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GeoSFM水文模型在西藏拉萨河流域的应用

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山地学报 2015年第6期33卷 751-758页

作者：除多达平向莉英罗布坚参 Shrestha Mandira Bajracharya sagar 中国气象局成都高原气象研究所拉萨分部西藏高原大气环境科学研究所西藏自治区水文水资源勘测局西藏自治区气象台国际山地综合发展中心(ICIMOD)

基于物理过程的半分布式水文模型USGS Geo SFM(Geospatial Stream Flow Model)对拉萨河2005年1—12月日径流量进行了模拟,并与同期的观测资料进行了对比。结果表明,Geo SFM模型在拉萨河流域的模拟效果较好,Nash-Sutcliffe效率系数为0.72... 详细信息

基于物理过程的半分布式水文模型USGS Geo SFM(Geospatial Stream Flow Model)对拉萨河2005年1—12月日径流量进行了模拟,并与同期的观测资料进行了对比。结果表明,Geo SFM模型在拉萨河流域的模拟效果较好,Nash-Sutcliffe效率系数为0.72,模拟和观测值之间的线性相关系数达0.89。由于Geo SFM模型输入参数较少,很多可以从应用广泛的全球或大尺度数据中获取,尤其是卫星遥感降水估算产品直接可以作为模型的降水驱动参数,所以在没有或缺少水文气象观测资料的地区应用前景广阔。

关键词：水文模型 GeoSFM 拉萨河西藏

Improved Self-Pruning for Broadcasting in Ad Hoc Wireless Networks

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Wireless Sensor Network 2017年第2期9卷 73-86页

作者： Raqeebir Rab Shaheed Ahmed Dewan sagar Nazmus Sakib Ahasanul Haque Majedul Islam Ashikur Rahman Department of Computer Science and Engineering Ahsanullah University of Science and Technology Dhaka Bangladesh Department of Computer Science and Engineering Bangladesh University of Engineering and Technology (BUET) Dhaka Bangladesh

Reducing number of forwarding nodes is the main focus of any broadcasting algorithm designed for ad-hoc wireless networks. All reliable broadcasting techniques can be broadly classified under proactive and reactive approaches. In proactive approach, a node selects a subset of its neighbors as forwarding node and announces the forwarding node list in the packet header during broadcast. On the other hand, no such forwarding list is generated in reactive approach. Rather, a node (cognitively) determines by itself whether to forward the packet or not based on neighbor information. Dominant pruning and Self-pruning are two example techniques that fall under proactive and reactive approach respectively. Between the two methods, dominant pruning shows better performance than self-pruning in reducing number of forwarding nodes as they work with extended neighbor knowledge. However, appended forwarding node list increases message overhead and consumes more bandwidth. As a result, the approach becomes non-scalable in large networks. In this paper, we propose a reactive broadcasting technique based on self-pruning. The proposed approach dubbed as “Improved Self-pruning based Broadcasting (ISB)” algorithm completes the broadcast with smaller packet header (i.e., with no overhead) but uses extended neighbor knowledge. Simulation results show that ISB outperforms dominant pruning and self-pruning. Furthermore, as the network gets more spread and denser, ISB works remarkably well.

关键词： Broadcasting Pruning Forwarding Set Heuristics

Target Oriented Synthesis and Mass Spectral Characterization of Curcumin-Phenformin Adduct： Potential Insights into the Role of this Conjugate as Anti-Diabetic and Anti-Cancer Agent

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Journal of Environmental Science and Engineering(A) 2016年第6期5卷 286-293页

作者： Bishambar Dayal Apexa Mehta sagar Patel Dhaval Shah Priyanka Chitkul Michael Anthony Lea 2 Department of Medicine Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA Department of Microbiology Biochemistry and Molecular Genetics Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA

Recently microwave-induced chemical synthesis of curcumin-metformin adduct to enhance the efficacy of metformin in preventing the formation of Advanced Glycation End Products （AGEs） has been reported from authors＇ laboratory. The present studies describe microwave-induced chemical synthesis and mass spectral characterization of curcumin-phenformin adducts using LC-MS/MS. The mechanism of formation and its analytical data via Thin-Layer Chromatography （TLC） combined with MS/MS fragmentation revealed a major six membered ring adduct and a minor eight membered ring isomer. A facile chemical synthesis and identification of major and minor isomers presented in this study may offer novel therapeutic strategies for inhibiting AGEs as well as anti-cancer treatments.

关键词： Diabetes mellitus advanced glycation end- products glycated human serum albumin curcumin phenformin metformin anti-cancer agents.

Mechanisms of triglyceride metabolism in patients with bile acid diarrhea

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World Journal of Gastroenterology 2016年第30期22卷 6757-6763页

作者： Nidhi Midhu sagar Michael McFarlane Chuka Nwokolo Karna Dev Bardhan Ramesh Pulendran Arasaradnam School of Medicine University of Warwick Coventry CV4 7AL United Kingdom Department of Gastroenterology University Hospitals Coventry and Warwickshire Coventry CV2 2DX United Kingdom Department of Gastroenterology Rotherham General Hospital NHS Trust Rotherham S60 2UD United Kingdom Clinical Sciences Research Institute University of Warwick Coventry CV2 2DX United Kingdom

