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HPDA/Zn as a CREB Inhibitor for Ultrasound imaging and Stabilization of Atherosclerosis Plaque+

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Chinese Journal of Chemistry 2023年第2期41卷 199-206页

作者： Linzi Chen Zhenqi Jiang Lifei Yang Ye Fang Shuwei Lu Ozioma U.Akakuru Shuaishuai Huang Juan Li suya ma Aiguo Wu Ningbo Yinzhou No.2 Hospital NingboZhejiang 315192China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiang 315201China School of Medical Technology Institute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China

Thrombosis,secondary to rupture of unstable plaque,is a fatal risk factor for myocardial infarction and ischemic *** present,more novel methods are needed for the diagnosis and treatment of vulnerable ***,we report a hollow polydopamine/Zn(HPDA/Zn)ultrasound contrast *** western-blot,Elisa,and other experiments,we found that in addition to having a good contrast-enhancement capability in ultrasound imaging in vitro and in vivo,HPDA/Zn also has the effect of reducing the expres-sion of *** protein and its downstream-regulated proteins and factors are closely related to the stability of ***/Zn has the effect of reducing the expression of CREB protein,which leads to the decrease of expression of MMP-9,the regulatory pro-tein downstream of the CREB *** addition,it also reduces the secretion of inflammatory factors hs-CRP and ***,HPDA/Zn can stabilize plaque by inhibiting CREB and reducing plaque vulnerable markers and inflammatory *** a word,HPDA/Zn is a kind of ultrasound contrast agent,which can stabilize plaques by inhibiting CREB protein.

关键词： Atherosclerosis Zinc Polymerization CREB Nanoparticles Ultrasound imaging

The diagnostic value of real-time shear wave elastography in early liver fibrosis among patients with chronic hepatitis B

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The diagnostic value of real-time shear wave elastography in...

Effects of ultrasound-targeted microbubble destruction combined with GSK-3 beta inhibition in atherosclerosis rabbits

2015年浙江省超声医学学术年会

作者： Zhang Yizhen ma suya Yinzhou No.2 Hospital

Objective To evaluate the value of real-time shear wave elastography(SWE)in diagnosis of early liver fibrosis(Sl and S2 period)among chronic hepatitis B(CHB)patients by detecting the liver Young’s elastic modulus *** 199 CHB patients who underwent liver biopsy in our hospital(Sl,S2 period:101 cases of Sl,98 cases of S2)and 78 healthy volunteers(control group)betweenwere inrolled in this study *** real-time SWE were

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Effects of ultrasound-targeted microbubble destruction combi...

Downregulation of GSK-3β Expression via Ultrasound-Targeted Microbubble Destruction Enhances Atherosclerotic Plaque Stability in New Zealand Rabbits

2019年浙江省医学会超声医学学术大会

作者： Lifei Yang suya ma Ningbo Yinzhou NO.2 Hospital

Accumulating evidence suggests that atherosclerosis(AS) is the underlying cause of vascular diseases, including heart disease and stroke. The current systemic therapies for AS such as lipid-lowering treatment, thrombolytic therapy or antioxidants are limited effective. Therefore, novel technology combined with new markers are urgently needed for AS treatment, especially for stabilizing AS plaque.

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Downregulation of GSK-3β Expression via Ultrasound-Targeted...

二维斑点追踪技术评价心房同步性与病态窦房结综合征伴发阵发性心房颤动的关系

2020年浙江省医学会超声医学学术大会

作者： Lifei Yang Lingzi Chen Ye Fang suya ma Department of Ultrasound Ningbo Urology and Nephrology Hospital Ningbo University School of Medicine

Accumulating evidence suggests that atherosclerosis (AS) is the underlying cause of vascular diseases,including heart disease and ***-targeted microbubble destruction (UTMD) technology provides a safe,efficient and effective system for drug delivery and gene transfection,which has broad application prospects in the treatmentof AS.

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中华医学超声杂志（电子版） 2018年第3期15卷 184-190页

作者：朱玲斐马苏亚谢晓红浙江省宁波市鄞州第二医院超声科 315100

目的采用二维斑点追踪技术评价心房同步性与病态窦房结综合征伴发阵发性心房颤动的关系。方法收集2015年1月至2016年8月在浙江省宁波市鄞州第二医院超声科行超声心动图检查的病态窦房结综合征患者。选择病态窦房结综合征不伴发阵发性心... 详细信息

目的采用二维斑点追踪技术评价心房同步性与病态窦房结综合征伴发阵发性心房颤动的关系。方法收集2015年1月至2016年8月在浙江省宁波市鄞州第二医院超声科行超声心动图检查的病态窦房结综合征患者。选择病态窦房结综合征不伴发阵发性心房颤动患者25例(病态窦房结综合征A组),病态窦房结综合征伴发阵发性心房颤动患者19例(病态窦房结综合征B组)。选择同期本科行超声心动图检查的健康志愿者28名作为健康对照组。采用超声心动图评价所有受检者左心室结构和功能参数,在获取右心房游离壁、房间隔和左心房游离壁二维斑点追踪图像后,测量心电图P波起始点至图像上舒张期第二个负向波的时间间期,代表右心房游离壁电-机械运动时间(P-RA)、房间隔电-机械运动时间(P-IAS)和左心房游离壁电-机械运动时间(P-LA),计算心房同步性参数。采用单因素方差分析比较3组受检者常规超声心动图参数、P-RA、P-IAS、P-LA及心房同步性参数差异,进一步组间两两比较采用SNK-q检验;采用Spearman相关分析法分析心房电-机械运动时间参数、心房同步性参数与阵发性心房颤动的相关性;绘制应用心房电-机械运动时间参数、心房同步性参数预测病态窦房结综合征伴发阵发性心房颤动的受试者工作特征(ROC)曲线。结果病态窦房结综合征A组、病态窦房结综合征B组患者左心房前后径(LAD)均大于健康对照组受检者,且差异均有统计学意义(q=4.18、5.37,P均man相关分析结果显示,P-LA、右心房内同步性、左心房内同步性和左右心房间同步性与病态窦房结综合征伴发阵发性心房颤动均呈正相关(r=0.61、0.55、0.75、0.78,P均<0.01),其中,左右心房间同步性与与病态窦房结综合征伴发阵发性心房颤动的相关性最佳。ROC曲线显示,P-LA预测病态窦房结综合征伴发阵发性心房颤动的最佳阈值为94 ms,敏感度和特异度分别为68.42%和76.00%,曲线下面积为0.764(95%CI0.612~0.879);右心房内同步性预测病态窦房结综合征伴发阵发性心房颤动的阈值为19 ms,敏感度和特异度分别为57.89%和76.00%,曲线下面积为0.714(95%CI 0.558~0.840);左心房同步性预测病态窦房结综合征伴发阵发性心房颤动的阈值为42 ms,敏感度和特异度分别为78.95%和76.00%,曲线下面积为0.860(95%CI 0.722~0.946);左右心房间同步性预测病态窦房结综合征伴发阵发性心房颤动的阈值为68 ms,敏感度和特异度分别为84.21%和84.00%,曲线下面积为0.859(95%CI0.721~0.945);ROC曲线下面积显示,左心房内同步性和左右心房间同步性预测病态窦房结综合征伴发阵发性心房颤动的效能优于右心房内同步性。结论心房电-机械运动时间参数和同步性参数与病态窦房结综合征伴发阵发性心房颤动关系密切。左心房内同步性和左右心房间同步性预测病态窦房结综合征伴发阵发性心房颤动的价值最佳。

关键词：超声心动描记术病态窦房结综合征阵发性心房颤动心房同步性

超声介导微泡在内皮祖细胞移植修复大鼠慢性移植物血管病中的应用

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中华超声影像学杂志 2016年第1期25卷 75-80页

作者：马骥马苏亚苑贤贤方晔陈烽宁波大学医学院影像医学与核医学专业 315000 宁波大学医学院外科学 315000 宁波市鄞州第二医院超声科

目的探讨超声介导的微泡破坏（US＋MB）促进内皮祖细胞（EPCs）移植治疗大鼠慢性移植物血管病（CAV）的可行性。方法体外分离、培养及鉴定大鼠EPCs并建立大鼠腹主动脉移植模型。实验分为4组，空白对照组无特殊处理；异系移植对照组尾静... 详细信息

目的探讨超声介导的微泡破坏（US＋MB）促进内皮祖细胞（EPCs）移植治疗大鼠慢性移植物血管病（CAV）的可行性。方法体外分离、培养及鉴定大鼠EPCs并建立大鼠腹主动脉移植模型。实验分为4组，空白对照组无特殊处理；异系移植对照组尾静脉注射1ml生理盐水IEPCs治疗组尾静脉注射1mlEPCs悬液；Us＋MB＋EPCs组先在体外予超声波破坏微泡作用后再经尾静脉输注1mlEPCs悬液。8周后取出移植血管进行组织病理学观察，测量内膜厚度，免疫组化检测SDF-1α表达，RT—PCR定量分析SDF-1α及TNF-α在移植动脉的表达。结果异系移植对照组、EPCs治疗组、US＋MB＋EPCs组内膜厚度、炎症反应程度及因子表达水平与空白对照组相比差异均有统计学意义（P〈0．05），其中US＋MB＋EPCs组移植动脉内膜增生程度最小（P〈0．05），炎症反应最轻，SDF-1α表达水平最高，TNF-α的表达水平最低（P〈0．05）。结论超声介导微泡破坏可有效促进EPCs修复CAV中受损的内膜，延缓病变的进展。

关键词：超声处理微气泡内皮祖细胞慢性移植物血管病

Elasticity meets topology

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National Science Review 2024年第6期11卷 84-85页

作者： Guancong ma Department of Physics Hong Kong Baptist University

We are surrounded by environments and items that are made from solid materials in our daily life. Any physical contact with any items is a mechanical disturbance that produces mechanical *** underlines the crucial role that such vibrations play in our daily interactions,highlighting the need for a deeper understanding and improved manipulation of these fundamental phenomena.

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Uniform decomposition of velocity gradient tensor

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Journal of Hydrodynamics 2024年第1期36卷 24-34页

作者： Chenxi ma Chaoqun Liu Department of mathematics University of Texas at ArlingtonArlingtonTXUSA

In this paper,the principal decomposition of the velocity gradient tensor[∇v]is discussed in 3 cases based on the discriminant∆:∆0 with 3 distinct real eigen values,and∆=0 with 1 or 2 distinct real eigen *** velocity gradient tensor can also be classified as rotation point,which can be decomposed into three parts,i.e.,rotation[R],shear[S]and stretching/compression[SC],and non-rotation point,we defined a new resistance term[L],and the tensor can be decomposed into three parts,i.e.,resistance[L],shear[S]and stretching/compression[SC].Example matric are also displayed to demonstrate the new *** of principal decomposition between 3 different cases,and between Resistance and Liutex will also be discussed.

关键词： Velocity gradient Liutex resistance fluid kinematics

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei ma Lin Li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical *** the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing *** were the main components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution