Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MS^e

作     者：Kumar Katragunta Bandi Siva Niharika Kondepudi PRRao Vadaparthi Nadendla Rama Rao Ashok Kumar Tiwari Katragadda Suresh Babu 

作者机构：Centre for Natural Products and Traditional KnowledgeCSIR-Indian Institute of Chemical TechnologyHyderabad500007India Chalapathi Institute of Pharmaceutical SciencesLamGuntur522034India College of Pharmaceutical SciencesAcharya Nagarjuna UniversityNagarjuna NagarGuntur522510India 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2019年第9卷第6期

页      面：414-422页

核心收录：

学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 0817[工学-化学工程与技术] 0703[理学-化学] 0702[理学-物理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Dr.S.Chandrasekhar,Director,CSIR-IICT,for the financial grant under MLP-0030 CSIR for financial support(IICT Communication No.IICT/Pubs/2018/183gs5) 

主　　题：Boswellia serrata Herbal formulations Quantification UPLC-Q-tof-MSe Boswellic acids Tirucallic acids 

摘      要：Boswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quanti cation of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto-boswellic acid(2),-b Boswellic acid(3),-Boswellic acid(4),3-O-Acetyl--boswellic acid(5)and 3-O-Acetyl--boswellic acid b(6)in commercial herbal products containing *** as an *** UPLCbwith Q-Tof-MS/MS makes the better identi cation of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quanti cation of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituenBoswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quantification of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto b-boswellic acid(2),ɑ-Boswellic acid(3),b-Boswellic acid(4),3-O-Acetyl-ɑ-boswellic acid(5)and 3-O-Acetyl-b-boswellic acid(6)in commercial herbal products containing *** as an *** UPLC with Q-Tof-MS/MS makes the better identification of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quantification of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituents were identified and characterized with the help of LC-Q-Tof-MS/MS fragmentation data and various isoforms of boswellic acids and tirucallic acids in *** oleo-gum-resin extract were *** were identi ed and characterized with the help of LC-Q-Tof-MS/MS