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Monoclonal antibody for COVID-19: Unveiling the recipe of a new cocktail

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World Journal of Respirology 2023年第1期12卷 1-9页

作者： Jyoti Bajpai surya kant Ajay Kumar Verma Akshyaya Pradhan Department ofRespiratory Medicine King George’s Medical UniversityLucknow 226003India Department ofCardiology King George’s Medical UniversityLucknow 226003India

The coronavirus disease 2019(COVID-19)pandemic has had a tremendous adverse impact on the global health system,public sector,and social aspects.It is unarguably the worst pandemic of the century.However,COVID-19 management is a mystery in front of us,and an authentic treatment is urgently needed.Various repurposed drugs,like ivermectin,remdesivir,tocilizumab,baricitinib,etc.,have been used to treat COVID-19,but none are promising.Antibody therapy and their combinations are emerging modalities for treating moderate COVID-19,and they have shown the potential to reduce hospitalisations.One antibody monotherapy,bamlanivimab,and two cocktails,casirivimab/imdevimab and bamlanivimab/esterivimab,have received authorization for emergency use by the United States Food and Drug Administration for the treatment of mild COVID-19 in high risk individuals.The European Emergency has made similar recommendations for use of the drug in COVID-19 patients without oxygen therapy.This brief review will focus on monoclonal antibodies and their combination cocktail therapy in managing COVID-19 infection.

关键词： SARS-CoV-2 Mild COVID-19 Antibodies Risk factors

Molecular Profiling of Drug Resistant Isolates of <i>Mycobacterium tuberculosis</i>in North India

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Advances in Microbiology 2012年第3期2卷 317-326页

作者： Dinesh K. Tripath Kanchan Srivastava surya kant Kishore K. Srivastava Department of Microbiology Central Drug Research Institute Lucknow India Department of Pulmonary Medicine CSMMU Lucknow India

Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem because treatment is complicated, cure rates are well below those for drug susceptible tuberculosis (TB), and patients may remain infectious for months or years despite receiving the best available therapy. To gain a better understanding of MDR-TB, we characterized isolates recovered from 69 patients with MDR-TB, by use of IS6110 restriction fragment-length polymorphism (RFLP) analysis;spacer oligonucleotide genotyping (i.e. spoligotyping). Clinical isolates from patients with tuberculosis have been considered to contain clonally expanded Mycobacterium tuberculosis (MTB) strain. Over the years, the identification method based on IS6110 insertion sequences has been established as the standard for typing strains of MTB. IS6110 RFLP fingerprinting is very convincing when it is applied to classify MTB isolates harboring a large number of IS6110 in their chromosomes. Therefore, in the present study we have characterized the isolates from the patients suffering from MDR TB, on the basis of conserved Variable Number Tandem Repeats (VNTR), Direct Repeats (DR) and Insertion Sequences (IS) IS6110 elements. The polymorphic data showed significant level of dissimilarities among all the MDR isolates of MTB. Comparative studies with the DR and VNTR data substantiate that polymorphism occur among MDR-TB cases as shown by the number of repeats present in different clinical isolates.

关键词： Mycobacterium Drug Resistance IS6110 Polymorphism

Effectiveness of lukewarm water compress on reduction of breast pain and breast engorgement among post-cesarean section mothers

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中西医结合护理杂志(英文) 2023年第3期5卷 167-172页

作者： Soni CHAUHAN Kumari NUTAN Monica AGRAWAL surya kant TIWARI Nursing Tutor Yatharth Nursing College and Paramedical InstituteChandauliUttar PradeshIndia Institute of Nursing King George’s Medical UniversityLucknowUttar PradeshIndia Professor Cum Vice-Principal M.V.P.Samaj’s Institute of Nursing EducationNashikMaharashtraIndia Department of Obstetrics and Gynecology King George’s Medical UniversityLucknowUttar PradeshIndia

Objective:The study aimed to assess the effectiveness of lukewarm water compress on breast pain and breast engorgement among post-cesarean primiparous mothers.Materials and Methods:This quasi-experimental posttest-only design was conducted with 60 post-cesarean section primiparous mothers between October 2018 and January 2019.A simple random sampling technique was used to allocate 30 participants to both experimental and control groups.The experimental group received lukewarm water compress using a sponge cloth for 20 min twice a day on the second,third,and fourth postnatal days.The control group received routine hospital care.Breast pain and engorgement were assessed using the Visual Analog Pain Scale and Breast Engorgement Assessment Scale on the third,fourth,and fifth postnatal days.Results:Significant differences were observed between the experimental and control groups on day 1 and day 3 in terms of breast pain and engorgement scores among post-cesarean section mothers(P0.05).Conclusion:Lukewarm water compress is effective in reducing breast pain and engorgement in post-cesarean primiparous mothers.Future research can include randomized controlled trials to evaluate the effectiveness of different therapies in treating breast pain and engorgement.

关键词： Effectiveness lukewarm water compress post-cesarean section postnatal posttest only primiparous

Prevalence and predictors of smartphone addiction and insomnia among nurses working in the outpatient department after the second wave of the coronavirus disease 2019 pandemic

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Journal of Integrative Nursing 2023年第4期5卷 273-279页

作者： Manisha MEHRA Poonam JOSHI surya kant TIWARI Praveen AGGRAWAL Kamlesh CHANDELIA Srinithya RAGHAVAN Department of Nursing Services All India Institute of Medical SciencesNew DelhiIndia College of Nursing All India Institute of Medical SciencesKalyaniWest BengalIndia College of Nursing All India Institute of Medical SciencesRaebareliUttar PradeshIndia Department of Emergency Medicine All India Institute of Medical SciencesNew DelhiIndia Department of In-Service Education All India Institute of Medical SciencesNew DelhiIndia

Objectives:The present study aims to assess the prevalence and predictors of smartphone addiction and insomnia among nurses working in the outpatient department(OPD)after the second wave of the coronavirus disease 2019(COVID-19)pandemic.Materials and Methods:A descriptive,cross-sectional study was carried out among 117 OPD nurses between October and December 2021 using a purposive sampling technique.Two self-reported standardized scales,the Smartphone Addiction Scale-ShortVersion and Insomnia Severity Index were used.Kolmogorov–Smirnov test,Mann–Whitney U,and Kruskal–Wallis Htest were used.Pearson’s correlation and Scatter plot were used to determine the relationship between the study variables.A stepwise multiple linear regression analysis was also performed.Results:The majority of participants had slight smartphone addiction(78.6%)and suffered from sub-threshold to severe forms of insomnia(73.5%).A significant mild positive correlation was found between smartphone addiction and insomnia(r=0.195,P<0.05).Stepwise multivariate logistic regression analysis predicted factors such as female gender and exposure to smartphones for more than 5 years influencing smartphone addiction.A strong influence of exposure to the smartphone for more than 5 years was found on insomnia severity.Conclusion:Smartphone addiction and insomnia were identified problems among nurses working in the OPD after the second wave of the COVID-19 pandemic,requiring an urgent need to identify and manage various factors responsible for smartphone addiction and insomnia such as female gender and years of exposure to smartphones.

关键词： Coronavirus disease 2019 insomnia nurses sleeping disturbances smartphone addiction

Assessment of Phytochemical, Antioxidant and Antimicrobial Activities of Some Medicinal Plants from Kaski District of Nepal

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American Journal of Plant Sciences 2020年第9期11卷 1383-1397页

作者： Lekha Nath Khanal Khaga Raj Sharma Yuba Raj Pokharel surya kant Kalauni Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal Faculty of Life Science and Biotechnology South Asian University New Delhi India

Medicinal plants have been known to treat simple to life-threatening diseases in different communities of Nepal for many years. This study aims to analyze the phytochemicals as plant secondary metabolites, evaluate the antioxidant and antibacterial activities of Rubus ellipticus, Ziziphus mauritiana, Pyrus pashia, and Drynaria coronans extracts that are commonly being used as traditional medicine. Phytochemical analysis was performed to investigate the plant’s secondary metabolites such as polyphenols, alkaloids, flavonoids, terpenoids, reducing sugar, glycosides, tannins, carotene, phytosterols, coumarins, saponins, and anthracenes. The methanol extracts of the plants were used to evaluate the in vitro antioxidant activity by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical and the antibacterial activity against Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 700603), Escherichia

关键词： Medicinal Plant Phytochemical Antioxidant Antibacterial Activity Resazurin