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Challenges and opportunities in the treatment of ulcerative colitis

World Journal of Pharmacology 2015年第2期4卷 219-226页

作者： sunil ashokrao nirmal sunil Shivaji Gangurde Pratiksha Shankar Dumbre Subodh Chandra Pal Subhash Chandra Mandal Department of Pharmacognosy Pravara Rural College of Pharmacy Biotechnology Centre Post Graduate InstituteDr. PDKVMaharashtra 413736India Sarswati Vidyabhavan College of Pharmacy Department of Pharmacognosy NDMVP’s College of Pharmacy Pharmacognosy and Phytotherapy Research Laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur University

Ulcerative colitis(UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Many synthetic drugs are available for the treatment of UC like 5-aminosalicylic acid, oral or systemic corticosteroids, immunomodulator, etc. but these drugs are associated with many serious side effects after long term use or have certain disadvantage or not suitable for the use in some patients. In short synthetic drugs have many disadvantages and for this reason effective and safe alternative drug treatment for the UC is the challenge. Herbal drugs are found to be very promising results of the treatment of UC and enzymatic level. Researchers explored many herbal drugs for the treatment and even many more may found effective in the treatment of UC. At this point we feel herbal medicine is the better alternative for the treatment of UC.

关键词：溃疡性结肠炎直肠治疗方法临床分析

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Amaranthus roxburghianus root extract in combination with piperine as a potential treatment of ulcerative colitis in mice

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Journal of Integrative Medicine 2013年第3期11卷 206-212页

作者： sunil A.nirmal Jayashri M.Ingale Shashikant R.Pattan Sanjay B.Bhawar Department of Pharmacognosy Pravara Rural College of PharmacyLoni 413736MaharashtraIndia Department of Pharmaceutical Chemistry Pravara Rural College of PharmacyLoni 413736MaharashtraIndia Department of Pharmacology Pravara Rural College of PharmacyLoni 413736MaharashtraIndia

OBJECTIVE： The present work was undertaken to determine the effects of Amaranthus roxburghianus Nevski. （Amaranthaceae） root alone and in combination with piperine in treating ulcerative colitis （UC） in mice. METHODS： Swiss albino mice were divided into seven groups （n = 6）. Standard group received prednisolone （5 mg/kg, intraperitoneally）. Treatment groups received hydroalcoholic extract of roots of A. roxburghianus （50 and 100 mg/kg, per oral） and a combination of hydroalcoholic extract of roots of A. roxburghianus （50 and 100 mg/kg, per oral） and piperine （5 mg/kg, per oral）. Ulcer index, colitis severity, myeloperoxidase （MPO）, malondialdehyde and glutathione were estimated from blood and tissue. Column chromatography of the extract was done and purified fractions were analyzed by gas chromatography-mass spectroscopy （GC-MS）. RESULTS： Treatment with the combination of hydroalcoholic extract of A. roxburghianus and piperine showed minimal ulceration, hemorrhage, necrosis and leucocyte infiltration by histopathological observation. Acetic acid increased MPO levels in blood and colon tissue to 355 U/mL and 385 U/mg, respectively. The combination of hydroalcoholic extract of A. roxburghianus （100 mg/kg） and piperine （5 mg/kg） significantly decreased MPO in blood and tissue to 182 U/mL and 193 U/mg, respectively （P 〈 0.05）. Similarly, this combination significantly reduced malondialdehyde levels and increased glutathione levels in blood and tissue. Various phytoconstituents were detected by GC-MS. CONCLUSION： The combination of hydroalcoholic extract of A. roxburghianus and piperine is effective in the treatment of UC and the effects are comparable with the standard drug prednisolone. 4H-pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl, eugenol and benzene, and 1-（1,5-dimethyl-4-hexenyl）-4-methyl are reported having analgesic, anti-inflammatory, and antioxidant properties; they may play a role in the biological activity of A. roxburghianus root.

关键词： Amaranthus plant extracts ulcerative colitis myeloperoxidase malondialdehyde glutathione mice

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