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Cellular & Molecular Immunology 2017年第4期14卷 360-370页

作者： Cynthia M Fehres Sanne Duinkerken sven cm bruijns Hakan Kalay Sandra J van Vliet Martino Ambrosini Tanja D de Gruijl Wendy WJ Unger Juan J Garcia-Vallejo Yvette van Kooyk Department of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam the Netherlands Department of Medical Oncology VU University Medical Center Amsterdam the Netherlands

The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin contains several antigen-presenting cell subsets with specialized functions. In particular, the capacity to cross-present exogenous antigens to CD8^＋ T cells is of interest for the design of effective immunotherapies against viruses or cancer. Here, we show that primary human Langerhans cells （LCs） were able to cross-present a synthetic long peptide （SLP） to CD8^＋ T cells. In addition, modification of this SLP using antibodies against the receptor langerin, but not dectin-1, further enhanced the cross-presenting capacity of LCs through routing of internalized antigens to less proteolytic early endosome antigen 1 ^＋ early endosomes. The potency of LCs to enhance CD8^＋ T-cell responses could be further increased through activation of LCs with the toll-like receptor 3 ligand polyinosinic：polycytidylic acid （phC）. Altogether, the data provide evidence that human LCs are able to cross-present antigens after langerin-mediated internalization. Furthermore, the potential for antigen modification to target LCs specifically provides a rationale for generating effective anti-tumor or anti-viral cytotoxic T lymphocyte responses.

关键词： antigen cross-presentation dectin-1 early endosomes human Langerhans cells langerin

Counting and measuring particles sized from soot to pollen

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China Particuology 2007年第5期5卷 359-361页

作者： Martin Schmidt sven Schütz Leander Mlter Palas GmbH Greschbachstr. 3b76229 KarlsruheGermany

For number concentration measurements of superfine particles a condensation nucleus counter （CNC） is frequently used. The combination of a new CNC module with a white light aerosol spectrometer and a passive collector makes possible accurate time-resolved determination of particle number within the overall size range of 10 nm to 40 μm and at concentrations up to 10^5 particles/cm^3. With the aerosol spectrometer a high time-resolved particle size determination is also possible in the size range of 0.3-40 μm up to the same high number concentrations of 10^5 particles/cm^3.

关键词： CNC Particles Size

Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography

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Light(Science & Applications) 2019年第1期8卷 553-562页

作者： Kausik Basak Xose Luis Dean-Ben sven Gottschalk Michael Reiss Daniel Razansky Faculty of Medicine Technical University MunichMunichGermany Institute for Biological and Medical Imaging Helmholtz Center MunichNeuherbergGermany Faculty of Medicine and Institute of Pharmacology and Toxicology University of ZurichZurichSwitzerland Institute for Biomedical Engineering and Department of Information Technology and Electrical Engineering ETH ZurichZurichSwitzerland Institute of Advanced Studies and Research JIS UniversityKolkataWest BengalIndia

Despite the importance of placental function in embryonic development,it remains poorly understood and challenging to characterize,primarily due to the lack of non-invasive imaging tools capable of monitoring placental and foetal oxygenation and perfusion parameters during *** developed an optoacoustic tomography approach for real-time imaging through entire ~4 cm cross-sections of pregnant *** changes in both maternal and embryo regions were studied at different gestation days when subjected to an oxygen breathing challenge and perfusion with indocyanine *** phenotyping of the cross-sectional scans highlighted different internal organs,whereas multi-wavelength acquisitions enabled non-invasive label-free spectroscopic assessment of blood-oxygenation parameters in foeto-placental regions,rendering a strong correlation with the amount of oxygen ***,the placental function in protecting the embryo from extrinsically administered agents was *** proposed methodology may potentially further serve as a probing mechanism to appraise embryo development during pregnancy in the clinical setting.

