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Tungstophosphoric acid catalyzed synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinoline analogs

Chinese Chemical Letters 2013年第10期24卷 941-944页

作者： Ratchanok Pingaew supaluk prachayasittikul Somsak Ruchirawat Virapong prachayasittikul Department of Chemistry Faculty of ScienceSrinakharinwirot University Center of Data Mining and Biomedical Informatics Faculty of Medical TechnologyMahidol University Chulabhorn Research Institute Chulabhorn Graduate Institute and Center of Excellence on Environmental Health and Toxicology (EHT) Department of Clinical Microbiology and Applied Technology Faculty of Medical TechnologyMahidol University

An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl- 1,2,3,4-tetrahydroisoquinolines 3 using the modified Pictet-Spengler reaction of N-sulfonylphenylethy- lamines 1 an... 详细信息

关键词： Pictet-Spengler reaction Isoquinoline Heteropoly acid Sulfonamide

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Neuroprotective effect of Spilanthes acmella Murr. on pesticide-induced neuronal cells death

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 35-41页

作者： Wilasinee Suwanjang Bongkot Khongniam Sujittra Srisung supaluk prachayasittikul Virapong prachayasittikul Center for Research and Innovation Faculty of Medical TechnologyMahidol University Department of Chemistry Faculty of ScienceSrinakharinwirot University Center of Data Mining and Biomedical Informatics Faculty of Medical TechnologyMahidol University Department of Clinical Microbiology and Applied Technology Faculty of Medical TechnologyMahidol University

Objective: To investigate protective effects of Spilanthes acmella(S,acmella) Murr,extracts against pesticide-induced neuronal cells death and to elucidate the underlying molecular mechanism in dopaminergic(SH-SY5Y) cells lines,Methods: Cell viability of SH-SY5 Y cells was studied by treating the cells with various concentration of pirimicarb for 24 hr,Neuroprotective effect of S,acmella Murr,extracts was investigated by adding the plant extracts to the medium for 24 hr prior to the incubation with 100 μM H_2O_2 or with pirimicarb for 24 hr,Control-untreated cells were incubated with the culture medium,Cell viability was measured by MTT assay,calpain and calpastatin expressions were analyzed by Western blotting and immunocytochemistry,Results: Pretreatment of SH-SY5 Y cells with S,acmella Murr,extracts(1 μg/m L) for 24 hr significantly increased the dopaminergic neurons in pirimicarb-induced neurotoxicity,In addition,pretreatment with the S,acmella Murr,extracts led to decreased calpain but increased calpastatin protein levels,Conclusion: S,acmella Murr,extracts exerted neuroprotective effect,via an alteration of calcium homeostasis,against pirimicarb induced neurotoxicity,The S,acmella Murr,might be a potential natural candidate with neuroprotective activity.

关键词： Spilanthes acmella Murr. Pirimicarb Pesticide Neuronal cell Calpain Calpastatin

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Attenuation of oxidative stress-induced neuronal cell death by Hydnophytum formicar-um Jack.

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Asian Pacific Journal of Tropical Medicine 2018年第7期11卷 415-422页

作者： Naw Hser Gay Kamonrat Phopin Wilasinee Suwanjang Waralee Ruankham Prapimpun Wongchitrat supaluk prachayasittikul Virapong prachayasittikul Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Department of Medical Laboratory Technology University of Medical TechnologyYangon Center for Research and Innovation Faculty of Medical Technology Mahidol University Center of Data Mining and Biomedical Informatics Faculty of Medical Technology Mahidol University

Objective: To investigate protective effects of Hydnophytum formicarum Jack.(H. formicarum) extracts via regulation of SIRT1-FOXO3a-ADAM10 signaling and antioxidant activity against H_2O_2-induced neurotoxicity in neuroblastoma SH-SY5Y cells. Methods: Cell viability and apoptosis of neuronal cells pretreated with H. formicarum Jack. extracts under oxidative stress were determined by MTT assay and flow cytometry. The intracellular reactive oxygen species(ROS) was performed using Carboxy-DCFDA assay. Additionally, a profile of protein expressions related to neuroprotection was detected by western blot analysis. Results: The plant extracts(methanol and ethyl acetate) elicited protective effects on the neuronal cell death as performed by the MTT assay and by apoptosis analysis via the activation of BCL-2. Both ethyl acetate and methanol extracts exerted inhibitory effects against H_2O_2-induced ROS generation in the SH-SY5Y cells. Furthermore, the possible mechanism of neuroprotection of H. formicarum Jack. was observed through its antioxidant properties by maintaining the levels of catalase and SOD2 proteins as well as activating SIRT1-FOXO3a pathway. Importantly, pretreatment of neuronal cells with H. formicarum Jack. significantly recovered the levels of ADAM10 protein compared with the H_2O_2 treatment alone. Conclusions: The recent findings suggest the protective effects of H. formicarum Jack. plant extracts on attenuating H_2O_2-induced neurotoxicity in human SH-SY5Y cells.

关键词： Hydnophytum formicarum Jack. Antioxidant enzymes SIRT1 ADAM10 Neuroprotection

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