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454例丙型肝炎病毒感染患者单用干扰素治疗的长期随访:多疗程干扰素治疗或许可降低肝细胞癌的危险并增加存活率

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 61-62页

作者： Akuta N. suzuki f. suzuki Y. 杨媛 Department of Gastroenterology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-0001 Japan Dr.

Objective. The long-term effects of multi-course interferon (IfN) monotherapy in patients infected with hepatitis C virus (HCV) are still unclear. Material and methods. To evaluate the effects of multi-course IfN on hepatocarcinogenesis and survival, a follow-up study was conducted comprising 454 consecutively recruited non-cirrhotic naive patients infected with HCV, who had received IfN monotherapy between 1987 and 1992. The median follow-up was 11.3 years. Results. A sustained response (SR) after the first IfN was achieved by 152 patients (33.5%) (Group A). Of 302 patients (66.5%) with non-SR after the first IfN, 130 patients (28.6%) did not receive additional IfN (Group B), and the remaining 172 patients (37.9%) received multi-course IfN monotherapy (Group C). With regard to hepatocarcinogenesis and survival rates for liverrelated deaths, Groups A and C both showed significantly better long-term clinical outcome than Group B (p factors were identified by multivariate analyses (fibrosis stage 3, Group B, and age ≥50) for all patients and two factors (fibrosis stage 3 and age ≥50) for Group C associated with hepatocarcinogenesis. With regard to hepatocarcinogenesis rates according to the mean alanine aminotransferase (ALAT) levels during the IfN-free period in Group C, significantly higher rates were noted in patients with ALAT levels above 1.5 ×the upper normal limit (17.6%)-than those below the limit (0%) (p fN monotherapy reduces the risk of hepatocarcinogenesis and increases survival, and low ALAT levels during the IfN-free period are associated with lower hepatocarcinogenesis rates in multi-course IfN.

关键词：干扰素治疗肝细胞癌丙型肝炎病毒免疫应答随访研究癌发生率多变量分析秩检验

Design and fabrication of gas cell targets for laboratory astrophysics experiments on the Orion high-power laser facility

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High Power Laser Science and Engineering 2017年第3期5卷 62-66页

作者： C.Spindloe D.Wyatt S.Astbury G.f.Swadling T.Clayson C.Stehlé J.M.foster E.Gumbrell R.Charles C.N.Danson P.Brummitt f.suzuki-Vidal Current address： Lawrence Livermore National Laboratory California 94550 USA

This paper describes the design and fabrication of a range of ‘gas cell' microtargets produced by the Target fabrication Group in the Central Laser facility(CLf) for academic access experiments on the Orion laser facility at the Atomic Weapons Establishment(AWE). The experiments were carried out by an academic consortium led by Imperial College London. The underlying target methodology was an evolution of a range of targets used for experiments on radiative shocks and involved the fabrication of a precision machined cell containing a number of apertures for interaction foils or diagnostic windows. The interior of the cell was gas-filled before laser irradiation. This paper details the assembly processes, thin film requirements and micro-machining processes needed to produce the targets. Also described is the implementation of a gas-fill system to produce targets that are filled to a pressure of 0.1–1 bar. The paper discusses the challenges that are posed by such a target.

关键词： astrophysics microtargets

在黄斑裂孔手术中吲哚青绿辅助内界膜剥离的回顾性研究

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 29-30页

作者： Ando f. Sasano K. suzuki f. Ohba N. 王媛

To report visual outcomes after peeling of the internal limiting membrane (ILM ) using a brief application of low dose indocyanine green (ICG) for macular hole repair. Prospective, nonrandomized interventional case series. A consecutive se ries of 16 eyes of 14 patients with full thickness macular hole underwent vitre ctomy and peeling of the ILM with an intravitreal application of 0.05%ICG for l ess than 10 seconds. The ILM could be removed uneventfully in 5 of 16 cases afte r a single ICG application and in 11 cases after a second ICG application. The m acular hole was closed in 15 (93.7%) of 16 cases after a single surgery and in one case after a repeat surgery, as evaluated by optical coherence tomography. A significant visual acuity improvement was achieved as the mean logarithm of the minimum angle of resolution was from 0.600 preoperatively (equivalent to approx imately 5/20 in the conventional 20 foot numerator form) to 0.213 (12/20) at the end of follow up (P f the cases developed peripheral visual fi eld defect. Ophthalmoscopies or optic coherence tomographic images did not revea l any disruption at the level of the retinal pigment epithelium. A brief intravi treal application of low dose ICG may provide a safe ILM peeling in vitreomacula r surgeries.

关键词：内界膜剥离黄斑裂孔吲哚青绿视网膜色素上皮术后视力最小视角干预性视野缺损检眼镜检查短期使用

单一干扰素治疗年轻慢性丙型肝炎病毒感染者的疗效

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 40-41页

作者： Uka K. suzuki f. Akuta N. 陈云茹 Department of Gastroenterology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan

Background. Suppression of the progression to cirrhosis and hepatocellular carcinoma is important, especially for young hepatitis C virus (HCV)-infected patients. The aim of this study was to analyze the response to interferon (IfN) monotherapy in young HCV patients. Methods. Between 1989 and 2002, 1021 anti-HCV-positive patients hospitalized at Toranomon Hospital received IfN monotherapy. Among these patients, 144 were ≤35 years of age,while the remaining 877 were 36-73 years old. We retrospectively identified 209 patients with known dates of blood transfusion (i.e., start of HCV infection) among the 1021 patients. IfN treatment lasted 6 months. Results. HCV RNA level (P fied as determinants of the response to IfN monotherapy in 1021 patients. Moreover, in patients with high viral load and genotype 1b, the sustained virological response (SVR) rate was significantly higher in those aged ≤35 years than in older patients (P f blood transfusion,a longer duration of infection negatively influenced the SVR rate. In the 209 patients, multivariate analysis identified HCV RNA level (P f infection (P = 0.049) as determinants of SVR. Conclusions. The response of IfN monotherapy is better in patients aged ≤35 years than in older patients, probably because of mild stage histology, the effect of host-related factors, and shorter period of infection. Long-term IfN monotherapy may be suitable for young women who desire to become pregnant or those with anemia.

关键词：干扰素治疗肝组织学检查丙型肝炎病毒单一治疗丙肝抗体病毒学应答病毒感染病毒载量感染期

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-fNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-fNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

在不影响人足细胞(前)肾素受体信号下,阿利吉仑能抑制细胞内血管紧张素Ⅱ水平

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中华高血压杂志 2010年第7期18卷 698-698页

作者： Sakoda M Ichihara A Kurauchi-Mito A Narita T Kinou-chi K Murohashi-Bokuda K Saleem MA Nishiyama A suzuki f Itoh H 黄晓斌

Design Method of Guide Vane for Wells Turbine

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Journal of Thermal Science 2006年第2期15卷 126-131页

作者： Masami suzuki Department of Mechanical Engineering Graduate School of Engineering The University of Tokyo

Guide vanes are installed in the Wells turbine in order to improve its efficiency, self-rotating characteristics and off design performance with stall. This work attempts to explain the role of these guide vanes on the basis of momentum theory. It is shown that the upstream vanes are more effective in enhancing efficiency than the downstream ones. A design method for guide vanes is suggested based on experimental data and potential theory. Experimental studies carried out by the author confirm the theory proposed.

关键词： wells turbine guide vane cascade potential flow wave energy converter ocean engineering

2型糖尿病对慢性丙肝患者发生肝癌及其他恶性肿瘤风险的影响

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消化肿瘤杂志(电子版) 2013年第1期 15-15页

作者： Arase Y Kobayashi M suzuki f 张信华蔡世荣

目的采用回顾性队列研究,探讨日本慢性丙肝患者停用干扰素治疗后恶性肿瘤发生的危险因素。方法纳入4302名慢性丙肝患者,均接受过干扰素抗病毒治疗并已停药。研究的主要终点是患者首诊恶性肿瘤。以Kaplan-Meier和Cox风险模型计算生存率... 详细信息

目的采用回顾性队列研究,探讨日本慢性丙肝患者停用干扰素治疗后恶性肿瘤发生的危险因素。方法纳入4302名慢性丙肝患者,均接受过干扰素抗病毒治疗并已停药。研究的主要终点是患者首诊恶性肿瘤。以Kaplan-Meier和Cox风险模型计算生存率和相关影响因素。结果患者平均随访时间为8.1年。随访期内共有606名患者发生恶性肿瘤,其中肝细胞癌393例,其他恶性肿瘤213例,主要为胃癌(36例)和结肠癌(35例)。本组患者肝癌的5、10、15年累积发病率分别为4.3%、10.5%和19.7%。研究显示,以下因素显著增加肝癌发生风险(P<0.05):肝硬化(HR=50.1)、未获得持续的病毒学应答(HR=4.93)、男性(HR=1.67)、年龄≥50岁、累计酒精摄取总量超过200 kg(HR=1.45)以及合并2型糖尿病(HR=1.73,95%CI:1.30-2.30)。对于糖尿病患者,若糖化血红蛋白水平控制在7.0%以下,在随访期内,其肝癌发生风险显著下降(危险比0.56,95%CI:0.33-0.89,P=0.015)。本组其他恶性肿瘤5、10、15年的累积发病率分别为2.4%、5.1%和9.8%。以下因素增加其他肿瘤的发生风险:年龄≥50岁、吸烟指数(每天吸烟包数×吸烟年数)≥20(HR=1.89)以及2型糖尿病(HR=1.70,95%CI:1.14-2.53)。若控制血糖使平均糖化血红蛋白低于7.0%水平,其他恶性肿瘤的发生风险下降,但差异无统计学意义(危险比0.62,P=0.170)。结论经过干扰素治疗的HCV阳性患者,若合并2型糖尿病,其罹患肝细胞癌或其他恶性肿瘤的风险约升高1.7倍。同时,这部分患者若能有效控制血糖,使糖化血红蛋白低于7%的水平,将显著降低其肝细胞癌的发生风险。

关键词：慢性丙肝型糖尿病肝癌肝脏肿瘤恶性肿瘤患者

日本慢性HBV感染者应用干扰素治疗6个月的疗效

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 46-46页

作者： suzuki f. Arase Y. Akuta N. 赵天智 Department of Gastroenterology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan

Background: In Japan, there are few studies of long-term (more than 1 month) interferon (IfN) therapy for chronic hepatitis B (CHB). In this retrospective study, we investigated the efficacy and predictors of response to 6-month IfN therapy. Methods: We analyzed 66 Japanese patie nts with CHB who were treated with IfN for 6 months. They comprised patients who were hepatitis B e antigen (HBeAg)-positive (n = 45) and -negative (n = 21). One (2%), 8 (12%), and 51 (77%) patients were infected with hepatitis B virus (HBV) genotypes A, B, and C, respectively. Responders in patients positive for HBeAg were defined as those who showed normalization of serum alanine aminotransferase (ALT) level, HBeAg loss, and HBV DNA negativity at 6 months after completion of IfNtherapy. In patients negative for HBeAg, responders were defined as those patients who showed normalization of ALT level and HBV DNA negativity at the same 6-month time point. Results: Of the 45 patients with HBeAg at the commencement of IfN therapy,9 (20%) were responders. Young patients, especially those with a high serum ALT level, were significantly more likely to respond to IfN therapy. Of the 21 patients negative for HBeAg, 13 (62%) were responders. There were no significant differences in clinical characteristics between responders and nonresponders among patients negative for HBeAg. Multivariate analyses identified HBeAg negativity and young age as independent factors associated with a positive response to 6-month IfN therapy. However, long-term follow-up of the treated patients showed a fall in the response rate. Conclusions: The response rate to 6-month IfN therapy among HBeAg-positive patients was low. However, young patients may require long-term IfN therapy.

关键词：干扰素治疗治疗应答应答者阴性患者乙型肝炎应答率多变量分析