关键词： rendering placental sectional

Flip-chip-type high- T_c gradiometer for biomagnetic measurements in unshielded environment

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Science China Mathematics 2000年第1期43卷 82-87页

作者：田永君王天生陈珂漆汉宏陈烈郑东宁 sven LINZEN Frank SCHMIDL Paul SEIDEL National Laboratory for Superconductivity Institute of Physics Chinese Academy of Sciences Beijing 100080 China College of Materials Science and Chemical Engineering Yanshan University Qinhuangdao 066004 China Institut fur Festkorperphysik Friedrich-Schiller-Universitat Jena D-07743 Jena Germany Institut fur Festkorperphysik Friedrich-Schiller-Universitat Jena D-07743 Jena Germany A flip-chip-type gradiometer has been constructed with a 10 mm ×5 mm planar DC-SQUID gradiometer fabricated on a SrTiO3 bicrystal substrate and a flux transformer made from a YB-CO* /YBCO/CeO2/YSZ multilayer on a φ50.8 mm Si wafer. The coupling coefficient between the flux transformer and the planar gradiometer is 0.18. The transformer increases effectively the resolution of the gradiometer. A magnetic field gradient resolution of 73 fT.cm-1.Hz-1/2 in the white region and 596 fT.cm-1Hz-1/2 at 1 Hz has been obtained. High quality magnetocardiogram signals have been successfully measured by using this flip-chip-type gradiometer in an unshielded environment.

A flip-chip-type gradiometer has been constructed with a 10 mm × 5 mm planar DCSQUID gradiometer fabricated on a SrTiO3 bicrystal substrate and a flux transformer made from a YBCO*/YBCO/CeO2/YSZ multilayer on ?50.8 mm Si wafer. The coupling coefficient between the flux transformer and the planar gradiometer is 0.18. The transformer increases effectively the resolution of the gradiometer. A magnetic field gradient resolution of 73 ***?1Hz?1/2 in the white region and 596 ***?1Hz?1/2 at 1 Hz has been obtained. High quality magnetocardiogram signals have been successfully measured by using this flip-chip-type gradiometer in an unshielded environment.

关键词： high-T_c SQUIDs gradiometer magnetocardiogram.

Slight Structural Disorder in Bithiophene-based Random Terpolymers with Improved Power Conversion Efficiency for Polymer Solar Cells

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Chinese Journal of Polymer Science 2018年第10期36卷 1129-1138页

作者： Meng-Han Wang Zhong-Yuan Xue Zhi-Wei Wang Wei-Hua Ning Yu Zhong Ya-Nan Liu Chun-Feng Zhang sven Huettner You-Tian Tao Key Lab for Flexible Electronics &Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China Macromolecular Chemistry Ⅰ Universitat Bayreuth 30 Universitatsstr 95447 Bayreuth Germany

A series of random terpolymers P2-P5 were designed and synthesized by randomly embedding 5 mol%, 10 mol%, 15 mol% and 25 mol% feed ratios of low cost 2,2-bithiophene as the third monomer to the famous donor-acceptor （D-A） type copolymer PTBT-Th （P1）. All polymers showed similar molecular weight with number-average molecular weight （Mn） and weight-average molecular weight （Mw） in the range of （59-74） and （93-114） kg·mol-1, respectively, to ensure a fair comparison on the structure-property relationships. Compared with the control copolymer PTBT-Th, the random terpolymers exhibited enhanced absorption intensity in a wide range from 400 nm to 650 nm in both solution and film as well as in polymer/PC71BM blends. From grazing incident wide-angle X-ray diffraction （GIWAXS）, compared with the regularly alternated copolymer PTB7-Th, the random terpolymers demonstrated mild structural disorder with reduced （100） lamellar stacking and slightly weakened （010） π-π stacking for the polymers as well as slightly reduced PC71BM aggregation in polymer/PC71BM blends. However, the measured hole mobility for terpolymers （（1.20-3.73） × 10 -4 cm2·V-1·s-1） was evaluated to be comparable or even higher than 1.35 × 10 -4 cm2·V-1 ·s-1 of the alternative copolymer. Enhanced average power conversion efficiency （PCE） from 7.35% to 8.11% and 7.79% to 8.37% was observed in both conventional and inverted device architectures from copolymer P1 to terpolymers P4, while further increasing the 2,2-bithiophene feed ratio decreased the PCE.

关键词： Bithiophene-based random terpolymers Structural disorder Polymer solar cells Photovoltaic properties

Counting particle measurement within the size range from soot to pollen

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Counting particle measurement within the size range from soo...

