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Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： Andreia Monteiro susana Monteiro Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

Experimental modelling of flocculation processes-the case of Paraiba do Sul Estuary

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International Journal of Sediment Research 2014年第3期29卷 378-390页

作者： Alfredo TRENTO susana VINZON Department of Hydraulics National University of LitoralSanta FeArgentina Programa de Engenharia Oceanica(PEnO)/COPPE Federal University of Rio de JaneiroRio de JaneiroBrazil

The aggregation dynamics of fine sediments was analysed through laboratory tests using Couette and disk *** was shown that floc sizes tend to increase as concentrations grow both in fresh and salt water,in agreement with the aggregation theory,and that equilibrium diameters are slightly greater in salt environments for flocs developed either under shear stress or by differential *** transport and the aggregation processes were preliminarily studied in the estuary of the Paraiba do Sul River using a particle tracking model and field *** floc breakup process by shear stress was included in the *** stresses,which were determined by fractal dimensions and differential density,were accounted *** the calibration of the collision efficiency coefficients,the numerical model was able to predict floc sizes comparable with those measured at the Paraiba do Sul estuary,which,in turn,were similar to those obtained during the laboratory experiments in the Couette flocculator.

关键词： Flocs Flocculators Transport proceses Paraiba do Sul

Indentation Size Effect inβCuAlBe and Cu-2Be Alloys

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Acta Metallurgica Sinica(English Letters) 2021年第12期34卷 1669-1678页

作者： susana Montecinos Sebastian Tognana Walter Salgueiro IFIMAT Facultad de Ciencias ExactasUniversidad Nacional del Centro de La Provincia de Buenos AiresPinto 3997000 TandilArgentina Consejo Nacional de Investigaciones Científicas y Técnicas CONICET Av.Rivadavia 1917C1033AAJ Buenos AiresArgentina CIFICEN(UNCPBA-CICPBA-CONICET) Pinto 3997000 TandilArgentina Comisión de Investigaciones Científicas de la Provincia de Bs.As Calle 526 entre 10 y 111900 La PlataArgentina

The indentation size effect(ISE)was studied by instrumented nanoindentation and Vickers hardness measurements on polycrystalline copper,βCuAlBe pseudoelastic and age-hardenable CuBe *** in the load-depth curves at different loads would suggest a change in the behavior of the materials as the load *** was estimated at different loads taking into account the pile-up in each case,which was estimated from the images of the topography obtained by atomic force microscopy(AFM).The effect of the microstructure of Cu-2Be(wt%)samples on the ISE was also *** each copper alloy,the Nix and Gao model was applied to the hardness-depth curves,and significant differences were found for the parameters *** is in the constant nanohardness regime for depths below 500 nm,while microhardness exhibits the ISE *** behavior of the nanohardness and the plastic strain with the depth is almost *** presents the lowest values of plastic strains due to the pseudoelastic effect,while Cu presents an almost constant value around 8%,which corresponds to the highest plastic strain obtained.

关键词： Hardness Pseudoelasticity Copper alloys Plasticity Indentation size effect

A STOPPING CRITERION FOR HIGHER-ORDER SWEEPING SCHEMES FOR STATIC HAMILTON-JACOBI EQUATIONS

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Journal of Computational Mathematics 2010年第4期28卷 552-568页

作者： susana Serna Jianliang Qian Department of Mathematics University of California Los Angeles CA 90095 USA Department de Matematiques Universitat Autonoma de Barcelona 8193 Bellaterra Spain Department of Mathematics Michigan State University East Lansing MI 48824 USA

We propose an effective stopping criterion for higher-order fast sweeping schemes for static Hamilton-Jacobi equations based on ratios of three consecutive iterations. To design the new stopping criterion we analyze the convergence of the first-order Lax-Friedrichs sweeping scheme by using the theory of nonlinear iteration. In addition, we propose a fifth-order Weighted PowerENO sweeping scheme for static Hamilton-Jacobi equations with convex Hamiltonians and present numerical examples that validate the effectiveness of the new stopping criterion.

关键词： Fast sweeping methods Gauss-Seidel iteration High order accuracy Static Hamilton-Jacobi equations Eikonal equations.

Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule

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Neural Regeneration Research 2020年第10期15卷 1846-1847页

作者： susana Laura González Universidad de Buenos Aires Facultad de Medicina Departamento de Bioquímica Humana Buenos Aires Laboratorio de Nocicepción y Dolor Neuropático Instituto de Biología y Medicina Experimental

Central nervous system(CNS)injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes,including oxidative stress,neuroinflammation,excitotoxicity,demyelination and neurotransmission *** the past decades,valuable experimental investigations have helped to clarify the role and timing of these multiple molecular and cellular mechanisms in each of these particular disorders,which usually overlap and critically contribute to long-term ***,up to now,no definite cures or effective disease-modifying therapies are available for any of these *** has led to an active search of novel therapeutic approaches,including the repositioning of existing drugs for new indications,as a valid approach to promptly move candidate molecules to clinical trials.

