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Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case report

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World Journal of Clinical Cases 2024年第2期12卷 412-417页

作者： Allison Akers susan read John Feldman Casey Gooden Diana P English Department of Obstetrics and Gynecology University of South FloridaTampaFL 33606United States Department of Gynecologic Oncology Sky Ridge Medical CenterLone TreeCO 80124United States Department of Radiology University of South FloridaTampaFL 33606United States Department of Pathology University of South FloridaTampaFL 33606United States

BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in *** metastases are associated with poor *** following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized *** SUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node *** biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic *** received concurrent cisplatin with external beam radiation *** up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic *** was lost to follow up for six *** was re-imaged on re-presentation and found to have widely metastatic disease including breast *** biopsy confirmed programmed death-ligand 1 positive metastatic cervical *** patient received six cycles of carboplatin and paclitaxel with *** imaging demonstrated *** continued on pembrolizumab with disease *** Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis *** history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the ***,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.

关键词： Cervical adenocarcinoma Breast metastases Immunotherapy Pembrolizumab Carboplatin Paclitaxel Case report

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Resolving place names in Amdo and Kham:A gazetteer for the Hengduan Mountains region of Southwest China

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植物分类学报 2006年第6期44卷 721-732页

作者： susan L. KELLEY Arnold Arboretum and Harvard University Herbaria 22 Divinity Avenue Cambridge MA 02138-2020 U.S.A.

Perhaps no region on earth presents such a confusing array of place names as does the area made up of the former provinces of Kham and Amdo in historic Tibet (Xizang). Within these areas, cities, towns, villages, mountains, lakes and other geographic features have at least two names applied to them, one Tibetan, the other Chinese. Overlying this indigenous nomenclature are the names applied by outsiders, mostly Europeans, each of whom used their native language to transliterate the names they heard or read from Tibetan or Chinese script, and names in the languages of other ethnic minorities who live within the area. Adding to the confusion are the conflicting “standards” for transliterating Tibetan and Chinese names. To resolve the inconsistencies and uncertainties of place names in this region, a multilingual gazetteer and thesaurus was prepared. The gazetteer-thesaurus was compiled to be used as a tool for correlating the often radically different names assigned to a single place or feature and to provide the geographic coordinates for each. The impetus for this project was the need to assign geographic coordinates to plant specimens collected in the area since the latter part of the 19th century up until the advent and widespread use of Global Positioning System (GPS) receivers in the 1990s. Georeferencing specimens is necessary for plotting the historical distribution of species and for more completely understanding the information contained on specimen labels. Knowing the distribution of plants is important for answering phylogenetic questions, determining local and widespread biogeographical patterns, identifying areas of unusually high diversity or endemism, and determining areas in need of special protection. The value of such a gazetteer, however, extends well beyond the field of botany. It is intended to be of use to anyone with a desire to know the nomenclatural history of places in the area and for pinpointing with a fair degree of accuracy the location

关键词： Tibet (Xizang) Amdo Kham Hengduan Mountains gazetteer biodiversity Geographic Information Systems (GIS) herbarium conservation georeferencing.

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Semioethics and Literary Writing:Between Peirce and Bakhtin

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Language and Semiotic Studies 2017年第1期3卷 13-30页

作者： susan Petrilli The University of Bari Aldo Moro Italy

In the early phase of its development, semiotics was understood as "semeiotics" and studied symptoms. Today we propose to recover this ancient dimension of semiotics focussed on health, care and the quality of life, and reorganise it in semioethical terms. In fact, as interference increases in communication between the historico-social sphere and the biological, between culture and nature, between the semiosphere and the biosphere, the need for a "semioethical turn" in the study of signs with an understanding of the relation of signs to values has become ever more *** writing is particularly interesting from this perspective thanks to its extraordinary capacity to stage values that animate life to the best in terms of the properly human. These values are characterized by high degrees of opening to the other, by responsiveness/answerability toward the other, by a propensity for listening to the other, for giving time to the *** on relations of distancing and at once of affinity among signs, metaphor—or more broadly imagery, fi gurative language—is emblematic of literary writing, though not limited to it. As amply demonstrated by Victoria Welby, far from serving as a mere decorative supplement, the fi gurative dimension of expression is structural to signifying processes, to the acquisition itself of knowledge and understanding. Welby's work may be read as prefi guring recent trends in language studies as represented by cognitive linguistics *** Bakhtin has also made an important contribution in this sense. He has developed the study of signs in terms of moral philosophy and, in fact, his approach to semiotics is easily oriented in the sense of semioethics. In such a framework he evidences the close relationship between sign studies and literary writing. For a full understanding of the sense of Bakhtin's approach to studies on verbal language, it is important to highlight his insistence on the inexorable interconnection—which he descr

关键词： answerability/responsiveness cognition creativity intertextuality listening

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Food poisoning associated methemoglobinemia: Time to wake up

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World Journal of Emergency Medicine 2020年第2期11卷 127-128页

作者： Kamal Kant Sahu Amos Lal Ajay Mishra susan George Department of Internal Medicine Saint Vincent HospitalWorcesterMassachusetts 01608USA

Dear editor,With interest we read the recent article on methemoglobinemia by Chan et al.[1]Through this letter,we would like to add few additional comments regarding methemoglobinemia and its relevance in medicine practice with regards to food *** Chan et al[1]successfully managed their patient of methemoglobinemia and could pinpoint choy sum as the responsible agent,we wonder if there were any more cases of choy sum related to methemoglobinemia detected at the same time in the community?

关键词： letter 1] editor

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A gap-free genome assembly of Chlamydomonas reinhardtii anddetection of translocations induced by CRISPR-mediated mutagenesis

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Plant Communications 2023年第2期4卷 249-271页

作者： Zachary L.Payne Gervette M.Penny Tychele N.Turner susan K.Dutcher Department of Genetics Washington University School of MedicineSaint LouisMO 63110USA

Genomic assemblies of the unicellular green alga Chlamydomonas reinhardtii have provided important resources for ***,assembly errors,large gaps,and unplaced scaffolds as well as strain-specific variants currently impede many types of *** combining PacBio HiFi and Oxford Nanopore long-read technologies,we generated a de novo genome assembly for strain CC-5816,derived from crosses of strains CC-125 and *** methods of evaluating genome completeness and base-pair error rate suggest that the final telomere-to-telomere assembly is highly *** CC-5816 assembly enabled previously difficult analyses that include characterization of the 17 centromeres,rDNA arrays on three chromosomes,and 56 insertions of organellar DNA into the nuclear *** Nanopore sequencing,we identified sites of cytosine(CpG)methylation,which are enriched at *** analyzed CRISPR-Cas9 insertional mutants in the PF23 *** of the three alleles produced progeny that displayed patterns of meiotic inviability that suggested the presence of a chromosomal *** Nanopore reads from pf23-2 and pf23-3 onto the CC-5816 genome showed that these two strains each carry a translocation that was initiated at the PF23 gene locus on chromosome 11 and joined with chromosomes 5 or 3,*** translocations were verified by demonstrating linkage between loci on the two translocated chromosomes in meiotic *** three pf23 alleles display the expected short-cilia phenotype,and immunoblotting showed that pf23-2 lacks the PF23 *** CC-5816 genome assembly will undoubtedly provide an important tool for the Chlamydomonas research community.

