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Weibull Probability Model for Fracture Strength of Aluminium (1101)-Alumina Particle Reinforced Metal Matrix Composite

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Journal of Materials Science & Technology 2009年第3期25卷 341-343页

作者： A. suresh babu V. Jayabalan Department of Manufacturing Engineering Anna University

In recent times, conventional materials are replaced by metal matrix composites （MMCs） due to their high specific strength and modulus. Strength reliability, one of the key factors restricting wider use of composite materials in various applications, is commonly characterized by Weibull strength distribution function. In the present work, statistical analysis of the strength data of 15% volume alumina particle （mean size 15 um） reinforced in aluminum alloy （1101 grade alloy） fabricated by stir casting method was carried out using Weibull probability model. Twelve tension tests were performed according to ASTM B577 standards and the test data, the corresponding Weibull distribution was obtained. Finally the reliability of the composite behavior in terms of its fracture strength was presented to ensure the reliability of composites for suitable applications. An important implication of the present study is that the Weibull distribution describes the experimentally measured strength data more appropriately.

关键词： Weibull distribution Fracture strength Metal matrix composite

Improved Monarchy Butterfly Optimization Algorithm (IMBO): Intrusion Detection Using Mapreduce Framework Based Optimized ANU-Net

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Computers, Materials & Continua 2023年第6期75卷 5887-5909页

作者： Kunda suresh babu Yamarthi Narasimha Rao School of Computer Science and Engineering VIT-AP UniversityAmaravathi522237Andhra PradeshIndia

The demand for cybersecurity is rising recently due to the rapid improvement of network *** a primary defense mechanism,an intrusion detection system(IDS)was anticipated to adapt and secure com-puting infrastructures from the constantly evolving,sophisticated threat ***,various deep learning methods have been put forth;however,these methods struggle to recognize all forms of assaults,especially infrequent attacks,because of network traffic imbalances and a shortage of aberrant traffic samples for model *** work introduces deep learning(DL)based Attention based Nested U-Net(ANU-Net)for intrusion detection to address these issues and enhance detection *** this IDS model,the first data preprocessing is carried out in three stages:duplication elimi-nation,label transformation,and data *** the features are extracted and selected based on the Improved Flower Pollination Algorithm(IFPA).The Improved Monarchy Butterfly Optimization Algorithm(IMBO),a new metaheuristic,is used to modify the hyper-parameters in ANU-Net,effectively increasing the learning rate for spatial-temporal information and resolving the imbalance *** the use of parallel programming,the MapReduce architecture reduces computation complexity while signifi-cantly accelerating *** publicly available data sets were used to evaluate and test the *** investigational outcomes suggest that the proposed technique can more efficiently boost the performances of IDS under the scenario of unbalanced *** proposed method achieves above 98%accuracy and classifies various attacks significantly well compared to other classifiers.

关键词： Intrusion detection system(IDS) attention based nested U-Net

Gelatin and lipidoid integrate to create gelasomes to enhance siRNA delivery with low toxicity

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Bioactive Materials 2024年第10期40卷 557-570页

作者： Abilash Gangula Dhananjay suresh Agasthya suresh babu Zhaohui Li Anandhi Upendran Raghuraman Kannan Department of Radiology University of MissouriColumbi1MO65212USA Department of Bioengineering University of MissouriColumbi1MO65212USA Department of Medical Pharmacology and Physiology University of MissouriColumbi1MO65212USA Ellis Fischel Cancer Center University of MissouriColumbi1MO65212USA

