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非ST段抬高的急性冠脉综合征患者肾小球滤过率与随后死亡率的关系:来自5个心肌缺血溶栓治疗临床试验的13307例患者的观察结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 27-28页

作者： gibson C.m. Dumaine R.L. Gelfand E.V. 刘豫

To determine the association of glomerular filtration rate (GFR) with clinical outcomes in the setting of non-ST-segment elevation acute coronary syndromes(NSTE-ACS). Data were pooled from five NSTE-ACS TImI trials(TImI 11A and B, TImI 12, OPUS-TImI 16 and TACTICS-TImI 18) and were available in 13 307 patients. GFR was assessed as a continuous and a categorical variable(normal: ≥90 mL/min/1.73 m2,n=4952; mildly decreased: 60-89 mL/min/1.73 m2, n=6262; and moderately to severely decreased GFR: mL/min/1.73 m2, n=2093). There was an independent association between decreasing GFR and mortality at 30 days (OR 1.19, 95%CI 1.12-1.27, pmonths (OR 1.16, 95%CI 1.11-1.22, pmbination of TImI risk score(TRS) and decreasing GFR provided further mortality risk stratification with highest 30-day and 6-month mortality rates among patients with the lowest GFR who also had a TRS ≥5(9.1%and 15.4%, respectively). Decreasing GFR was also independently associated with stroke and recurrent ischaemia at 30-days as well as with major bleeding (pmpaired GFR is associated with higher mortality as well as higher rates of thrombotic and major bleeding events, independent of TRS.

关键词：急性冠脉综合征 ST段抬高临床试验肾小球滤过率危险分层出血事件分类变量连续变量栓塞率 OPUS

Crystallization of mg-based bulk metallic glass

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中国有色金属学会会刊：英文版 2006年第4期16卷 833-837页

作者：陈刚 m. FERRY School of materials Science and Engineering Jiangsu University Zhenjiang 212013 China School of materials Science and Engineering Univers ity of New South Wales Sydney NSW 2054 Australia

mg-based bulk metallic glass fabricated by conventional copper mould method was aged at different temperatures. X-ray diffractometry(XRD), scanning electron microscopy(SEm), atomic force microscopy(AFm) and focused ion beam(FIB) miller were employed to examine specimens obtained under different conditions. The crystallization of mg-based bulk metallic glass depends upon both the aging temperature and the aging time. As temperature increases or the holding time increases, the microstructure of the aged specimen varies from glassy one to crystalline one plus glassy phase and then to absolutely multiphase crystalline one. From the FIB images, it is clear that mg-based bulk metallic glass could not only crystallize completely but also display dendrite-like growth style. From the AFm images, there are not only significant variations of microstructures but also surface morphology of specimens obtained under different conditions. It is proposed that the surface morphology varies as the treating temperature increases. The Vickers hardness of different specimens increases as the fraction of crystalline phase (s) increases.

关键词：镁合金大块金属玻璃结晶化显微结构

比较应用裸金属支架与药物洗脱支架行经皮冠状动脉介入治疗非ST段抬高型急性冠状动脉综合征对生物标记物水平的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 11-12页

作者： gibson C.m. Karmpaliotis D. Kosmidou I. 杨海涛 TImI Study Group Cardiovascular Division Brigham and Women's Hospital Boston MA United States Dr.

Drug-eluting stents(DESs) deliver biphasic(early and late)-elution of anti-inflammatory compounds. We therefore hypothesized that DESs would be associated with early reductions in inflammatory biomarker release after percutaneous coronary intervention(PCI). A total of 741 patients with non-ST-elevation acute coronary syndrome underwent PCI in the Randomized Trial to Evaluate the Relative PROTECTion against Post-PCI microvascular Dysfunction and Post-PCI Ischemia among Anti-Platelet and Anti-Thrombotic Agents(PROTECT) Thrombolysis In myocardial Infarction 30 study of eptifibatide and reduced-dose antithrombin compared with bivalirudin. Serial biomarkers C-reactive protein, troponin, creatine kinase-mB, soluble CD40 ligand, interleukin-6, prothrombin fragment F1.2, and RANTES(regulated on activation, normal T-cell expressed and secreted) were assessed through 24 hours after PCI. DES use was at the investigator’s discretion. Patients treated with DESs(n=665) versus bare metal stents(n=139) were more likely to have patent arteries before PCI(92.0%vs 86.6%, p=0.04), Thrombolysis In myocardial Infarction myocardial perfusion grade 3(57.9%vs 47.7%, p=0.033), and the left anterior descending artery as the culprit artery(38.5%vs 18.3%, pmong patients undergoing DES implantation(median 2.1 vs 3.5 mg/L for C-reactive protein, median 0.11 vs 0.41 ng/ml for troponin), even after adjustment for randomized treatment, clopidogrel before treatment, diabetes mellitus status, epicardial patency, left anterior descending artery location, and myocardial perfusion(p=0.036 and p=0.039, respectively). Interleukin-6 was lower with DESs on univariate analysis but not multivariate analysis. Creatine kinase-mB, soluble sCD40 ligand, prothrombin fragment F1.2, and RANTES did not differ by DES use. In conclusion, patients undergoing DES implantation achieved more reductions in periprocedural markers of inflammation and necrosis