Bile acids(BAs) are essential for the absorption of lipids. BA synthesis is inhibited through intestinal farnesoid X receptor(FXR) activity. BA sequestration is known to influence BA metabolism and control serum lipid concentrations. Animal data has demonstrated a regulatory role for the FXR in triglyceride metabolism. FXR inhibits hepatic lipogenesis by inhibiting the expression of sterol regulatory element binding protein 1c via small heterodimer primer activity. Conversely, FXR promotes free fatty acids oxidation by inducing the expression of peroxisome proliferator-activated receptor α. FXR can reduce the expression of microsomal triglyceride transfer protein, which regulates the assembly of very low-density lipoproteins(VLDL). FXR activation in turn promotes the clearance of circulating triglycerides by inducing apolipoprotein C-Ⅱ, very low-density lipoproteins receptor(VLDL-R) and the expression of Syndecan-1 together with the repression of apolipoprotein C-Ⅲ, which increases lipoprotein lipase activity. There is currently minimal clinical data on triglyceride metabolism in patients with bile acid diarrhoea(BAD). Emerging data suggests that a third of patients with BAD have hypertriglyceridemia. Further research is required to establish the risk of hypertriglyceridaemia in patients with BAD and elicit the mechanisms behind this, allowing for targeted treatment.

关键词： Bile acids Bile acid diarrhea Triglycerides Farnesoid X receptor

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自动温度补偿测量仪

中国检验检测 1992年第4期 31-32页

作者： Paul sagar 何平

由于制造商要提高质量,公差变得日益严格。实际上它们开始接近和超过传统测量仪器和环境条件的极限。温度是引起工业测量误差的最显著的原因。但是技术发展使得测量仪可以自动补偿温度变化。温度补偿测量仪不用离线计算、查表、辅助设备... 详细信息

由于制造商要提高质量,公差变得日益严格。实际上它们开始接近和超过传统测量仪器和环境条件的极限。温度是引起工业测量误差的最显著的原因。但是技术发展使得测量仪可以自动补偿温度变化。温度补偿测量仪不用离线计算、查表、辅助设备,几秒即可完成。

关键词：测量仪温度补偿温度校正公差范围

Giant Cerebriform Nevus Cell Nevus of the Scalp: A Case Report

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SCREENING OF POTATO VARIETIES AGAINST MOSAICS AND LEAF ROLL DISEASES

Open Journal of Modern Neurosurgery（现代神经外科学进展） 2024年第1期

作者： Mohamed El Hassimi Cissé N’daraw Ndoye Anne Aurore Sankale Pauline Diousse Abdoulaye Diop Alvine Nah Doe sagar Diop Momar Codé Ba Seydou Boubakar Badiane

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SCREENING OF POTATO VARIETIES AGAINST MOSAICS AND LEAF ROLL ...

A COMPARATIVE STUDY ON MANAGEMENT OF POTATO VIRAL DISEASES USING INSECTICIDES AND PLANT EXTRACTS

The ⅩⅤth International Plant Protection Congress

作者： M.S.PATIL S.sagar V.R.KULKARNI Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad-580005 Karnataka India Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad-580005 Karnataka India Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad-580005 Karnataka India

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A COMPARATIVE STUDY ON MANAGEMENT OF POTATO VIRAL DISEASES U...

SPIO-shRNA分子探针用于荷瘤裸鼠MR检查的最佳扫描浓度探讨

The ⅩⅤth International Plant Protection Congress

作者： M.S.PATIL S.sagar V.R.KULKARNI Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad - 580005 Karnataka India Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad - 580005 Karnataka India Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad - 580005 Karnataka India

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东南大学学报（医学版） 2017年第3期36卷 311-317页

作者：廖蕤堃曾丹妮张竹张力强 sagar Thapa 文明重庆医科大学附属第一医院放射科重庆400016

目的:探讨SPIO-shRNA分子探针在活体荷瘤裸鼠肿瘤区域组织信号的变化情况,阐明分子探针用于荷瘤裸鼠的最佳扫描浓度。方法:将30只BALB/c荷瘤裸鼠随机分为5组,每组6只,在既定扫描时间(探针注射前及注射后27 h)分别以含铁量为6、12、18、2... 详细信息

目的:探讨SPIO-shRNA分子探针在活体荷瘤裸鼠肿瘤区域组织信号的变化情况,阐明分子探针用于荷瘤裸鼠的最佳扫描浓度。方法:将30只BALB/c荷瘤裸鼠随机分为5组,每组6只,在既定扫描时间(探针注射前及注射后27 h)分别以含铁量为6、12、18、24、30 mg·kg^(-1)尾静脉注射并同步行MR检查,测量肿瘤组织及对侧对应区域肌肉组织在各浓度组的信号强度变化。每次检查完成后立即处死裸鼠,取肿瘤组织及肌肉组织行HE及普鲁士蓝染色,并在光镜下观察。结果:6、12、18 mg·kg^(-1)组裸鼠探针注射后均存活,24、30 mg·kg^(-1)组探针注射后及扫描过程中出现部分裸鼠死亡;各浓度组间肿瘤组织体积差异无统计学意义(P>0.05);MR各扫描序列以T_2WI及T_2*序列的信号改变最明显;各浓度组比较,肿瘤组织信号强度在18、24、30 mg·kg^(-1)组较其余组差异明显(P0.05);HE染色显示肿瘤组织结构紊乱,细胞核异型性较多;普鲁士蓝染色表明不同浓度组肿瘤组织中均存在蓝染的铁颗粒,其中18、24、30 mg·kg^(-1)组蓝染颗粒分布密集。结论:SPIO-shRNA分子探针能成功靶向于肿瘤组织,且最佳扫描浓度(含铁量)为18 mg·kg^(-1)。

关键词：超顺磁性氧化铁分子探针磁共振成像扫描浓度裸鼠