RNAi therapeutics possess the potential to cure many uncurable human *** instance,RNAi therapeutics using liposomes showed remarkable survival benefits in patients with liver ***,the extension of liposomes to deliver RNA to cure other ailments has largely been ***,researchers are focusing on designing and testing different combinations of materials for versatile RNA delivery ***,an efficient and safe RNA delivery platform has not been *** this work,we have developed a new class of RNA-delivery vehicle called“Gelasomes,”using an incongruous combination of gelatin and lipidoid to exploit each material’s unique properties while overcoming their inherent *** low in vivo toxicity of Gelasomes is attributed to the exterior gelatin layers that shield the exposure of cationic lipidoid-siRNA clusters and yet present a biocompatible ***,toxicity studies in mice indicate that repeated administration of Gelasomes(up to 48 mg/kg BW)is well-tolerated with no notable changes in body weight,hematology,or serum ***,the gelatin outer layer efficiently protects siRNA from serum degradation(48 h),preserving its functionality beyond two months of ***,Gelasomes possess dual siRNA conjugation modes,i.e.,electrostatic binding with lipidoid core and covalent attachment to gelatin *** bivalency coupled with lipidoids’high transfection efficiency rendered Gelasomes with remarkably high gene silencing efficiency(>90%)at very low treatment doses in vitro(40μg/mL).In vivo studies further confirmed the high gene silencing ability of Gelasomes in non-small cell lung tumor mouse *** new platform is tunable on all fronts:size,degree of surface coating,and biomolecule *** the lipidoid C14-tail to a C8-tail yielded Gelasomes of reduced *** lipidoids with different carbon lengths are synthesizable,we can develop a library of Gelasomes with d

关键词： doses integrate render

A systematic review of climate change impacts,adaptation strategies,and policy development in West Africa

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Regional Sustainability 2024年第2期5卷 13-25页

作者： Camillus Abawiera WONGNAA Alex Amoah SEYRAM suresh babu Department of Agricultural Economics Agribusiness and ExtensionKwame Nkrumah University of Science and TechnologyKumasi00233Ghana International Food Policy Research Institute Washington20005USA

Climate change studies are diverse with no single study giving a comprehensive review of climate change impacts,adaptation strategies,and policy development in West *** unavailability of an all-inclusive study to serve as a guide for practitioners affects the effectiveness of climate change adaptation strategies proposed and adopted in the West African *** purpose of this study was to review the impacts of climate change risks on the crop,fishery,and livestock sectors,as well as the climate change adaptation strategies and climate-related policies aimed at helping to build resilient agricultural production systems in West *** review process followed a series of rigorous stages until the final selection of 56 articles published from 2009 to ***,the results highlighted the adverse effects of climate change risks on food *** found a continuous decline in food crop ***,the livestock sector experienced morbidity and mortality,as well as reduction in meat and milk *** fishery sector recorded loss of fingerlings,reduction in fish stocks,and destruction of mariculture and *** West Africa,climate-smart agriculture technologies,physical protection of fishing,and inclusion of gender perspectives in programs appear to be the major adaptation *** study therefore recommends the inclusion of ecosystem and biodiversity restoration,weather insurance,replacement of unsafe vessels,and strengthening gender equality in all climate change mitigation programs,as these will help to secure enough food for present and future generations.

关键词： Climate change Climate extreme events Food security Adaptation strategies Climate-smart agriculture West Africa

Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MS^e

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Journal of Pharmaceutical Analysis 2019年第6期9卷 414-422页

作者： Kumar Katragunta Bandi Siva Niharika Kondepudi PRRao Vadaparthi Nadendla Rama Rao Ashok Kumar Tiwari Katragadda suresh babu Centre for Natural Products and Traditional Knowledge CSIR-Indian Institute of Chemical TechnologyHyderabad500007India Chalapathi Institute of Pharmaceutical Sciences LamGuntur522034India College of Pharmaceutical Sciences Acharya Nagarjuna UniversityNagarjuna NagarGuntur522510India

Boswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quanti cation of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto-boswellic acid(2),-b Boswellic acid(3),-Boswellic acid(4),3-O-Acetyl--boswellic acid(5)and 3-O-Acetyl--boswellic acid b(6)in commercial herbal products containing *** as an *** UPLCbwith Q-Tof-MS/MS makes the better identi cation of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quanti cation of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituenBoswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quantification of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto b-boswellic acid(2),ɑ-Boswellic acid(3),b-Boswellic acid(4),3-O-Acetyl-ɑ-boswellic acid(5)and 3-O-Acetyl-b-boswellic acid(6)in commercial herbal products containing *** as an *** UPLC with Q-Tof-MS/MS makes the better identification of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quantification of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituents were identified and characterized with the help of LC-Q-Tof-MS/MS fragmentation data and various isoforms of boswellic acids and tirucallic acids in *** oleo-gum-resin extract were *** were identi ed and characterized with the help of LC-Q-Tof-MS/MS

