检索结果-南通市图书馆

A rare case of pigmented Bowen disease of the nail fold

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第12期133卷 1503-1504页

作者： sushmita pradhan Si-Liang Xue Department of Dermatovenereology West China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:Bowen disease(BD)is a squamous cell carcinoma in situ that can progress into invasive carcinoma.[1]Pigmented BDis a rare variant of squamous cell carcinoma in situ that can be diagnosed *** is usually characterized by slow-growing,welldefined,and non-uniform hyperpigmented plaque.[2]It is also characterized by the increased melanin pigment in the epidermis or papillary dermis in addition to the alteration of *** a study,7(1.67%)of 420 BD cases were pigmented.[1]Although the exact underlying mechanism of pigmented BD is unclear,pigmentation is due to the presence of an increased number of melanocytic hyperplasia by hypertrophic dendritic processes dispersed through the tumor.[3]Pigmented BD with no scaling and keratosis indicates well-differentiated stages of atypical keratinocytes developing melanin.[3]Later atypical keratinocytes result in loss of pigmentation,keratosis,and ***,we present a rare case of pigmented BD on the proximal nail fold.

关键词： Bowen squamous rare

Dermoscopic clues for sebaceous carcinoma arising in nevus sebaceous

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第17期133卷 2121-2122页

作者： sushmita pradhan Hui Xiao He-Li Yang Yu-Ping Ran Department of Dermatovenereology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatovenereology Chengdu BOE HospitalChengduSichuan 610200China

To the Editor:Sebaceous carcinoma(SC)is a rare cutaneous malignant tumor differentiated from the epithelium lining and arising from the sebaceous gland.[1]Consequently,nevus sebaceous(NS)tends to develop into a benign or malignant neoplasm.[2]Herein,we report dermoscopic findings in a rare case of SC arising in NS with protruding nodule in erosive erythematous surface rapidly arising from yellow pigment plaque resulting in no *** is a powerful diagnostic tool to generate a preoperative diagnosis.

关键词： epithelium yellow rare

在线全文

学校读者我要写书评

暂无评论

痤疮相关微生物菌群间相互作用机制研究进展

中国皮肤性病学杂志 2021年第2期35卷 222-227页

作者：徐小茜 sushmita pradhan 冉玉平四川大学华西医院皮肤性病科四川成都610041

痤疮是毛囊皮脂腺的一种慢性炎症性疾病,痤疮皮损内主要菌群包括丙酸杆菌、葡萄球菌、马拉色菌等,各菌通过分泌、诱导合成各种细胞因子、蛋白酶、脂肪酸,彼此形成复杂的分子信号网络,最终调控宿主皮肤细胞内外的炎症反应。本文就痤疮皮... 详细信息

痤疮是毛囊皮脂腺的一种慢性炎症性疾病,痤疮皮损内主要菌群包括丙酸杆菌、葡萄球菌、马拉色菌等,各菌通过分泌、诱导合成各种细胞因子、蛋白酶、脂肪酸,彼此形成复杂的分子信号网络,最终调控宿主皮肤细胞内外的炎症反应。本文就痤疮皮损中主要的细菌与真菌间的相互作用及可能机制进行阐述。

关键词：寻常痤疮痤疮丙酸杆菌表皮葡萄球菌金黄色葡萄球菌马拉色菌

伊曲康唑胶囊微丸在蒸馏水、牛奶、可乐中溶出度分析

在线全文

学校读者我要写书评

暂无评论

中国皮肤性病学杂志 2018年第2期32卷 129-134页

作者：徐小茜汤明海 sushmita pradhan 冉玉平四川大学华西医院皮肤性病科四川成都610041 四川大学国家生物治疗重点实验室药代动力学科四川成都610041

目的临床上发现用可乐或牛奶送服伊曲康唑胶囊可提高其生物利用度和治疗效果,本研究旨在比较伊曲康唑胶囊微丸在蒸馏水、牛奶(全脂、低脂以及脱脂牛奶,伊利乳业)和可乐(可口可乐)中的溶出度。方法进行伊曲康唑微丸溶出度试验,采用液相色... 详细信息

