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GnRH-Agonist Trigger versus Human Chorionic Gonadotrophin (HCG) Trigger in Cases of Controlled Ovarian Stimulation;Randomized Controlled Trial

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Open Journal of Obstetrics and Gynecology 2021年第11期11卷 1452-1460页

作者： Mohamed Elmahdy suzan elsharkawy Department of Obstetrics and Gynecology Faculty of Medicine Alexandria University Alexandria Egypt

Objectives: The aim of the study was to compare the efficacy and safety of GnRH-agonist to the human chorionic gonadotrophin (HCG) trigger in cases of simple ovarian stimulation. Study design: Randomized controlled trial was conducted on 291 women complaining of unexplained infertility visiting Elshatby Maternity University Hospital from February to December 2019. Trial registration unique ID is PACTR202001787868341 (https://***/). Age included from 20 - 43 years. All patients were stimulated by the sequential stimulation protocol using letrozole then FSH injection, when the criteria of ovulation trigger were reached; cases were randomized into two groups using closed envelopes method.

关键词： GnRH Agonist HCG Ovulation Trigger OHSS

Sero-Prevalence of HBV, HCV and HEV among the Egyptian Pregnant Females

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Open Journal of Obstetrics and Gynecology 2019年第10期9卷 1429-1438页

作者： suzan Samir elsharkawy Wael Samir Elgazayerli Lecturer at Department of Obstetrics and Gynecology Faculty of Medicine Alexandria University Alexandria Egypt

Background: Viral hepatitis in pregnant women can be caused by multiple types of hepatitis viruses and can cause a wide range of symptoms and complications, ranging from asymptomatic infection to maternal and fetal deaths. Objective: The aim of this study was to evaluate the sero-prevalence and the associated factors of viral hepatitis B (HBV), viral hepatitis C (HCV) and viral hepatitis E (HEV) among the Egyptian pregnant females. Methods: This cross-sectional study was conducted in the period from January to July 2017 in two selected antenatal clinics;El-shat by maternity university hospital at Alexandria city and El-Behera health insurance antenatal clinic at Damanhur city on 261 apparently healthy gravid women. Eligible women were evaluated by a questionnaire about socio-demographic data and viral serological tests were done at El-shat by maternity University Hospital Laboratory. Results: The overall HBs-Ag sero-prevalence in the pregnant women included in this study was 7 cases (2.7%) and HCV-RNA PCR was 4 cases (1.5%). Of the total study participants, none of them (0%) were anti-HEV IgM positive and 48 cases (18.4%) were anti-HEV IgG positive. According to our results, neither age of the woman, place of residence, past family history of hepatitis virus infection nor having a pet animal had any strong association to be considered as an associated factor for acquiring HEV infection. Conclusion: Although it seems that there are many improvements in the prevalence of different hepatitis viruses in the country, hepatitis viral infections are still high enough to continue their preventive programs and health education, to protect the mothers and their fetuses from the hazardous effects of these serious infections.

关键词： Viral Hepatitis Hepatitis B Virus Hepatitis C Virus Hepatitis E Virus Pregnant Women

Effect of Cumulus Cells on the Efficiency of Vitrified-Thawed Immature Cattle Oocytes

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Open Journal of Obstetrics and Gynecology 2019年第5期9卷 669-678页

作者： Samia Mohamed Abd-El Rheem suzan elsharkawy Theriogenology Department Faculty of Veterinary Medicine Alexandria University Alexandria Egypt Gynecology and Obstetrics Department Faculty of Medicine Alexandria University Alexandria Egypt

The present work was designed to examine the effect of the presence or absence of cumulus cells on the efficiency of vitrification of immature cattle oocytes. In our experiment, we had two groups: group 1, immature cattle oocytes with cumulus cells and group 2, immature cattle oocytes without cumulus cells. The two groups underwent vitrification using 20% ethylene glycol and 20% DMSO, and then thawed, and in vitro matured in TCM-199 medium and examined after 22 hours for assessment of nuclear maturation. Higher survival rate (p < 0.05) after thawing was observed in group 1 (84.6%) than group 2 (57.8%). After in-vitro maturation, the rate of MII oocytes was significantly higher (p < 0.05) in group 1 (74.4%) than group 2 (47.7%). In conclusion, the cumulus cells are very important in increasing the survivability and developmental rate of vitrified-thawed immature cattle oocytes.

关键词： Cumulus Cells Vitrified-Thawed Immature Oocytes Cattle

The Tumor Infiltrating Lymphocytes (TILs): Did We Find the Missed Piece of the Huge Puzzle?

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Open Journal of Obstetrics and Gynecology 2021年第2期11卷 146-161页

作者： suzan Samir elsharkawy Mohamed Abd Elrheem Samia Abd Elrheem Department of Obstetrics and Gynecology Faculty of Medicine Alexandria University Alexandria Egypt

Tumor infiltrating lymphocytes (TILs) are used in evaluating the prognosis and determining treatment of different types of cancer with variable degrees of success. The usage of checkpoint inhibitor immunotherapy as a treatment variety for cancer and Adoptive cell therapy is associated with many complications, severe side effects and high expenses. Recently, in a limited number of metastatic GIT and breast cancers, the identification of T-cell specific against so-called tumor neo-antigens and Adoptive transfer of those lymphocytes resulted in some improvement. In 2020, Detection of a T cell receptor (TCR) in a T cell clone that recognized and killed most human cancer cell lines in vitro via the monomorphic MHC class I-related protein MR1, offers an opportunity for pan-cancer therapy Twenty three years earlier, Moist Heat was used successfully to activate a whole different and new immune response that was able to detect genetic mutation in the affected cancer cells and cured many cases of squamous and basal cell carcinomas. In this commentary review, we aimed to revise the literature for updates of TILs usage in cancer prognosis and treatment.

关键词： Tumor Infiltrating Lymphocytes Cancer Checkpoint Inhibitor Adoptive Cell Therapy T Cell Receptor (TCR) Moist Heat Pan-Cancer Therapy Squamous Cell Carcinoma Basal Cell Carcinomas

Endometrial Preparation for Frozen Embryo Transfer by Supplemented Natural Cycle versus Hormone Replacement Cycle in Regularly Cycling Women

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Open Journal of Obstetrics and Gynecology 2019年第6期9卷 827-837页

作者： suzan Samir elsharkawy Tamer Hanafy Mahmoud Mervat Sheikh-Elarab Elsedeek Eman Monier Abd Elkader Amer Faculty of Medicine University of Alexandria Alexandria Egypt Ministry of Health Hospitals Alexandria Egypt

BACKGROUND: The first successful pregnancy from a frozen-thawed embryo transfer (FTET) was reported in 1983 and after more than three decades, significant changes have been introduced into clinical practice. OBJECTIVE: To compare endometrial preparation for frozen thawed embryo transfer (FTET) in supplemented natural cycle (NC) by hCG (human chorionic gonadotropin) versus HRT (hormonal replacement therapy) by estrogen and progesterone in regularly cycling women. METHODS: A prospective trial was conducted on 40 patients that were divided into two treatment groups. The first group underwent endometrial preparation by supplemented natural cycle by HCG, and the second group underwent endometrial preparation by HRT (estrogen and progesterone). RESULTS: No significant difference was revealed between the two groups regarding ongoing clinical pregnancy rate. CONCLUSION: This study concluded that there is no significant difference in clinical pregnancy rate between the two methods of endometrial preparation for frozen thawed embryo transfer;supplemented natural cycle by hCG or HRT by estrogen and progesterone, in regularly cycling women.