Factors That Promote Remission in Individuals with Schizophrenia

第九届全国气溶胶会议暨第三届海峡两岸气溶胶技术研讨会

作者： Martin Schmidt sven Schütz Leander M lter Palas~ GmbH Greschbachstr.3b76229 KarlsruheGermany

In many gaseous multi-phase systems,like in the atmosphere,in exhaust gases etc.,there are particles which are too small to be measured directly by conventional detection mechanisms with regard to their number and to their *** temporally resolved detection of these parameters is however important because the particle size and particle number can have a substantial influence on the health *** the breathing air,or they may affect the efficiency and the lifetime of filters *** technology. To measure the number of small particles within the range of 5 nm to 1 μm condensation nucleus counters,so called CNCs,are *** CNCs are developed usually for laboratory measurements and are sensitive in relation to fluctuations of the temperature and of the air pressure in the atmosphere. The combination of a new condensation module,the CNC-04,with the white light aerosol spectrometer welas and the passive collector Sigma-2 makes possible an almost accurate time-resolved determination of the particle number within the range of approx.10 nm to 40 μm. With the welas-system a temporally high-resolved particle size determination is possible in the ranges 0,3-17 μm or 0.7-40 μm also in high concentrations up to 10 particles/cm. Due to the combination of the welas with the new CNC-04 module,the number of smallest particles down to 10 nm can,for the first time,be accurately determined with a counting procedure also in concentrations up to 10 particles/***,the new device combination is suitable particularly for measurements in the outside air, the more so as the number concentration of atmospheric particles＜100 nm can increase easily up to 10 particles/cm. Since for the high-resolved size and quantity determination of particles＞0.3 μm one uses the same device as for the counting of the up-condensed smaller particles,both measurements are identical concerning the counting ***,the measurement results can be clearly combined computationally. Furthermor

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Open Journal of Nursing 2019年第9期9卷 935-950页

作者： Maivor Olsson-Tall Bertil Marklund sven Kylen Eric Carlstrom Lars Helldin Siv Back-Pettersson Department of Psychiatry NU-Health Care HospitalTrollhattanSweden Academy of Sahlgrenska Institute of MedicineUniversity of GothenburgGothenburgSweden Centre on Health Care Improvement and Innovation Chalmers University of TechnologyGothenburgSweden Narhalsan Research and Development Primary Health Care Region Vastra GotalandSweden Fyrbodal Health Academy County Administration of West SwedenSweden Academy of Sahlgrenska Institute of Health and Care SciencesUniversity of GothenburgGothenburgSweden University of South-East Norway WestfoldNorway Institute of Psychology Karlstad UniversityKarlstadSweden

The knowledge about factors contributing to remission among individuals with schizophrenia is still missing. Studies show that the number of individuals’ reaching remission is varying among psychiatric outpatient care centres. Therefore, the purpose was to investigate case managers (cm) perception of care interventions promoting remission. Semi-structured interviews were conducted with cm (n = 12) and data were analysed with qualitative content analysis. The results show that cm needs to possess competence, master assessment structure and process. These key-points appear to be of crucial importance for a successful promotion of remission among individuals with schizophrenia.

关键词： Assessment Case Managers Remission Teamwork Schizophrenia

Current-induced degradation and lifetime prediction of 310 nm ultraviolet light-emitting diodes

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Photonics Research 2019年第7期7卷 14-18页

作者： Jan Ruschel Johannes Glaab Batoul Beidoun Neysha Lobo Ploch Jens Rass Tim Kolbe Arne Knauer Markus Weyers sven Einfeldt Michael Kneissl Ferdinand-Braun-Institut Leibniz-Institut fur HochstfrequenztechnikGustav-Kirchhoff-Str.412489 BerlinGermany Technische Universitat Berlin Institut fur FestkorperphysikHardenbergstr.36EW6-710623 BerlinGermany

The impact of operation current on the degradation behavior of 310 nm UV LEDs is investigated over 1000 h of stress. It ranges from 50 to 300 mA and corresponds to current densities from 34 to 201 A/cm^*** separate the impact of current from that of temperature, the junction temperature is kept constant by adjusting the heat sink temperature. Higher current was found to strongly accelerate the optical power reduction during operation. A mathematical model for lifetime prediction is *** indicates that lifetime is inversely proportional to the cube of the current density, suggesting the involvement of Auger recombinati on.

关键词： degradation light-emitting diodes lifetime

Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME

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World Journal of Gastroenterology 2016年第41期22卷 9127-9140页

作者： Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov sven Seiwerth Predrag Sikiric Departments of Pharmacology and Pathology Medical Faculty University of Zagreb 10000 Zagreb Croatia

AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addi

关键词： Esophagogastric anastomosis L-NAME Aggravation BPC 157 L-arginine Curative treatment Rats

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应用生态工程 1