关键词： Boswellia serrata Herbal formulations Quantification UPLC-Q-tof-MSe Boswellic acids Tirucallic acids

Development and validation of a stability-indicating RP–HPLC method for estimation of atazanavir sulfate in bulk

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Journal of Pharmaceutical Analysis 2017年第2期7卷 134-140页

作者： S.Dey S.Subhasis Patro N.suresh babu P.N.Murthy S.K.Panda Dr.B.C.Roy College of Pharmacy&Allied Health Sciences Meghnad Saha SaraniBidhannagarDurgapur713206West BengalIndia Royal College of Pharmacy and Health Sciences Dist.-GanjamBerhampur 760002OrissaIndia

A stability-indicating reverse phase–high performance liquid chromatography（RP–HPLC） method was developed and validated for the determination of atazanavir sulfate in tablet dosage forms using C_（18） column Phenomenix（250 mm×4.6 mm, 5 μm） with a mobile phase consisting of 900 mL of HPLC grade methanol and100 mL of water of HPLC grade. The pH was adjusted to 3.55 with acetic acid. The mobile phase was sonicated for 10 min and filtered through a 0.45 μm membrane filter at a flow rate of 0.5 mL/min. The detection was carried out at 249 nm and retention time of atazanavir sulfate was found to be 8.323 min. Linearity was observed from 10 to 90 μg/mL（coefficient of determination R^2 was 0.999） with equation, y=23.427x＋*** sulfate was subjected to stress conditions including acidic, alkaline, oxidation, photolysis and thermal degradation, and the results showed that it was more sensitive towards acidic degradation. The method was validated as per ICH guidelines.

关键词： Atazanavir sulfate RP–HPLC Isocratic elution Validation Stability indicating

LC–HRMS determination of piperine on rat dried blood spots: A pharmacokinetic study

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Journal of Pharmaceutical Analysis 2016年第1期6卷 18-23页

作者： Bokka Ramesh P. Rajesh Rao Vadaparthi Genji Sukumar Nemali Manjula Katragadda suresh babu Potturi Sita Devi Natural Products Chemistry Division Indian Institute of Chemical Technology Tarnaka Hyderabad 500607 India

A liquid chromatography-high resolution mass spectrometry （LC-HRMS） method was developed and validated for the determination of piperine （PPR） on dried blood spots （DBS）. DBS samples were prepared by spiking the whole blood with analyte to produce 30 μL of blood spots on specimen collection cards. Chromatographic separation was achieved on an Atlantis dC18 column using acetonitrile and water （0.1% formic acid）（85：15, v/v） as mobile phase in an isocratic mode of elution at a flow rate of 0.75 mL/min. MS detection was carried out in electrospray positive ion mode for the target ions and monitored at m/z 286.1465 for PPR and 272.1303 for the internal standard （IS）. The developed method exhibited a linear dynamic range over 0.01-2000 ng/mL for PPR on DBS. The overall extraction recovery of PPR from DBS was 92.5%. Influence of hematocrit and spot volume on DBS was also evaluated and found to be well within the acceptable limits. The method was successfully applied to pharmacokinetic studies of PPR in rats.

关键词： Dried blood spot LC-HRMS Piperine Pharmacokinetics Trichostachine

Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway

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Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 337-345页

作者： VGM.Naidu Bandari Uma Mahesh Ashwini Kumar Giddam Kuppan Rajendran Dinesh babu Jian Ding K suresh babu B Ramesh Rajeswara Rao Pragada Gopalakrishnakone P Venom & Toxin Research Programme Department of AnatomyYong Loo Lin School of Medicine4 Medical DriveNational University of SingaporeSingapore-117597 Currently affiliated to Department of Pharmacology & Toxicology National Institute of Pharmaceutical Education & Research(NIPER)BalanagarHyderabadA.PIndia-500037 Department of pharmacology A.U.College of pharmaceutical SciencesAndhra universityVishakhapatnamAndhra PradeshIndia-530003 Natural Products Laboratory Indian Institute of Chemical TechnologyUppal RoadHyderabad 500 607India

Objective:To evaluate the anti-proliferative and apoptogenic activity of ethyl acetate extract from the leaves of Memecylon edule(EtAc-LME) in MKN-74,NUGC gastric cancer cells and non cancerous gastric mucous cells(GES-1),and to explore the mechanism of EtAc-LME induced ***:The mechanism of EtAc-LME induced apoptosis was explored by analysing the activation of pro-caspases,PARP cleavage,expression of cytochrome-c (Cyt-c) was determined by western blotting,mRNA expression of Bcl-2,Bax by RT-PCR,loss of mitochondrial potential using DiOC6 dye,annexin binding assay and its influence on cell cycle arrest by flow ***:The results indicated that EtAc-LME inhibited the gastric cancer cell growth in dose-dependent manner and cytotoxicity was more towards the gastric cancer cells(NUCC and MKN-74) compared to normal gastric cells(GES-1),suggesting more specific cytotoxicity to the malignant *** expression of Cyt-c and subsequent activation of caspases-3 and down regulation of Bcl-2 and loss in mitochondrial potential in EtAc-LME treated MKN-74 and NUGC cells suggested that EtAc-LME induced apoptosis by mitochondrial dependent ***:The present findings suggest that ethyl acetate extract of Memecylon edule induces apoptosis selectively in gastric cancer cells emphasizing the importance of this traditional medicine for its potential in the treatment of gastric cancer.

关键词： Memecylon edule Anti-cancer Gastric cancer Apoptosis

Studies on composite solid propellant with tri-modal ammonium perchlorate containing an ultrafine fraction

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Defence Technology（防务技术） 2017年第4期13卷 239-245页

作者： K.V. suresh babu P. Kanaka Raju C.R. Thomas A. Syed Hamed K.N. Ninan Solid Propellant Space Booster Plant Satish Dhawan Space Centre Sriharikota 524124 India Rocket Propellant Plant Vikram Sarabhai Space Centre Thiruvananthapuram 695 022 India Department of Chemistry Indian Institute of Space Science and Technology Thiruvananthapuram 695 547 India

Composite solid propellant is prepared using tri-modal Ammonium perchlorate(AP)containing coarse,fine and ultrafine fractions of AP with average particle size(APS)340,40 and 5 mm respectively,in various compositions and their rheological,mechanical and burn rate characteristics are *** optimum combination of AP coarse to fine to ultrafine weight fraction was obtained by testing of series of propellant samples by varying the AP fractions at fixed solid *** concentration of aluminium was maintained constant throughout the experiments for ballistics *** propellant formulation prepared using AP with coarse to fine to ultrafine ratio of 67:24:9 has lowest viscosity for the propellant paste and highest tensile strength due to dense packing as supported by the literature.A minimum modulus value was also observed at 9 wt.%of ultrafine AP concentration indicates the maximum solids packing density at this ratio of AP *** burn rate is evaluated at different pressures to obtain pressure *** of ultrafine fraction of AP in propellant increased burn rate without adversely affecting the pressure *** solid loading propellants are prepared by increased AP concentration from 67 to 71 wt.%using AP with coarse to fine to ultrafine ratio of67:24:*** solid content up to 89 wt.%was achieved and hence increased solid motor *** unloading viscosity showed a trend with increased AP content and the propellant couldn't able to cast beyond 71 wt.%of *** properties were also studied and from the experiments noticed that%elongation decreased with increased AP content from 67 to 71 wt.%,whereas tensile strength and modulus *** rate increased with increased AP content and observed that pressure exponent also increased and it is high for the propellant containing with 71 wt.%of AP due to increased oxidiser to fuel *** composite solid propellant is prepared by using burn rate modifie

关键词： Ammonium perchlorate Composite propellant Burn rate Copper chromite Iron oxide