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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Evaluation of Hypervisor stability towards Insider Attacks

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Journal of Electronic science and Technology 2016年第1期14卷 37-42页

作者： Roman Kulikov svetlana Kolesnikova the Department of Computer systems Design and security National Research University of Information Technology

Virtualization technology plays a key role in cloud ***,the security issues of virtualization tools（hypervisors,emulators,etc.） should be under precise ***,threats of insider attacks are *** virtualization tools and hypervisors have been poorly protected from this type of ***,hypervisor is one of the most critical elements in cloud computing ***,hypervisor vulnerabilities analysis is ***,a formal model of insider attack on hypervisor is ***,on the basis of the formal attack model,we propose a new methodology of hypervisor stability *** this paper,certain security countermeasures are considered that should be integrated in hypervisor software architecture.

关键词： Cloud computing hypervisor insider attack hypervisor stability virtualization virtual machine

A mild, configurable, flexible CoNi-LDH(v)/Zn battery based on H-vacancy-induced reversible Zn^(2+) intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv sam s.Yoon Qufu Wei Key Laboratory of Eco–textiles Ministry of EducationJiangnan UniversityWuxi 214122JiangsuChina School of Mechanical EngineeringKorea UniversitySeoul 136–713Republic of Korea Received 12 August 2024Revis

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide (CoNi-LDH) as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH(v)) were constructed on a flexible carbon cloth (CC) substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH(v)@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnsO4electrolyte (pH=4).The battery delivered an excellent specific capacity (225 mA h g^(-1),0.26 mA h cm^(-2)),acceptable cycling stability(53.9%,900 cycles),and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn^(2+)and the extravasation of NO_(3)-generated channels and space for Zn^(2+)transport and storage,together enabling an excellent Zn^(2+)storage ***,a sandwich-structured solid-state CoNi-LDH(v)@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

Modeling net-charge fluctuations in heavy-ion collisions at the LHC

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Chinese Physics C 2025年第1期49卷 281-289页

作者： G.O.Ambaryan A.s.Chernyshov G.Kh.Eyyubova V.L.Korotkikh I.P.Lokhtin s.V.Petrushanko A.M.snigirev E.E.Zabrodin Physics Department Lomonosov Moscow State UniversityRU-119991 MoscowRussia skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityRU-119991 MoscowRussia Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear ResearchRU-141980 DubnaRussia Department of Physics University of OsloN-0316 OsloNorway

Analysis of Pb+Pb data for net-charge fluctuations at LHC energies using the HYDJET++model is *** strongly intensive quantities D and Σ were used to remove the effects related to system volume *** employed two versions of HYDJET++for the *** first one is the standard or default version,whereas the second one is a modification that takes into account explicit event-by-event conservation of the electric net-charge of produced *** inclusion of the canonical net-charge conservation in the model allows for better description of the experimental data obtained by the ALICE and CMs Collaborations.A comparison with calculations from other models is also presented.

关键词： relativistic heavy-ion collisions net-charge fluctuations strongly intensive variables canonical charge conservation

On the interfacial behavior of a one-dimensional hexagonal piezoelectric quasicrystal film based on the beam theory

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Applied Mathematics and Mechanics(English Edition) 2025年第2期46卷 289-304页

作者： Wenkai ZHANG C.s.LU Minghao ZHAO Cuiying FAN Huayang DANG school of Mechanics and safety Engineering Zhengzhou University school of Civil and Mechanical Engineering Curtin University school of Mechanical Engineering Zhengzhou University

In this paper, the mechanical response of a one-dimensional (1D) hexagonal piezoelectric quasicrystal (PQC) thin film is analyzed under electric and temperature loads. Based on the Euler-Bernoulli beam theory, a theoretical model is proposed, resulting in coupled governing integral equations that account for interfacial normal and shear stresses. To numerically solve these integral equations, an expansion method using orthogonal Chebyshev polynomials is employed. The results provide insights into the interfacial stresses, axial force, as well as axial and vertical deformations of the PQC ***, fracture criteria, including stress intensity factors, mode angles, and the Jintegral, are evaluated. The solution is compared with the membrane theory, neglecting the normal stress and bending deformation. Finally, the effects of stiffness and aspect ratio on the PQC film are thoroughly discussed. This study serves as a valuable guide for controlling the mechanical response and conducting safety assessments of PQC film systems.

关键词： one-dimensional (1D) hexagonal piezoelectric quasicrystal (PQC) film beam theory electric and temperature loads Chebyshev polynomial interfacial behavior O343.1

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Predicting Maximum Lifespan Limits at Mean Menopausal Age

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Journal of Mathematical Research with Applications 2025年第1期45卷 133-142页

作者： M.sUMATHI s.ANTONY CARLA Department of Mathematics N.M.S.S.Vellaichamy Nadar College Research scholar (Part-time) Madurai Kamaraj University

The age at which a woman enters natural menopause has also been associated to death from any cause. Menopause is a natural component of aging that happens between the ages of 45 and 55, with the average menopausal age being 51. Previous research has revealed the age at which women reach menopause, but there is no evidence to support the link between menopause and longevity. We made a study in assessing the limits of maximum lifespan at menopausal age in our previous article. In this paper, we aim to predict the maximum lifespan of women at mean menopausal age.

关键词： menopause mean menopause maximum lifespan scale parameter shape parame-ter aging modified Weibull distribution

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI H.GHANDVAR E.JUMAEV s.KHATIR T.CUONG-LE school of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for Engineering Application and Technology solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： double curved beam finite element method functionally graded porous (FGP) material intermediate straight beam O313 vibration analysis

CONTROLLING THE 3D NANOsCALE ORGANIZATION OF BULK HETEROJUNCTION POLYMER sOLAR CELLs

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Chinese Journal of Polymer science 2009年第1期27卷 85-92页

作者： svetlana s.van Bavel Erwan sourty Gijsbertus de With Joachim Loos Laboratory of Materials and Interface Chemistry Soft Matter Cryo-TEM Research UnitEindhoven University of TechnologyP.O.Box 513NL-5600 MB EindhovenThe Netherlands Dutch Polymer Institute P.O.Box 902NL-5600 AX EindhovenThe Netherlands Laboratory of Materials and Interface Chemistrt Soft Matter Cryo-TEM Research UnitEindhoven University of TechnologyP.O.Box 513NL-5600 MB EindhovenThe Netherlands FEI Company Achtseweg Noord 5NL-565I GG EindhovenThe Netherlands

In this study,the three dimensional nanoscale organization in the photoactive layers of poly(3-hexylthiophene) (P3HT) and a methanofullerene derivative (PCBM) is revealed by transmission electron *** annealing treatment,either at elevated temperature or during slow solvent evaporation,nanoscale interpenetrating networks are formed with high crystalline order and favorable concentration gradients of both components through the thickness of the photoactive *** a tailored morphology account...

关键词： Polymer solar cells Morphology Electron tomography Device performance