart Limestone has the heterogeneous distribution of diagenetic and tectonic features throughout its extent.The observed diagenetic sequence is micritization,calcite cementation,dissolution,neomorphism,pyritization and compaction.The results highlight that open and partially filled fractures may provide an interconnected network to promote fluid mobility,leading to higher values of fracture permeability.The porosity values of the pore matrix were greater than fracture,resulting a significant impact on reservoir storage capacity.In contrast,a negative impact on reservoir potential has been shown by stylolites,veins and dissolution seams.However,based on the overall studies,the Lockhart Limestone revealed the prospect of a good reservoir unit in th

关键词： lockhart limestone discrete fracture network modelling facies-diagenesis reservoir potential Nizampur Basin petroleum geology

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