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Developing A Framework.for Low-Volume Road Implementation of Pervious Concrete Pavements

International Journal of Transportation Science and Technology 2015年第1期4卷 77-91页

作者： Sonia Rahman Andrew B.Northmore Vimy Henderson susan L.Tighe Department of Civil and Environmental Engineering University of Waterloo 200 University Avenue West Waterloo ONCanada N2L 3G1 Pavement and Material Engineer Golder Associates 6925 Century Avenue Suite#100MississaugaOntarioCanada L5N 7K2 Pavement and Transportation Technology Department of Civil and Environmental Engineering University of Waterloo 200 University Avenue West Waterloo ONCanada N2L 3G1

Pervious concrete pavement is one of the promising pavement technologies,as it can help overcome traditional pavement environmental impacts,assist with stormwater management,and provide an effective low impact development *** are many benefits associated with pervious concrete pavement such as assisting with water filtration,absorbing heavy metals and reducing *** most significant aspect,which draws the attention of environmental agencies and cities and municipalities,is its ability to reduce storm water *** concrete is documented as the paramount solution in storm water management by the United States Environmental Protection *** it has been used in the southern United States for years,the practice of using pervious concrete is more recent in northern climates where freeze thaw is *** Canada,several pervious concrete park.ng lots have been constructed over the past few *** barriers exist for implementing the technology,as designers are not always fully informed on the various functional and structural design *** this paper,a framework.is developed to identify how pervious concrete can be integrated into lowvolume *** paper also summarizes the structural performance and drainage characteristics of pervious concrete park.ng lots constructed in various provinces of Canada,demonstrating the viability of pervious concrete for low-volume northern applications.

关键词： concrete storm Canada

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PIM k.nase inhibition:co-targeted therapeutic approaches in prostate cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2430-2439页

作者： Sabina Luszczak.Christopher k.mar Vignesh k.ishna Sathyadevan Benjamin S.Simpson k.thy A.Gately Hayley C.Whitak.r susan Heavey Molecular Diagnostics and Therapeutics Group University College LondonLondonUK Trinity Translational Medicine Institute St.James’s Hospital DublinDublin 8DublinIreland

PIM k.nases have been shown to play a role in prostate cancer development and progression,as well as in some of the hallmark. of cancer,especially proliferation and *** upregulation in prostate cancer has been correlated with decreased patient overall survival and therapy *** efforts to inhibit PIM with monotherapies have been hampered by compensatory upregulation of other pathways and drug toxicity,and as such,it has been suggested that co-targeting PIM with other treatment approaches may permit lower doses and be a more viable option in the ***,we present the rationale and basis for cotargeting PIM with inhibitors of PI3k.mTOR/Ak.,JAk.STAT,MYC,stemness,and RNA Polymerase I transcription,along with other therapies,including androgen deprivation,radiotherapy,chemotherapy,and *** combined approaches could potentially be used as neoadjuvant therapies,limiting the development of resistance to treatments or sensitizing cells to other *** determine which drugs should be combined with PIM inhibitors for each patient,it will be k.y to develop companion diagnostics that predict response to each co-targeted option,hopefully providing a personalized medicine pathway for subsets of prostate cancer patients in the future.

关键词： targeted doses viable

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Time spent in hospital after liver transplantation:Effects of primary liver disease and comorbidity

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World Journal of Transplantation 2016年第4期6卷 743-750页

作者： Chutwichai Tovik.ai susan C Charman Raaj k.Praseedom Alexander E Gimson Jan van der Meulen Hepatopancreatobiliary and Transplant Surgery Unit Division of General Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Mahidol University Clinical Effectiveness Unit the Royal College of Surgeons of England Department of Surgery University of Cambridge Department of Health Services Research and Policy London School of Hygiene and Tropical Medicine Liver Transplant Unit Addenbrooke’s Hospital Cambridge University Hospital NHS Foundation Trust

AIM To explore the effect of primary liver disease and comorbidities on transplant length of stay(TLOS) and LOS in later admissions in the first two years after liver transplantation(LLOS). METHODS A link.d United k.ngdom Liver Transplant Audit- Hospital Episode Statistics database of patients who received a first adult liver transplant between 1997 and 2010 in Englandwas analysed. Patients who died within the first two years were excluded from the primary analysis, but a sensitivity analysis was also performed including all patients. Multivariable linear regression was used to evaluate the impact of primary liver disease and comorbidities on TLOS and LLOS. RESULTS In 3772 patients, the mean(95%CI) TLOS was 24.8(24.2 to 25.5) d, and the mean LLOS was 24.2(22.9 to 25.5) d. Compared to patients with cancer, we found that the largest difference in TLOS was seen for acute hepatic failure group(6.1 d; 2.8 to 9.4) and the largest increase in LLOS was seen for other liver disease group(14.8 d; 8.1 to 21.5). Patients with cardiovascular disease had 8.5 d(5.7 to 11.3) longer TLOS and 6.0 d(0.2 to 11.9) longer LLOS, compare to those without. Patients with congestive cardiac failure had 7.6 d longer TLOS than those without. Other comorbidities did not significantly increase TLOS nor *** The time patients spent in hospital varied according to their primary liver disease and some comorbidities. Time spent in hospital of patients with cancer was relatively short compared to most other indications. Cardiovascular disease and congestive cardiac failure were the comorbidities with a strong impact on increased LOS.

关键词： Length of stay Hospital stay Comorbidity Liver transplantation

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研究发现。磁共振成像增加前列腺癌检出并减少过度诊断

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英国医学杂志中文版 2018年第7期21卷 373-374页

作者： susan Mayor 彭浩(译) 伦敦北京煤炭总医院肿瘤科

与标准的经直肠超声引导下活检相比，根据磁共振成像（MRI）结果指导靶向活检可使具有临床意义的前列腺癌栓出率提高12％。这是首次比较2种方法在疑似前列腺癌患者中应用的一项大型随机试验.

关键词：还原剂前列腺 MRI 癌症学习

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英国研究发现,16岁以下儿童在放学途中具有最高的遇刺风险

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英国医学杂志中文版 2019年第4期22卷 201-202页

作者： susan Mayor 周全(译) 伦敦北京世纪坛医院病理科

英国一项大型研究发现:16岁以下儿童在放学途中具有最高的遇刺风险。“大部分儿童遇刺事件发生在刚放学后,且主要发生在接近学校和家的地方”,来自英国伦敦玛丽皇后大学(Queen Mary University of London )创伤医学中心由Paul Vulliamy... 详细信息

英国一项大型研究发现:16岁以下儿童在放学途中具有最高的遇刺风险。“大部分儿童遇刺事件发生在刚放学后,且主要发生在接近学校和家的地方”,来自英国伦敦玛丽皇后大学(Queen Mary University of London )创伤医学中心由Paul Vulliamy领导的研究团队声明。

关键词：英国儿童风险医学中心研究团队

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Functional analysis of human Na^+/k.+-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes

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World Journal of Biological Chemistry 2014年第2期5卷 240-253页

作者： susan Spiller Thomas Friedrich Institute of Chemistry Technical University of Berlin D-10623 Berlin Germany

AIM: Functional characterization of ATP1A2 mutations that are related to familial or sporadic hemiplegic migraine(FHM2, SHM). METHODS: cRNA of human Na+/k.-ATPase α2- and β1-subunits were injected in Xenopus laevis oocytes. FHM2 or SHM mutations of residues located in putative α/β interaction sites or in the α2-subunit's C-terminal region were investigated. Mutants were analyzed by the twoelectrode voltage-clamp(TEVC) technique on Xenopus oocytes. Stationary k.-induced Na+/k. pump currents were measured, and the voltage dependence of apparent k. affinity was investigated. Transient currents were recorded as ouabain-sensitive currents in Na+ buffers to analyze k.netics and voltage-dependent presteady state charge translocations. The expression of constructs was verified by preparation of plasma membrane and total membrane fractions of cRNA-injected oocytes. RESULTS: Compared to the wild-type enzyme, the mutants G900R and E902k.showed no significant dif-ferences in the voltage dependence of k.-induced currents, and analysis of the transient currents indicated that the extracellular Na+ affinity was not affected. Mutant G855R showed no pump activity detectable by TEVC. Also for L994del and Y1009X, pump currents could not be recorded. Analysis of the plasma and total membrane fractions showed that the expressed proteins were not or only minimally targeted to the plasma membrane. Whereas the mutation k.003E had no impact on k. interaction, D999H affected the voltage dependence of k.-induced currents. Furthermore, k.netics of the transient currents was altered compared to the wild-type enzyme, and the apparent affinity for extracellular Na+ was reduced. CONCLUSION: The investigated FHM2/SHM mutations influence protein function differently depending on the structural impact of the mutated residue.

关键词： Na+/k.-ATPase Electrophysiology Voltage dependence Familial hemiplegic migraine C-terminus β -subunit

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Is tumor cell specificity distinct from tumor selectivity in vivo?A quantitative NIR molecular imaging analysis of nanoliposome targeting

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Nano Research 2021年第5期14卷 1344-1354页

作者： Girgis Obaid k.mberley Samk.e k.nneth Tichauer Shazia Bano Yeonjae Park.Zachary Silber Sassan Hodge susan Callaghan Mina Guirguis Srivalleesha Mallidi Brian Pogue Tayyaba Hasan Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Bioengineering University of Texas at DallasRichardsonTX75080USA Thayer School of Engineering Dartmouth CollegeHanoverNH037551USA Armour College of Engineering Illinois Institute of TechnologyChicagoIL60616USA Division of Health Sciences and Technology Harvard University and Massachusetts Institute of TechnologyCambridgeMA02139USA

The significance and ability for receptor targeted nanoliposomes(tNLs)to bind to their molecular targets in solid tumors in vivo has been questioned,particularly as the efficiency of their tumor accumulation and selectivity is not always predictive of their efficacy or molecular *** study presents,for the first time,in situ near-infrared(NIR)molecular imaging-based quantitation of the in vivo specificity of tNLs for their target receptors,as opposed to tumor selectivity,which includes influences of enhanced tumor permeability and *** show that neither tumor delivery nor selectivity(tumor-to-normal ratio)of cetuximab and IRDye conjugated tNLs correlate with epidermal growth factor receptor(EGFR)expression in U251,U87,and 9L tumors,and in fact underrepresent their imaging-derived molecular specificity by up to 94.2%.Conversely,their in vivo specificity,which we quantify as the concentration of tNL-reported tumor EGFR provided by NIR molecular imaging,correlates positively with EGFR expression levels in vitro and ex vivo(Pearson’s r=0.92 and 0.96,respectively).This study provides a unique opportunity to address the problematic disconnect between tNL synthesis and in vivo *** findings encourage their continued adoption as platforms for precision medicine,and facilitates intelligent synthesis and patient customization in order to improve safety profiles and therapeutic outcomes.

关键词： molecular recognition receptors nanoparticles specificity cancer

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乔纳金苹果

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河北果树 1992年第1期 44-46页

作者： Roger D. Way susan k. Brown 王同坤庞海珍

乔纳金是世界上许多地区形成商品化规模生产的少数品种之一,由于乔纳金被介绍只不过是二十年前的事,所以尚未达到生产高峰,不过正在迅速增加,将来具有很大的生产潜力。乔纳金是由康奈尔大学的纽约州立农业试验站育成并发表的,1943年在... 详细信息

乔纳金是世界上许多地区形成商品化规模生产的少数品种之一,由于乔纳金被介绍只不过是二十年前的事,所以尚未达到生产高峰,不过正在迅速增加,将来具有很大的生产潜力。乔纳金是由康奈尔大学的纽约州立农业试验站育成并发表的,1943年在果园中对金冠树上的花进行去雄,并对其柱头授以红玉的花粉。1946年,把这个杂交组合的52株自根实生苗定植在第一试验园中。1953年,这批实生苗的有些植株首次结果,其中有一株产生了显著优异的果实,便被选出作进一步的评价。当时确定编号为:N.Y.43013—1。

关键词：乔纳金苹果品种生苗康奈尔大学自根苹果栽培苹果种植生产潜力农业试验站杂交组合

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高血压治疗的新进展

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中国实用乡村医生杂志 2007年第10期14卷 44-46页

作者： Michael k. Magill k.ren Gunning Phar susan Saffel-Shrier Christopher Gay 吴迪 University of Utah School of Medicine Salt Lake City Utah 中国医科大学七年制临床医学系

高血压是病人去看医生最常见的原因。年龄超过65岁的老龄人口中，有一半以上患有高血压，通常是单纯收缩期高血压。人们对控制血压越来越多的重视使得1972年以来中风导致的死亡人数下降了将近60％，缺血性心脏病导致的死亡人数也下降了5... 详细信息

高血压是病人去看医生最常见的原因。年龄超过65岁的老龄人口中，有一半以上患有高血压，通常是单纯收缩期高血压。人们对控制血压越来越多的重视使得1972年以来中风导致的死亡人数下降了将近60％，缺血性心脏病导致的死亡人数也下降了53％。然而在美国，只有70％的高血压患者对自己的健康状况感到担忧，59％的患者接受治疗，34％的患者的血压得到了有效控制。

关键词：高血压治疗进展

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Risk.factors for musculosk.letal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model

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Military Medical Research 2022年第4期9卷 444-483页

作者： Stefan Sammito Vedran Hadzic Thomas k.rak.lis k.ren R.k.lly susan P.Proctor Ainars Stepens Graham White Wes O.Zimmermann Section Experimental Aerospace Medicine Research German Air Force Centre of Aerospace MedicineFlughafenstraBe 151147 CologneGermany Occupational Medicine Faculty of MedicineOtto-Von-Guericke-University of Magdeburg39120 MagdeburgGermany Faculty of Sport University of Ljubljana1000 LjubljanaSlovenia Defence Research and Development Canada TorontoON M3K 2C9Canada Warfighter Performance Naval Health Research CenterSan DiegoCA 921063599USA Military Performance Division US Army Research Institute of Environmental MedicineNatickMA 01760USA Research Service VA Boston Healthcare SystemBostonMA 02130USA Centre for Military Medicine Research Riga Stradins UniversityRiga 1007Latvia Human and Social Sciences Group Defense Science and Technology LaboratoryPortsdown Hill RoadFareham PO176ADUK Department of Military Sports Medicine Royal Netherlands Army3584 AB UtrechtThe Netherlands Department of Military/Emergency Medicine Uniformed Services University of the Health SciencesBethesdaMD 20814USA.

Back.round: Musculosk.letal injuries(MSk.s) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSk.s affect members of the military during initial training,operational training, and deployment and have a direct negative impact on overall troop readiness. Currently, a systematic overview of all risk.factors for MSk.s in the military is not ***: A systematic literature search was carried out using the PubMed, Ovid/Medline, and Web of Science databases from January 1, 2000 to September 10, 2019. Additionally, a reference list scan was performed(using the “snowball method”). Thereafter, an international, multidisciplinary expert panel scored the level of evidence per risk.factor, and a classification of modifiable/non-modifiable was ***: In total, 176 original papers and 3 meta-analyses were included in the review. A list of 57 reported potential risk.factors was formed. For 21 risk.factors, the level of evidence was considered moderate or strong. Based on this literature review and an in-depth analysis, the expert panel developed a model to display the most relevant risk.factors identified, introducing the idea of the “order of importance” and including concepts that are modifiable/nonmodifiable, as well as extrinsic/intrinsic risk.***: This is the qualitative systematic review of studies on risk.factors for MSk.s in the military that has attempted to be all-inclusive. A total of 57 different potential risk.factors were identified, and a new, prioritizing injury model was developed. This model may help us to understand risk.factors that can be addressed, and in which order they should be prioritized when planning intervention strategies within military groups.

关键词： Military Musculosk.letal injuries Risk.factors Prevention Intervention Injury

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