关键词： injuries disorders drugs

Evaluation of design schemes for urban squares in arid climate cities,Mendoza,Argentina

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Building Simulation 2021年第3期14卷 763-777页

作者： susana Stocco Maria Alicia Canton Erica Correa INAHE-Instituto de Ambiente Habitat yEnergia-CONICETMendozaArgentina

The design of urban squares in the city of Mendoza,Argentina,is based on aesthetic and landscaping criteria without consider strategies to enhance the benefits that green areas generate on the city's micrometeorological *** paper aims to evaluate different design alternatives with the purpose to determine which proportion and distribution of green and sealed areas contributes to achieve the best conditions in terms of thermal behavior and ***-met software was used to simulate thermal conditions over twenty three scenarios,and COMFA method was employed to determine comfort in the scenarios that show the best thermal behaviour and are representative of current design *** results show that the most effective scheme for the memorial squares rehabilitation is the one concentrating 60%of woodlot around a sealed center with an area that does not exceed 20%the square *** effective alternative is the one concentrating 60%of woodlot at the center of the *** findings highlight the importance of an adequate relation between proportion and distribution of woodlot/sealed areas to improve thermal performance and comfort conditions of open spaces.

关键词： design of urban squares effective scheme of design alternativas de diseno proportion green/sealed distribution green/sealed

The role of culture for coastal disaster risk reduction measures:Empirical evidence from northern and southern Europe

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Advances in Climate Change Research 2020年第4期11卷 297-309页

作者： Grit MARTINEZ susana COSTAS Oscar FERREIRA Ecologic Institute Berlin10717Germany Centro de Investigacao Marinha e Ambiental(CIMA) Universidade do AlgarveFaro8005-139Portugal Centro de Investigacao Marinha e Ambiental(CIMA) Faculty of Sciences and TechnologyUniversidade do AlgarveFaro8005-139Portugal

Recent and historic high-impact events have demonstrated significant flood risks to many coastal areas in Europe and across the *** the behavior of humans in relation to risk management poses grand challenges for both natural and social sciences and *** study analyzes the cultural aspects of coastal risk management and illustrates path-dependencies of concrete disaster risk reduction measures in relation to local contexts in European coastal regions in Northern and South Western *** adopts a comparative approach by targeting risk perception and risk management related to coastal floods and erosion,induced by storms and sea level rise,in two contrasting coastal areas:German coastal state SchleswigeHolstein at the Baltic Sea(especially the communities Eckernf€orde and Timmendorfer Strand)and the Portuguese barrier island system of Ria Formosa(especially the community of Faro Beach).Both regions are very low lying with only a few meters above sea level and exposed to similar hazards such as erosion and floods induced by coastal storms,and while they are both attractive touristic destinations,they are culturally,socio-economically and politically very *** geographical and the socio-cultural contexts of the case study regions are assessed first using an explorative approach,followed by an analysis of the relevance of cultural aspects for the implementation of disaster risk reduction *** study addresses both first responders(city authorities,citizens)and *** is found that the choice of risk reduction measures hinges on the values underlying people's perspectives about the desired outcomes of specific measures and that the role of identity and meaning making are still undervalued in decision making *** concludes that subjective capacities formed by cultural identities,knowledge,trust coupled with a variety of factors of socio-economic and political texture are important to understand local decision making

关键词： Culture Values Knowledge Risk perception Disaster risk reduction measures Coastal zones Baltic Sea Atlantic

Human immunology and immunotherapy:main achievements and challenges

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Cellular & Molecular Immunology 2021年第4期18卷 805-828页

作者： Jezabel Varade susana Magadan Africa Gonzalez-Fernandez ONBIO Centro de Investigaciones BiomedicasUniversidade de VigoImmunology GroupCampus Universitario LagoasMarcosende36310 VigoSpain Instituto de Investigacidn Sanitaria Galicia Sur(IIS-Galicia Sur) ERGAS-UVIGOVigoSpain

The immune system is a fascinating world of cells,soluble factors,interacting cells,and tissues,all of which are *** highly complex nature of the immune system makes it difficult to view it as a whole,but researchers are now trying to put all the pieces of the puzzle together to obtain a more complete *** development of new specialized equipment and immunological techniques,genetic approaches,animal models,and a long list of monoclonal antibodies,among many other factors,are improving our knowledge of this sophisticated *** different types of cell subsets,soluble factors,membrane molecules,and cell functionalities are some aspects that we are starting to understand,together with their roles in health,aging,and *** knowledge is filling many of the gaps,and in some cases,it has led to changes in our previous assumptions;e.g.,adaptive immune cells were previously thought to be unique memory cells until trained innate immunity was observed,and several innate immune cells with features similar to those of cytokine-secreting T cells have been ***,we have improved our knowledge not only regarding immune-mediated illnesses and how the immune system works and interacts with other systems and components(such as the microbiome)but also in terms of ways to manipulate this system through *** development of different types of immunotherapies,including vaccines(prophylactic and therapeutic),and the use of pathogens,m onodonal antibodies,recombinant proteins,cytokines,and cellular immunotherapies,are changing the way in which we approach many diseases,especially cancer.

关键词： Vaccines CAR T cells Trained immunity Microbiota Cancer Monoclonal antibodies