关键词：药物洗脱支架 ST段抬高裸金属支架介入治疗生物标记物比伐卢定依替巴肽肌钙蛋白心肌灌注

Development of tropoelastin-functionalized anisotropic PCL scaffolds for musculoskeletal tissue engineering

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Regenerative Biomaterials 2023年第1期10卷 64-72页

作者： miao Zhang Ziyu Wang Anyu Zhang Linyang Liu Suzanne m.mithieux marcela m.m.Bilek Anthony S.Weiss Charles Perkins Centre The University of SydneySydneyNSW 2006Australia School of Life and Environmental Sciences The University of SydneySydneyNSW 2006Australia Applied and Plasma Physics Laboratory School of PhysicsThe University of SydneySydneyNSW 2006Australia School of Biomedical Engineering The University of SydneySydneyNSW 2006Australia sydney Nano Institute The University of SydneySydneyNSW 2006Australia

The highly organized extracellular matrix(ECm)of musculoskeletal tissues,encompassing tendons,ligaments and muscles,is structurally anisotropic,hierarchical and *** features collectively contribute to their unique *** studies have investigated the effect of tissue-engineered scaffold anisotropy on cell morphology and organization for musculoskeletal tissue repair and regeneration,but the hierarchical arrangement of ECm and compartmentalization are not typically ***,we present a method for multi-compartmental scaffold design that allows for physical mimicry of the spatial architecture of musculoskeletal tissue in regenerative *** design is based on an ECm-inspired macromolecule ***(PCL)scaffolds were fabricated with aligned fibers by electrospinning and mechanical stretching,and then surface-functionalized with the cell-supporting ECm protein molecule,tropoelastin(TE).TE was attached using two alternative methods that allowed for either physisorption or covalent attachment,where the latter was achieved by plasma ion immersion implantation(PIII).Aligned fibers stimulated cell elongation and improved cell alignment,in contrast to randomly oriented *** coatings bound by physisorption or covalently following 200 s PIII treatment promoted fibroblast *** represents the first cytocompatibility assessment of novel PIII-treated TE-coated PCL *** demonstrate their versatility,these 2D anisotropic PCL scaffolds were assembled into 3D hierarchical constructs with an internally compartmentalized structure to mimic the structure of musculoskeletal tissue.

关键词： tropoelastin PCL musculoskeletal tissue engineering plasma immersion ion implantation electrospinning anisotropy hierarchical

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火线驰骋

汽车生活 2008年第6期 74-85页

作者： Oliver marriage Peter gibson 臧赟华

全新的梅赛德斯C63 AmG和雷克萨斯IS F信誓旦旦,扬言要瓜分顶级豪车的市场。我们将它们同宝马最新的4门m3和目前该车系的佼佼者Audi RS4放到一起同场竞技,看看哪一台可以让驾驶者最为吃惊。

关键词：变速箱引擎驾驶宝马方向盘奥迪排气管人民币扭矩经济性

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1 OF A KIND Z系第一步

汽车与运动 2015年第4期 98-103页

作者： STUART GALLAGHER DREW gibson 吕思达

BmW Z1的设计称得上是前无古人后无来者,除了这个古怪的车门之外,它还有什么其他特别之处呢?BmW制造出像i3和i8这样的车型我们应该感到惊讶吗?除了正常的三厢车、X系列的四驱车型,巴伐利亚的工程师同样能制造出i3和i8这种特别的车型,但... 详细信息

BmW Z1的设计称得上是前无古人后无来者,除了这个古怪的车门之外,它还有什么其他特别之处呢?BmW制造出像i3和i8这样的车型我们应该感到惊讶吗?除了正常的三厢车、X系列的四驱车型,巴伐利亚的工程师同样能制造出i3和i8这种特别的车型,但这并不是BmW第一次制造出这种令人出乎意料的车型。忽略明显的运动特别版,例如CSL Batmobiles和E30 m3,BmW的产品目录上都是一些乐趣折中的车型,上一款有意思的车要追溯到1956年那台华丽的507Roadster。70年代。

关键词：四驱车产品目录亚罗楔形 OF A KIND Z 利亚防倾杆后悬架前挡风玻璃麦弗逊

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阿斯顿·马丁的N24之路

汽车与运动 2014年第9期 122-123页

作者： Richard meaden Drew gibson 范围

阿斯顿·马丁和纽伯格林N24的关系起源于2006年,那时候一个小工程师团队和一个纯业余车手阵容,包括阿斯顿马丁的CEO Ulrich Bez驾驶着公路版的V8 Vantage参加世界上竞争最为激烈的24小时耐力赛。今年阿斯顿·马丁带着职业赛车手和专门... 详细信息

阿斯顿·马丁和纽伯格林N24的关系起源于2006年,那时候一个小工程师团队和一个纯业余车手阵容,包括阿斯顿马丁的CEO Ulrich Bez驾驶着公路版的V8 Vantage参加世界上竞争最为激烈的24小时耐力赛。今年阿斯顿·马丁带着职业赛车手和专门为比赛而设计的阿斯顿·马丁赛车参加了适用Vantage车型的所有比赛。这一组别有超过170辆赛车参赛,AmR仅使用了一台V12 Vantage GT3参赛,由Darren Turner,Stefan mücke和Pedro Lamy驾驶。

关键词：阿斯顿·马丁 N24 阿斯顿马丁 Turner Stefan 保时捷凯伦泄漏问题 German