关键词： alga reference genome de novo PacBio Nanopore structural variation

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reading and Interpreting the Histone Acylation Code

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Genomics, Proteomics & Bioinformatics 2016年第6期14卷 329-332页

作者： Jelly H.M.Soffers Xuanying Li susan M.Abmayr Jerry L.Workman Stowers Institute Jor Medical Research Kansas CityMO 64111USA Department of Anatomy and Cell Biology University of Kansas Medical CenterKansas CityKS 66160USA

Decades of research has explored the epigenetic control of gene expression and the impact of histone post-translational modifications （PTMs）, such as acetylation, on chromatin remodel- ing. Indeed, the writers, readers, and erasers of lysine acetylation are increasingly well understood. Recent studies have added crotonylation, butyrylation, and propionylation to the types of acylations by which histones are modified, and identified the YEATS protein domain as a critical reader of crotonylation. Now, Haitao Li, David Allis, and their col- leagues expand the scope of protein domains capable of read- ing crotonyl-lysine （Kcr） to include double PHD finger （DPF） domains. Importantly, the mechanism through which these domains recognize Kcr is quite distinct from their recognition by the YEATS domain [1]. In this highlight, we discuss recognition of acylated histones by the bromodomain （BRD）, the YEATS domain, and PHD fingers. We contrast the structural basis for their recognition of histones modified by acetylation and more recently discovered histone crotonylation [2-6].

关键词： PHD reading and Interpreting the Histone Acylation Code

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我们到达那里了吗？女性主义叙事学的交叉性未来(英文)

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外国文学研究 2010年第4期32卷 32-41页

作者：苏珊S.兰瑟布兰迪斯大学国际叙事学研究协会

自"走向女性主义叙事学"(1986)一文发表以来,女性主义和叙事学都发生了巨大的变化。女性主义解构了性别的基要性概念,而对于语境和认知的思考也使得叙事学更为复杂化。女性主义叙事学对其帮助营造的"后经典"环境做出了富有成果的反应。... 详细信息

自"走向女性主义叙事学"(1986)一文发表以来,女性主义和叙事学都发生了巨大的变化。女性主义解构了性别的基要性概念,而对于语境和认知的思考也使得叙事学更为复杂化。女性主义叙事学对其帮助营造的"后经典"环境做出了富有成果的反应。本文雄心勃勃地提出一个集体合作的议程,通过交叉性的女性主义,不仅可以绘制跨越时空的叙事模式图式,而且也可以被这些叙事模式所映射,进而解释差异的原因,创造一种深度地域性的,因而跨文化和跨历史的叙事学。本文作者还将进一步表明"交叉性"本身就是一个叙事课题,因此女性主义可以用叙事术语加以解读;而且简要地提出"否定性情节"的概念,以此作为一种途径思考叙事给女性研究带来的启示,并在此基础上得出结论:把女性主义叙事学看作是一个合作性的课题需要多个领域众多国际学者的共同努力。

关键词：叙事女性主义情节交叉性叙事学

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材料的重要性

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风景园林 2019年第7期26卷 26-44页

作者： [加拿大]苏珊·赫林顿吕回(译) 魏方(校) 加拿大温哥华英属哥伦比亚大学建筑与景观学院风景园林专业系清华大学建筑学院景观学系北京林业大学园林学院

《材料的重要性》是《景观设计理论》的一段节选。《景观设计理论》旨在不使用专业术语或其他领域假说的前提下,结合景观设计过程向学生介绍内在理论思想。《材料的重要性》是本书的五章之一。每一章针对特定理论,解释了其基础和来源,... 详细信息

《材料的重要性》是《景观设计理论》的一段节选。《景观设计理论》旨在不使用专业术语或其他领域假说的前提下,结合景观设计过程向学生介绍内在理论思想。《材料的重要性》是本书的五章之一。每一章针对特定理论,解释了其基础和来源,探讨了它对设计的重要性,列举了20—21世纪与其相关的设计案例,整理了该理论的辩论(尤其是有关现代和后现代思想),最后还有相关阅读材料清单和需要学生们思考的问题。本文分为如下3个部分:第一部分,物质性,介绍'辩证唯物主义''媒介即信息''物质实践'和'编码'等理论及其在设计中的运用;第二部分,通过'建构表达''地貌代理人策略''石材的面层''材料的暗示''人造,但不是伪造'等理论,介绍材料的真实性及其在设计中的运用;第三部分,复写理论及应用,包括'剩余物''复写的展示性''未来的复写'和'虚构的复写'等内容。

关键词：理论设计物质性材料真实性复写

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