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Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations

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World Journal of Transplantation 2024年第2期14卷 40-47页

作者： Darya m Herscovici Katherine m.cooper Alessandro Colletta michelle Rightmyer Alexandra Shingina Lauren D Feld Department of medicine UMass Chan Medical SchoolWorcesterMA 01655United States Division of Transplant Nutrition UMass Chan Medical SchoolWorcesterMA 01655United States Department of medicine Vanderbilt University Medical CenterNashvilleTN 37215United States Division of Gastroenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Sarcopenic obesity increases the risk of mortality in patients with liver disease awaiting liver transplantation and in the post-transplant *** recommendations for individuals with sarcopenia differ from recommendations for patients with obesity or sarcopenic *** these nutrition guidelines have been established in non-cirrhotic patients,established guidelines for liver transplant candidates with sarcopenic obesity are *** this paper,we review existing literature on sarcopenic obesity in patients with chronic liver disease and address opportunities to improve nutritional counseling in patients awaiting liver transplantation.

关键词： Nutrition Sarcopenia Sarcopenic obesity Liver transplant Cirrhosis Chronic liver disease Body composition myostatin

Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(Am)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and Am methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based Am *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

An electropenetrography waveform library for the probing and ingestion behaviors of Culex tarsalis on human hands

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Insect Science 2024年第4期31卷 1165-1186页

作者： Anastasia m.W.cooper Samuel B.Jameson Victoria Pickens Cameron Osborne Elaine A.Backus Kristopher Silver Dana N.mitzel Department of Entomology Kansas State UniversityManhattanKansasUSA Department of Tropical medicine Tulane University School of Public Health and Tropical MedicineNew OrleansLos AngelesUSA USDA Agricultural Research Service San Joaquin Valley Agricultural Sciences CenterParlierCaliforniaUSA National Bio and Agro-Defense Facility USDA Agricultural Research ServiceManhattanKansasUSA

Culex tarsalis Coquillett(Diptera:Culicidae)mosquitoes are capable of vectoring numerous pathogens affecting public and animal ***,the probing behaviors of mosquitoes are poorly understood because they occur in opaque ***(EPG)has the potential to elucidate these behaviors by recording the electrical signals generated during *** used an AC–DC EPG with variable input resistors(Ri levels)to construct a waveform library for *** feeding on human *** events associated with mosquito probing were used to characterize waveforms at four Ri levels and with two electrical current *** optimal settings for EPG recordings of *** probing on human hands was an Ri level of 10^(7)Ohms using an applied signal of 150 millivolts alternating *** for *** included those previously observed and associated with probing behaviors in Aedes aegypti L.(Diptera:Culicidae):waveform families J(surface salivation),K(stylet penetration through the skin),L(types 1 and 2,search for a blood vessel/ingestion site),m(types 1 and 2,ingestion),N(type 1,an unknown behavior which may be a resting and digestion phase),and W(withdrawal).However,we also observed variations in the waveforms not described in ***,which we named types L3,m3,m4,and *** investigation enhances our understanding of mosquito probing *** also provides a new tool for the automated calculation of peak *** work will facilitate future pathogen acquisition and transmission studies and help identify new pest and disease management targets.

关键词： AC-DC blood feeders electrical penetration graph EPG human hands mosquitoes waveform library

Efficient training of ANN potentials by including atomic forces via Taylor expansion and application to water and a transition-metal oxide

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npj Computational materials 2020年第1期6卷 1205-1218页

作者： April m.cooper Johannes Kästner Alexander Urban Nongnuch Artrith School of Chemistry University of St AndrewsSt AndrewsUK Institute for Theoretical Chemistry University of StuttgartStuttgartGermany Department of Chemical Engineering Columbia UniversityNew YorkNYUSA

Artificial neural network(ANN)potentials enable the efficient large-scale atomistic modeling of complex materials with near firstprinciples *** molecular dynamics simulations,accurate energies and interatomic forces are a prerequisite,but training ANN potentials simultaneously on energies and forces from electronic structure calculations is computationally ***,we introduce an efficient alternative method for the training of ANN potentials on energy and force information,based on an extrapolation of the total energy via a Taylor *** translating the force information to approximate energies,the quadratic scaling with the number of atoms exhibited by conventional force-training methods can be avoided,which enables the training on reference datasets containing complex atomic structures.

关键词： forces enable atomic

Object-Based method Outperforms Per-Pixel method for Land Cover Classification in a Protected Area of the Brazilian Atlantic Rainforest Region

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Pedosphere 2013年第3期23卷 290-297页

作者： T.RITTL m.cooper R.J.HECK m.V.R.BALLESTER Department of Soil Quality University of Wageningen Department of Soil Science University of So Paulo School of Environmental Sciences University of Guelph Center for Nuclear Energy in Agriculture (CENA) University of So Paulo

Conventional image classification based on pixels hinders the possibilities to obtain information contained in images, while modern object-based classification methods increase the acquisition of information about the object and the context in which it is inserted in the image. The objective of this study was to investigate the performance of different classification methods for land cover mapping in the vicinity of the Alto Ribeira Tourist State Park, a Brazilian Atlantic rainforest area. Two classification methods were tested, including i） a hybrid per-pixel classification using the image processing software ERDAS Imagine version 9.1 and ii） an object-based classification using the software eCognition version 5. In the first method, six different classes were established, while in the second method, another two classes were established in addition to the six classes in the first method. Accuracy assessment of the classification results presented showed that the object-based classification with a Kappa index value of 0.8687 outperformed the per-pixel classification with a Kappa index value of 0.2224. Application of the user＇s knowledge during the object-based classification process achieved the desired quality; therefore, the use of inter-relationships between objects, superelasses, subclasses, and neighboring classes were critical to improving the efficiency of land cover classification.

关键词： accuracy assessment image classification Kappa index user's knowledge

Environmental and landscape influences on the spatial and temporal distribution of a cattle herd in a South Texas rangeland

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Ecological Processes 2020年第1期9卷 443-460页

作者： Christopher Cheleuitte-Nieves Humberto L.Perotto-Baldivieso XBen Wu susa. m.cooper Department of Ecosystem Science and management Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present address:Center of Comparative medicine and Pathology Memorial Sloan Kettering Cancer CenterWeill Cornell Medicineand Hospital for Special Surgery408 East 69th StreetZ-913New YorkNY 10021USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&m AgriLife Research 1619 Garner Field RoadUvaldeTX 78801USA

The multiple spatial and temporal parameters affecting cattle herd distribution and activity dynamics can significantly affect resource utilization but are not fully *** aim of this study was to determine whether current animal tracking technology and spatio-temporal analysis tools can be used to integrate multi-scale information on herd distribution patterns as a function of seasonal forage production,periods of the day,animal activity,and landscape *** and activity information of 11 free-ranging cows within a 31-member herd was obtained at 5-min intervals by using GPS collars for 1 year within a 457-ha ranch in the semi-arid rangelands of South *** biomass was calculated with satellite *** analysis of cattle distribution and landscape features was conducted with *** spread was greatest during the growing *** the year,during midday,the herd showed smaller spread and greater use of shade patches than any other time of *** also aggregated under trees in winter,particularly during the *** was no statistically significant overall pattern of seasonal changes in the use of water and supplemental feeding areas,but a trend toward highest use during the ***,significantly different diurnal patterns in the use of supplemental feed and water were observed within each *** study found a strong influence of shade patches relative to the influence of water and supplemental feeding areas on the diurnal and seasonal movement patterns of cattle in shrub-dominated *** this study used only 11 tracked cows in a 31-member herd,the results indicated that techniques such as seasonal and diurnal GPS tracking,GIS,and remote sensing data enable evaluation of multiple spatial and temporal dynamics of cattle distribution and activity *** smaller spread during the dry winter season associated with the observed aggregation of individuals in water and supplemental feeding ar

关键词： Cattle behavior Cross-scale interactions GPS collars Group dispersion Normalized difference vegetation index(NDVI) Thermoregulation Ungulate grazing patterns

Association patterns reveal dispersalaggregation dynamics among cattle in a South Texas Rangeland,USA

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Ecological Processes 2018年第1期7卷 323-332页

作者： Christopher Cheleuitte-Nieves Humberto L.Perotto-Baldivieso X.Ben Wu susa. m.cooper Department of Ecosystem Science and management Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present Address:Center of Comparative medicine and Pathology Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center1300 York Ave.E-703ENew YorkNY 10065USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&m AgriLife Research 1619 Garner Field RoadUvaldeTX 78801USA

Introduction:The spatial association dynamics of free-ranging cattle herds are not fully understood;however,they can have a direct influence on the spatial patterns of resource *** aim of our study was to examine new analytical methods of identifying the spatio-temporal patterns of behavioral dynamics that determine cattle herd dispersal in the semi-arid rangelands of South *** fitted 10 free-ranging cows with global positioning system collars and obtained positions every 5 min for each animal for 21-day trials,twice during the summer and winter *** used an association pattern recognition software(ASSOC1)and the herd center of gravity to identify the spatial and temporal thresholds that defined dispersion-aggregation patterns and individual position to determine their relation to social ***:The association pattern defining herd membership was that animals spent 70%of their time within 200 m of each *** ranking did not appear to influence association membership or position within the *** cattle showed a more dispersed distribution during summer,but in winter,herd members behaved in a more aggregated *** distribution is contrary to patterns described in more northerly and mountainous ***:The spatial thresholds of the cattle herd and the overall distance of all members to the center of the herd were smaller during winter and larger during summer,indicating that this study herd congregated during the winter and dispersed during the *** this study uses a herd of 10 individuals in a 100 ha pasture to evaluate spatio-temporal dynamics,our results provide evidence of the ability of current tracking and spatial association tools to detect and quantify seasonal changes in cattle herd dispersion-aggregation *** use of these data collection and analysis methods could prove useful in larger cattle herds,increase our understanding of herd spatiotemporal behavior,and subsequently he

关键词： Bos taurus Global positioning system(GPS) GPS collar Herd dispersal Social dominance Sub-herd Spatiotemporal pattern of resource use

COVID-19 associated liver injury:A general review with special consideration of pregnancy and obstetric outcomes

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World Journal of Gastroenterology 2022年第42期28卷 6017-6033页

作者： Katherine m.cooper Alessandro Colletta Alison m.Asirwatham Tiffany A.moore Simas Deepika Devuni Department of medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Department of Obstetrics and Gynecology University of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Departments of Pediatrics Psychiatryand Population&Quantitative Health SciencesUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Division of Gastroenterology and Hepatology University of Massachusetts Chan Medical SchoolWorcesterMA 1605United States

Liver injury is an increasingly recognized extra-pulmonary manifestation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** disease 2019(COVID-19)associated liver injury(COVALI)is a clinical syndrome encompassing all patients with biochemical liver injury identified in the setting of SARS-CoV-2 *** profound clinical implications,its pathophysiology is poorly ***,most information on COVALI is derived from the general population and may not be applicable to individuals under-represented in research,including pregnant *** manuscript reviews:Clinical features of COVALI,leading theories of COVALI,and existing literature on COVALI during pregnancy,a topic not widely explored in the ***,we synthesized data from the general and perinatal populations that demonstrates COVALI to be a hepatocellular transaminitis that is likely induced by systemic inflammation and that is strongly associated with disease severity and poorer clinical outcome,and offered perspective on approaching transaminitis in the potentially COVID-19 positive patient in the obstetric setting.

关键词： COVID-19 liver injury Pregnancy Perinatal liver disease Systemic inflammation Special populations

The third cleavage geometry of Xenopus embryos is altered in a hypogeomagnetic field

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The third cleavage geometry of Xenopus embryos is altered in...