关键词： Intracytoplasmic Sperm Injection (ICSI) Infertility Frozen Cycles

Viable Second Trimester Cervical Ectopic Pregnancy Managed Successfully with Uterine Preservation: Case Report

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Open Journal of Obstetrics and Gynecology 2021年第9期11卷 1236-1247页

作者： suzan elsharkawy Abdullah Elrashidy Nazem Badran Gawed Ekbal Shahda Yakob Salamah Elnagar Ashraf Elaggan Amr Mostafa Mohamed Abdelaziz Assistant Professor of Obstetrics and Gynecology Alexandria University ARE and Consultant of Obstetrics and Gynecology Hail General Hospital Hail KSA Consultant of Urology King Khalid Hospital Hail KSA Consultants of Obstetrics and Gynecology Alkasim Maternity Hospital Alkasim KSA Consultants of Obstetrics and Gynecology Hail General Hospital Hail KSA Consultants of Radiology King Salman Hospital Hail KSA Faculty of Medicine Mansoura University Mansoura Egypt

Cervical pregnancy is a rare clinical entity that accounts for less than 1% of all ectopic pregnancies. It results from implantation of the blastocyst in the cervical canal below the level of the internal os. Although non-tubal ectopic pregnancies account for only 5% of ectopics, they contribute to a significant morbidity. The cornerstone in the management of cervical ectopic is early diagnosis by high index of suspension and a qualified sonographer. Management options for cervical ectopic pregnancies range from conservative drug treatment to radical hysterectomy. Over the last few years, the mortality and morbidity rates of ectopic pregnancies have been reduced. This is mainly due to the early recognition of the condition and the wide availability of minimally invasive surgical procedures. We present a case of a 33-year-old woman that was 16 weeks pregnant. She presented initially with recurrent vaginal bleeding followed by minimal lower abdominal pain. Her early US scans were misleading. Several weeks later, a follow up MRI scan suggested cervical ectopic. She was managed surgically with uterine preservation.

关键词： Ectopic Pregnancy Cervical Ectopic Uterine Artery Embolization Hystroscopic Resection Conservative Management of Ectopic Methotrexate Cervical Tamponade Bakri Balloon Cervical Cerclage

MXene@c-MWCNT Adhesive Silica Nanofiber Membranes Enhancing Electromagnetic Interference Shielding and Thermal Insulation Performance in Extreme Environments

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Nano-Micro Letters 2024年第10期16卷 82-98页

作者： Ziyuan Han Yutao Niu Xuetao Shi Duo Pan Hu Liu Hua Qiu Weihua Chen Ben Bin Xu Zeinhom MEl-Bahy Hua Hou Eman Ramadan elsharkawy Mohammed AAmin Chuntai Liu Zhanhu Guo Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002People's Republic of China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026People's Republic of China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123People's Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072People's Republic of China College of Chemistry&Green Catalysis Center Zhengzhou UniversityZhengzhou 450001People's Republic of China Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18UK Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt Department of Chemistry Faculty of ScienceNorthern Border UniversityArarSaudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia

A lightweight flexible thermally stable composite is fabricated by com-bining silica nanofiber membranes(SNM)with MXene@c-MWCNT hybrid *** flexible SNM with outstanding thermal insulation are prepared from tetraethyl orthosilicate hydrolysis and condensation by electrospinning and high-temperature calcination;the MXene@c-MWCNT_(x:y)films are prepared by vacuum filtration *** particular,the SNM and MXene@c-MWCNT_(6:4)as one unit layer(SMC_(1))are bonded together with 5 wt%polyvinyl alcohol(PVA)solution,which exhibits low thermal conductivity(0.066 W m^(-1)K^(-1))and good electromagnetic interference(EMI)shielding performance(average EMI SE_(T),37.8 dB).With the increase in func-tional unit layer,the overall thermal insulation performance of the whole composite film(SMC_(x))remains stable,and EMI shielding performance is greatly improved,especially for SMC_(3)with three unit layers,the average EMI SET is as high as 55.4 *** addition,the organic combination of rigid SNM and tough MXene@c-MWCNT_(6:4)makes SMC_(x)exhibit good mechanical tensile ***,SMC_(x)exhibit stable EMI shielding and excellent thermal insulation even in extreme heat and cold ***,this work provides a novel design idea and important reference value for EMI shielding and thermal insulation components used in extreme environmental protection equipment in the future.

关键词： SiO_(2)nanofiber membranes MXene@c-MWCNT Composite film Thermal insulation Electromagnetic interference shielding

Analysing user daylight preferences in heritage buildings using virtual reality

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Building Simulation 2022年第9期15卷 1561-1576页

作者： Mohamed Marzouk Maryam elsharkawy Ayman Mahmoud Department of Structural Engineering Faculty of EngineeringCairo University12613GizaEgypt Department of Architecture Engineering Faculty of EngineeringCairo University12613GizaEgypt

Technology has always been creating effective ways to support human *** virtual reality(IVR)has emerged to engage users in a simulated world,and this has gained the interest of a wide variety of users in the heritage industry.A historical case study built in the early 19th century is considered for an adaptive reuse *** palace is located in Cairo,Egypt,and named after Prince Omar *** current palace state incorporates a smashed top-lit zone,which is being studied and analyzed for daylighting *** simulated distinct optimum skylight configurations are suggested for the redesign where the selection should not be based solely on simulation data,but should consider real-user *** daylight design criteria are previously based on simulation data that do not necessarily indicate the users'*** utilizing user interactive tools such as IVR to test daylight redesign options,a whole new dimension is *** this study,the VR users’survey data is statistically analyzed using Statistical Package for Social Sciences(SPSS),where results revealed that the assessment attributes succeeded in reflecting the users'preferences;which,motivated designers to consider potential users’daylight preferences in reused *** paper highlights the most significant emotional attributes that provide cost-effective and reliable information concerned with the performance of daylight in IVR before design *** study compares and analyzes the effect of three skylight designs(Cases A,B&C)on the users'perception before design implementation using(IVR)***-eight participants have contributed to the study,providing their feedback on six attributes namely:Pleasant,Contrasting,Brightness,Uniform Distribution,Visual Comfort,and *** attributes are evaluated for the three cases in space using five scale rating values to reveal that the"Pleasant"attribute is most reliable in the study to reflect th

关键词： daylight preferences heritage buildings rehabilitation immersive virtual reality statistical analysis

Fibrosis regression following hepatitis C antiviral therapy

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World Journal of Hepatology 2022年第6期14卷 1120-1130页

作者： Aisha elsharkawy Reham Samir Mohamed El-Kassas Department of Endemic Medicine and Hepatogastroenterology Faculty of MedicineCairo UniversityCairo 11566Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Hepatitis C virus(HCV)infection is one of the most common causes of liver *** is a major etiological factor of continuous liver injury by triggering an uncontrolled inflammatory response,causing liver fibrosis and *** fibrosis is a dynamic process that can be reversible upon timely cessation of the injurious agent,which in cases of HCV is represented by the sustained virological response(SVR)following antiviral ***-acting antiviral therapy has recently revolutionized HCV therapy and minimized *** fibrosis can be assessed with variable invasive and non-invasive methods,with certain *** the broad validation of the diagnostic and prognostic value of non-invasive modalities of assessment of liver fibrosis in patients with HCV,the proper interpretation of liver stiffness measurement in patients after SVR remains *** is also still a debate whether this regression is caused by the resolution of liver injury following treatment of HCV,rather than true fibrosis *** of liver fibrosis can possess a positive impact on patient's quality of life reducing the incidence of ***,fibrosis regression does not abolish the risk of developing hepatocellular carcinoma,which mandates regular screening of patients with advanced fibrosis.

关键词： Fibrosis regression Hepatitis C virus Direct-acting antivirals Hepatocellular carcinoma Liver fibrosis Cirrhosis