Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography

作     者：Kausik Basak Xose Luis Dean-Ben Sven Gottschalk Michael Reiss Daniel Razansky 

作者机构：Faculty of MedicineTechnical University MunichMunichGermany Institute for Biological and Medical ImagingHelmholtz Center MunichNeuherbergGermany Faculty of Medicine and Institute of Pharmacology and ToxicologyUniversity of ZurichZurichSwitzerland Institute for Biomedical Engineering and Department of Information Technology and Electrical EngineeringETH ZurichZurichSwitzerland Institute of Advanced Studies and ResearchJIS UniversityKolkataWest BengalIndia 

出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)

年 卷 期：2019年第8卷第1期

页      面：553-562页

核心收录：

学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：partially supported by the European Research Council Consolidator grant ERC-2015-CoG-682379 funded by the University Foundation Fellowship of the Technical University of Munich 

主　　题：rendering placental sectional 

摘      要：Despite the importance of placental function in embryonic development,it remains poorly understood and challenging to characterize,primarily due to the lack of non-invasive imaging tools capable of monitoring placental and foetal oxygenation and perfusion parameters during *** developed an optoacoustic tomography approach for real-time imaging through entire ~4 cm cross-sections of pregnant *** changes in both maternal and embryo regions were studied at different gestation days when subjected to an oxygen breathing challenge and perfusion with indocyanine *** phenotyping of the cross-sectional scans highlighted different internal organs,whereas multi-wavelength acquisitions enabled non-invasive label-free spectroscopic assessment of blood-oxygenation parameters in foeto-placental regions,rendering a strong correlation with the amount of oxygen ***,the placental function in protecting the embryo from extrinsically administered agents was *** proposed methodology may potentially further serve as a probing mechanism to appraise embryo development during pregnancy in the clinical setting.