目的临床上发现用可乐或牛奶送服伊曲康唑胶囊可提高其生物利用度和治疗效果,本研究旨在比较伊曲康唑胶囊微丸在蒸馏水、牛奶(全脂、低脂以及脱脂牛奶,伊利乳业)和可乐(可口可乐)中的溶出度。方法进行伊曲康唑微丸溶出度试验,采用液相色谱-串联质谱法对伊曲康唑微丸在溶出度试验中不同阶段的溶出浓度进行检测。结果自然pH的蒸馏水、牛奶、可乐中,伊曲康唑溶出度:可乐>牛奶>蒸馏水。从溶解平均最高浓度来看,可乐溶解伊曲康唑的能力约是牛奶的2.36~3.19倍,是蒸馏水的10.37倍。在蛋白质含量相同的情况下,全脂牛奶(脂肪6%)在牛奶中溶出能力最强。结论推荐临床上使用可乐或者全脂牛奶送服伊曲康唑胶囊,可增加药物溶出度,促进胃肠道吸收。

关键词：伊曲康唑胶囊微丸蒸馏水可乐全脂牛奶低脂牛奶脱脂牛奶液相色谱-串联质谱法

Nail Psoriasis in a Child Observed Under Ultraviolet Dermoscopy Treated by a Topical Biological Agent Cream:A Case Report

在线全文

学校读者我要写书评

暂无评论

International Journal of Dermatology and Venereology 2021年第4期4卷 251-253页

作者： Run-Yan Gao sushmita pradhan Yu-Ping Ran Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China

Introduction:Nail psoriasis is a type of psoriasis involving nail lesions characterized by pitting,onycholysis,longitudinal ridges,and subungual *** herein describe a 9-year-old girl with nail psoriasis who presented with nail crumbling and was treated with topical cream containing 45μg/g mouse monoclonal antibody to human *** presentation:A 9-year-old Chinese girl presented with a 6-month history of a rough,thickened fingernail and *** plate crumbling,onycholysis,and fissured periungual folds were observed under dermoscopy and ultraviolet *** nails were soaked in warm water,then topical wrapped with Abcream cream *** about 4 months of treatment,the nails significantly improved by both dermoscopy and ultraviolet-dermoscopy ***:Due to the different wavelengths of light emitted by polarized light dermatoscope and ultraviolet-dermatoscope,the characteristics of observation will be *** acts by antagonizing human interleukin-8,inhibiting leukocyte chemotaxis and neovascularization,and regulating the abnormal proliferation and differentiation of ***:Ultraviolet-dermoscopy is pivotal in evaluating the severity and potency of nail *** Abcream can be regarded as a new drug for the treatment of nail psoriasis in children.

关键词： nail psoriasis ultraviolet dermoscopy mouse monoclonal antibody to human interleukin-8 cream

Nevus Sebaceus promotes Malassezia globosa overgrowth damaging the hair root

在线全文

学校读者我要写书评

暂无评论

Nevus Sebaceus promotes Malassezia globosa overgrowth damagi...

中国菌物学会2018年学术年会

作者： pradhan sushmita RAN Xin ZHANG Chaoliang RAN Yuping Department of Dermatovenereology West China Hospital of Sichuan University State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan University

Nevus sebaceus is a benign hamartoma of the skin usually present at birth having tendency to thicken and become verrucous around puberty. Malassezia is a unique type of fungi forming a monophyletic group of basidiomycetous yeasts. Though Malassezia are normal part of skin flora appearing on areas rich in sebaceous glands such as face, scalp,upper chest, and back, causing several skin diseases such as seborrheic dermatitis, scalp psoriasis and folliculitis. A 3-month-old infant from Southwest China was presented to the dermatology clinic with a yellow-orange hairless plaque on scalp since birth and a 2-month history of yellow-greasy scales over the plaque. The dermatological examination revealed 2 x 2 hairless, solitary, yellow-orange plaque with a smooth surface along the yellow scales over the lesion. Fluorescence microscope with fluorescent staining of the scales showed numerous hyphae and spores. Scanning electron microscopy observed multiple Malassezia yeasts adhering to the surface of the hair root. Histopathological examination of a part of the lesion revealed varying degrees of acanthosis, underdeveloped sebaceous glands and immature hair follicles in dermis with fungal elements of multiple spores in the epidermis. A fungal culture grew Malassezia globosa（GenBank No. MH550149）,the identity of which was confirmed by polymerase-chain-reaction based sequence analysis. Nevus sebaceus mimicking fungal infection with Malassezia globosa affecting the hair root was diagnosed. The main cause of greasy scales over the scalp is Malassezia globosa and Malassezia restricta. Due to the Malassezia yeast growing in the hair follicles, it invades the hair follicle dermal root sheath. Intercellular lipids（ceramide） excreted from the sebaceous glands is required by Malassezia damaging the hair root. The patient received 1% natifine hydrochloride and 0.25% ketoconazole cream, 2%ketoconazole shampoo, and 0.025% retinoids cream for one month. The patient’s treatment regimen was co

关键词： Malassezia globosa Nevus sebaceus hair roots sebaceous gland

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

伊曲康唑口服液治疗婴儿脓癣五例并文献复习

中国麻风皮肤病杂志 2023年第4期39卷 236-241页

作者：张牧秋庄凯文冉昕周宜可 sushmita pradhan 冉玉平四川大学华西医院皮肤性病科四川成都610041 四川大学华西临床医学院四川成都610041

本文报道5例经由伊曲康唑口服液治疗成功的婴儿脓癣并复习相关文献。5例患儿,年龄2~12个月,临床表现为头皮红斑、鳞屑、脓肿、脱发,诊断依据为皮肤镜下病发特点及取病发行钙荧光白染色后荧光显微镜检确认真菌孢子和(或)菌丝累及毛干、... 详细信息

本文报道5例经由伊曲康唑口服液治疗成功的婴儿脓癣并复习相关文献。5例患儿,年龄2~12个月,临床表现为头皮红斑、鳞屑、脓肿、脱发,诊断依据为皮肤镜下病发特点及取病发行钙荧光白染色后荧光显微镜检确认真菌孢子和(或)菌丝累及毛干、头皮。5例经伊曲康唑口服液5 mg/kg·d治疗后均痊愈,疗程3~12周。1例治疗过程中出现可逆性轻度短暂腹泻,未停药逐渐缓解。通过文献检索到7例伊曲康唑治疗婴儿头癣的报道,对病例特点及疗效进行分析总结。伊曲康唑口服液治疗婴儿头癣方便、安全、有效且耐受性良好。

关键词：婴儿头癣脓癣皮肤镜钙荧光白染色荧光显微镜检伊曲康唑口服液

Gene expression profiles of peripheral blood mononuclear cells from patients with atopic dermatitis stimulated with Malassezia globosa

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第22期134卷 2759-2761页

作者： Mao Lu Ya-Ling Dai Xin Ran sushmita pradhan Hai-Rong Liu Mei Ou Hong-Mei Wu Yu-Ping Ran Department of Dermatovenereology Sichuan University West China HospitalChengduSichuan 610041China Department of Dermatovenereology The First Affiliated Hospital of Chengdu Medical CollegeChengduSichuan 610500China Department of Laboratory Medicine The First Affiliated Hospital of Chengdu Medical CollegeChengduSichuan 610500China.

To the Editor:Malassezia located in the skin of patients with atopic dermatitis(AD)might be related to its pathogenesis,consisting of Malassezia globosa and Malassezia restricta as the dominant species.[1]However,the specific molecular mechanisms of Malassezia on host immune cells from AD patients are still *** our study,the Affymetrix Human Prime View array was used to detect the effect of *** on the gene expression of peripheral blood mononuclear cells(PBMCs)from AD patients,which was favorable to further understand the role of Malassezia colonization in the pathogenesis of AD.

关键词： patients dermatitis pathogenesis

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit Kumar pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs